M N Diringer

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. pmc Red blood cell transfusion in patients with subarachnoid hemorrhage: a multidisciplinary North American survey
    Andreas H Kramer
    Department of Critical Care Medicine, Hotchkiss Brain Institute, Foothills Medical Center, University of Calgary, 1403 29th Street NW, Calgary, AB T2N 2T9, Canada
    Crit Care 15:R30. 2011
  2. pmc Clinical review: Prevention and therapy of vasospasm in subarachnoid hemorrhage
    Salah G Keyrouz
    Neurology Neurosurgery Intensive Care Unit, Department of Neurology, Washington University School of Medicine, South Euclid Avenue, St Louis, MO 63110, USA
    Crit Care 11:220. 2007
  3. ncbi request reprint Does modification of the Innsbruck and the Glasgow Coma Scales improve their ability to predict functional outcome?
    M N Diringer
    Department of Neurology, Washington University School of Medicine, St Louis, MO, USA
    Arch Neurol 54:606-11. 1997
  4. doi request reprint Risk of thromboembolic events in controlled trials of rFVIIa in spontaneous intracerebral hemorrhage
    Michael N Diringer
    Department of Neurology, Campus Box 8111, Washington University School of Medicine, 660 South Euclid Ave, St Louis, MO 63110, USA
    Stroke 39:850-6. 2008
  5. ncbi request reprint Regional cerebrovascular and metabolic effects of hyperventilation after severe traumatic brain injury
    Michael N Diringer
    Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosurg 96:103-8. 2002
  6. ncbi request reprint Impact of recombinant activated factor VII on health-related quality of life after intracerebral hemorrhage
    Michael N Diringer
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Cerebrovasc Dis 24:219-25. 2007
  7. ncbi request reprint Effect of hyperoxia on cerebral metabolic rate for oxygen measured using positron emission tomography in patients with acute severe head injury
    Michael N Diringer
    Department of Neurology, Neurology Neurosurgery Intensive Care Unit, Barnes Jewish Hospital, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosurg 106:526-9. 2007
  8. ncbi request reprint Hemodynamic manipulation in the neuro-intensive care unit: cerebral perfusion pressure therapy in head injury and hemodynamic augmentation for cerebral vasospasm
    Michael N Diringer
    Neurology Neurosurgery Intensive Care Unit, Barnes Jewish Hospital, Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Curr Opin Crit Care 13:156-62. 2007
  9. ncbi request reprint Hyponatremia in neurologic patients: consequences and approaches to treatment
    Michael N Diringer
    Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Neurologist 12:117-26. 2006
  10. pmc Hyperoxia: good or bad for the injured brain?
    Michael N Diringer
    Neurology Neurosurgery Intensive Care Unit, Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Curr Opin Crit Care 14:167-71. 2008

Detail Information

Publications83

  1. pmc Red blood cell transfusion in patients with subarachnoid hemorrhage: a multidisciplinary North American survey
    Andreas H Kramer
    Department of Critical Care Medicine, Hotchkiss Brain Institute, Foothills Medical Center, University of Calgary, 1403 29th Street NW, Calgary, AB T2N 2T9, Canada
    Crit Care 15:R30. 2011
    ..It remains unclear whether this association can be modified with more aggressive use of red blood cell (RBC) transfusions. The degree to which restrictive thresholds have been adopted in neurocritical care patients remains unknown...
  2. pmc Clinical review: Prevention and therapy of vasospasm in subarachnoid hemorrhage
    Salah G Keyrouz
    Neurology Neurosurgery Intensive Care Unit, Department of Neurology, Washington University School of Medicine, South Euclid Avenue, St Louis, MO 63110, USA
    Crit Care 11:220. 2007
    ..Currently, the most promising are magnesium sulfate, 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors, nitric oxide donors and endothelin-1 antagonists. This paper reviews established and emerging therapies for vasospasm...
  3. ncbi request reprint Does modification of the Innsbruck and the Glasgow Coma Scales improve their ability to predict functional outcome?
    M N Diringer
    Department of Neurology, Washington University School of Medicine, St Louis, MO, USA
    Arch Neurol 54:606-11. 1997
    ..The accurate prediction of functional outcome requires the development of multivariate models. To enhance their contribution to such models, the predictive power of each component must be optimized...
  4. doi request reprint Risk of thromboembolic events in controlled trials of rFVIIa in spontaneous intracerebral hemorrhage
    Michael N Diringer
    Department of Neurology, Campus Box 8111, Washington University School of Medicine, 660 South Euclid Ave, St Louis, MO 63110, USA
    Stroke 39:850-6. 2008
    ..Despite low incidences of such events in rFVIIa-treated hemophiliacs, the frequency in older patients with more atherosclerosis and immobility has yet to be defined...
  5. ncbi request reprint Regional cerebrovascular and metabolic effects of hyperventilation after severe traumatic brain injury
    Michael N Diringer
    Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosurg 96:103-8. 2002
    ..In the present study they sought to determine if hyperventilation lowers CBF below the ischemic threshold of 18 to 20 ml/100 g/ min in any brain region and if those reductions cause energy failure (defined as a fall in CMRO2)...
  6. ncbi request reprint Impact of recombinant activated factor VII on health-related quality of life after intracerebral hemorrhage
    Michael N Diringer
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Cerebrovasc Dis 24:219-25. 2007
    ..29%) and poor outcome (modified Rankin Scale, mRS, 4-6, 53 vs. 69%). This analysis was performed to determine the impact of rFVIIa on health-related quality of life (HRQoL) in those patients...
  7. ncbi request reprint Effect of hyperoxia on cerebral metabolic rate for oxygen measured using positron emission tomography in patients with acute severe head injury
    Michael N Diringer
    Department of Neurology, Neurology Neurosurgery Intensive Care Unit, Barnes Jewish Hospital, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosurg 106:526-9. 2007
    ....
  8. ncbi request reprint Hemodynamic manipulation in the neuro-intensive care unit: cerebral perfusion pressure therapy in head injury and hemodynamic augmentation for cerebral vasospasm
    Michael N Diringer
    Neurology Neurosurgery Intensive Care Unit, Barnes Jewish Hospital, Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Curr Opin Crit Care 13:156-62. 2007
    ....
  9. ncbi request reprint Hyponatremia in neurologic patients: consequences and approaches to treatment
    Michael N Diringer
    Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Neurologist 12:117-26. 2006
    ..Hyponatremia is a common fluid-electrolyte disturbance, particularly in patients with neurologic disorders, in part because of the major role the central nervous system (CNS) plays in the regulation of sodium and water homeostasis...
  10. pmc Hyperoxia: good or bad for the injured brain?
    Michael N Diringer
    Neurology Neurosurgery Intensive Care Unit, Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Curr Opin Crit Care 14:167-71. 2008
    ....
  11. doi request reprint Critical care management of patients following aneurysmal subarachnoid hemorrhage: recommendations from the Neurocritical Care Society's Multidisciplinary Consensus Conference
    Michael N Diringer
    Neurology Neurosurgery Intensive Care Unit, Washington University, St Louis, MO, USA
    Neurocrit Care 15:211-40. 2011
    ..Strong consideration was given to providing guidance and recommendations for all issues faced in the daily management of SAH patients, even in the absence of high quality data...
  12. ncbi request reprint To clip or to coil acutely ruptured intracranial aneurysms: update on the debate
    Michael N Diringer
    Neurology Neurosurgery Intensive Care Unit, Department of Neurology, Washington University, St Louis, Missouri 63110, USA
    Curr Opin Crit Care 11:121-5. 2005
    ....
  13. ncbi request reprint Hydrocephalus: a previously unrecognized predictor of poor outcome from supratentorial intracerebral hemorrhage
    M N Diringer
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Stroke 29:1352-7. 1998
    ..The purpose of this study was to determine whether the presence of hydrocephalus after ICH would predict mortality and functional outcome...
  14. ncbi request reprint Predictors of acute hospital costs for treatment of ischemic stroke in an academic center
    M N Diringer
    Department of Neurology, Program in Occupational Therapy, Washington University School of Medicine, St Louis, MO 63110, USA
    Stroke 30:724-8. 1999
    ..We sought to determine predictors of acute hospital costs in patients presenting with acute ischemic stroke to an academic center using a stroke management team to coordinate care...
  15. doi request reprint Thromboembolic events with recombinant activated factor VII in spontaneous intracerebral hemorrhage: results from the Factor Seven for Acute Hemorrhagic Stroke (FAST) trial
    Michael N Diringer
    Department of Neurology, Box 8111, Washington University, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Stroke 41:48-53. 2010
    ..Use of recombinant activated factor VII (rFVIIa) could increase TEs in high-risk patients. Factor Seven for Acute Hemorrhagic Stroke (FAST) trial data were reviewed to define the frequency of and risk factors for TE with rFVIIa...
  16. ncbi request reprint No reduction in cerebral metabolism as a result of early moderate hyperventilation following severe traumatic brain injury
    M N Diringer
    Department of Neurology and Neurological Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosurg 92:7-13. 2000
    ..The authors tested the hypothesis that moderate hyperventilation induced early after TBI would not produce a reduction in CBF severe enough to cause cerebral energy failure (CBF that is insufficient to meet metabolic needs)...
  17. pmc Management of aneurysmal subarachnoid hemorrhage
    Michael N Diringer
    Washington University School of Medicine, St Louis, MO, USA
    Crit Care Med 37:432-40. 2009
    ..Cardiopulmonary complications are common. The management of patients with SAH focuses on the anticipation, prevention, and management of these secondary complications...
  18. ncbi request reprint Admission to a neurologic/neurosurgical intensive care unit is associated with reduced mortality rate after intracerebral hemorrhage
    M N Diringer
    Neurology Neurosurgery Intensive Care Unit, Department of Neurology and Program in Occupational Therapy, Washington University School of Medicine, St Louis, MO 63110, USA
    Crit Care Med 29:635-40. 2001
    ..To determine whether mortality rate after intracerebral hemorrhage (ICH) is lower in patients admitted to a neurologic or neurosurgical (neuro) intensive care unit (ICU) compared to those admitted to general ICUs...
  19. ncbi request reprint Hypoperfusion without ischemia surrounding acute intracerebral hemorrhage
    A R Zazulia
    Department of Neurology and Neurological Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA
    J Cereb Blood Flow Metab 21:804-10. 2001
    ..Thus, the authors found no evidence for ischemia in the periclot zone of hypoperfusion in acute ICH patients studied 5 to 22 hours after hemorrhage onset...
  20. ncbi request reprint Autoregulation of cerebral blood flow surrounding acute (6 to 22 hours) intracerebral hemorrhage
    W J Powers
    Department of Neurology and Neurological Surgery, Lillian Strauss Institute for Neuroscience, Washington University School of Medicine, St Louis, MO 631101, USA
    Neurology 57:18-24. 2001
    ..The authors undertook this study to provide further information on the changes in whole-brain and periclot regional CBF that occur with pharmacologic reductions in mean arterial pressure (MAP) in patients with acute ICH...
  21. ncbi request reprint Safety of hemodynamic augmentation in patients treated with Guglielmi detachable coils after acute aneurysmal subarachnoid hemorrhage
    V Aiyagari
    Neurology/Neurosurgery Intensive Care Unit, Department of Neurology Washington University School of Medicine, St Louis, MO, USA
    Stroke 32:1994-7. 2001
    ..No patient had rebleeding or any significant complication during the course of therapy. CONCLUSIONS: Based on this limited series of patients, we believe that it may be safe to use HA in patients treated with GDC for SAH...
  22. doi request reprint Efficacy and safety of recombinant activated factor VII for acute intracerebral hemorrhage
    Stephan A Mayer
    Department of Neurology, Columbia University College of Physicians and Surgeons, New York, USA
    N Engl J Med 358:2127-37. 2008
    ..We performed this phase 3 trial to confirm a previous study in which recombinant activated factor VII (rFVIIa) reduced growth of the hematoma and improved survival and functional outcomes...
  23. ncbi request reprint Progression of mass effect after intracerebral hemorrhage
    A R Zazulia
    Departments of Neurology and Neurological Surgery, Lillian Strauss Institute for Neuroscience of the Jewish Hospital of St Louis, MO, USA
    Stroke 30:1167-73. 1999
    ..Our goal was to determine the time course and cause for progression of mass effect after ICH...
  24. ncbi request reprint Mannitol bolus preferentially shrinks non-infarcted brain in patients with ischemic stroke
    T O Videen
    Department of Neurology and Neurological Surgery, Washington University School of Medicine, St Louis, MO, USA
    Neurology 57:2120-2. 2001
    ..1 +/- 2.8 mL (0.6%, p < 0.005). Brain in the noninfarcted hemisphere shrank more (0.8 +/- 0.4%) than in the infarcted hemisphere (0.0 +/- 0.5%, p < 0.05)...
  25. ncbi request reprint Effects of induced hypertension on transcranial Doppler ultrasound velocities in patients after subarachnoid hemorrhage
    E M Manno
    Neurology Neurosurgery Intensive Care Unit, Washington University School of Medicine, St Louis, MO 63110, USA
    Stroke 29:422-8. 1998
    ..To study this possibility, we performed continuous TCD monitoring of the middle cerebral artery during the induction and withdrawal of induced hypertension in patients after subarachnoid hemorrhage...
  26. ncbi request reprint Osmole gap in neurologic-neurosurgical intensive care unit: Its normal value, calculation, and relationship with mannitol serum concentrations
    Edgar J García-Morales
    Department of Neurology, Washington University School of Medicine, St Louis, MO, USA
    Crit Care Med 32:986-91. 2004
    ....
  27. pmc Factors associated with the development of anemia after subarachnoid hemorrhage
    Tomoko R Sampson
    Department of Neurology, Washington University School of Medicine, 660 S Euclid Ave, Campus Box 8111, Saint Louis, MO 63110, USA
    Neurocrit Care 12:4-9. 2010
    ..Identifying factors associated with anemia may facilitate targeted interventions, such as the use of erythropoiesis-stimulating agents, which could minimize the burden of anemia and reduce red blood cell (RBC) transfusion requirements...
  28. ncbi request reprint Effect of intraarterial papaverine and/or angioplasty on the cerebral veins in patients with vasospasm after subarachnoid hemorrhage due to ruptured intracranial aneurysms
    Ayman A Elsayed
    Department of Radiology, Washington University School of Medicine, St Louis, Missouri 63110 1076, USA
    Neurosurg Focus 21:E16. 2006
    ..The goal in this study was to determine if there was a change in intracranial venous diameters after endovascular treatment of carotid distribution vasospasm caused by subarachnoid hemorrhage...
  29. ncbi request reprint Hemodynamic monitoring in the neurological intensive care unit
    A Venkatesh
    Neurology Neuro Surgery Intensive Care Unit, Washington University School of Medicine, St. Louis, MO 63110, USA
    Neurol India 49:S9-18. 2001
    ..The neurointensivist thus needs to approach these issues differently from the approach an internist or general intensivist would take...
  30. pmc Variation in osmotic response to sustained mannitol administration
    Salah G Keyrouz
    Department of Neurology and Neurological Surgery, Washington University, St Louis, MO, 63110, USA
    Neurocrit Care 9:204-9. 2008
    ..Some patients do not respond to sustained mannitol administration with the expected rise in serum osmolality, and this may correlate with lack of therapeutic efficacy...
  31. ncbi request reprint Factors associated with withdrawal of mechanical ventilation in a neurology/neurosurgery intensive care unit
    M N Diringer
    Neurology/Neurosurgery Intensive Care Unit, Department of Neurology and Neurological Surgery, Washington University, St. Louis, MO, USA
    Crit Care Med 29:1792-7. 2001
    ..Care is less likely to be withdrawn from African-American patients or those who had surgery...
  32. ncbi request reprint Effect of normal saline bolus on cerebral blood flow in regions with low baseline flow in patients with vasospasm following subarachnoid hemorrhage
    Sarah C Jost
    Department of Neurology, Neurological Surgery, and Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosurg 103:25-30. 2005
    ..The purpose of this study was to examine the effects of volume expansion on regional (r)CBF in patients with DIND following SAH...
  33. ncbi request reprint Early mortality following spontaneous intracerebral hemorrhage
    J A Zurasky
    Neurology Neurosurgery Intensive Care Unit, Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Neurology 64:725-7. 2005
    ..Brain death was more common in African Americans, whereas life-sustaining interventions were withdrawn or limited early more often in whites...
  34. ncbi request reprint Sodium disturbances frequently encountered in a neurologic intensive care unit
    M N Diringer
    Neurology/Neurosurgery Intensive Care Unit, Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA
    Neurol India 49:S19-30. 2001
    ..Patients with SAH and hyponatremia should not be fluid restricted because of the risk of exacerbating vasospasm but treated with large volumes of isotonic or mildly hypertonic saline...
  35. pmc Reversible left ventricular dysfunction associated with raised troponin I after subarachnoid haemorrhage does not preclude successful heart transplantation
    E Deibert
    Neurology Neurosurgery Intensive Care Unit, Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Heart 84:205-7. 2000
    ..Awareness of this phenomenon in the acutely ill neurologic population needs to be raised in order to prevent the unnecessary rejection of donor hearts...
  36. ncbi request reprint Perihematomal mitochondrial dysfunction after intracerebral hemorrhage
    Jeong Sook Kim-Han
    Department of Neurology, Washington University, St Louis, MO, USA
    Stroke 37:2457-62. 2006
    ..We sought to determine whether reduced mitochondrial respiratory function could account for reduced metabolic demand in ICH patients...
  37. pmc Red blood cell transfusion increases cerebral oxygen delivery in anemic patients with subarachnoid hemorrhage
    Rajat Dhar
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Stroke 40:3039-44. 2009
    ..However, the cerebral response to transfusion remains uncertain, because higher hemoglobin may increase viscosity and further impair cerebral blood flow (CBF) in the setting of vasospasm...
  38. pmc The burden of the systemic inflammatory response predicts vasospasm and outcome after subarachnoid hemorrhage
    Rajat Dhar
    Neurology Neurosurgery Intensive Care Unit, Department of Neurology and Neurological Surgery, Washington University School of Medicine, 660 S Euclid Ave, Campus Box 8111, Saint Louis, MO 63110, USA
    Neurocrit Care 8:404-12. 2008
    ..We ascertained the frequency and predictors of SIRS after spontaneous SAH, and determined whether degree of early systemic inflammation predicted the occurrence of vasospasm and clinical outcome...
  39. ncbi request reprint Hypernatremia in the neurologic intensive care unit: how high is too high?
    Venkatesh Aiyagari
    Neurology Neurosurgery Intensive Care Unit, Departments of Neurology and Neurosurgery, Washington University School of Medicine, St Louis, MO, USA
    J Crit Care 21:163-72. 2006
    ..In conclusion, hypernatremia is common in the NNICU, more so in patients treated with mannitol. In this population, severe (but not mild or moderate) hypernatremia is independently associated with increased mortality...
  40. ncbi request reprint Postprocedure ischemic events after treatment of intracranial aneurysms with Guglielmi detachable coils
    Colin P Derdeyn
    Interventional Neuroradiology Service, Washington University School of Medicine, St Louis, MO, USA
    J Neurosurg 96:837-43. 2002
    ..The purpose of the present study is to investigate possible risk factors for thromboembolic events and to determine their frequency and time course...
  41. doi request reprint Near-complete resolution of angiographic cerebral vasospasm after extreme elevation of mean arterial pressure: case report
    Wilson Z Ray
    Department of Neurological Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Surg Neurol 72:347-53; discussion 353-4. 2009
    ..This case report is only the second to provide compelling evidence that hypertension can lead to direct dilation of vasospastic arteries, thereby providing valuable insight into its potential mechanism...
  42. ncbi request reprint Osmotic therapy: fact and fiction
    Michael N Diringer
    Neurology Neurosurgery Intensive Care Unit and Stroke Research Center, Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Neurocrit Care 1:219-33. 2004
    ....
  43. pmc Cerebral hemodynamic and metabolic effects of equi-osmolar doses mannitol and 23.4% saline in patients with edema following large ischemic stroke
    Michael N Diringer
    Departments of Neurology and Neurological Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Neurocrit Care 14:11-7. 2011
    ....
  44. ncbi request reprint Safety and feasibility of recombinant factor VIIa for acute intracerebral hemorrhage
    Stephan A Mayer
    Department of Neurology, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Stroke 36:74-9. 2005
    ..Activated recombinant factor VII (rFVIIa) promotes hemostasis at sites of vascular injury and may minimize hematoma growth after ICH...
  45. ncbi request reprint Hourly blood pressure monitoring after intravenous tissue plasminogen activator for ischemic stroke: does everyone need it?
    Venkatesh Aiyagari
    Department of Neurology, Washington University School of Medicine, Campus Box 8111, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Stroke 35:2326-30. 2004
    ..We postulated that patients whose BP is not initially elevated are unlikely to have elevated BP later and, therefore, may not need prolonged BP monitoring...
  46. ncbi request reprint Sensitivity to changes in disability after stroke: a comparison of four scales useful in clinical trials
    Alexander W Dromerick
    Department of Neurology and Program in Occupational Therapy, Washington University School of Medicine, St Louis, MO 63110, USA
    J Rehabil Res Dev 40:1-8. 2003
    ..Though ADL scales may take longer to administer, their increased sensitivity may make them more useful in treatment trials by allowing fewer subjects to be enrolled...
  47. ncbi request reprint CoolGard/Cool Line catheter system
    Venkatesh Aiyagari
    Neurology Neurosurgery Intensive Care Unit, Washington University School of Medicine, St Louis, MO 63110, USA
    Neurocrit Care 1:209-11. 2004
  48. ncbi request reprint Factors predicting prognosis after decompressive hemicraniectomy for hemispheric infarction
    A A Rabinstein
    Department of Neurology, University of Miami School of Medicine, Miami, FL, USA
    Neurology 67:891-3. 2006
    ..On multivariate analysis, older age independently predicted poor recovery (odds ratio 2.9 per 10-year increase in age)...
  49. ncbi request reprint Determinants of intracerebral hemorrhage growth: an exploratory analysis
    Joseph P Broderick
    Department of Neurology, The Neuroscience Institute, University of Cincinnati Medical Center, Cincinnati, OH, USA
    Stroke 38:1072-5. 2007
    ..We report an exploratory analysis from a randomized study of recombinant activated factor VII (rFVIIa) in patients with intracerebral hemorrhage (ICH) examining potential factors associated with hemorrhage growth...
  50. ncbi request reprint Elevated body temperature independently contributes to increased length of stay in neurologic intensive care unit patients
    Michael N Diringer
    Neurology Neurosurgery Intensive Care Unit, Washington University, St Louis, MO, USA
    Crit Care Med 32:1489-95. 2004
    ....
  51. ncbi request reprint Recombinant activated factor VII for acute intracerebral hemorrhage
    Stephan A Mayer
    Department of Neurology, Columbia University College of Physicians and Surgeons, New York, USA
    N Engl J Med 352:777-85. 2005
    ..We sought to determine whether recombinant activated factor VII (rFVIIa) can reduce hematoma growth after intracerebral hemorrhage...
  52. doi request reprint Temperature management in acute neurologic disorders
    Yekaterina K Axelrod
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110 1093, USA
    Neurol Clin 26:585-603, xi. 2008
    ..This article presents a detailed analysis of trials of induced hypothermia in patients with acute neurologic insults and describes methods of fever control...
  53. ncbi request reprint Osmolality not predictive of mannitol-induced acute renal insufficiency
    Francisco de Assis Aquino Gondim
    Neurology Neurosurgery Intensive Care Unit, Departments of Neurology and Neurosurgery, Washington University, St Louis, Missouri 63110, USA
    J Neurosurg 103:444-7. 2005
    ..The goal of this study was to determine risk factors and outcomes of MI-ARI and to determine whether osmolality is associated with MI-ARI...
  54. ncbi request reprint Safety and technical efficacy of over-the-wire balloons for the treatment of subarachnoid hemorrhage-induced cerebral vasospasm
    Anna Terry
    Department of Neurological Surgery, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Neurosurg Focus 21:E14. 2006
    ..The authors assess the procedural safety and technical efficacy of these newer devices...
  55. ncbi request reprint Temperature management in acute neurologic disorders
    Yekaterina K Axelrod
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110 1093, USA
    Crit Care Clin 22:767-85; abstract x. 2006
    ..This article presents a detailed analysis of trails of induced hypothermia in patients with acute neurologic insults and describes methods of fever control...
  56. ncbi request reprint Elevated troponin levels are associated with higher mortality following intracerebral hemorrhage
    Angela Hays
    Department of Neurology, Washington University, St Louis, MO, USA
    Neurology 66:1330-4. 2006
    ..The authors performed a retrospective study to ascertain whether elevated cardiac troponin I (cTnI) influences outcome from intracerebral hemorrhage (ICH)...
  57. ncbi request reprint Recombinant activated factor VII for acute intracerebral hemorrhage: US phase IIA trial
    Stephan A Mayer
    Department of Neurology, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Neurocrit Care 4:206-14. 2006
    ..We conducted this trial to evaluate the safety of activated recombinant factor VII (rFVIIa; NovoSeven) for preventing early hematoma growth in acute ICH...
  58. ncbi request reprint Untreated subarachnoid hemorrhage: who, why, and when?
    Fang Qu
    Neurology Neurosurgery Intensive Care Unit, Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosurg 100:244-9. 2004
    ..Nevertheless, some patients with SAH do not receive such therapy. The objective of this study was to characterize the patients who do not receive treatment...
  59. doi request reprint Hypothermia for refractory status epilepticus
    Jesse J Corry
    Department of Neurology, Washington University School of Medicine, St Louis, MO, 63110, USA
    Neurocrit Care 9:189-97. 2008
    ..Hypothermia has been shown to suppress epileptiform activity experimentally, but has not previously been used as a primary modality to control SE in humans...
  60. pmc Autoregulation after ischaemic stroke
    William J Powers
    Department of Neurology, University of North Carolina School of Medicine, North Carolina 27599 7025, USA
    J Hypertens 27:2218-22. 2009
    ..Data from human participants have failed to resolve the question whether cerebral blood flow (CBF) in the peri-infarct region will decrease due to impaired autoregulation when systemic mean arterial pressure (MAP) is rapidly reduced...
  61. doi request reprint Early endovascular coiling of posterior communicating artery saccular aneurysm in the setting of Staphylococcus bacteremia: case report and review of the literature
    Wilson Z Ray
    Department of Neurological Surgery, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri, USA
    Neurosurgery 66:E847. 2010
    ..In this report, the authors present a case of aneurysmal subarachnoid hemorrhage and active bacteremia in which intravenous antibiotics and early endovascular therapy were successfully used. A review of the literature is also provided...
  62. ncbi request reprint Treatment of fever in the neurologic intensive care unit with a catheter-based heat exchange system
    Michael N Diringer
    Department of Neurology, Washington University School of Medicine, St Louis, MO, USA
    Crit Care Med 32:559-64. 2004
    ..Fever is common in patients with acute neurologic illness and independently predicts poor outcome. Conventional means of treating fever are not very effective in this population...
  63. pmc Use of recombinant factor VIIa in patients with warfarin-associated intracranial hemorrhage
    David L Brody
    Neurology Neurosurgery Intensive Care Unit, Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Neurocrit Care 2:263-7. 2005
    ..Current therapies are associated with significant complications and/or prolonged time to correction of coagulopathy. Recombinant factor VIIa (FVIIa) might allow faster and safer correction of coagulopathy...
  64. doi request reprint Factor VIIa for ICH: behind the scenes of an academic-industry collaborative trial
    Stephan A Mayer
    Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Int J Stroke 2:164-8. 2007
  65. ncbi request reprint Traumatic brain injury and hyperventilation
    Michael N Diringer
    J Neurosurg 96:155-7. 2002
  66. ncbi request reprint Testing the utility of an intervention
    Michael N Diringer
    Crit Care Med 31:2413; author reply 2413-4. 2003
  67. ncbi request reprint Improved outcome with aggressive treatment of hyperglycemia: hype or hope?
    Michael N Diringer
    Neurology 64:1330-1. 2005
  68. ncbi request reprint Dynamics of intraventricular hemorrhage in patients with spontaneous intracerebral hemorrhage: risk factors, clinical impact, and effect of hemostatic therapy with recombinant activated factor VII
    Thorsten Steiner
    Department of Neurology, Univesity of Heidelberg, Heidelberg, Germany
    Neurosurgery 59:767-73; discussion 773-4. 2006
    ..To evaluate predictors of intraventricular hemorrhage (IVH) and IVH growth, impact of IVH growth on outcome, and impact of recombinant activated factor VII (rFVIIa) in patients with intracerebral hemorrhage (ICH)...
  69. doi request reprint Timing is everything in intracerebral hemorrhage
    Thorsten Steiner
    Stroke 39:e117-8; author reply e119-20. 2008
  70. ncbi request reprint Subarachnoid hemorrhage: a multiple-organ system disease
    Michael N Diringer
    Crit Care Med 31:1884-5. 2003
  71. ncbi request reprint Fever control and its impact on outcomes: what is the evidence?
    Venkatesh Aiyagari
    Department of Neurology and Rehabilitation, University of Illinois, Chicago, IL 60062, USA
    J Neurol Sci 261:39-46. 2007
    ..These devices appear to be more effective than conventional means and might allow us to design studies that definitively answer the question: "Does controlling fever improve outcome?"..
  72. ncbi request reprint What do we really understand about head injury?
    Michael N Diringer
    Neurocrit Care 2:3. 2005
  73. ncbi request reprint Bringing order to chaos
    Michael N Diringer
    Crit Care Med 32:2346. 2004
  74. ncbi request reprint Heads-up on hemicraniectomy
    Michael N Diringer
    Neurology 63:1997-8. 2004
  75. ncbi request reprint Treatment of severe coagulopathy after gunshot injury to the head using recombinant activated factor VII
    Venkatesh Aiyagari
    Department of Neurology and Rehabilitation, University of Illinois, Chicago, 60612, USA
    J Crit Care 20:176-9. 2005
    ..In this report, we describe 3 such patients who were treated with activated factor VII (FVIIa) to stop ongoing hemorrhage that was refractory to conventional treatment...
  76. ncbi request reprint Resuscitation of sudden cardiac death: a mandate for neurology and emergency medicine
    Sandra M Schneider
    Neurology 59:484-5. 2002
  77. ncbi request reprint Evidence-based medicine: what do you do when there's no evidence?
    Michael N Diringer
    Crit Care Med 31:659-60. 2003
  78. ncbi request reprint Is aggressive treatment of hyperglycemia for everyone?
    Michael N Diringer
    Crit Care Med 34:930-1. 2006
  79. ncbi request reprint Response to discussion by Dr Philip Hébert. Use of recombinant activated factor VIIa (FVIIa) in severe head injury
    Venkatesh Aiyagari
    J Crit Care 21:115-6; author reply 116. 2006
  80. ncbi request reprint Core curriculum and competencies for advanced training in neurological intensive care: United Council for Neurologic Subspecialties guidelines
    Stephan A Mayer
    United Council for Neurologic Subspecialties, St Paul, MN 55116, USA
    Neurocrit Care 5:159-65. 2006
  81. ncbi request reprint Program requirements for fellowship training in neurological intensive care: United Council for Neurologic Subspecialties guidelines
    Stephan A Mayer
    United Council for Neuroloic Subspecialties, St Paul, MN 55116, USA
    Neurocrit Care 5:166-71. 2006
  82. ncbi request reprint Withholding care in intracerebral hemorrhage: realistic compassion or self-fulfilling prophecy?
    Alejandro A Rabinstein
    Neurology 68:1647-8. 2007
  83. ncbi request reprint Neurointensivists: part of the problem or part of the solution?
    Cherylee W J Chang
    Crit Care Med 36:2963-4; author reply 2965. 2008