G J Despotis

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. ncbi Effects of platelets and white blood cells and antiplatelet agent C7E3 (Reopro) on a new test of PAF procoagulant activity of whole blood
    G J Despotis
    Department of Anesthesiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Thromb Res 86:205-19. 1997
  2. ncbi Management approaches to platelet-related microvascular bleeding in cardiothoracic surgery
    G J Despotis
    Department of Anesthesiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Ann Thorac Surg 70:S20-32. 2000
  3. ncbi Anticoagulation monitoring during cardiac surgery: a review of current and emerging techniques
    G J Despotis
    Department of Anesthesiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Anesthesiology 91:1122-51. 1999
  4. ncbi A comparison between continuous infusion versus standard bolus administration of heparin based on monitoring in cardiac surgery
    G J Despotis
    Department of Anesthesiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Blood Coagul Fibrinolysis 8:419-30. 1997
  5. ncbi Monitoring of hemostasis in cardiac surgical patients: impact of point-of-care testing on blood loss and transfusion outcomes
    G J Despotis
    Department of Anesthesiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Clin Chem 43:1684-96. 1997
  6. ncbi Mechanisms and attenuation of hemostatic activation during extracorporeal circulation
    G J Despotis
    Department of Anesthesiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Ann Thorac Surg 72:S1821-31. 2001
  7. ncbi Antiischemic effects of nicardipine and nitroglycerin after coronary artery bypass grafting
    I A Apostolidou
    Department of Anesthesiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Ann Thorac Surg 67:417-22. 1999
  8. ncbi The relationship between hirudin and activated clotting time: implications for patients with heparin-induced thrombocytopenia undergoing cardiac surgery
    G J Despotis
    Departments of Anesthesiology, Pathology and ImmunologyWashington University School of Medicine, St. Louis, Missouri 63110, USA
    Anesth Analg 93:28-32. 2001
  9. ncbi Transfusion medicine : support of patients undergoing cardiac surgery
    L T Goodnough
    Department of Medicine and Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri 63110, USA
    Am J Cardiovasc Drugs 1:337-51. 2001
  10. ncbi A randomized trial of acute normovolemic hemodilution compared to preoperative autologous blood donation in total knee arthroplasty
    L T Goodnough
    Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Vox Sang 77:11-6. 1999

Detail Information

Publications16

  1. ncbi Effects of platelets and white blood cells and antiplatelet agent C7E3 (Reopro) on a new test of PAF procoagulant activity of whole blood
    G J Despotis
    Department of Anesthesiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Thromb Res 86:205-19. 1997
    ..A dose-dependent reduction in clot ratio values was also observed with increasing concentrations of c7E3. This test can reliably detect platelet dysfunction only if the platelet count is > 50,000 and the WBC is normal...
  2. ncbi Management approaches to platelet-related microvascular bleeding in cardiothoracic surgery
    G J Despotis
    Department of Anesthesiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Ann Thorac Surg 70:S20-32. 2000
    ..The ability to reduce the unnecessary use of blood products and to decrease operative time or reexploration rates has important consequences for blood inventory, blood costs, and overall health care costs...
  3. ncbi Anticoagulation monitoring during cardiac surgery: a review of current and emerging techniques
    G J Despotis
    Department of Anesthesiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Anesthesiology 91:1122-51. 1999
    ..e., when empiric protocols result in excessive protamine doses). More well-controlled studies are needed to better define the importance of anticoagulation management during CPB...
  4. ncbi A comparison between continuous infusion versus standard bolus administration of heparin based on monitoring in cardiac surgery
    G J Despotis
    Department of Anesthesiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Blood Coagul Fibrinolysis 8:419-30. 1997
    ..Therefore, an optimal approach might involve the combined use of these regimens...
  5. ncbi Monitoring of hemostasis in cardiac surgical patients: impact of point-of-care testing on blood loss and transfusion outcomes
    G J Despotis
    Department of Anesthesiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Clin Chem 43:1684-96. 1997
    ....
  6. ncbi Mechanisms and attenuation of hemostatic activation during extracorporeal circulation
    G J Despotis
    Department of Anesthesiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Ann Thorac Surg 72:S1821-31. 2001
    ..The ability to reduce blood product transfusions and to decrease operative times and reexploration rates favorably affects patient outcomes, availability of blood products, and overall health care costs...
  7. ncbi Antiischemic effects of nicardipine and nitroglycerin after coronary artery bypass grafting
    I A Apostolidou
    Department of Anesthesiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Ann Thorac Surg 67:417-22. 1999
    ....
  8. ncbi The relationship between hirudin and activated clotting time: implications for patients with heparin-induced thrombocytopenia undergoing cardiac surgery
    G J Despotis
    Departments of Anesthesiology, Pathology and ImmunologyWashington University School of Medicine, St. Louis, Missouri 63110, USA
    Anesth Analg 93:28-32. 2001
    ..Implications: A modified activated clotting time test system that may be helpful in monitoring hirudin anticoagulation in patients with heparin-induced thrombocytopenia during cardiac surgery with cardiopulmonary bypass is described...
  9. ncbi Transfusion medicine : support of patients undergoing cardiac surgery
    L T Goodnough
    Department of Medicine and Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri 63110, USA
    Am J Cardiovasc Drugs 1:337-51. 2001
    ..Controlled clinical trials comparing the costs of these agents with clinical outcomes, along with tolerability profiles in patients at risk for substantial perioperative bleeding are needed...
  10. ncbi A randomized trial of acute normovolemic hemodilution compared to preoperative autologous blood donation in total knee arthroplasty
    L T Goodnough
    Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Vox Sang 77:11-6. 1999
    ..Patients undergoing revision or bilateral knee arthroplasties require adjunctive therapy to autologous blood procurement to further reduce allogeneic blood exposure...
  11. ncbi Comparison of structured use of routine laboratory tests or near-patient assessment with clinical judgement in the management of bleeding after cardiac surgery
    M S Avidan
    Department of Anesthesiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Br J Anaesth 92:178-86. 2004
    ....
  12. ncbi Occurrence of myocardial ischemia immediately after coronary revascularization using radial arterial conduits
    I A Apostolidou
    Department of Anesthesiology, Division of Cardiothoracic Anesthesia, Washington University School of Medicine, St Louis, MO 63110, USA
    J Cardiothorac Vasc Anesth 15:433-8. 2001
    ..To assess the incidence of myocardial ischemia in patients receiving radial arterial and left internal thoracic arterial conduits (RA+LITA) during the postrevascularization period...
  13. ncbi A randomized trial comparing acute normovolemic hemodilution and preoperative autologous blood donation in total hip arthroplasty
    L T Goodnough
    Departments of Medicine and Pathology, Anesthesia, and Orthopedics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Transfusion 40:1054-7. 2000
    ..Therefore, a prospective, randomized study was conducted to compare these techniques in patients undergoing primary total hip arthroplasty...
  14. ncbi Future directions in utilization review: the role of transfusion algorithms
    L T Goodnough
    Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Transfus Sci 19:97-105. 1998
    ..The use of point-of-care assays and transfusion algorithms may provide an effective concurrent method of utilization review of blood products in the surgical setting...
  15. ncbi Recombinant human antithrombin III restores heparin responsiveness and decreases activation of coagulation in heparin-resistant patients during cardiopulmonary bypass
    M S Avidan
    Department of Anesthesiology and Cardiothoracic Surgery, Washington University School of Medicine, 660 South Euclid, St Louis, MO 63110, USA
    J Thorac Cardiovasc Surg 130:107-13. 2005
    ..We sought to evaluate the efficacy of recombinant human antithrombin III for restoration of heparin responsiveness in heparin-resistant patients scheduled for cardiac surgery...
  16. ncbi Warfarin therapy does not increase bleeding in patients undergoing heart transplantation
    C D Morris
    Joseph B. Whitehead Department of Surgery, Emory University School of Medicine, Atlanta, Georgia, USA
    Ann Thorac Surg 72:714-8. 2001
    ..Preoperative warfarin may be safely continued in patients awaiting heart transplantation...