M L Dustin

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. ncbi request reprint The immunological synapse and the actin cytoskeleton: molecular hardware for T cell signaling
    M L Dustin
    Department of Pathology and Immunology, Washington University School of Medicine, 660 S Euclid Ave, St Louis MO 63110, USA
    Nat Immunol 1:23-9. 2000
  2. ncbi request reprint The immunological synapse
    S K Bromley
    Department of Pathology and Immunology, Washington University School of Medicine, 660 S. Euclid Ave, St. Louis, Missouri 63110, USA
    Annu Rev Immunol 19:375-96. 2001
  3. ncbi request reprint Environmental control of immunological synapse formation and duration
    M L Dustin
    Center for Immunology, Washington University School of Medicine, 660 S Euclid Ave, St Louis, MO 63110, USA
    Trends Immunol 22:192-4. 2001
  4. pmc Adhesion-activating phorbol ester increases the mobility of leukocyte integrin LFA-1 in cultured lymphocytes
    D F Kucik
    Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    J Clin Invest 97:2139-44. 1996
  5. ncbi request reprint Adhesive bond dynamics in contacts between T lymphocytes and glass-supported planar bilayers reconstituted with the immunoglobulin-related adhesion molecule CD58
    M L Dustin
    Center for Immunology and the Department of Pathology, Washington University School of Medicine, Box 8118, St Louis, Missouri 63110, USA
    J Biol Chem 272:15782-8. 1997
  6. pmc Antigen receptor engagement delivers a stop signal to migrating T lymphocytes
    M L Dustin
    Center for Immunology and Department of Pathology, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 94:3909-13. 1997
  7. ncbi request reprint A novel adaptor protein orchestrates receptor patterning and cytoskeletal polarity in T-cell contacts
    M L Dustin
    Department of Pathology and Center for Immunology, Washington University School of Medicine, Saint Louis, Missouri 63110, USA
    Cell 94:667-77. 1998
  8. ncbi request reprint Making a little affinity go a long way: a topological view of LFA-1 regulation
    M L Dustin
    Department of Pathology, Washington University School of Medicine, St Louis, MO 63110, USA
    Cell Adhes Commun 6:255-62. 1998
  9. ncbi request reprint The immunological synapse and CD28-CD80 interactions
    S K Bromley
    Department of Pathology and Immunology, Washington University School of Medicine, 660 S Euclid Ave, St Louis MO, USA
    Nat Immunol 2:1159-66. 2001

Collaborators

Detail Information

Publications9

  1. ncbi request reprint The immunological synapse and the actin cytoskeleton: molecular hardware for T cell signaling
    M L Dustin
    Department of Pathology and Immunology, Washington University School of Medicine, 660 S Euclid Ave, St Louis MO 63110, USA
    Nat Immunol 1:23-9. 2000
    ..This review focuses on the recent convergence of cell biology and immunology studies to explain the role of the actin cytoskeleton in creating the molecular basis for immunological synapse formation and T cell signaling...
  2. ncbi request reprint The immunological synapse
    S K Bromley
    Department of Pathology and Immunology, Washington University School of Medicine, 660 S. Euclid Ave, St. Louis, Missouri 63110, USA
    Annu Rev Immunol 19:375-96. 2001
    ..The APC may also play an active role in immunological synapse formation, particularly for activation of naïve T cells...
  3. ncbi request reprint Environmental control of immunological synapse formation and duration
    M L Dustin
    Center for Immunology, Washington University School of Medicine, 660 S Euclid Ave, St Louis, MO 63110, USA
    Trends Immunol 22:192-4. 2001
    ..Here, we propose a model that reconciles immunological synapse formation and serial encounters based on environmental control of immunological synapse formation...
  4. pmc Adhesion-activating phorbol ester increases the mobility of leukocyte integrin LFA-1 in cultured lymphocytes
    D F Kucik
    Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    J Clin Invest 97:2139-44. 1996
    ..Cytochalasin D led to an equivalent increase in mobility and, at low doses, stimulated adhesion, implying that the nonadhesive state of LFA-1 is actively maintained by the lymphocyte cytoskeleton...
  5. ncbi request reprint Adhesive bond dynamics in contacts between T lymphocytes and glass-supported planar bilayers reconstituted with the immunoglobulin-related adhesion molecule CD58
    M L Dustin
    Center for Immunology and the Department of Pathology, Washington University School of Medicine, Box 8118, St Louis, Missouri 63110, USA
    J Biol Chem 272:15782-8. 1997
    ..These findings have implications for the mechanism of signaling by CD2 and the mechanism of cell detachment from large numbers of transient interactions...
  6. pmc Antigen receptor engagement delivers a stop signal to migrating T lymphocytes
    M L Dustin
    Center for Immunology and Department of Pathology, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 94:3909-13. 1997
    ..We propose that the stop signal is an early and essential event in T cell activation that also will play an important role in control of T cell migration...
  7. ncbi request reprint A novel adaptor protein orchestrates receptor patterning and cytoskeletal polarity in T-cell contacts
    M L Dustin
    Department of Pathology and Center for Immunology, Washington University School of Medicine, Saint Louis, Missouri 63110, USA
    Cell 94:667-77. 1998
    ..This novel protein, called CD2AP, is likely to facilitate receptor patterning in the contact area by linking specific adhesion receptors to the cytoskeleton...
  8. ncbi request reprint Making a little affinity go a long way: a topological view of LFA-1 regulation
    M L Dustin
    Department of Pathology, Washington University School of Medicine, St Louis, MO 63110, USA
    Cell Adhes Commun 6:255-62. 1998
    ..I propose that coordination of these processes allows rapid interconversion between stable adhesion and detachment...
  9. ncbi request reprint The immunological synapse and CD28-CD80 interactions
    S K Bromley
    Department of Pathology and Immunology, Washington University School of Medicine, 660 S Euclid Ave, St Louis MO, USA
    Nat Immunol 2:1159-66. 2001
    ....