Samir K El-Mofty

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. ncbi Psammomatoid and trabecular juvenile ossifying fibroma of the craniofacial skeleton: two distinct clinicopathologic entities
    Samir El-Mofty
    Department of Oral and Maxillofacial Pathology, Washington University School of Medicine, St Louis, MO 63110, USA
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 93:296-304. 2002
  2. ncbi Prevalence of human papillomavirus type 16 DNA in squamous cell carcinoma of the palatine tonsil, and not the oral cavity, in young patients: a distinct clinicopathologic and molecular disease entity
    Samir K El-Mofty
    Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Surg Pathol 27:1463-70. 2003
  3. ncbi Prevalence of high-risk human papillomavirus DNA in nonkeratinizing (cylindrical cell) carcinoma of the sinonasal tract: a distinct clinicopathologic and molecular disease entity
    Samir K El-Mofty
    Department of Pathology and Immunology, Washington University School of Medicine, 660 S Euclid, Campus Box 8118, St Louis, MO 63110, USA
    Am J Surg Pathol 29:1367-72. 2005
  4. ncbi Metachronous squamous cell carcinomas evolving from independent oropharyngeal and pulmonary squamous papillomas: association with human papillomavirus 11 and lack of aberrant p53, Rb, and p16 protein expression
    Haodong Xu
    Lauren V. Ackerman Laboratory of Surgical Pathology, Washington University School of Medicine, St. Louis, MO 63110-1093, USA
    Hum Pathol 35:1419-22. 2004
  5. ncbi Partial p16 staining in oropharyngeal squamous cell carcinoma: extent and pattern correlate with human papillomavirus RNA status
    James S Lewis
    Department of Pathology and Immunology, Washington University, St Louis, MO 63110, USA
    Mod Pathol 25:1212-20. 2012
  6. ncbi Human papillomavirus-positive basaloid squamous cell carcinomas of the upper aerodigestive tract: a distinct clinicopathologic and molecular subtype of basaloid squamous cell carcinoma
    Rebecca D Chernock
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Hum Pathol 41:1016-23. 2010
  7. ncbi p16 positive oropharyngeal squamous cell carcinoma:an entity with a favorable prognosis regardless of tumor HPV status
    James S Lewis
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Surg Pathol 34:1088-96. 2010
  8. ncbi Human papillomavirus (HPV)-related oropharyngeal nonkeratinizing squamous cell carcinoma: characterization of a distinct phenotype
    Samir K El-Mofty
    Washington University School of Medicine, St Louis, MO 63110, USA
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 101:339-45. 2006
  9. ncbi Undifferentiated carcinoma of the oropharynx: a human papillomavirus-associated tumor with a favorable prognosis
    Danielle H Carpenter
    Department of Pathology and Immunology, Division of Anatomic and Molecular Pathology, Washington University, St Louis, MO, USA
    Mod Pathol 24:1306-12. 2011
  10. ncbi Human papillomavirus-related squamous cell carcinoma of the oropharynx: a comparative study in whites and African Americans
    Rebecca D Chernock
    Department of Pathology and Immunology, Washington University School of Medicine, 660 S Euclid Ave, Campus Box 8118, St Louis, MO 63110, USA
    Arch Otolaryngol Head Neck Surg 137:163-9. 2011

Detail Information

Publications27

  1. ncbi Psammomatoid and trabecular juvenile ossifying fibroma of the craniofacial skeleton: two distinct clinicopathologic entities
    Samir El-Mofty
    Department of Oral and Maxillofacial Pathology, Washington University School of Medicine, St Louis, MO 63110, USA
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 93:296-304. 2002
    ....
  2. ncbi Prevalence of human papillomavirus type 16 DNA in squamous cell carcinoma of the palatine tonsil, and not the oral cavity, in young patients: a distinct clinicopathologic and molecular disease entity
    Samir K El-Mofty
    Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Surg Pathol 27:1463-70. 2003
    ..The HPV-positive carcinomas have a distinct histopathologic and immunophenotypic features...
  3. ncbi Prevalence of high-risk human papillomavirus DNA in nonkeratinizing (cylindrical cell) carcinoma of the sinonasal tract: a distinct clinicopathologic and molecular disease entity
    Samir K El-Mofty
    Department of Pathology and Immunology, Washington University School of Medicine, 660 S Euclid, Campus Box 8118, St Louis, MO 63110, USA
    Am J Surg Pathol 29:1367-72. 2005
    ....
  4. ncbi Metachronous squamous cell carcinomas evolving from independent oropharyngeal and pulmonary squamous papillomas: association with human papillomavirus 11 and lack of aberrant p53, Rb, and p16 protein expression
    Haodong Xu
    Lauren V. Ackerman Laboratory of Surgical Pathology, Washington University School of Medicine, St. Louis, MO 63110-1093, USA
    Hum Pathol 35:1419-22. 2004
    ..These observations indicate that human papillomavirus 11-associated neoplastic transformation and tumor progression in the respiratory tract may not involve aberrant regulation of the p53 and Rb signaling pathways...
  5. ncbi Partial p16 staining in oropharyngeal squamous cell carcinoma: extent and pattern correlate with human papillomavirus RNA status
    James S Lewis
    Department of Pathology and Immunology, Washington University, St Louis, MO 63110, USA
    Mod Pathol 25:1212-20. 2012
    ..These results support that greater than 75% p16 staining or, alternatively, >50% staining combined with >25% confluent areas, are suitable cutoffs for defining positivity...
  6. ncbi Human papillomavirus-positive basaloid squamous cell carcinomas of the upper aerodigestive tract: a distinct clinicopathologic and molecular subtype of basaloid squamous cell carcinoma
    Rebecca D Chernock
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Hum Pathol 41:1016-23. 2010
    ..These tumors occur almost exclusively in the oropharynx, are molecularly distinct from their human papillomavirus-negative counterparts, and have a more favorable clinical outcome...
  7. ncbi p16 positive oropharyngeal squamous cell carcinoma:an entity with a favorable prognosis regardless of tumor HPV status
    James S Lewis
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Surg Pathol 34:1088-96. 2010
    ..Many recommend use of both p16 immunohistochemistry and HPV in situ hybridization (ISH). A significant minority of tumors are p16 positive and HPV ISH negative, the significance of which is unclear...
  8. ncbi Human papillomavirus (HPV)-related oropharyngeal nonkeratinizing squamous cell carcinoma: characterization of a distinct phenotype
    Samir K El-Mofty
    Washington University School of Medicine, St Louis, MO 63110, USA
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 101:339-45. 2006
    ..It is concluded that NKCa of the tonsils and base of tongue is a distinct subtype of squamous cell carcinoma of the head and neck with high prevalence of HPV DNA and a characteristic immunophenotype...
  9. ncbi Undifferentiated carcinoma of the oropharynx: a human papillomavirus-associated tumor with a favorable prognosis
    Danielle H Carpenter
    Department of Pathology and Immunology, Division of Anatomic and Molecular Pathology, Washington University, St Louis, MO, USA
    Mod Pathol 24:1306-12. 2011
    ..Disease-specific survival is comparable to published rates for other HPV-related oropharyngeal squamous cell carcinoma variants and is better than that of HPV-negative carcinomas...
  10. ncbi Human papillomavirus-related squamous cell carcinoma of the oropharynx: a comparative study in whites and African Americans
    Rebecca D Chernock
    Department of Pathology and Immunology, Washington University School of Medicine, 660 S Euclid Ave, Campus Box 8118, St Louis, MO 63110, USA
    Arch Otolaryngol Head Neck Surg 137:163-9. 2011
    ..To evaluate the frequency of human papillomavirus-related oropharyngeal squamous cell carcinoma in African Americans and whites and to examine patient outcomes in these 2 groups...
  11. ncbi Adenosquamous carcinoma of the head and neck: relationship to human papillomavirus and review of the literature
    Ramya P Masand
    Department of Pathology and Immunology, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Head Neck Pathol 5:108-16. 2011
    ..Head and neck ADSC appears to be a mixed variant that can be further classified according to its HPV status...
  12. ncbi HPV-related nonkeratinizing squamous cell carcinoma of the oropharynx: utility of microscopic features in predicting patient outcome
    Rebecca D Chernock
    Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid, Campus Box 8118, St Louis, MO 63110, USA
    Head Neck Pathol 3:186-94. 2009
    ..NK SCC histology strongly predicts HPV-association and better patient survival compared to K SCC. Hybrid SCC appears to have an intermediate frequency of HPV-association and patient survival...
  13. ncbi Detection and significance of human papillomavirus, CDKN2A(p16) and CDKN1A(p21) expression in squamous cell carcinoma of the larynx
    Rebecca D Chernock
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Mod Pathol 26:223-31. 2013
    ..Because of this, CDKN2A(p16) should not be used as a definitive surrogate marker of HPV-driven tumors in the larynx...
  14. ncbi Recognition of nonkeratinizing morphology in oropharyngeal squamous cell carcinoma - a prospective cohort and interobserver variability study
    James S Lewis
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Histopathology 60:427-36. 2012
    ....
  15. ncbi Human papillomavirus and oropharynx cancer: biology, detection and clinical implications
    Clint T Allen
    Department of Otolaryngology Head and Neck Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Laryngoscope 120:1756-72. 2010
    ..To review evidence for the role of human papillomavirus (HPV) in the etiology of oropharyngeal cancers, methods of viral detection, and the resulting clinical implications...
  16. ncbi Expression of p16, Rb, and p53 proteins in squamous cell carcinomas of the anorectal region harboring human papillomavirus DNA
    Danielle W Lu
    Lauren V. Ackerman Laboratory of Surgical Pathology, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri 63110, USA
    Mod Pathol 16:692-9. 2003
    ....
  17. ncbi Absence of Merkel cell polyomavirus in primary parotid high-grade neuroendocrine carcinomas regardless of cytokeratin 20 immunophenotype
    Rebecca D Chernock
    Departments of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA
    Am J Surg Pathol 35:1806-11. 2011
    ..Furthermore, viral testing may aid in distinguishing the 2 tumor types, as a positive result would favor a metastasis...
  18. ncbi Infectious pseudotumors: red herrings in head and neck pathology
    Samir K El-Mofty
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA
    Head Neck Pathol 6:58-63. 2012
    ..Accurately identifying these lesions and the specific causative agent is of particular significance since they can be successfully treated with antibiotics...
  19. ncbi Plasmablastic lymphoma of head and neck: report of two new cases and correlation with c-myc and IgVH gene mutation status
    Anjum Hassan
    Department of Pathology and Immunology, Division of Anatomic Pathology, Washington University School of Medicine, 660 South Euclid Ave, St Louis, MO 63110, USA
    Head Neck Pathol 1:150-5. 2007
    ..The immunophenotype of our second case (BCL-6(-)/CD138(+)/MUM-1(+)) also suggests a post-germinal center B-cell origin. However, IgV(H) hypermutation analysis was not possible in this case...
  20. ncbi Human papillomavirus (HPV) related carcinomas of the upper aerodigestive tract
    Samir K El-Mofty
    Washington University, St Louis, MO, USA
    Head Neck Pathol 1:181-5. 2007
    ..An anti-HPV vaccine has recently been made available for prevention of cervical cancer. The impact of the vaccine on the prevalence of HPV related carcinomas of the UADT is currently not known but likely beneficial...
  21. ncbi Histologic identification of human papillomavirus (HPV)-related squamous cell carcinoma in cervical lymph nodes: a reliable predictor of the site of an occult head and neck primary carcinoma
    Samir K El-Mofty
    Department of Pathology and Immunology, Division of Anatomic and Molecular Pathology, Washington University School of Medicine, 660 S Euclid Ave, St Louis, MO 63110, USA
    Head Neck Pathol 2:163-8. 2008
    ..Identifying HPV-related SCC in the lymph nodes may thus provide a means for localizing the primary tumor site...
  22. ncbi Alternative epithelial markers in sarcomatoid carcinomas of the head and neck, lung, and bladder-p63, MOC-31, and TTF-1
    James S Lewis
    Department of Pathology and Immunology, Division of Anatomic Pathology, Washington University in St Louis, School of Medicine, St Louis, MO, USA
    Mod Pathol 18:1471-81. 2005
    ..In conclusion, immunostaining beyond traditional pan-cytokeratin and epithelial membrane antigen may have diagnostic utility in this context...
  23. ncbi HPV-related squamous cell carcinoma variants in the head and neck
    Samir K El-Mofty
    Department of Pathology and Immunology, Washington University School of Medicine, 660 S Euclid Ave, Campus Box 8118, St Louis, MO, USA
    Head Neck Pathol 6:S55-62. 2012
    ..Because of this, it is prudent at this stage not to alter management protocols as a result of identification of HPV in these variants and to await additional studies...
  24. ncbi Large cell neuroendocrine carcinoma of the larynx: definition of an entity
    James S Lewis
    Departments of Pathology and Immunology, Otolaryngology Head and Neck Surgery, Washington University in St Louis, St Louis, MO 63110, USA
    Head Neck Pathol 4:198-207. 2010
    ....
  25. ncbi Pseudotumor of the tracheal-laryngeal junction with unusual morphologic features caused by Rhodococcus equi infection
    Shreeram Akilesh
    Department of Pathology and Immunology, Barnes Jewish Hospital, St Louis, MO 63110, USA
    Head Neck Pathol 5:395-400. 2011
    ..We also explore the pathogenetic mechanisms that may contribute to the distinctive histologic appearance of Rhodococcus-associated pseudotumors...
  26. ncbi Utility of high molecular weight cytokeratins, but not p63, in the differential diagnosis of neuroendocrine and basaloid carcinomas of the head and neck
    Maria F Serrano
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Hum Pathol 39:591-8. 2008
    ..We conclude that high molecular weight cytokeratin immunostaining is helpful in distinguishing high-grade neuroendocrine carcinomas from similar tumor types...
  27. ncbi Cystic lymphoid hyperplasia of the parotid gland in HIV-positive and HIV-negative patients: quantitative immunopathology
    Friederike H Kreisel
    Department of Pathology and Immunology, Washington University Medical Center, St Louis, MO 63110, USA
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 109:567-74. 2010
    ..They share a common microscopic appearance characterized by epimyoepithelial islands and/or epithelial lined cysts in a lymphoid stroma. However, they differ greatly regarding their etiology, clinical presentation, and management...