Affiliation: Washington University School of Medicine
Mahajan S, Decker C, Yang Z, Veis D, Mellins E, Faccio R. Plcγ2/Tmem178 dependent pathway in myeloid cells modulates the pathogenesis of cytokine storm syndrome. J Autoimmun. 2019;: pubmed publisher
..Our data identify a novel Plcγ2/Tmem178 axis as a modulator of inflammatory cytokine production by monocytes/macrophages. We also find that loss of Tmem178 accentuates the pro-inflammatory responses in CSS. ..
D Amico L, Mahajan S, Capietto A, Yang Z, Zamani A, Ricci B, et al
. Dickkopf-related protein 1 (Dkk1) regulates the accumulation and function of myeloid derived suppressor cells in cancer. J Exp Med. 2016;213:827-40 pubmed publisher
..We establish a novel immunomodulatory role for Dkk1 in regulating tumor-induced immune suppression via targeting Î²-catenin in MDSCs. ..
Decker C, Yang Z, Rimer R, Park Min K, Macaubas C, Mellins E, et al
. Tmem178 acts in a novel negative feedback loop targeting NFATc1 to regulate bone mass. Proc Natl Acad Sci U S A. 2015;112:15654-9 pubmed publisher
..In sum, these findings identify an essential role for Tmem178 to maintain skeletal mass and limit pathological bone loss. ..
Yang Z, Kim S, Mahajan S, Zamani A, Faccio R. Phospholipase C?1 (PLC?1) Controls Osteoclast Numbers via Colony-stimulating Factor 1 (CSF-1)-dependent Diacylglycerol/?-Catenin/CyclinD1 Pathway. J Biol Chem. 2017;292:1178-1186 pubmed publisher
..Taken together, our study shows that PLC?1 controls OC numbers via a CSF-1-dependent DAG/?-catenin/cyclinD1 pathway. ..