Yunfeng Feng

Summary

Affiliation: Washington University
Location: St. Louis, USA

Publications

  1. pmc LIM protein Ajuba functions as a nuclear receptor corepressor and negatively regulates retinoic acid signaling
    Zhaoyuan Hou
    The Wistar Institute, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 107:2938-43. 2010
  2. pmc Ajuba LIM proteins are negative regulators of the Hippo signaling pathway
    Meghna Das Thakur
    Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Curr Biol 20:657-62. 2010
  3. pmc Prediction of sphingosine 1-phosphate-stimulated endothelial cell migration rates using biochemical measurements
    Shannon K Alford
    Department of Biomedical Engineering, Washington University in St Louis, Campus Box 1097, One Brookings Dr, St Louis, MO 61130, USA
    Ann Biomed Eng 38:2775-90. 2010
  4. pmc A distinctive role for focal adhesion proteins in three-dimensional cell motility
    Stephanie I Fraley
    Department of Chemical and Biomolecular Engineering, The Johns Hopkins University, Baltimore, Maryland 21218, USA
    Nat Cell Biol 12:598-604. 2010
  5. pmc LIM-domain proteins, LIMD1, Ajuba, and WTIP are required for microRNA-mediated gene silencing
    Victoria James
    School of Biomedical Sciences, University of Nottingham Medical School, Queen s Medical Centre, Nottingham NG7 2UH, United Kingdom
    Proc Natl Acad Sci U S A 107:12499-504. 2010
  6. doi request reprint Regulation of U6 promoter activity by transcriptional interference in viral vector-based RNAi
    Linghu Nie
    Key Laboratory of Genome Sciences and Information, Cancer Biology and Genetics Group, Beijing Institute of Genomics, Chinese Acadamy of Sciences, Beijing 100029, China
    Genomics Proteomics Bioinformatics 8:170-9. 2010
  7. doi request reprint A multifunctional lentiviral-based gene knockdown with concurrent rescue that controls for off-target effects of RNAi
    Yunfeng Feng
    Department of Medicine, Washington University, St Louis, MO 63110, USA
    Genomics Proteomics Bioinformatics 8:238-45. 2010
  8. pmc LIS1 regulates osteoclast formation and function through its interactions with dynein/dynactin and Plekhm1
    Shiqiao Ye
    Center for Osteoporosis and Metabolic Bone Diseases, Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Arkansas for Medical Sciences and the Central Arkansas Veterans Healthcare System, Little Rock, Arkansas, United States of America
    PLoS ONE 6:e27285. 2011
  9. doi request reprint The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity
    Daniel E Foxler
    School of Biomedical Sciences, University of Nottingham, Queen s Medical Centre, NG7 2UH, UK
    Nat Cell Biol 14:201-8. 2012
  10. pmc Curcumin inhibits gene expression of receptor for advanced glycation end-products (RAGE) in hepatic stellate cells in vitro by elevating PPARγ activity and attenuating oxidative stress
    Jianguo Lin
    Department of Pathology, School of Medicine, Saint Louis University, St Louis, MO 63104, USA
    Br J Pharmacol 166:2212-27. 2012

Collaborators

Detail Information

Publications29

  1. pmc LIM protein Ajuba functions as a nuclear receptor corepressor and negatively regulates retinoic acid signaling
    Zhaoyuan Hou
    The Wistar Institute, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 107:2938-43. 2010
    ....
  2. pmc Ajuba LIM proteins are negative regulators of the Hippo signaling pathway
    Meghna Das Thakur
    Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Curr Biol 20:657-62. 2010
    ..This work describes a novel role for the Ajuba LIM proteins as negative regulators of the Hippo signaling pathway...
  3. pmc Prediction of sphingosine 1-phosphate-stimulated endothelial cell migration rates using biochemical measurements
    Shannon K Alford
    Department of Biomedical Engineering, Washington University in St Louis, Campus Box 1097, One Brookings Dr, St Louis, MO 61130, USA
    Ann Biomed Eng 38:2775-90. 2010
    ..g., 5-15 min post-stimulation). These results demonstrated that biochemical measurements might be useful in predicting rates of endothelial cell migration...
  4. pmc A distinctive role for focal adhesion proteins in three-dimensional cell motility
    Stephanie I Fraley
    Department of Chemical and Biomolecular Engineering, The Johns Hopkins University, Baltimore, Maryland 21218, USA
    Nat Cell Biol 12:598-604. 2010
    ..This study shows that membrane protrusions constitute a critical motility/matrix-traction module that drives cell motility in a 3D matrix...
  5. pmc LIM-domain proteins, LIMD1, Ajuba, and WTIP are required for microRNA-mediated gene silencing
    Victoria James
    School of Biomedical Sciences, University of Nottingham Medical School, Queen s Medical Centre, Nottingham NG7 2UH, United Kingdom
    Proc Natl Acad Sci U S A 107:12499-504. 2010
    ....
  6. doi request reprint Regulation of U6 promoter activity by transcriptional interference in viral vector-based RNAi
    Linghu Nie
    Key Laboratory of Genome Sciences and Information, Cancer Biology and Genetics Group, Beijing Institute of Genomics, Chinese Acadamy of Sciences, Beijing 100029, China
    Genomics Proteomics Bioinformatics 8:170-9. 2010
    ..Our results indicate that U6 promoter activity can be affected by TI in a proximal promoter-specific and arrangement-dependent manner...
  7. doi request reprint A multifunctional lentiviral-based gene knockdown with concurrent rescue that controls for off-target effects of RNAi
    Yunfeng Feng
    Department of Medicine, Washington University, St Louis, MO 63110, USA
    Genomics Proteomics Bioinformatics 8:238-45. 2010
    ..This system provides not only an internal control for RNAi off-target effects, but also the potential tool for rapid structure-function analyses and gene therapy...
  8. pmc LIS1 regulates osteoclast formation and function through its interactions with dynein/dynactin and Plekhm1
    Shiqiao Ye
    Center for Osteoporosis and Metabolic Bone Diseases, Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Arkansas for Medical Sciences and the Central Arkansas Veterans Healthcare System, Little Rock, Arkansas, United States of America
    PLoS ONE 6:e27285. 2011
    ..These results indicate that LIS1 is a previously unrecognized regulator of osteoclast formation, microtubule organization, and lysosomal secretion by virtue of its ability to modulate dynein function and Plekhm1...
  9. doi request reprint The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity
    Daniel E Foxler
    School of Biomedical Sciences, University of Nottingham, Queen s Medical Centre, NG7 2UH, UK
    Nat Cell Biol 14:201-8. 2012
    ..LIMD1 family member proteins Ajuba and WTIP also bind to VHL and PHDs 1 and 3, indicating that these LIM domain-containing proteins represent a previously unrecognized group of hypoxic regulators...
  10. pmc Curcumin inhibits gene expression of receptor for advanced glycation end-products (RAGE) in hepatic stellate cells in vitro by elevating PPARγ activity and attenuating oxidative stress
    Jianguo Lin
    Department of Pathology, School of Medicine, Saint Louis University, St Louis, MO 63104, USA
    Br J Pharmacol 166:2212-27. 2012
    ..We hypothesize that curcumin eliminates the effects of AGEs by suppressing gene expression of RAGE...
  11. doi request reprint Dimensional and temporal controls of three-dimensional cell migration by zyxin and binding partners
    Stephanie I Fraley
    Department of Chemical and Biomolecular Engineering, The Johns Hopkins University, 3400 N Charles Street, Maryland Hall Room 223, Baltimore, Maryland 21218, USA
    Nat Commun 3:719. 2012
    ..These results also suggest that the zyxin/α-actinin/p130Cas module may ensure that motile cells in a three-dimensional matrix explore the largest space possible in minimum time...
  12. pmc Actin cap associated focal adhesions and their distinct role in cellular mechanosensing
    Dong Hwee Kim
    Johns Hopkins Physical Sciences in Oncology Center, The Johns Hopkins University, Baltimore, Maryland 21218, USA
    Sci Rep 2:555. 2012
    ..These results establish the perinuclear actin cap and associated ACAFAs as major mediators of cellular mechanosensing and a critical element of the physical pathway that transduce mechanical cues all the way to the nucleus...
  13. doi request reprint Effect of focal adhesion proteins on endothelial cell adhesion, motility and orientation response to cyclic strain
    Hai Ngu
    Department of Biomedical Engineering, Washington University in St Louis, Campus Box 1097, One Brookings Drive, St Louis, MO 63130, USA
    Ann Biomed Eng 38:208-22. 2010
    ..These results suggest that zyxin and its interaction with alpha-actinin are important in the regulation of endothelial cell adhesive strength, motility and orientation response to mechanical stretching...
  14. doi request reprint Down-regulation of Rap1GAP via promoter hypermethylation promotes melanoma cell proliferation, survival, and migration
    Hong Zheng
    Department of Internal Medicine, Division of Dermatology and Hematology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cancer Res 69:449-57. 2009
    ..Taken together, our findings indicate that down-regulation of Rap1GAP via promoter hypermethylation promotes melanoma cell proliferation, survival, and migration...
  15. pmc {alpha}-Catenin mediates initial E-cadherin-dependent cell-cell recognition and subsequent bond strengthening
    Saumendra Bajpai
    Department of Chemical and Biomolecular Engineering, and Howard Hughes Medical Institute Graduate Training Program and Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, Maryland 21218, USA
    Proc Natl Acad Sci U S A 105:18331-6. 2008
    ....
  16. ncbi request reprint Cytoplasmic retention of HIV-1 regulatory protein Vpr by protein-protein interaction with a novel human cytoplasmic protein VprBP
    S Zhang
    Institute for Molecular Virology, St Louis University School of Medicine, 3681 Park Avenue, St Louis, MO 63110, USA
    Gene 263:131-40. 2001
    ..We hypothesize that Vpr interaction with VprBP may cause changes in the host cell cytoplasm that affect HIV-1 pathogenesis as well as HIV-1 replication...
  17. pmc The LIM protein Ajuba influences p130Cas localization and Rac1 activity during cell migration
    Stephen J Pratt
    Department of Medicine, Washington University, St Louis, MO 63130, USA
    J Cell Biol 168:813-24. 2005
    ....
  18. pmc The LIM protein Ajuba regulates phosphatidylinositol 4,5-bisphosphate levels in migrating cells through an interaction with and activation of PIPKI alpha
    Marina Kisseleva
    Department of Medicine and Cell Biology, Washington University, 660 S Euclid Avenue, St Louis, MO 63110 1010, USA
    Mol Cell Biol 25:3956-66. 2005
    ..Thus, in addition to its effects upon Rac activity Ajuba can also influence cell migration through regulation of PI(4,5)P2 synthesis through direct activation of PIPKIalpha enzyme activity...
  19. pmc The LIM protein Ajuba influences interleukin-1-induced NF-kappaB activation by affecting the assembly and activity of the protein kinase Czeta/p62/TRAF6 signaling complex
    Yungfeng Feng
    Department of Medicine, Washington University, St Louis, Missouri 63110, USA
    Mol Cell Biol 25:4010-22. 2005
    ..We propose that Ajuba is a new cytosolic component of the IL-1 signaling pathway modulating IL-1-induced NF-kappaB activation by influencing the assembly and activity of the aPKC/p62/TRAF6 multiprotein signaling complex...
  20. ncbi request reprint Ras-associated protein-1 regulates extracellular signal-regulated kinase activation and migration in melanoma cells: two processes important to melanoma tumorigenesis and metastasis
    Ling Gao
    Division of Dermatology, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Cancer Res 66:7880-8. 2006
    ..Taken together, these results show that Rap1 is involved in the activation of MAPK pathway and integrin activation in human melanoma and suggest a potential role for Rap1 in melanoma tumorigenesis and metastasis...
  21. ncbi request reprint The LIM protein, Limd1, regulates AP-1 activation through an interaction with Traf6 to influence osteoclast development
    Yunfeng Feng
    Department of Medicine, Washington University, St Louis, Missouri 63110, USA
    J Biol Chem 282:39-48. 2007
    ..These results implicate Limd1 as a potentially important regulator of osteoclast development under conditions of stress...
  22. pmc Phosphatidylinositol 3-kinase activation is required to form the NKG2D immunological synapse
    Emanuele Giurisato
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Mol Cell Biol 27:8583-99. 2007
    ..These results provide new insights into the mechanism of immunological synapse formation and also demonstrate how multiple mechanisms can be used to recruit the same signaling proteins to the plasma membrane...
  23. doi request reprint Actin stress fiber pre-extension in human aortic endothelial cells
    Lan Lu
    Department of Biomedical Engineering, Washington University, St Louis, Missouri 63130, USA
    Cell Motil Cytoskeleton 65:281-94. 2008
    ..Unlike pre-extension, the morphology of the compressed SFs is partially determined by MTs and IFs which appear to support the SFs along their lengths...
  24. pmc Ajuba LIM proteins are snail/slug corepressors required for neural crest development in Xenopus
    Ellen M Langer
    Department of Medicine, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Dev Cell 14:424-36. 2008
    ....
  25. doi request reprint α-actinin1 and 4 tyrosine phosphorylation is critical for stress fiber establishment, maintenance and focal adhesion maturation
    Yunfeng Feng
    Departments of Medicine, Washington University, St Louis, MO 63110, USA
    Exp Cell Res 319:1124-35. 2013
    ..Further rescue experiments demonstrate that the tyrosine phosphorylation of α-actinin1 at Y12 and α-actinin4 at Y265 is critical for dorsal stress fiber establishment, transverse arc maintenance and focal adhesion maturation...