Hongxin Dong

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. pmc Corticosterone and related receptor expression are associated with increased beta-amyloid plaques in isolated Tg2576 mice
    H Dong
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Neuroscience 155:154-63. 2008
  2. ncbi Quantitative trait loci linked to thalamus and cortex gray matter volumes in BXD recombinant inbred mice
    H Dong
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Heredity (Edinb) 99:62-9. 2007
  3. pmc Spatial relationship between synapse loss and beta-amyloid deposition in Tg2576 mice
    Hongxin Dong
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Comp Neurol 500:311-21. 2007
  4. pmc Effects of memantine on neuronal structure and conditioned fear in the Tg2576 mouse model of Alzheimer's disease
    Hongxin Dong
    Departments of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Neuropsychopharmacology 33:3226-36. 2008
  5. pmc Genetic influences on hippocampal structure and function in recombinant inbred mice
    Maureen V Martin
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA
    Behav Brain Res 196:78-83. 2009
  6. pmc Effects of voluntary and forced exercise on plaque deposition, hippocampal volume, and behavior in the Tg2576 mouse model of Alzheimer's disease
    Carla M Yuede
    Department of Psychiatry, Washington University School of Medicine, Campus Box 8134, 660 South Euclid Ave, St Louis, MO 63110, USA
    Neurobiol Dis 35:426-32. 2009
  7. ncbi Low dose quetiapine reverses deficits in contextual and cued fear conditioning in rats with excitotoxin-induced hippocampal neuropathy
    Maureen V Martin
    Department of Psychiatry Box 8134, Washington University School of Medicine, 660 S Euclid, St Louis, MO 63110, United States
    Pharmacol Biochem Behav 82:263-9. 2005
  8. ncbi Independent quantitative trait loci influence ventral and dorsal hippocampal volume in recombinant inbred strains of mice
    Maureen V Martin
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Genes Brain Behav 5:614-23. 2006
  9. pmc Cholinesterase inhibitors ameliorate behavioral deficits induced by MK-801 in mice
    John G Csernansky
    Department of Psychiatry, Washington University School of Medicine, 660 S Euclid, St Louis, MO 63110, USA
    Neuropsychopharmacology 30:2135-43. 2005
  10. pmc Acetylcholinesterase inhibitors ameliorate behavioral deficits in the Tg2576 mouse model of Alzheimer's disease
    Hongxin Dong
    Department of Psychiatry, Washington University School of Medicine, Campus Box 8134, 660 South Euclid Ave, St Louis, MO 63110, USA
    Psychopharmacology (Berl) 181:145-52. 2005

Detail Information

Publications20

  1. pmc Corticosterone and related receptor expression are associated with increased beta-amyloid plaques in isolated Tg2576 mice
    H Dong
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Neuroscience 155:154-63. 2008
    ..These results suggest that isolation stress increases corticosterone levels and GR and CRFR1 expression in conjunction with increases in brain tissue Abeta levels and Abeta plaque deposition in the Tg2576 mouse model of AD...
  2. ncbi Quantitative trait loci linked to thalamus and cortex gray matter volumes in BXD recombinant inbred mice
    H Dong
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Heredity (Edinb) 99:62-9. 2007
    ..71). These results suggest that there are separate and shared genetic influences on the development of the thalamus and cerebral cortex...
  3. pmc Spatial relationship between synapse loss and beta-amyloid deposition in Tg2576 mice
    Hongxin Dong
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Comp Neurol 500:311-21. 2007
    ..These results provide the first quantitative morphological evidence at the ultrastructure level of a spatial relationship between beta-amyloid plaques and synapse loss within the hippocampus and the entorhinal cortex of Tg2576 mice...
  4. pmc Effects of memantine on neuronal structure and conditioned fear in the Tg2576 mouse model of Alzheimer's disease
    Hongxin Dong
    Departments of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Neuropsychopharmacology 33:3226-36. 2008
    ..These results suggest that chronic memantine administration may have both neuroprotective and neurotoxic effects in a mouse model of AD...
  5. pmc Genetic influences on hippocampal structure and function in recombinant inbred mice
    Maureen V Martin
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA
    Behav Brain Res 196:78-83. 2009
    ....
  6. pmc Effects of voluntary and forced exercise on plaque deposition, hippocampal volume, and behavior in the Tg2576 mouse model of Alzheimer's disease
    Carla M Yuede
    Department of Psychiatry, Washington University School of Medicine, Campus Box 8134, 660 South Euclid Ave, St Louis, MO 63110, USA
    Neurobiol Dis 35:426-32. 2009
    ..The results indicate that voluntary exercise may be superior to forced exercise for reducing certain aspects of AD-like deficits - i.e., plaque deposition and memory impairment, in a mouse model of AD...
  7. ncbi Low dose quetiapine reverses deficits in contextual and cued fear conditioning in rats with excitotoxin-induced hippocampal neuropathy
    Maureen V Martin
    Department of Psychiatry Box 8134, Washington University School of Medicine, 660 S Euclid, St Louis, MO 63110, United States
    Pharmacol Biochem Behav 82:263-9. 2005
    ..These results may be relevant to the effects of quetiapine and other antipsychotic drugs on memory deficits in patients with schizophrenia...
  8. ncbi Independent quantitative trait loci influence ventral and dorsal hippocampal volume in recombinant inbred strains of mice
    Maureen V Martin
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Genes Brain Behav 5:614-23. 2006
    ..These findings suggest that the development of the ventral and dorsal components of the hippocampus is influenced by separate genetic loci...
  9. pmc Cholinesterase inhibitors ameliorate behavioral deficits induced by MK-801 in mice
    John G Csernansky
    Department of Psychiatry, Washington University School of Medicine, 660 S Euclid, St Louis, MO 63110, USA
    Neuropsychopharmacology 30:2135-43. 2005
    ....
  10. pmc Acetylcholinesterase inhibitors ameliorate behavioral deficits in the Tg2576 mouse model of Alzheimer's disease
    Hongxin Dong
    Department of Psychiatry, Washington University School of Medicine, Campus Box 8134, 660 South Euclid Ave, St Louis, MO 63110, USA
    Psychopharmacology (Berl) 181:145-52. 2005
    ..Transgenic mice that overexpress the human form of amyloid precursor protein and develop deposits of beta-amyloid (Abeta) and behavioral deficits during adulthood are useful for investigating this question...
  11. ncbi Intracerebroventricular kainic acid administration to neonatal rats alters interneuron development in the hippocampus
    Hongxin Dong
    Department of Psychiatry, Washington University School of Medicine, Campus Box 8134, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Brain Res Dev Brain Res 145:81-92. 2003
    ..The functional impact of these changes may be relevant to the pathogenesis of neuropsychiatric disorders, such as schizophrenia...
  12. pmc Anti-dementia drugs and hippocampal-dependent memory in rodents
    Carla M Yuede
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Behav Pharmacol 18:347-63. 2007
    ..Suggestions for future research are offered...
  13. ncbi Hippocampal neurogenesis follows kainic acid-induced apoptosis in neonatal rats
    Hongxin Dong
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 23:1742-9. 2003
    ..KA administration resulted in both neuronal apoptosis and neurogenesis within the CA3 subfield, suggesting that the purpose of neurogenesis in the CA3 is to replace neurons lost to apoptosis...
  14. pmc Acute stress increases interstitial fluid amyloid-beta via corticotropin-releasing factor and neuronal activity
    Jae Eun Kang
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 104:10673-8. 2007
    ..Thus, behavioral stressors can rapidly increase ISF Abeta through neuronal activity in a CRF-dependent manner, and the results suggest a mechanism by which behavioral stress may affect Alzheimer's disease pathogenesis...
  15. ncbi Neuroprotective effects of olanzapine in a rat model of neurodevelopmental injury
    John G Csernansky
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Pharmacol Biochem Behav 83:208-13. 2006
    ..These results suggest that olanzapine has neuroprotective effects in a rat model of neurodevelopmental insult, and may be relevant to the observed effects of atypical antipsychotic drugs on brain structure in patients with schizophrenia...
  16. pmc Plasma cortisol and progression of dementia in subjects with Alzheimer-type dementia
    John G Csernansky
    Alzheimer s Disease Research Center and the Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Psychiatry 163:2164-9. 2006
    ....
  17. ncbi Mechanical and cold allodynia in a rat spinal cord contusion model
    Young Wook Yoon
    Department of Neurology, and Center for the Study of Nervous System Injury, Washington University School of Medicine, St Louis, MO 63110, USA
    Somatosens Mot Res 21:25-31. 2004
    ..The least severe injury (6.25 mm) most consistently caused a decreased hindpaw threshold to mechanical stimulation and an increased withdrawal frequency to cold...
  18. ncbi Enhanced oligodendrocyte survival after spinal cord injury in Bax-deficient mice and mice with delayed Wallerian degeneration
    Hongxin Dong
    Department of Neurology, Spinal Cord Injury Neuro Rehabilitation Section, Restorative Treatment and Research Program, and Center for the Study of Nervous System Injury, Washington University School of Medicine, St Louis, Missouri 63108, USA
    J Neurosci 23:8682-91. 2003
    ..On the basis of these data, we hypothesize that the Wallerian degeneration of white matter axons that follows SCI removes axonal support and induces apoptotic death in oligodendrocytes by triggering Bax expression...
  19. ncbi Modulation of hippocampal cell proliferation, memory, and amyloid plaque deposition in APPsw (Tg2576) mutant mice by isolation stress
    H Dong
    Department of Psychiatry, Washington University School of Medicine, Campus Box 8134, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Neuroscience 127:601-9. 2004
    ..These results suggest that stress may have an impact on the underlying disease process associated with Alzheimer's disease...
  20. ncbi Immediate and delayed hippocampal neuronal loss induced by kainic acid during early postnatal development in the rat
    William M Humphrey
    Department of Psychiatry, Washington University School of Medicine, Campus Box 8134, 660 South Euclid Ave, St Louis, MO 63110, USA
    Brain Res Dev Brain Res 137:1-12. 2002
    ..These findings may be relevant to the pathogenesis of some neuropsychiatric disorders, where early CNS injury is not apparent until the onset of clinical symptoms in young adulthood...