Erik R Dubberke

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..The 3 articles that follow in this supplement address the diagnosis and treatment of initial and recurrent CDI, and current practice guidelines for the prevention and control of CDI in the hospital setting...

..difficile, and antibiotic stewardship. Hospitalists, as coordinators of care for each patient and advocates for quality care, can spearhead these efforts...

..Electronic surveillance was highly sensitive, specific, and showed good to excellent agreement for hospital-onset; community-onset, study facility-associated; indeterminate; and recurrent CDI...

..difficile infection. Studies are needed to define the optimal prevention practices and to investigate novel prevention methods...

..None suffered from any CDI-related adverse events. In conclusion, clinical presentation is important when interpreting C. difficile diagnostic assays...

..To develop and validate a risk prediction model that could identify patients at high risk for Clostridium difficile infection (CDI) before they develop disease...

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..difficile toxin assay results...

..To evaluate the impact of cases of community-onset, healthcare facility (HCF)-associated Clostridium difficile infection (CDI) on the incidence and outbreak detection of CDI...

..Whether ICD-9-CM code rank order affects CDI prevalence estimates is important because the National Hospital Discharge Survey (NHDS) and the Nationwide Inpatient Sample (NIS) have varying limits on the number of ICD-9-CM codes collected...

..difficile on perceived CDI burden, positive predictive value, and false-positive results...

..Even in a nonoutbreak setting, CDAD had a statistically significant negative impact on patient illness and death, and the impact of CDAD persisted beyond hospital discharge...

..To assess Clostridium difficile infection (CDI)-related colectomy rates by CDI surveillance definitions and over time at multiple healthcare facilities...

..In addition, intensivists should be ready to implement systems changes related to notification, isolation precautions and prevention, and environmental cleaning in the ICU...

..6, 95% CI 1.1-6.2). CDAD is a significant cause of morbidity and mortality in allogeneic HSCT patients, but modifiable risk factors exist. Further study is needed to determine the best methods of decreasing patients' risk of CDAD...

..The purpose of this study was to determine risk factors for endemic CDAD, including CDAD pressure, a modified version of colonization pressure...

..There are few data on the short-term and long-term attributable costs of CDAD. The objective of this study was to determine the acute and 180-day attributable inpatient costs of CDAD...

..The objective of this study was to determine whether the decreased CDI incidence related to the change in EIA resulted in adverse patient outcomes...

..To provide a general understanding of Clostridium difficile infection with a focus on recent publications that evaluate the disease in solid organ transplant recipients...

..The purpose of this study was to evaluate CDAD pressure, a modified form of colonization pressure based on symptomatic CDAD cases, as a risk factor for CDAD...

..We sought to determine whether CDAD incidence has increased specifically in hospitalized patients with IBD. We also explored possible differences in the risk for and time to presentation of CDAD between IBD and non-IBD patients...

..difficile environmental contamination at various health care facilities in a metropolitan area and determine if the North American pulsed field gel electrophoresis type 1 (NAP1) strain was present...

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..To describe the characteristics and clinical outcomes of hematopoietic stem cell transplant (HSCT) recipients who received adjunctive cytomegalovirus intravenous immune globulin (CMV-IVIG) for probable or proven CMV disease...

..Activation of p38-MK2 in infected animals and humans suggests that this pathway is a key driver of intestinal inflammation in patients with CDI...

..Risk factors for any S aureus and MRSA colonization on admission in oncology patients are consistent with previous studies in general populations. In addition, recent chemotherapy as a risk factor is a unique finding in this population...

..This article seeks to provide a broad understanding of CDI in the intensive care unit, with special emphasis on risk factor identification, treatment options, and disease prevention...

..Patients with severe CDAD had significantly shorter median survival times and more adverse outcomes than patients with mild or moderate CDAD...

..To more completely assess its economic burden, we performed a review of available literature that reported costs associated with the infection...

..Few data exist on the clinical presentation of influenza in hospitalized patients, which may be distinct from the clinical presentation of influenza in ambulatory patients because of underlying medical conditions and medications...

..In general, micafungin is well tolerated and has favorable safety and drug-interaction profiles...

..In this article the authors report a case of adenoviral meningoencephalitis caused by serotype 26 and its identification, not described previously, in cerebrospinal fluid (CSF) by PCR and brain tissue by immunohistochemical staining...

..The investigation found an increase in CDI-related colectomies for CDI not associated with the study institution. Electronically available data facilitated surveillance for severe CDI...

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..Sparks, MD). Identifying the most sensitive method of recovery will allow for further study of asymptomatic C. difficile carriers and their role in the epidemiology of C. difficile...

..The correlation between toxin assay results and ICD-9 codes was good (K = 0.72, p<0.01). The sensitivity of the ICD-9 codes was 78% and the specificity was 99.7%...

..The platform is reproducible with minimal intra- or interassay variability. This method exhibited a discriminatory index of 0.954 and is therefore comparable to more arduous typing systems, such as pulsed-field gel electrophoresis...