Deborah E Dobson

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. pmc Two functionally divergent UDP-Gal nucleotide sugar transporters participate in phosphoglycan synthesis in Leishmania major
    Althea A Capul
    Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Biol Chem 282:14006-17. 2007
  2. ncbi request reprint Identification of genes encoding arabinosyltransferases (SCA) mediating developmental modifications of lipophosphoglycan required for sand fly transmission of leishmania major
    Deborah E Dobson
    Department of Molecular Microbiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 278:28840-8. 2003
  3. pmc Leishmania major survival in selective Phlebotomus papatasi sand fly vector requires a specific SCG-encoded lipophosphoglycan galactosylation pattern
    Deborah E Dobson
    Department of Molecular Microbiology, Washington University Medical School, St Louis, Missouri, United States of America
    PLoS Pathog 6:e1001185. 2010
  4. ncbi request reprint Genomic organization and expression of the expanded SCG/L/R gene family of Leishmania major: internal clusters and telomeric localization of SCGs mediating species-specific LPG modifications
    Deborah E Dobson
    Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Mol Biochem Parasitol 146:231-41. 2006
  5. pmc Demonstration of genetic exchange during cyclical development of Leishmania in the sand fly vector
    Natalia S Akopyants
    Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Science 324:265-8. 2009
  6. ncbi request reprint Functional identification of galactosyltransferases (SCGs) required for species-specific modifications of the lipophosphoglycan adhesin controlling Leishmania major-sand fly interactions
    Deborah E Dobson
    Department of Molecular Microbiology, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
    J Biol Chem 278:15523-31. 2003
  7. ncbi request reprint Flypaper for parasites
    Stephen M Beverley
    Department of Molecular Microbiology, Washington University Medical School, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Cell 119:311-2. 2004
  8. pmc The genome of the kinetoplastid parasite, Leishmania major
    Alasdair C Ivens
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK
    Science 309:436-42. 2005
  9. ncbi request reprint Demonstration by heterologous expression that the Leishmania SCA1 gene encodes an arabinopyranosyltransferase
    Mamta Goswami
    Department of Biochemistry, University of Kentucky Medical Center, Lexington, KY 40536, USA
    Glycobiology 16:230-6. 2006

Collaborators

  • S M Beverley
  • Shaden Kamhawi
  • Natalia S Akopyants
  • Althea A Capul
  • Salvatore J Turco
  • Mamta Goswami
  • Alasdair C Ivens
  • David L Sacks
  • Nathan Peters
  • Nicola Kimblin
  • Phillip Lawyer
  • Rachel Patrick
  • Nagila Secundino
  • Tamara Barron
  • Bénédicte Purnelle
  • Martin Pentony
  • John Woodward
  • Andre Goffeau
  • Steve Squares
  • Alfred Beck
  • Siri Nelson
  • Christiane Hertz-Fowler
  • David Masuy
  • Arlette Goble
  • Laura Robertson
  • Christopher S Peacock
  • Nathalie Bason
  • Philip Attipoe
  • Atashi Anupama
  • Lee Murphy
  • Susan O'neil
  • Angela K Cruz
  • Jacquie Schein
  • Katja Borzym
  • Jenefer M Blackwell
  • Robert M Davies
  • David C Schwartz
  • Bart Barrell
  • Gholam Fazelina
  • Ester Rabbinowitsch
  • Eithon Cadag
  • Christy Vogt
  • David Horn
  • Zina Apostolou
  • Deborah F Smith
  • Marco Marra
  • Kathy Seeger
  • Marie Adele Rajandream
  • Karen Oliver
  • Claire Price
  • Dhileep Sivam
  • Thomas M Pohl
  • Ellen Sisk
  • Simon Rutter
  • Joel Rinta
  • Richard M R Coulson
  • Rita Aert
  • Yiting Huang
  • Gordana Bothe
  • Ann Cronin
  • Shulamit Michaeli
  • Holger Wedler
  • Heesun Shin
  • Elizabeth A Worthey
  • Jeremy C Mottram
  • Kenneth D Stuart
  • Andreas Duesterhoeft
  • Rob Squares
  • Valentina Tosato
  • Natasha Larke
  • Shiguo Zhou
  • Jeronimo C Ruiz
  • David Saunders
  • Silke Müller-Auer
  • Ellen Adlem
  • Claudia Gabel
  • Tim Warren
  • Tin Louie
  • Amber Seyler
  • Alberto Carlos Frasch
  • Heather Munden
  • Gautam Aggarwal
  • Lyudmila Litvin
  • Keith Matthews
  • Sven Klages
  • Richard Reinhardt
  • Laura Ciarloni
  • Audrey Fraser
  • Monika Fuchs
  • Johan Robben

Detail Information

Publications9

  1. pmc Two functionally divergent UDP-Gal nucleotide sugar transporters participate in phosphoglycan synthesis in Leishmania major
    Althea A Capul
    Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Biol Chem 282:14006-17. 2007
    ..Identification of these key NSTs in Leishmania will facilitate the dissection of glycoconjugate synthesis and its role(s) in the parasite life cycle and further our understanding of NSTs generally...
  2. ncbi request reprint Identification of genes encoding arabinosyltransferases (SCA) mediating developmental modifications of lipophosphoglycan required for sand fly transmission of leishmania major
    Deborah E Dobson
    Department of Molecular Microbiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 278:28840-8. 2003
    ..The SCA genes define a new family of eukaryotic betaAraTs and represent novel developmentally regulated LPG-modifying activities identified in Leishmania...
  3. pmc Leishmania major survival in selective Phlebotomus papatasi sand fly vector requires a specific SCG-encoded lipophosphoglycan galactosylation pattern
    Deborah E Dobson
    Department of Molecular Microbiology, Washington University Medical School, St Louis, Missouri, United States of America
    PLoS Pathog 6:e1001185. 2010
    ....
  4. ncbi request reprint Genomic organization and expression of the expanded SCG/L/R gene family of Leishmania major: internal clusters and telomeric localization of SCGs mediating species-specific LPG modifications
    Deborah E Dobson
    Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Mol Biochem Parasitol 146:231-41. 2006
    ..Potentially, telomeric localization of SCG genes may function primarily to facilitate gene conversion and the elaboration of functional evolutionary diversity in the degree of PG sc-galactosylation observed in other strains of L. major...
  5. pmc Demonstration of genetic exchange during cyclical development of Leishmania in the sand fly vector
    Natalia S Akopyants
    Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Science 324:265-8. 2009
    ....
  6. ncbi request reprint Functional identification of galactosyltransferases (SCGs) required for species-specific modifications of the lipophosphoglycan adhesin controlling Leishmania major-sand fly interactions
    Deborah E Dobson
    Department of Molecular Microbiology, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
    J Biol Chem 278:15523-31. 2003
    ..Thus the L. major genome encodes a family of SCGs with varying specificity and activity, and we propose that strain-specific LPG galactosylation patterns reflect differences in their expression...
  7. ncbi request reprint Flypaper for parasites
    Stephen M Beverley
    Department of Molecular Microbiology, Washington University Medical School, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Cell 119:311-2. 2004
    ..This interaction is critical for parasite survival in the midgut of its sand fly vector. The results open new avenues for studies of insect immunity, transmission binding vaccines, and host-parasite coevolution...
  8. pmc The genome of the kinetoplastid parasite, Leishmania major
    Alasdair C Ivens
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK
    Science 309:436-42. 2005
    ..Abundant RNA-binding proteins are encoded in the Tritryp genomes, consistent with active posttranscriptional regulation of gene expression...
  9. ncbi request reprint Demonstration by heterologous expression that the Leishmania SCA1 gene encodes an arabinopyranosyltransferase
    Mamta Goswami
    Department of Biochemistry, University of Kentucky Medical Center, Lexington, KY 40536, USA
    Glycobiology 16:230-6. 2006
    ..No activity was observed in the absence of LPG. These results demonstrate that SCA1 encodes a sc-D-ArapT and provide the first example of heterologous expression of a D-ArapT gene...