Gerald W Dorn

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. Dorn G. Mitochondrial pruning by Nix and BNip3: an essential function for cardiac-expressed death factors. J Cardiovasc Transl Res. 2010;3:374-83 pubmed publisher
  2. Dorn G. Evolving Concepts of Mitochondrial Dynamics. Annu Rev Physiol. 2018;: pubmed publisher
    ..Expected final online publication date for the Annual Review of Physiology Volume 81 is February 10, 2019. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates. ..
  3. Dorn G. Novel pharmacotherapies to abrogate postinfarction ventricular remodeling. Nat Rev Cardiol. 2009;6:283-91 pubmed publisher
    ..Therapeutic targeting of multiple organ systems involved in recovery after myocardial infarction might prove to be the best approach to improve patients' cardiac outcome. ..
  4. Shirihai O, Song M, Dorn G. How mitochondrial dynamism orchestrates mitophagy. Circ Res. 2015;116:1835-49 pubmed publisher
  5. Dorn G. Mitochondrial dynamism and heart disease: changing shape and shaping change. EMBO Mol Med. 2015;7:865-77 pubmed publisher
  6. Dorn G, Kitsis R. The mitochondrial dynamism-mitophagy-cell death interactome: multiple roles performed by members of a mitochondrial molecular ensemble. Circ Res. 2015;116:167-82 pubmed publisher
  7. Dorn G. Adrenergic signaling polymorphisms and their impact on cardiovascular disease. Physiol Rev. 2010;90:1013-62 pubmed publisher
  8. Dorn G. Molecular mechanisms that differentiate apoptosis from programmed necrosis. Toxicol Pathol. 2013;41:227-34 pubmed publisher
    ..Here, the different molecular mechanisms, effects, and pathophysiological implications of apoptosis and programmed necrosis are reviewed as they relate to heart failure and diabetes mediated by the Bcl-2 family protein, Nix. ..
  9. request reprint
    Dorn G. Mitochondrial dynamism and cardiac fate--a personal perspective. Circ J. 2013;77:1370-9 pubmed

More Information

Publications28

  1. Franco A, Zhang L, Matkovich S, Kovacs A, Dorn G. G-protein receptor kinases 2, 5 and 6 redundantly modulate Smoothened-GATA transcriptional crosstalk in fetal mouse hearts. J Mol Cell Cardiol. 2018;121:60-68 pubmed publisher
  2. Dorn G, Song M, Walsh K. Functional implications of mitofusin 2-mediated mitochondrial-SR tethering. J Mol Cell Cardiol. 2015;78:123-8 pubmed publisher
    ..This article is part of a Special Issue entitled "Mitochondria: From Basic Mitochondrial Biology to Cardiovascular Disease." ..
  3. Song M, Gong G, Burelle Y, Gustafsson Ã, Kitsis R, Matkovich S, et al. Interdependence of Parkin-Mediated Mitophagy and Mitochondrial Fission in Adult Mouse Hearts. Circ Res. 2015;117:346-51 pubmed publisher
    ..Ablating Drp1 in adult mouse cardiac myocytes not only interrupts mitochondrial fission, but also markedly upregulates Parkin, thus provoking mitophagic mitochondrial depletion that contributes to the lethal cardiomyopathy. ..
  4. Song M, Matkovich S, Zhang Y, Hammer D, Dorn G. Combined cardiomyocyte PKCδ and PKCε gene deletion uncovers their central role in restraining developmental and reactive heart growth. Sci Signal. 2015;8:ra39 pubmed publisher
    ..These growth-suppressing effects of novel PKCs have implications for therapeutic inhibition of PKCs in cancer, heart, and other diseases. ..
  5. Dorn G. Mitochondrial dynamics in heart disease. Biochim Biophys Acta. 2013;1833:233-41 pubmed publisher
    ..This article is part of a Special Issue entitled: Mitochondrial dynamics and physiology. ..
  6. Dorn G. Central Parkin: The evolving role of Parkin in the heart. Biochim Biophys Acta. 2016;1857:1307-1312 pubmed publisher
    ..This article is part of a Special Issue entitled 'EBEC 2016: 19th European Bioenergetics Conference, Riva del Garda, Italy, July 2-6, 2016. ..
  7. Song M, Dorn G. Mitoconfusion: noncanonical functioning of dynamism factors in static mitochondria of the heart. Cell Metab. 2015;21:195-205 pubmed publisher
  8. Dorn G. Parkin-dependent mitophagy in the heart. J Mol Cell Cardiol. 2016;95:42-9 pubmed publisher
    ..Recent findings have also uncovered an unsuspected role for Parkin-mediated mitochondrial turnover in the normal perinatal transformation of myocardial metabolism. ..
  9. Dorn G, Scorrano L. Two close, too close: sarcoplasmic reticulum-mitochondrial crosstalk and cardiomyocyte fate. Circ Res. 2010;107:689-99 pubmed publisher
    ..Here, we review our present understanding of the structural basis and the functional consequences of the close interaction between sarcoplasmic reticulum and mitochondria on cardiomyocyte function and death...
  10. Dorn G. GRK mythology: G-protein receptor kinases in cardiovascular disease. J Mol Med (Berl). 2009;87:455-63 pubmed publisher
    ..Here, recent developments are reviewed, with an emphasis on novel GRK functions and signaling pathways. ..
  11. Chen Y, Liu Y, Dorn G. Mitochondrial fusion is essential for organelle function and cardiac homeostasis. Circ Res. 2011;109:1327-31 pubmed publisher
    ..Interruption of mitochondrial fusion causes lethal cardiac failure at a time corresponding to 3 or 4 cycles of unopposed mitochondrial fission. ..
  12. Song M, Mihara K, Chen Y, Scorrano L, Dorn G. Mitochondrial fission and fusion factors reciprocally orchestrate mitophagic culling in mouse hearts and cultured fibroblasts. Cell Metab. 2015;21:273-85 pubmed publisher
    ..Drp1, MPTP, and cardiomyocyte mitophagy are functionally integrated. Mitochondrial fission and fusion have opposing roles during in vivo cardiac mitochondrial quality control. ..
  13. Dorn G, Clark C, Eschenbacher W, Kang M, Engelhard J, Warner S, et al. MARF and Opa1 control mitochondrial and cardiac function in Drosophila. Circ Res. 2011;108:12-7 pubmed publisher
    ..Postulated mitochondrial-endoplasmic reticulum interactions mediated uniquely by mfn2 appear dispensable to functioning of the fly heart. ..
  14. Song M, Chen Y, Gong G, Murphy E, Rabinovitch P, Dorn G. Super-suppression of mitochondrial reactive oxygen species signaling impairs compensatory autophagy in primary mitophagic cardiomyopathy. Circ Res. 2014;115:348-53 pubmed publisher
    ..A therapeutic window for mitochondrial ROS suppression should minimize the former while retaining the latter, which we achieved by expressing lower levels of catalase. ..
  15. Dorn G, Matkovich S, Eschenbacher W, Zhang Y. A human 3' miR-499 mutation alters cardiac mRNA targeting and function. Circ Res. 2012;110:958-67 pubmed publisher
    ..This first description of in vivo effects from a natural human miR mutation outside the seed sequence supports comprehensive studies of individual phenotypes or disease-modification conferred by miR mutations. ..
  16. Bhandari P, Song M, Dorn G. Dissociation of mitochondrial from sarcoplasmic reticular stress in Drosophila cardiomyopathy induced by molecularly distinct mitochondrial fusion defects. J Mol Cell Cardiol. 2015;80:71-80 pubmed publisher
  17. Gong G, Song M, Csordás G, Kelly D, Matkovich S, Dorn G. Parkin-mediated mitophagy directs perinatal cardiac metabolic maturation in mice. Science. 2015;350:aad2459 pubmed publisher
    ..Mitophagic mitochondrial removal underlies developmental cardiomyocyte mitochondrial plasticity and metabolic transitioning of perinatal hearts. ..
  18. Song M, Franco A, Fleischer J, Zhang L, Dorn G. Abrogating Mitochondrial Dynamics in Mouse Hearts Accelerates Mitochondrial Senescence. Cell Metab. 2017;26:872-883.e5 pubmed publisher
  19. Xu H, Dorn G, Shetty A, Parihar A, Dave T, Robinson S, et al. A Genome-Wide Association Study of Idiopathic Dilated Cardiomyopathy in African Americans. J Pers Med. 2018;8: pubmed publisher
    ..Our results suggest a novel locus for IDC in African Americans and provide additional insights into the genetic architecture and etiology. ..