C J Decker
Affiliation: Washington State University
- Turnover mechanisms of the stable yeast PGK1 mRNAD Muhlrad
Department of Molecular and Cellular Biology, Howard Hughes Medical Institute, University of Arizona, Tucson 85721
Mol Cell Biol 15:2145-56. 1995..These observations indicate that there are multiple mechanisms by which an individual transcript can be degraded following deadenylation...
- The exosome: a versatile RNA processing machineC J Decker
Department of Genetics, Washington State University, Pullman, Washington 99164 4234, USA
Curr Biol 8:R238-40. 1998..A conserved complex of multiple 3'-to-5' exonucleases has been discovered recently in eukaryotes. This essential complex, the exosome, is required for diverse RNA processing events...
- The target of rapamycin signaling pathway regulates mRNA turnover in the yeast Saccharomyces cerevisiaeA R Albig
School of Molecular Biosciences, Washington State University, Pullman, WA 99164-4234, USA
Mol Biol Cell 12:3428-38. 2001..In summary, the control of mRNA turnover by the TOR pathway is complex in that it specifically regulates the decay of some mRNAs and not others and that it appears to control decay by multiple mechanisms...
- Deadenylation of the unstable mRNA encoded by the yeast MFA2 gene leads to decapping followed by 5'-->3' digestion of the transcriptD Muhlrad
Department of Molecular and Cellular Biology, University of Arizona, Tucson 85721
Genes Dev 8:855-66. 1994..Because the poly(A) tail and the cap structure are found on essentially all mRNAs, this pathway could be a general mechanism for the decay of many eukaryotic transcripts...