Min Du


Affiliation: Washington State University
Country: USA


  1. Wang H, Mao X, Du M. Phytanic acid activates PPARα to promote beige adipogenic differentiation of preadipocytes. J Nutr Biochem. 2019;67:201-211 pubmed publisher
    ..Taken together, PA promotes beige adipogenic differentiation, but not the commitment of progenitor cells to the brown adipocyte lineage. PPARα is a key mediator during PA-induced beige/brown adipogenic differentiation. ..
  2. Han L, Li T, Du M, Chang R, Zhan B, Mao X. Beneficial Effects of Potentilla discolor Bunge Water Extract on Inflammatory Cytokines Release and Gut Microbiota in High-Fat Diet and Streptozotocin-Induced Type 2 Diabetic Mice. Nutrients. 2019;11: pubmed publisher
    ..Our results indicated that PDB might serve as a potential functional ingredient against diabetes and related inflammation. ..
  3. Son J, Chae S, Park B, Du M, Song W. Plasma apelin levels in overweight/obese adults following a single bout of exhaustive exercise: A preliminary cross-sectional study. Endocrinol Diabetes Nutr. 2019;66:278-290 pubmed publisher
    ..Thus, apelin secretion after a single exercise is dependent on gender and metabolic status of subjects. ..
  4. Zhao L, Du M, Gao J, Zhan B, Mao X. Label-free quantitative proteomic analysis of milk fat globule membrane proteins of yak and cow and identification of proteins associated with glucose and lipid metabolism. Food Chem. 2019;275:59-68 pubmed publisher
    ..These findings demonstrate that MFGM proteins contain potential bioactive ingredients for improving metabolic health. ..
  5. Zhao L, Wang B, Gomez N, de Avila J, Zhu M, Du M. Even a low dose of tamoxifen profoundly induces adipose tissue browning in female mice. Int J Obes (Lond). 2019;: pubmed publisher
  6. Zhao L, Zou T, Gomez N, Wang B, Zhu M, Du M. Raspberry alleviates obesity-induced inflammation and insulin resistance in skeletal muscle through activation of AMP-activated protein kinase (AMPK) α1. Nutr Diabetes. 2018;8:39 pubmed publisher
    ..AMPKα1 is an important mediator for the beneficial effects of raspberry through alleviating inflammatory responses and sensitizing insulin signaling in skeletal muscle of HFD-fed mice. ..
  7. Du M, Wang B, Fu X, Yang Q, Zhu M. Fetal programming in meat production. Meat Sci. 2015;109:40-7 pubmed publisher
    ..On the contrary, because fishes are able to generate new muscle fibers lifelong, the impact of early nutrition on fish growth performance is expected to be minor, which requires further studies. ..
  8. Fu X, Zhu M, Dodson M, Du M. AMP-activated protein kinase stimulates Warburg-like glycolysis and activation of satellite cells during muscle regeneration. J Biol Chem. 2015;290:26445-56 pubmed publisher
    ..Taken together, AMPKα1 is a critical mediator linking noncanonical Shh pathway to Warburg-like glycolysis in satellite cells, which is required for satellite activation and muscle regeneration. ..
  9. Fu X, Zhu M, Zhang S, Foretz M, Viollet B, Du M. Obesity Impairs Skeletal Muscle Regeneration Through Inhibition of AMPK. Diabetes. 2016;65:188-200 pubmed publisher
    ..In summary, AMPKα1 is a key mediator linking obesity and impaired muscle regeneration, providing a convenient drug target to facilitate muscle regeneration in obese populations. ..

More Information


  1. Wang B, Yang Q, Harris C, Nelson M, Busboom J, Zhu M, et al. Nutrigenomic regulation of adipose tissue development - role of retinoic acid: A review. Meat Sci. 2016;120:100-106 pubmed publisher
    ..In this review, we discuss nutritional regulation of adipogenesis, focusing on retinoic acid and its impact on epigenetic modifications of key adipogenic genes. ..
  2. Gao J, Song J, Du M, Mao X. Bovine α-Lactalbumin Hydrolysates (α-LAH) Ameliorate Adipose Insulin Resistance and Inflammation in High-Fat Diet-Fed C57BL/6J Mice. Nutrients. 2018;10: pubmed publisher
    ..These results suggested that bovine α-LAH could ameliorate adipose insulin resistance and inflammation through IKK and MAPK signaling pathways in HFD-fed C57BL/6J mice. ..
  3. Li T, Gao J, Du M, Song J, Mao X. Milk Fat Globule Membrane Attenuates High-Fat Diet-Induced Obesity by Inhibiting Adipogenesis and Increasing Uncoupling Protein 1 Expression in White Adipose Tissue of Mice. Nutrients. 2018;10: pubmed publisher
    ..Taken together, these findings provide evidence that MFGM may protect against diet-induced adiposity by suppressing adipogenesis and promoting brown-like transformation in WAT. ..
  4. Zou T, Wang B, Yang Q, de Avila J, Zhu M, You J, et al. Raspberry promotes brown and beige adipocyte development in mice fed high-fat diet through activation of AMP-activated protein kinase (AMPK) α1. J Nutr Biochem. 2018;55:157-164 pubmed publisher
    ..In conclusion, AMPKα1 is indispensable for the effects of RAS on brown and beige/brite adipocyte development, and prevention of obesity and metabolic dysfunction. ..
  5. Wang B, Wang Z, de Avila J, Zhu M, Zhang F, Gomez N, et al. Moderate alcohol intake induces thermogenic brown/beige adipocyte formation via elevating retinoic acid signaling. FASEB J. 2017;31:4612-4622 pubmed publisher
    ..J., Zhang, F., Gomez, N. A., Zhao, L., Tian, Q., Zhao, J., Maricelli, J., Zhang, H., Rodgers, B. D., Du, M. Moderate alcohol intake induces thermogenic brown/beige adipocyte formation via elevating retinoic acid signaling. ..
  6. Du M, Carlin K. Meat Science and Muscle Biology Symposium: extracellular matrix in skeletal muscle development and meat quality. J Anim Sci. 2012;90:922-3 pubmed publisher
  7. Zhao J, Yang Q, Zhang L, Liang X, Sun X, Wang B, et al. AMPK?1 deficiency suppresses brown adipogenesis in favor of fibrogenesis during brown adipose tissue development. Biochem Biophys Res Commun. 2017;491:508-514 pubmed publisher
    ..Taken together, our data demonstrated that AMPK?1 deficiency suppressed brown adipogenesis in favor of fibrogenesis during BAT development. ..
  8. Wang B, Fu X, Liang X, Wang Z, Yang Q, Zou T, et al. Maternal Retinoids Increase PDGFR?+ Progenitor Population and Beige Adipogenesis in Progeny by Stimulating Vascular Development. EBioMedicine. 2017;18:288-299 pubmed publisher
    ..Thus, enhancing maternal retinoids is an amiable therapeutic strategy to prevent obesity in offspring, especially for those born to obese mothers which account for one third of all pregnancies. ..
  9. Li T, Chen B, Du M, Song J, Cheng X, Wang X, et al. Casein Glycomacropeptide Hydrolysates Exert Cytoprotective Effect against Cellular Oxidative Stress by Up-Regulating HO-1 Expression in HepG2 Cells. Nutrients. 2017;9: pubmed publisher
    ..Our findings indicate that bovine casein glycomacropeptide hydrolysates might be a potential ingredient in the treatment of oxidative stress-related disorders and further studies are needed to investigate the protective effects in vivo. ..
  10. Yang Q, Liang X, Sun X, Zhang L, Fu X, Rogers C, et al. AMPK/?-Ketoglutarate Axis Dynamically Mediates DNA Demethylation in the Prdm16 Promoter and Brown Adipogenesis. Cell Metab. 2016;24:542-554 pubmed publisher
    ..In summary, AMPK is essential for the epigenetic control of BAT development through ?KG, thus linking a metabolite to progenitor cell differentiation and thermogenesis. ..
  11. Wang B, Yang G, Liang X, Zhu M, Du M. Grape seed extract prevents skeletal muscle wasting in interleukin 10 knockout mice. BMC Complement Altern Med. 2014;14:162 pubmed publisher
    ..GSE supplementation effectively prevents muscle wasting in IL10KO mice, showing that GSE can be used as an auxiliary treatment for muscle loss associated with chronic inflammation and frailty. ..