N B Farber

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. pmc Alcohol-induced neuroapoptosis in the fetal macaque brain
    Nuri B Farber
    Department of Psychiatry, Washington University, St Louis, MO 63110 1093, USA
    Neurobiol Dis 40:200-6. 2010
  2. ncbi request reprint Acute D2/D3 dopaminergic agonism but chronic D2/D3 antagonism prevents NMDA antagonist neurotoxicity
    Nuri B Farber
    Department of Psychiatry, Washington University, St Louis, Missouri, 63110 1093, USA
    Biol Psychiatry 60:630-8. 2006
  3. ncbi request reprint In the adult CNS, ethanol prevents rather than produces NMDA antagonist-induced neurotoxicity
    Nuri B Farber
    Department of Psychiatry, Washington University, Campus Box 8134 660 S Euclid Ave St Louis, MO, 63110 1093, USA
    Brain Res 1028:66-74. 2004
  4. ncbi request reprint Drugs of abuse that cause developing neurons to commit suicide
    Nuri B Farber
    Department of Psychiatry, Washington University, Campus Box 8134, 660 S Euclid Avenue, St Louis, MO 63110 1093, USA
    Brain Res Dev Brain Res 147:37-45. 2003
  5. ncbi request reprint Muscimol prevents NMDA antagonist neurotoxicity by activating GABAA receptors in several brain regions
    Nuri B Farber
    Department of Psychiatry, Washington University, Campus Box 8134, 660 S Euclid Ave, St Louis, MO 63110 1093, USA
    Brain Res 993:90-100. 2003
  6. ncbi request reprint Receptor mechanisms and circuitry underlying NMDA antagonist neurotoxicity
    N B Farber
    Department of Psychiatry, Washington University, St Louis, MO 63110, USA
    Mol Psychiatry 7:32-43. 2002
  7. ncbi request reprint The glutamate synapse in neuropsychiatric disorders. Focus on schizophrenia and Alzheimer's disease
    N B Farber
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 6310 1093, USA
    Prog Brain Res 116:421-37. 1998
  8. ncbi request reprint Increased neocortical neurofibrillary tangle density in subjects with Alzheimer disease and psychosis
    N B Farber
    Washington University, Department of Psychiatry, Campus Box 8134, 660 S Euclid Ave, St Louis, MO 63110 1009, USA
    Arch Gen Psychiatry 57:1165-73. 2000
  9. ncbi request reprint Antiepileptic drugs and agents that inhibit voltage-gated sodium channels prevent NMDA antagonist neurotoxicity
    N B Farber
    Department of Psychiatry, Washington University, St Louis, MO 63110 1093, USA
    Mol Psychiatry 7:726-33. 2002
  10. ncbi request reprint Excitotoxic neurodegeneration in Alzheimer disease. New hypothesis and new therapeutic strategies
    J W Olney
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA
    Arch Neurol 54:1234-40. 1997

Research Grants

Detail Information

Publications20

  1. pmc Alcohol-induced neuroapoptosis in the fetal macaque brain
    Nuri B Farber
    Department of Psychiatry, Washington University, St Louis, MO 63110 1093, USA
    Neurobiol Dis 40:200-6. 2010
    ..The observed increase in apoptosis was on the order of 60-fold. We propose that the apoptogenic action of alcohol could explain many of the neuropathological changes and long-term neuropsychiatric disturbances associated with human FASD...
  2. ncbi request reprint Acute D2/D3 dopaminergic agonism but chronic D2/D3 antagonism prevents NMDA antagonist neurotoxicity
    Nuri B Farber
    Department of Psychiatry, Washington University, St Louis, Missouri, 63110 1093, USA
    Biol Psychiatry 60:630-8. 2006
    ..Dopaminergic D2 and/or D3 agents can modify psychosis over days to weeks, suggesting involvement of these transmitter system(s)...
  3. ncbi request reprint In the adult CNS, ethanol prevents rather than produces NMDA antagonist-induced neurotoxicity
    Nuri B Farber
    Department of Psychiatry, Washington University, Campus Box 8134 660 S Euclid Ave St Louis, MO, 63110 1093, USA
    Brain Res 1028:66-74. 2004
    ..The inability of EtOH to acutely produce NAN in the adult CNS indicates that, in contrast to fetuses, brief exposure of the adult CNS to EtOH is non-toxic for neurons...
  4. ncbi request reprint Drugs of abuse that cause developing neurons to commit suicide
    Nuri B Farber
    Department of Psychiatry, Washington University, Campus Box 8134, 660 S Euclid Avenue, St Louis, MO 63110 1093, USA
    Brain Res Dev Brain Res 147:37-45. 2003
    ..g. phencyclidine, ketamine, benzodiazepines, barbiturates) also suppress neuronal activity and drive developing neurons to commit suicide...
  5. ncbi request reprint Muscimol prevents NMDA antagonist neurotoxicity by activating GABAA receptors in several brain regions
    Nuri B Farber
    Department of Psychiatry, Washington University, Campus Box 8134, 660 S Euclid Ave, St Louis, MO 63110 1093, USA
    Brain Res 993:90-100. 2003
    ..We conclude that GABAergic agents prevent NRHypo neurotoxicity mainly by activating GABA receptors in the anterior thalamus, diagonal band of Broca and RSC...
  6. ncbi request reprint Receptor mechanisms and circuitry underlying NMDA antagonist neurotoxicity
    N B Farber
    Department of Psychiatry, Washington University, St Louis, MO 63110, USA
    Mol Psychiatry 7:32-43. 2002
    ..Simultaneous excitotoxic stimulation of muscarinic (m(3)) and glutamate (AMPA/kainate) receptors on cerebrocortical neurons appears to be the proximal mechanism by which the neurotoxic and psychotomimetic effects of NRHypo are mediated...
  7. ncbi request reprint The glutamate synapse in neuropsychiatric disorders. Focus on schizophrenia and Alzheimer's disease
    N B Farber
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 6310 1093, USA
    Prog Brain Res 116:421-37. 1998
    ....
  8. ncbi request reprint Increased neocortical neurofibrillary tangle density in subjects with Alzheimer disease and psychosis
    N B Farber
    Washington University, Department of Psychiatry, Campus Box 8134, 660 S Euclid Ave, St Louis, MO 63110 1009, USA
    Arch Gen Psychiatry 57:1165-73. 2000
    ....
  9. ncbi request reprint Antiepileptic drugs and agents that inhibit voltage-gated sodium channels prevent NMDA antagonist neurotoxicity
    N B Farber
    Department of Psychiatry, Washington University, St Louis, MO 63110 1093, USA
    Mol Psychiatry 7:726-33. 2002
    ..Several of these agents have been found to be of clinical use in bipolar disorder. It would be of interest to determine whether these agents might have therapeutic benefits for conditions in which a NRHypo state may exist...
  10. ncbi request reprint Excitotoxic neurodegeneration in Alzheimer disease. New hypothesis and new therapeutic strategies
    J W Olney
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA
    Arch Neurol 54:1234-40. 1997
    ....
  11. ncbi request reprint NMDA receptor hypofunction model of schizophrenia
    J W Olney
    Department of Psychiatry, Washington University, School of Medicine, St Louis, MO 63110 1093, USA
    J Psychiatr Res 33:523-33. 1999
    ..In this article, we examine this hypothesis in terms of its strengths and weaknesses, its therapeutic implications and ways in which it can be further tested...
  12. ncbi request reprint Olanzapine and fluperlapine mimic clozapine in preventing MK-801 neurotoxicity
    N B Farber
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Schizophr Res 21:33-7. 1996
    ....
  13. ncbi request reprint Chronic but not acute estradiol treatment protects against the neurodegenerative effects of N-methyl-D-aspartate receptor antagonists
    William Dribben
    Department of Psychiatry, Division of Emergency Medicine, Washington University, St Louis, MO 63110, USA
    Endocrine 21:53-8. 2003
    ..05 in all cases). We conclude that chronic but not acute estradiol treatment reduces the severity of NRHypo-induced neurodegeneration...
  14. pmc Acute neonatal glucocorticoid exposure produces selective and rapid cerebellar neural progenitor cell apoptotic death
    K K Noguchi
    Department of Psychiatry, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110 1093, USA
    Cell Death Differ 15:1582-92. 2008
    ..This vulnerability may be related to the physiological role of glucocorticoids in regulating programmed cell death in the mammalian cerebellum...
  15. ncbi request reprint The NMDA receptor hypofunction model of psychosis
    Nuri B Farber
    Department of Psychiatry, Washington University, St Louis, Missouri 63110 1093, USA
    Ann N Y Acad Sci 1003:119-30. 2003
    ..In addition the possible role of NRHypo in the pathophysiology of idiopathic psychotic disorders will be considered...
  16. ncbi request reprint Age has a similar influence on the susceptibility to NMDA antagonist-induced neurodegeneration in most brain regions
    Kevin K Noguchi
    Department of Psychiatry, Washington University, Campus Box 8134, 660 S Euclid Avenue, St Louis, MO 63110 1093, USA
    Brain Res Dev Brain Res 158:82-91. 2005
    ....
  17. ncbi request reprint Drug-induced apoptotic neurodegeneration in the developing brain
    John W Olney
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Brain Pathol 12:488-98. 2002
    ....
  18. ncbi request reprint The enigma of fetal alcohol neurotoxicity
    John W Olney
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Ann Med 34:109-19. 2002
    ....
  19. pmc Architecture and neurocytology of monkey cingulate gyrus
    Brent A Vogt
    Cingulum NeuroSciences Institute, Manlius, New York 13104, USA
    J Comp Neurol 485:218-39. 2005
    ..This major revision of the architectural organization of monkey cingulate cortex provides a new context for connection studies and for devising models of neuron diseases...
  20. pmc Donepezil markedly potentiates memantine neurotoxicity in the adult rat brain
    Catherine E Creeley
    Department of Psychiatry, Washington University School of Medicine, Campus Box 8134, St Louis, MO 63110, USA
    Neurobiol Aging 29:153-67. 2008
    ..These findings raise questions about using this drug combination in AD, especially in the absence of evidence that the combination is beneficial, or that either drug arrests or reverses the disease process...

Research Grants6

  1. Neurodevelopmental Apoptosis
    Nuri Farber; Fiscal Year: 2007
    ..abstract_text> ..
  2. Glucocorticoids and Apoptosis of Cerebellar Neural Progenitor Cells
    Nuri Farber; Fiscal Year: 2007
    ....