Elisa Fabbrini

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. ncbi request reprint Methods for assessing intrahepatic fat content and steatosis
    Elisa Fabbrini
    Center for Human Nutrition, Division of Geriatrics and Nutritional Science, Washington University School of Medicine, St Louis, MO 63110, USA
    Curr Opin Clin Nutr Metab Care 12:474-81. 2009
  2. pmc Effect of fenofibrate and niacin on intrahepatic triglyceride content, very low-density lipoprotein kinetics, and insulin action in obese subjects with nonalcoholic fatty liver disease
    Elisa Fabbrini
    Center for Human Nutrition, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
    J Clin Endocrinol Metab 95:2727-35. 2010
  3. pmc Gastric bypass and banding equally improve insulin sensitivity and β cell function
    David Bradley
    Center for Human Nutrition, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 122:4667-74. 2012
  4. pmc Multiorgan insulin sensitivity in lean and obese subjects
    Caterina Conte
    Center for Human Nutrition and Atkins Center of Excellence in Obesity Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    Diabetes Care 35:1316-21. 2012
  5. pmc Relationship between adipose tissue lipolytic activity and skeletal muscle insulin resistance in nondiabetic women
    Faidon Magkos
    Center for Human Nutrition, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8031, St Louis, Missouri 63110, USA
    J Clin Endocrinol Metab 97:E1219-23. 2012
  6. pmc Validation of a novel index to assess insulin resistance of adipose tissue lipolytic activity in obese subjects
    Elisa Fabbrini
    Center for Human Nutrition and Atkins Center of Excellence in Obesity Medicine, Washington University School of Medicine, St Louis, MO, USA
    J Lipid Res 53:321-4. 2012
  7. pmc Association between specific adipose tissue CD4+ T-cell populations and insulin resistance in obese individuals
    Elisa Fabbrini
    Center for Human Nutrition, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Gastroenterology 145:366-74.e1-3. 2013
  8. pmc Increased whole-body adiposity without a concomitant increase in liver fat is not associated with augmented metabolic dysfunction
    Faidon Magkos
    Division of Geriatrics and Nutritional Science, Center for Human Nutrition, Washington University School of Medicine, St Louis, Missouri, USA
    Obesity (Silver Spring) 18:1510-5. 2010
  9. pmc Surgical removal of omental fat does not improve insulin sensitivity and cardiovascular risk factors in obese adults
    Elisa Fabbrini
    Center for Human Nutrition and Atkins Center of Excellence in Obesity Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    Gastroenterology 139:448-55. 2010
  10. pmc Alterations in fatty acid kinetics in obese adolescents with increased intrahepatic triglyceride content
    Elisa Fabbrini
    Center for Human Nutrition, Washington University School of Medicine, St Louis, Missouri, USA
    Obesity (Silver Spring) 17:25-9. 2009

Collaborators

Detail Information

Publications28

  1. ncbi request reprint Methods for assessing intrahepatic fat content and steatosis
    Elisa Fabbrini
    Center for Human Nutrition, Division of Geriatrics and Nutritional Science, Washington University School of Medicine, St Louis, MO 63110, USA
    Curr Opin Clin Nutr Metab Care 12:474-81. 2009
    ..Intrahepatic fat content is increasingly being recognized as an integral part of metabolic dysfunction. This article reviews available methods for the assessment of hepatic steatosis...
  2. pmc Effect of fenofibrate and niacin on intrahepatic triglyceride content, very low-density lipoprotein kinetics, and insulin action in obese subjects with nonalcoholic fatty liver disease
    Elisa Fabbrini
    Center for Human Nutrition, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
    J Clin Endocrinol Metab 95:2727-35. 2010
    ....
  3. pmc Gastric bypass and banding equally improve insulin sensitivity and β cell function
    David Bradley
    Center for Human Nutrition, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 122:4667-74. 2012
    ..We conclude that marked weight loss itself is primarily responsible for the therapeutic effects of RYGB and LAGB on insulin sensitivity, β cell function, and oral glucose tolerance in nondiabetic obese adults...
  4. pmc Multiorgan insulin sensitivity in lean and obese subjects
    Caterina Conte
    Center for Human Nutrition and Atkins Center of Excellence in Obesity Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    Diabetes Care 35:1316-21. 2012
    ..To provide a comprehensive assessment of multiorgan insulin sensitivity in lean and obese subjects with normal glucose tolerance...
  5. pmc Relationship between adipose tissue lipolytic activity and skeletal muscle insulin resistance in nondiabetic women
    Faidon Magkos
    Center for Human Nutrition, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8031, St Louis, Missouri 63110, USA
    J Clin Endocrinol Metab 97:E1219-23. 2012
    ..Increased adipose tissue lipolytic activity is considered an important factor in the pathogenesis of skeletal muscle insulin resistance associated with obesity...
  6. pmc Validation of a novel index to assess insulin resistance of adipose tissue lipolytic activity in obese subjects
    Elisa Fabbrini
    Center for Human Nutrition and Atkins Center of Excellence in Obesity Medicine, Washington University School of Medicine, St Louis, MO, USA
    J Lipid Res 53:321-4. 2012
    ..854, P < 0.001). These results demonstrate that the ATIRI provides a reliable index of adipose tissue insulin resistance in obese subjects...
  7. pmc Association between specific adipose tissue CD4+ T-cell populations and insulin resistance in obese individuals
    Elisa Fabbrini
    Center for Human Nutrition, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Gastroenterology 145:366-74.e1-3. 2013
    ..Insulin sensitivity was determined by using the hyperinsulinemic euglycemic clamp procedure...
  8. pmc Increased whole-body adiposity without a concomitant increase in liver fat is not associated with augmented metabolic dysfunction
    Faidon Magkos
    Division of Geriatrics and Nutritional Science, Center for Human Nutrition, Washington University School of Medicine, St Louis, Missouri, USA
    Obesity (Silver Spring) 18:1510-5. 2010
    ..608). We conclude that increased adiposity without a concomitant increase in IHTG content does not cause additional abnormalities in adipose tissue, skeletal muscle, and hepatic insulin sensitivity, or VLDL metabolism...
  9. pmc Surgical removal of omental fat does not improve insulin sensitivity and cardiovascular risk factors in obese adults
    Elisa Fabbrini
    Center for Human Nutrition and Atkins Center of Excellence in Obesity Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    Gastroenterology 139:448-55. 2010
    ..Therefore, a reduction in VAT is considered an important target of obesity therapy. We evaluated whether reducing VAT mass by surgical removal of the omentum improves insulin sensitivity and metabolic function in obese patients...
  10. pmc Alterations in fatty acid kinetics in obese adolescents with increased intrahepatic triglyceride content
    Elisa Fabbrini
    Center for Human Nutrition, Washington University School of Medicine, St Louis, Missouri, USA
    Obesity (Silver Spring) 17:25-9. 2009
    ..The purpose of this study was to evaluate whether adipose tissue lipolytic activity and the rate of fatty acid release into plasma are increased in obese adolescents with NAFLD...
  11. pmc Intrahepatic fat, not visceral fat, is linked with metabolic complications of obesity
    Elisa Fabbrini
    Center for Human Nutrition and Atkins Center of Excellence in Obesity Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 106:15430-5. 2009
    ..Furthermore, alterations in tissue fatty acid transport could be involved in the pathogenesis of ectopic triglyceride accumulation by redirecting plasma fatty acid uptake from adipose tissue toward other tissues...
  12. pmc Intrahepatic diacylglycerol content is associated with hepatic insulin resistance in obese subjects
    Faidon Magkos
    Center for Human Nutrition, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Gastroenterology 142:1444-6.e2. 2012
    ..609; P = .012), but not with intrahepatic ceramide or acylcarnitine. These data indicate that intrahepatic diacylglycerol is an important mediator of hepatic insulin resistance in obese people with nonalcoholic fatty liver disease...
  13. pmc Insulin sensitivity is not associated with palmitoleate availability in obese humans
    Elisa Fabbrini
    Center for Human Nutrition and Atkins Center of Excellence in Obesity Medicine, Washington University School of Medicine, St Louis, MO, USA
    J Lipid Res 52:808-12. 2011
    ..16 ± 0.04 mmol/l and 5.0% ± 0.4%, respectively). These data demonstrate that decreased palmitoleate in plasma and in VLDL is not associated with insulin resistance in skeletal muscle, liver, or adipose tissue in obese people...
  14. pmc Estrogen deficiency after menopause does not result in male very-low-density lipoprotein metabolism phenotype
    Faidon Magkos
    Center for Human Nutrition, Washington University School of Medicine, St Louis, MO 63110, USA
    J Clin Endocrinol Metab 95:3377-84. 2010
    ..The mechanisms responsible for this are unclear but are thought to be related to differences in the sex hormone milieu in men and women...
  15. pmc Liver, muscle, and adipose tissue insulin action is directly related to intrahepatic triglyceride content in obese subjects
    Kevin M Korenblat
    Center for Human Nutrition, Washington University School of Medicine, St Louis, Missouri, USA
    Gastroenterology 134:1369-75. 2008
    ....
  16. pmc Metabolic response to high-carbohydrate and low-carbohydrate meals in a nonhuman primate model
    Elisa Fabbrini
    Center for Human Nutrition and Atkins Center of Excellence in Obesity Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Physiol Endocrinol Metab 304:E444-51. 2013
    ..These observations demonstrate that LCHF diets cause minimal perturbations in glucose homeostasis and pancreatic β-cell activity...
  17. pmc Moderate effect of duodenal-jejunal bypass surgery on glucose homeostasis in patients with type 2 diabetes
    Samuel Klein
    Center for Human Nutrition, Washington University School of Medicine, St Louis, Missouri, USA
    Obesity (Silver Spring) 20:1266-72. 2012
    ..These findings suggest that altering the intestinal site of delivery of ingested nutrients has moderate therapeutic effects by improving β-cell function and glycemic control...
  18. pmc Lack of a relationship between plasma PCSK9 concentrations and hepatic lipoprotein kinetics in obese people
    Shelby Sullivan
    Center for Human Nutrition and Atkins Center of Excellence in Obesity Medicine, Washington University School of Medicine, St Louis, MO, USA
    Transl Res 158:302-6. 2011
    ..083, P = 0.614) or clearance rate (r = 0.032, P = 0.845). These data suggest that PCSK9 is likely involved in LDL-cholesterol metabolism, but it is not a clinically important regulator of VLDL kinetics in obese individuals...
  19. pmc Relationship between body fat mass and free fatty acid kinetics in men and women
    Bettina Mittendorfer
    Division of Geriatrics and Nutritional Science and Center for Human Nutrition, Washington University School of Medicine, St Louis, Missouri, USA
    Obesity (Silver Spring) 17:1872-7. 2009
    ....
  20. pmc Subclinical hypothyroidism and hyperthyroidism have opposite effects on hepatic very-low-density lipoprotein-triglyceride kinetics
    Elisa Fabbrini
    Center for Human Nutrition, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8031, St Louis, Missouri 63110, USA
    J Clin Endocrinol Metab 97:E414-8. 2012
    ..Clinically overt thyroid dysfunction is associated with alterations in triglyceride (TG) metabolism. The effect of subclinical thyroid disease on very-low-density lipoprotein (VLDL) kinetics is not known...
  21. pmc Evidence for regulated monoacylglycerol acyltransferase expression and activity in human liver
    Angela M Hall
    Center for Human Nutrition, Washington University School of Medicine, St Louis, MO, USA
    J Lipid Res 53:990-9. 2012
    ..These data suggest that the MGAT pathway is active and dynamically regulated in human liver and could be an important target for pharmacologic intervention for the treatment of obesity-related insulin resistance and NAFLD...
  22. pmc Dissociation between intrahepatic triglyceride content and insulin resistance in familial hypobetalipoproteinemia
    Anastassia Amaro
    Center for Human Nutrition and Atkins Center of Excellence in Obesity Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Gastroenterology 139:149-53. 2010
    ....
  23. pmc Portal vein and systemic adiponectin concentrations are closely linked with hepatic glucose and lipoprotein kinetics in extremely obese subjects
    Faidon Magkos
    Center for Human Nutrition, Washington University School of Medicine, St Louis, MO 63110, USA
    Metabolism 60:1641-8. 2011
    ..Additional studies are needed to elucidate the mechanism(s) responsible for the strong association we observed between adiponectin and hepatic substrate metabolism...
  24. ncbi request reprint Adipose and Muscle Tissue Profile of CD36 Transcripts in Obese Subjects Highlights the Role of CD36 in Fatty Acid Homeostasis and Insulin Resistance
    Terri A Pietka
    Department of Medicine, Center for Human Nutrition, Washington University, St Louis, MO
    Diabetes Care 37:1990-7. 2014
    ..For this, we determined the relationships between CD36 alternative transcripts, which can reflect tissue-specific CD36 regulation, and measures of FA metabolism and insulin resistance...
  25. pmc Obesity and nonalcoholic fatty liver disease: biochemical, metabolic, and clinical implications
    Elisa Fabbrini
    Center for Human Nutrition and Atkins Center of Excellence in Obesity Medicine, Washington University School of Medicine, St Louis, MO 63110 1093, USA
    Hepatology 51:679-89. 2010
    ..Understanding the precise factors involved in the pathogenesis and pathophysiology of NAFLD will provide important insights into the mechanisms responsible for the cardiometabolic complications of obesity...
  26. ncbi request reprint Effect of plasma uric Acid on antioxidant capacity, oxidative stress, and insulin sensitivity in obese subjects
    Elisa Fabbrini
    Center for Human Nutrition and Atkins Center of Excellence in Obesity Medicine, Washington University School of Medicine, St Louis, MO
    Diabetes 63:976-81. 2014
    ..These results demonstrate that circulating UA is a major antioxidant and might help protect against free-radical oxidative damage. However, oxidative stress is not a major determinant of insulin action in vivo. ..
  27. pmc Alterations in adipose tissue and hepatic lipid kinetics in obese men and women with nonalcoholic fatty liver disease
    Elisa Fabbrini
    Center for Human Nutrition, Washington University School of Medicine, St Louis, Missouri, USA
    Gastroenterology 134:424-31. 2008
    ..The purpose of this study was to evaluate TG metabolism in adipose tissue and liver in NAFLD...
  28. ncbi request reprint Fundamentals of cardiometabolic risk factor reduction: achieving and maintaining weight loss with pharmacotherapy or bariatric surgery
    Elisa Fabbrini
    Center for Human Nutrition, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Clin Cornerstone 9:41-8; discussion 49-51. 2008
    ..9 kg/m(2) with > or =1 severe obesity-related medical complication)...