Shadmehr Demehri

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. pmc Bi-compartmental communication contributes to the opposite proliferative behavior of Notch1-deficient hair follicle and epidermal keratinocytes
    Jonghyeob Lee
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, Box 8103, 660 South Euclid Avenue, Saint Louis, MO 63110, USA
    Development 134:2795-806. 2007
  2. pmc Notch-deficient skin induces a lethal systemic B-lymphoproliferative disorder by secreting TSLP, a sentinel for epidermal integrity
    Shadmehr Demehri
    Department of Developmental Biology, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS Biol 6:e123. 2008
  3. pmc The absence of a microbiota enhances TSLP expression in mice with defective skin barrier but does not affect the severity of their allergic inflammation
    Laura J Yockey
    Department of Developmental Biology, Washington University School of Medicine, St Louis, Missouri, USA
    J Invest Dermatol 133:2714-21. 2013
  4. pmc Elevated epidermal thymic stromal lymphopoietin levels establish an antitumor environment in the skin
    Shadmehr Demehri
    Department of Developmental Biology and Division of Dermatology, Washington University School of Medicine, Box 8103, 660 South Euclid Avenue, St Louis, MO 63110 1095, USA
    Cancer Cell 22:494-505. 2012
  5. pmc Epidermal Notch1 loss promotes skin tumorigenesis by impacting the stromal microenvironment
    Shadmehr Demehri
    Department of Developmental Biology, Division of Dermatology, Washington University School of Medicine, Saint Louis, MO 63110 1095, USA
    Cancer Cell 16:55-66. 2009
  6. pmc Notch signaling in bulge stem cells is not required for selection of hair follicle fate
    Shadmehr Demehri
    Department of Developmental Biology, Division of Dermatology, Washington University School of Medicine, Box 8103, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Development 136:891-6. 2009
  7. pmc Skin-derived TSLP triggers progression from epidermal-barrier defects to asthma
    Shadmehr Demehri
    Department of Developmental Biology and Division of Dermatology, Washington University School of Medicine, Saint Louis, Missouri, United States of America
    PLoS Biol 7:e1000067. 2009
  8. pmc Senescent stromal-derived osteopontin promotes preneoplastic cell growth
    Ermira Pazolli
    Department of Cell Biology and Physiology, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cancer Res 69:1230-9. 2009
  9. ncbi In vitro and in vivo activity of ATP-based kinase inhibitors AP23464 and AP23848 against activation-loop mutants of Kit
    Amie S Corbin
    Oregon Health and Science University, Cancer Institute, L592, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, USA
    Blood 106:227-34. 2005

Collaborators

  • P W Grigsby
  • Jeffrey I Gordon
  • Mitsuru Morimoto
  • Jeffrey H Miner
  • Michael J Holtzman
  • R Kopan
  • Laura J Yockey
  • Ermira Pazolli
  • Jonghyeob Lee
  • Amie S Corbin
  • Sindhu Manivasagam
  • Philip P Ahern
  • Omar Jassim
  • Mustafa Turkoz
  • John F Kearney
  • Ahu Turkoz
  • David Piwnica-Worms
  • Jun Jae Chung
  • Kelly Carbery
  • Jason Doherty
  • Xianmin Luo
  • Julie L Prior
  • Sarah Brehm
  • Lorena Salavaggione
  • Sheila A Stewart
  • Jacob M Basak
  • Ian J Griswold
  • William C Shakespeare
  • Michael W N Deininger
  • Brian J Druker
  • Raji Sundaramoorthi
  • Yihan Wang
  • Scott Wardwell
  • Tomi K Sawyer
  • John Iuliucci
  • Joseph Snodgrass
  • Michael C Heinrich
  • Chester A Metcalf
  • David Dalgarno

Detail Information

Publications9

  1. pmc Bi-compartmental communication contributes to the opposite proliferative behavior of Notch1-deficient hair follicle and epidermal keratinocytes
    Jonghyeob Lee
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, Box 8103, 660 South Euclid Avenue, Saint Louis, MO 63110, USA
    Development 134:2795-806. 2007
    ..These results suggest that Notch1 participates in a bi-compartmental signaling network that controls homeostasis, follicular proliferation rates and melanocyte population within the skin...
  2. pmc Notch-deficient skin induces a lethal systemic B-lymphoproliferative disorder by secreting TSLP, a sentinel for epidermal integrity
    Shadmehr Demehri
    Department of Developmental Biology, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS Biol 6:e123. 2008
    ..These observations demonstrate that local skin perturbations can drive a lethal systemic disease and have important implications for a wide range of humoral and autoimmune diseases with skin manifestations...
  3. pmc The absence of a microbiota enhances TSLP expression in mice with defective skin barrier but does not affect the severity of their allergic inflammation
    Laura J Yockey
    Department of Developmental Biology, Washington University School of Medicine, St Louis, Missouri, USA
    J Invest Dermatol 133:2714-21. 2013
    ..These findings suggest a role for the microbiota in ameliorating stress signals released by keratinocytes in response to perturbation in cutaneous barrier function. ..
  4. pmc Elevated epidermal thymic stromal lymphopoietin levels establish an antitumor environment in the skin
    Shadmehr Demehri
    Department of Developmental Biology and Division of Dermatology, Washington University School of Medicine, Box 8103, 660 South Euclid Avenue, St Louis, MO 63110 1095, USA
    Cancer Cell 22:494-505. 2012
    ..Importantly, TSLP overexpression in wild-type skin also caused resistance to tumorigenesis, confirming that TSLP functions as a tumor suppressor in the skin...
  5. pmc Epidermal Notch1 loss promotes skin tumorigenesis by impacting the stromal microenvironment
    Shadmehr Demehri
    Department of Developmental Biology, Division of Dermatology, Washington University School of Medicine, Saint Louis, MO 63110 1095, USA
    Cancer Cell 16:55-66. 2009
    ....
  6. pmc Notch signaling in bulge stem cells is not required for selection of hair follicle fate
    Shadmehr Demehri
    Department of Developmental Biology, Division of Dermatology, Washington University School of Medicine, Box 8103, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Development 136:891-6. 2009
    ..Taken together, our findings yield detailed insight into the function of Notch signaling in hair follicle stem cells and reveal the mechanism of the replacement of Notch-deficient adult hair follicles by epidermal cysts...
  7. pmc Skin-derived TSLP triggers progression from epidermal-barrier defects to asthma
    Shadmehr Demehri
    Department of Developmental Biology and Division of Dermatology, Washington University School of Medicine, Saint Louis, Missouri, United States of America
    PLoS Biol 7:e1000067. 2009
    ..Based on these findings, we propose that in addition to early treatment of the primary skin-barrier defects, selective inhibition of systemic TSLP may be the key to blocking the development of asthma in AD patients...
  8. pmc Senescent stromal-derived osteopontin promotes preneoplastic cell growth
    Ermira Pazolli
    Department of Cell Biology and Physiology, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cancer Res 69:1230-9. 2009
    ....
  9. ncbi In vitro and in vivo activity of ATP-based kinase inhibitors AP23464 and AP23848 against activation-loop mutants of Kit
    Amie S Corbin
    Oregon Health and Science University, Cancer Institute, L592, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, USA
    Blood 106:227-34. 2005
    ..Thus, AP23464 and AP23848 potently and selectively target activation-loop mutants of Kit in vitro and in vivo and could have therapeutic potential against D816V-expressing malignancies...