Research Topics
| Deborah E DobsonSummaryAffiliation: Washington University School of Medicine Country: USA Publications
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Detail Information
Publications
Two functionally divergent UDP-Gal nucleotide sugar transporters participate in phosphoglycan synthesis in Leishmania majorAlthea A Capul
Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO 63110, USA
J Biol Chem 282:14006-17. 2007..Identification of these key NSTs in Leishmania will facilitate the dissection of glycoconjugate synthesis and its role(s) in the parasite life cycle and further our understanding of NSTs generally...
Identification of genes encoding arabinosyltransferases (SCA) mediating developmental modifications of lipophosphoglycan required for sand fly transmission of leishmania majorDeborah E Dobson
Department of Molecular Microbiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Biol Chem 278:28840-8. 2003..The SCA genes define a new family of eukaryotic betaAraTs and represent novel developmentally regulated LPG-modifying activities identified in Leishmania...- Leishmania major survival in selective Phlebotomus papatasi sand fly vector requires a specific SCG-encoded lipophosphoglycan galactosylation patternDeborah E Dobson
Department of Molecular Microbiology, Washington University Medical School, St Louis, Missouri, United States of America
PLoS Pathog 6:e1001185. 2010.... - Genomic organization and expression of the expanded SCG/L/R gene family of Leishmania major: internal clusters and telomeric localization of SCGs mediating species-specific LPG modificationsDeborah E Dobson
Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA
Mol Biochem Parasitol 146:231-41. 2006..Potentially, telomeric localization of SCG genes may function primarily to facilitate gene conversion and the elaboration of functional evolutionary diversity in the degree of PG sc-galactosylation observed in other strains of L. major... - Demonstration of genetic exchange during cyclical development of Leishmania in the sand fly vectorNatalia S Akopyants
Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO 63110, USA
Science 324:265-8. 2009.... - Functional identification of galactosyltransferases (SCGs) required for species-specific modifications of the lipophosphoglycan adhesin controlling Leishmania major-sand fly interactionsDeborah E Dobson
Department of Molecular Microbiology, Washington University School of Medicine, 660 S. Euclid Avenue, St. Louis, MO 63110, USA
J Biol Chem 278:15523-31. 2003..Thus the L. major genome encodes a family of SCGs with varying specificity and activity, and we propose that strain-specific LPG galactosylation patterns reflect differences in their expression... - Flypaper for parasitesStephen M Beverley
Department of Molecular Microbiology, Washington University Medical School, 660 S. Euclid Avenue, St. Louis, MO 63110, USA
Cell 119:311-2. 2004..This interaction is critical for parasite survival in the midgut of its sand fly vector. The results open new avenues for studies of insect immunity, transmission binding vaccines, and host-parasite coevolution... - The genome of the kinetoplastid parasite, Leishmania majorAlasdair C Ivens
Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK
Science 309:436-42. 2005..Abundant RNA-binding proteins are encoded in the Tritryp genomes, consistent with active posttranscriptional regulation of gene expression... - Demonstration by heterologous expression that the Leishmania SCA1 gene encodes an arabinopyranosyltransferaseMamta Goswami
Department of Biochemistry, University of Kentucky Medical Center, Lexington, KY 40536, USA
Glycobiology 16:230-6. 2006..No activity was observed in the absence of LPG. These results demonstrate that SCA1 encodes a sc-D-ArapT and provide the first example of heterologous expression of a D-ArapT gene...