Samir K El-Mofty

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. ncbi request reprint Psammomatoid and trabecular juvenile ossifying fibroma of the craniofacial skeleton: two distinct clinicopathologic entities
    Samir El-Mofty
    Department of Oral and Maxillofacial Pathology, Washington University School of Medicine, St Louis, MO 63110, USA
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 93:296-304. 2002
  2. ncbi request reprint Prevalence of high-risk human papillomavirus DNA in nonkeratinizing (cylindrical cell) carcinoma of the sinonasal tract: a distinct clinicopathologic and molecular disease entity
    Samir K El-Mofty
    Department of Pathology and Immunology, Washington University School of Medicine, 660 S Euclid, Campus Box 8118, St Louis, MO 63110, USA
    Am J Surg Pathol 29:1367-72. 2005
  3. ncbi request reprint Prevalence of human papillomavirus type 16 DNA in squamous cell carcinoma of the palatine tonsil, and not the oral cavity, in young patients: a distinct clinicopathologic and molecular disease entity
    Samir K El-Mofty
    Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Surg Pathol 27:1463-70. 2003
  4. doi request reprint Papillary squamous cell carcinoma of the head and neck: clinicopathologic and molecular features with special reference to human papillomavirus
    Mitra Mehrad
    Departments of Pathology and Immunology Department of Otolaryngology Head and Neck Surgery Division of Biostatistics, Washington University School of Medicine, St Louis, MO Advanced Cell Diagnostics Inc, Hayward, CA
    Am J Surg Pathol 37:1349-56. 2013
  5. doi request reprint Verrucous carcinomas of the head and neck, including those with associated squamous cell carcinoma, lack transcriptionally active high-risk human papillomavirus
    Kalyani R Patel
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Hum Pathol 44:2385-92. 2013
  6. ncbi request reprint Metachronous squamous cell carcinomas evolving from independent oropharyngeal and pulmonary squamous papillomas: association with human papillomavirus 11 and lack of aberrant p53, Rb, and p16 protein expression
    Haodong Xu
    Lauren V Ackerman Laboratory of Surgical Pathology, Washington University School of Medicine, St Louis, MO 63110 1093, USA
    Hum Pathol 35:1419-22. 2004
  7. pmc Detection and significance of human papillomavirus, CDKN2A(p16) and CDKN1A(p21) expression in squamous cell carcinoma of the larynx
    Rebecca D Chernock
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Mod Pathol 26:223-31. 2013
  8. doi request reprint Partial p16 staining in oropharyngeal squamous cell carcinoma: extent and pattern correlate with human papillomavirus RNA status
    James S Lewis
    Department of Pathology and Immunology, Washington University, St Louis, MO 63110, USA
    Mod Pathol 25:1212-20. 2012
  9. pmc Human papillomavirus-positive basaloid squamous cell carcinomas of the upper aerodigestive tract: a distinct clinicopathologic and molecular subtype of basaloid squamous cell carcinoma
    Rebecca D Chernock
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Hum Pathol 41:1016-23. 2010
  10. pmc p16 positive oropharyngeal squamous cell carcinoma:an entity with a favorable prognosis regardless of tumor HPV status
    James S Lewis
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Surg Pathol 34:1088-96. 2010

Collaborators

Detail Information

Publications33

  1. ncbi request reprint Psammomatoid and trabecular juvenile ossifying fibroma of the craniofacial skeleton: two distinct clinicopathologic entities
    Samir El-Mofty
    Department of Oral and Maxillofacial Pathology, Washington University School of Medicine, St Louis, MO 63110, USA
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 93:296-304. 2002
    ....
  2. ncbi request reprint Prevalence of high-risk human papillomavirus DNA in nonkeratinizing (cylindrical cell) carcinoma of the sinonasal tract: a distinct clinicopathologic and molecular disease entity
    Samir K El-Mofty
    Department of Pathology and Immunology, Washington University School of Medicine, 660 S Euclid, Campus Box 8118, St Louis, MO 63110, USA
    Am J Surg Pathol 29:1367-72. 2005
    ....
  3. ncbi request reprint Prevalence of human papillomavirus type 16 DNA in squamous cell carcinoma of the palatine tonsil, and not the oral cavity, in young patients: a distinct clinicopathologic and molecular disease entity
    Samir K El-Mofty
    Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Surg Pathol 27:1463-70. 2003
    ..The HPV-positive carcinomas have a distinct histopathologic and immunophenotypic features...
  4. doi request reprint Papillary squamous cell carcinoma of the head and neck: clinicopathologic and molecular features with special reference to human papillomavirus
    Mitra Mehrad
    Departments of Pathology and Immunology Department of Otolaryngology Head and Neck Surgery Division of Biostatistics, Washington University School of Medicine, St Louis, MO Advanced Cell Diagnostics Inc, Hayward, CA
    Am J Surg Pathol 37:1349-56. 2013
    ..Overall survival, disease-specific survival, and disease-free survival were favorable and did not significantly differ by anatomic subsite. However, HPV-related tumors showed a trend toward better survival. ..
  5. doi request reprint Verrucous carcinomas of the head and neck, including those with associated squamous cell carcinoma, lack transcriptionally active high-risk human papillomavirus
    Kalyani R Patel
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Hum Pathol 44:2385-92. 2013
    ..These findings argue that verrucous carcinoma and its related squamous cell carcinomas are not HPV-driven tumors. ..
  6. ncbi request reprint Metachronous squamous cell carcinomas evolving from independent oropharyngeal and pulmonary squamous papillomas: association with human papillomavirus 11 and lack of aberrant p53, Rb, and p16 protein expression
    Haodong Xu
    Lauren V Ackerman Laboratory of Surgical Pathology, Washington University School of Medicine, St Louis, MO 63110 1093, USA
    Hum Pathol 35:1419-22. 2004
    ..These observations indicate that human papillomavirus 11-associated neoplastic transformation and tumor progression in the respiratory tract may not involve aberrant regulation of the p53 and Rb signaling pathways...
  7. pmc Detection and significance of human papillomavirus, CDKN2A(p16) and CDKN1A(p21) expression in squamous cell carcinoma of the larynx
    Rebecca D Chernock
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Mod Pathol 26:223-31. 2013
    ..Because of this, CDKN2A(p16) should not be used as a definitive surrogate marker of HPV-driven tumors in the larynx...
  8. doi request reprint Partial p16 staining in oropharyngeal squamous cell carcinoma: extent and pattern correlate with human papillomavirus RNA status
    James S Lewis
    Department of Pathology and Immunology, Washington University, St Louis, MO 63110, USA
    Mod Pathol 25:1212-20. 2012
    ..These results support that greater than 75% p16 staining or, alternatively, >50% staining combined with >25% confluent areas, are suitable cutoffs for defining positivity...
  9. pmc Human papillomavirus-positive basaloid squamous cell carcinomas of the upper aerodigestive tract: a distinct clinicopathologic and molecular subtype of basaloid squamous cell carcinoma
    Rebecca D Chernock
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Hum Pathol 41:1016-23. 2010
    ..These tumors occur almost exclusively in the oropharynx, are molecularly distinct from their human papillomavirus-negative counterparts, and have a more favorable clinical outcome...
  10. pmc p16 positive oropharyngeal squamous cell carcinoma:an entity with a favorable prognosis regardless of tumor HPV status
    James S Lewis
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Surg Pathol 34:1088-96. 2010
    ..Many recommend use of both p16 immunohistochemistry and HPV in situ hybridization (ISH). A significant minority of tumors are p16 positive and HPV ISH negative, the significance of which is unclear...
  11. ncbi request reprint Human papillomavirus (HPV)-related oropharyngeal nonkeratinizing squamous cell carcinoma: characterization of a distinct phenotype
    Samir K El-Mofty
    Washington University School of Medicine, St Louis, MO 63110, USA
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 101:339-45. 2006
    ..It is concluded that NKCa of the tonsils and base of tongue is a distinct subtype of squamous cell carcinoma of the head and neck with high prevalence of HPV DNA and a characteristic immunophenotype...
  12. doi request reprint Undifferentiated carcinoma of the oropharynx: a human papillomavirus-associated tumor with a favorable prognosis
    Danielle H Carpenter
    Department of Pathology and Immunology, Division of Anatomic and Molecular Pathology, Washington University, St Louis, MO, USA
    Mod Pathol 24:1306-12. 2011
    ..Disease-specific survival is comparable to published rates for other HPV-related oropharyngeal squamous cell carcinoma variants and is better than that of HPV-negative carcinomas...
  13. pmc Human papillomavirus-related squamous cell carcinoma of the oropharynx: a comparative study in whites and African Americans
    Rebecca D Chernock
    Department of Pathology and Immunology, Washington University School of Medicine, 660 S Euclid Ave, Campus Box 8118, St Louis, MO 63110, USA
    Arch Otolaryngol Head Neck Surg 137:163-9. 2011
    ..To evaluate the frequency of human papillomavirus-related oropharyngeal squamous cell carcinoma in African Americans and whites and to examine patient outcomes in these 2 groups...
  14. pmc HPV-related nonkeratinizing squamous cell carcinoma of the oropharynx: utility of microscopic features in predicting patient outcome
    Rebecca D Chernock
    Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid, Campus Box 8118, St Louis, MO 63110, USA
    Head Neck Pathol 3:186-94. 2009
    ..NK SCC histology strongly predicts HPV-association and better patient survival compared to K SCC. Hybrid SCC appears to have an intermediate frequency of HPV-association and patient survival...
  15. pmc Adenosquamous carcinoma of the head and neck: relationship to human papillomavirus and review of the literature
    Ramya P Masand
    Department of Pathology and Immunology, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Head Neck Pathol 5:108-16. 2011
    ..Head and neck ADSC appears to be a mixed variant that can be further classified according to its HPV status...
  16. doi request reprint Mammaglobin and S-100 immunoreactivity in salivary gland carcinomas other than mammary analogue secretory carcinoma
    Kalyani R Patel
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Hum Pathol 44:2501-8. 2013
    ..This indicates a need for caution in the use of immunohistochemistry for diagnosing MASC, especially in the absence of cytogenetic confirmation. ..
  17. doi request reprint Napsin A expression in anaplastic, poorly differentiated, and micropapillary pattern thyroid carcinomas
    Rebecca D Chernock
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA
    Am J Surg Pathol 37:1215-22. 2013
    ..PAX8 may be diagnostically useful to distinguish these napsin A-positive thyroid carcinomas from lung adenocarcinomas, which are PAX8 negative. ..
  18. pmc Cyclin D1-a prognostic marker in oropharyngeal squamous cell carcinoma that is tightly associated with high-risk human papillomavirus status
    Juliette B Scantlebury
    Department of Pathology and Immunology, Washington University, St Louis, MO 63110, USA
    Hum Pathol 44:1672-80. 2013
    ....
  19. pmc Recognition of nonkeratinizing morphology in oropharyngeal squamous cell carcinoma - a prospective cohort and interobserver variability study
    James S Lewis
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Histopathology 60:427-36. 2012
    ....
  20. doi request reprint Absence of Merkel cell polyomavirus in primary parotid high-grade neuroendocrine carcinomas regardless of cytokeratin 20 immunophenotype
    Rebecca D Chernock
    Departments of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA
    Am J Surg Pathol 35:1806-11. 2011
    ..Furthermore, viral testing may aid in distinguishing the 2 tumor types, as a positive result would favor a metastasis...
  21. doi request reprint Human papillomavirus and oropharynx cancer: biology, detection and clinical implications
    Clint T Allen
    Department of Otolaryngology Head and Neck Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Laryngoscope 120:1756-72. 2010
    ..To review evidence for the role of human papillomavirus (HPV) in the etiology of oropharyngeal cancers, methods of viral detection, and the resulting clinical implications...
  22. ncbi request reprint Expression of p16, Rb, and p53 proteins in squamous cell carcinomas of the anorectal region harboring human papillomavirus DNA
    Danielle W Lu
    Lauren V Ackerman Laboratory of Surgical Pathology, Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Mod Pathol 16:692-9. 2003
    ....
  23. pmc Infectious pseudotumors: red herrings in head and neck pathology
    Samir K El-Mofty
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA
    Head Neck Pathol 6:58-63. 2012
    ..Accurately identifying these lesions and the specific causative agent is of particular significance since they can be successfully treated with antibiotics...
  24. pmc Plasmablastic lymphoma of head and neck: report of two new cases and correlation with c-myc and IgVH gene mutation status
    Anjum Hassan
    Department of Pathology and Immunology, Division of Anatomic Pathology, Washington University School of Medicine, 660 South Euclid Ave, St Louis, MO 63110, USA
    Head Neck Pathol 1:150-5. 2007
    ..The immunophenotype of our second case (BCL-6(-)/CD138(+)/MUM-1(+)) also suggests a post-germinal center B-cell origin. However, IgV(H) hypermutation analysis was not possible in this case...
  25. pmc Histologic identification of human papillomavirus (HPV)-related squamous cell carcinoma in cervical lymph nodes: a reliable predictor of the site of an occult head and neck primary carcinoma
    Samir K El-Mofty
    Department of Pathology and Immunology, Division of Anatomic and Molecular Pathology, Washington University School of Medicine, 660 S Euclid Ave, St Louis, MO 63110, USA
    Head Neck Pathol 2:163-8. 2008
    ..Identifying HPV-related SCC in the lymph nodes may thus provide a means for localizing the primary tumor site...
  26. pmc Human papillomavirus (HPV) related carcinomas of the upper aerodigestive tract
    Samir K El-Mofty
    Washington University, St Louis, MO, USA
    Head Neck Pathol 1:181-5. 2007
    ..An anti-HPV vaccine has recently been made available for prevention of cervical cancer. The impact of the vaccine on the prevalence of HPV related carcinomas of the UADT is currently not known but likely beneficial...
  27. ncbi request reprint Alternative epithelial markers in sarcomatoid carcinomas of the head and neck, lung, and bladder-p63, MOC-31, and TTF-1
    James S Lewis
    Department of Pathology and Immunology, Division of Anatomic Pathology, Washington University in St Louis, School of Medicine, St Louis, MO, USA
    Mod Pathol 18:1471-81. 2005
    ..In conclusion, immunostaining beyond traditional pan-cytokeratin and epithelial membrane antigen may have diagnostic utility in this context...
  28. pmc HPV-related squamous cell carcinoma variants in the head and neck
    Samir K El-Mofty
    Department of Pathology and Immunology, Washington University School of Medicine, 660 S Euclid Ave, Campus Box 8118, St Louis, MO, USA
    Head Neck Pathol 6:S55-62. 2012
    ..Because of this, it is prudent at this stage not to alter management protocols as a result of identification of HPV in these variants and to await additional studies...
  29. pmc Large cell neuroendocrine carcinoma of the larynx: definition of an entity
    James S Lewis
    Departments of Pathology and Immunology, Otolaryngology Head and Neck Surgery, Washington University in St Louis, St Louis, MO 63110, USA
    Head Neck Pathol 4:198-207. 2010
    ....
  30. doi request reprint In myofibroblastic sarcomas of the head and neck, mitotic activity and necrosis define grade: a case study and literature review
    Chunyu Cai
    Department of Pathology and Immunology, Washington University School of Medicine, 660 S Euclid Ave, Campus Box 8118, St Louis, MO, USA
    Virchows Arch 463:827-36. 2013
    ..We found that MFSs with 6 or more mitoses per 10 high power fields and/or presence of spontaneous necrosis were accompanied by a higher mortality rate that is statistically significant...
  31. pmc Pseudotumor of the tracheal-laryngeal junction with unusual morphologic features caused by Rhodococcus equi infection
    Shreeram Akilesh
    Department of Pathology and Immunology, Barnes Jewish Hospital, St Louis, MO 63110, USA
    Head Neck Pathol 5:395-400. 2011
    ..We also explore the pathogenetic mechanisms that may contribute to the distinctive histologic appearance of Rhodococcus-associated pseudotumors...
  32. doi request reprint Utility of high molecular weight cytokeratins, but not p63, in the differential diagnosis of neuroendocrine and basaloid carcinomas of the head and neck
    Maria F Serrano
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Hum Pathol 39:591-8. 2008
    ..We conclude that high molecular weight cytokeratin immunostaining is helpful in distinguishing high-grade neuroendocrine carcinomas from similar tumor types...
  33. doi request reprint Cystic lymphoid hyperplasia of the parotid gland in HIV-positive and HIV-negative patients: quantitative immunopathology
    Friederike H Kreisel
    Department of Pathology and Immunology, Washington University Medical Center, St Louis, MO 63110, USA
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 109:567-74. 2010
    ..They share a common microscopic appearance characterized by epimyoepithelial islands and/or epithelial lined cysts in a lymphoid stroma. However, they differ greatly regarding their etiology, clinical presentation, and management...