Research Topics
| W C DavisSummaryAffiliation: Washington State University Country: USA Publications
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Detail Information
Publications
Use of the mannan receptor to selectively target vaccine antigens for processing and antigen presentation through the MHC class I and class II pathwaysW C Davis
Department of Veterinary Microbiology and Pathology, CVM, Washington State University, Pullman, Washington 99164 7040, USA
Ann N Y Acad Sci 969:119-25. 2002....- An in vivo model to investigate lymphocyte-mediated immunity during acute hemoparasitic infections. Use of a monoclonal antibody to selectively deplete CD4+ T lymphocytes from thymectomized calvesR A Valdez
United States Department of Agriculture, Agricultural Research Service, Animal Disease Research Unit, P O Box 646630, Pullman, WA 99164 6630, USA
Ann N Y Acad Sci 916:233-6. 2000..In subsequent planned studies, thymectomized calves depleted of CD4+ T lymphocytes will be experimentally infected with A. marginale and parameters of disease compared between depleted and non-depleted calves... - The role of IL-10 in iNOS and cytokine mRNA expression during in vitro differentiation of bovine mononuclear phagocytesW L Goff
Animal Disease Research Unit, USDA ARS, Pullman, Washington 99164 7030, USA
J Interferon Cytokine Res 18:139-49. 1998..These results provide evidence for IL-10 regulation of some bovine mononuclear phagocyte effector functions... - Age-related innate immune response in calves to Babesia bovis involves IL-12 induction and IL-10 modulationW L Goff
Animal Diseases Research Unit, USDA ARS, Pullman, Washington 99164, USA
Ann N Y Acad Sci 969:164-8. 2002..Also in contrast with calves, there was no detectable antibody response before death in adults. A vigorous CD8+ T-cell expansion occurred in the spleens of both calves and adults... 
B-lymphocyte proliferation during bovine leukemia virus-induced persistent lymphocytosis is enhanced by T-lymphocyte-derived interleukin-2E S Trueblood
Department of Veterinary Microbiology and Pathology, Washington State University, Pullman 99164, USA
J Virol 72:3169-77. 1998..Collectively, these findings strongly suggest that increased T-lymphocyte expression of IL-2 in BLV-infected cows contributes to development and/or maintenance of persistent B lymphocytosis...- The use of crossreactive monoclonal antibodies to characterize the immune system of the water buffalo (Bubalus bubalis)W C Davis
Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, Pullman, WA 99164 7040, USA
J Vet Sci 2:103-9. 2001..In addition to identifying a useful set of reagents, the study has provided insight into the composition of the immune system of the water buffalo (Bubalus bubalis)... - Flow cytometric analysis of an immunodeficiency disorder affecting juvenile llamasW C Davis
Departments of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, Pullman, WA 99164 7040, USA
Vet Immunol Immunopathol 74:103-20. 2000..The findings suggest JLIDS is attributable to an autosomal recessive genetic defect in the development of B-cells... - IL-4 protects adult C57BL/6 mice from prolonged Cryptosporidium parvum infection: analysis of CD4+alpha beta+IFN-gamma+ and CD4+alpha beta+IL-4+ lymphocytes in gut-associated lymphoid tissue during resolution of infectionS A Aguirre
Department of Veterinary Microbiology and Pathology, Washington State University, Pullman 99164, USA
J Immunol 161:1891-900. 1998..However, neither IL-4 nor IFN-gamma was required for the final clearance of infection from the intestinal tract of adult mice... - Comparison of the unique characteristics of the immune system in different species of mammalsW C Davis
Department of Veterinary Microbiology and Pathology, Washington State University, Pullman 99164 7040, USA
Vet Immunol Immunopathol 63:7-13. 1998..The difference noted emphasize that it will not be possible to fully understand the role of cytokines in immune regulation without comparative studies that include analysis of cytokine function in additional species... - Phenotypic comparison of ileal intraepithelial lymphocyte populations of suckling and weaned calvesC R Wyatt
Department of Veterinary Microbiology and Pathology, Washington State University, College of Veterinary Medicine, Pullman 99164, USA
Vet Immunol Immunopathol 67:213-22. 1999..However, substantial numbers of IgA+ and IgG1+ cells were observed in weaned calf ileum. Together, the data are consistent with ongoing postnatal maturation of the gut mucosal immune system... - Long-term in vivo depletion of functional CD4+ T lymphocytes from calves requires both thymectomy and anti-CD4 monoclonal antibody treatmentR A Valdez
United States Department of Agriculture, Agricultural Research Service, Animal Disease Research Unit, Pullman, WA 99164 6630, USA
Immunology 102:426-33. 2001..The results of this study demonstrate that both thymectomy and treatment with anti-CD4 mAb are required for long-term in vivo depletion of functional bovine CD4+ T lymphocytes... - Scavenger receptor cysteine-rich domains 9 and 11 of WC1 are receptors for the WC1 counter receptorJ S Ahn
Department of Veterinary Microbiology and Pathology, Washington State University, Pullman 99164-7040, USA
J Leukoc Biol 72:382-90. 2002..These results and the finding of conserved signaling motifs in the cytoplasmic tail suggest WC1 may be an accessory molecule... - Analysis of monoclonal antibodies reacting with molecules expressed on gammadelta T-cellsW C Davis
Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, P O Box 647040, Pullman, WA 99164 7040, USA
Vet Immunol Immunopathol 80:53-62. 2001..A new mAb (PPT16) added late to the workshop following a request by the workshop chairs appeared to recognize a determinant expressed on the gammadelta TCR/CD3 molecular complex... - Analysis of monoclonal antibodies that recognize gamma delta T/null cellsW C Davis
Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, Pullman 99164 7040, USA
Vet Immunol Immunopathol 60:305-16. 1998..Three mAbs did not form clusters. Three mAbs predicted to recognize TcR in the first workshop (020 [PT14A], 021 [PT79A], and 022 [MUC127A]) and mAb PGBL22A were shown to immunoprecipitate a 37, 40 kDa heterodimer... - Spontaneously proliferating lymphocytes from bovine leukaemia virus-infected, lymphocytotic cattle are not the virus-expressing lymphocytes, as these cells are delayed in G(0)/G(1) of the cell cycle and are spared from apoptosisD M Stone
Department of Veterinary Microbiology and Pathology, Washington State University, PO Box 647040, Pullman, WA 99164, USA
J Gen Virol 81:971-81. 2000..This may be due to an effect of virus on CD4 T lymphocytes, as depletion of CD4 T lymphocytes significantly decreased spontaneous proliferation... - Cellular prion protein is expressed on peripheral blood mononuclear cells but not platelets of normal and scrapie-infected sheepL M Herrmann
United States Department of Agriculture, Agricultural Research Service, Animal Disease Research Unit, 3003 ADBF, Washington State University, Pullman, WA 99164 6630, USA
Haematologica 86:146-53. 2001..As a first step in understanding the disease requirements in the natural scrapie host, the presence of PrPc was evaluated in peripheral blood cells from five normal and five scrapie-infected Suffolk sheep... - Cloning of bovine CD69J S Ahn
Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, Pullman, WA 99164 7040, USA
Vet Immunol Immunopathol 88:43-8. 2002..In addition, the cytoplasmic tail of bovine CD69 has two casein kinase-2 (CK-2) phosphorylation sites. These data suggest that bovine CD69 plays an important role in the activation of lymphocytes... - CD5 is dissociated from the B-cell receptor in B cells from bovine leukemia virus-infected, persistently lymphocytotic cattle: consequences to B-cell receptor-mediated apoptosisG H Cantor
Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington 99164 7040, USA
J Virol 75:1689-96. 2001..Disruption of CD5-BCR interactions and subsequent decreased apoptosis and increased survival in antigenically stimulated B cells may be a mechanism of BLV-induced PL... - The Anaplasma marginale msp5 gene encodes a 19-kilodalton protein conserved in all recognized Anaplasma speciesE S Visser
Department of Veterinary Microbiology and Pathology, Washington State University, Pullman 99164-7040
Infect Immun 60:5139-44. 1992..The presence of antibody to the epitope defined by monoclonal antibody ANAF16C1 in all postinfection sera tested indicates that this epitope is a potential diagnostic antigen for use in identifying persistently infected cattle... - Bovine mammary immune response to an experimental intramammary infection with a Staphylococcus aureus strain containing a gene for staphylococcal enterotoxin C1T L Ebling
Department of Animal Sciences, Washington State University, Pullman 99164, USA
J Dairy Sci 84:2044-50. 2001..05). Results do not support the hypothesis that the presence of the gene for SEC1 alters the mammary BoCD4 or BoCD8 T lymphocyte response to infection... - IL-4 and IL-10 inhibition of IFN-gamma- and TNF-alpha-dependent nitric oxide production from bovine mononuclear phagocytes exposed to Babesia bovis merozoitesW L Goff
Animal Disease Research Unit, USDA ARS, Washington State University, 3003 ADBF, P O Box 646630, Pullman, WA 99164 6630, USA
Vet Immunol Immunopathol 84:237-51. 2002..However, while merozoites plus IFN-gamma induced TNF-alpha mRNA expression in MDM, NO was not produced. Both IL-4 and IL-10 inhibited expression of iNOS and production of NO in merozoite-stimulated monocytes... - Kinetic modeling and analysis of a vesicle system for immunosensor developmentY Y Yu
Department of Chemical Engineering, Washington State University, Pullman 99164 2710, USA
Biosens Bioelectron 12:135-44. 1997.... - Tissue distribution of CD6 and CD6 ligand in cattle: expression of the CD6 ligand (CD166) in the autonomic nervous system of cattle and the humanA Konno
Department of Biomedical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan
J Leukoc Biol 69:944-50. 2001..These results show that the bovine orthologue of CD166 was constitutively expressed in the autonomic nervous systems of cattle and suggest that CD6(+) lymphocytes adhere to CD166(+) autonomic nerve terminals via CD6... - Early induction of humoral and cellular immune responses during experimental Mycobacterium avium subsp. paratuberculosis infection of calvesW R Waters
Bacterial Diseases of Livestock Research Unit, National Animal Disease Center, Agricultural Research Service, United States Department of Agriculture, Ames, Iowa 50010, USA
Infect Immun 71:5130-8. 2003..Additionally, this study confirms that mycobacteria-specific antibody is detectable early in the course of experimental Johne's disease, even preceding the development of specific cell-mediated responses... - Establishment of Neospora caninum antigen-specific T cell lines of primarily CD4 T cellsW Tuo
Animal Parasitic Diseases Laboratory, ANRI, USDA ARS, Beltsville, MD 20705, USA
Parasite Immunol 26:243-6. 2004..caninum antigens. This research will enhance our understanding of bovine CMI to neosporosis and may facilitate development of a proven neosporosis vaccine... - Cell proliferation, apoptosis, and B- and T-lymphocytes in Peyer's patches of the ileum, in thymus and in lymph nodes of preterm calves, and in full-term calves at birth and on day 5 of lifeC W David
Division of Nutrition and Physiology, Institute of Animal Genetics, Nutrition and Housing, Faculty of Veterinary Medicine, University of Berne, CH-3012 Berne, Switzerland
J Dairy Sci 86:3321-9. 2003..In conclusion, proliferation and apoptosis rates and numbers of B- and T- lymphocytes in Peyer's patches in ileum, thymus, and LM and LP exhibited different developmental changes and were affected by feeding... - Identity of activation molecule 3 on superantigen-stimulated bovine cells is CD26S U Lee
Department of Microbiology, Molecular Biology, and Biochemistry, University of Idaho, Moscow, Idaho 83844, USA
Infect Immun 69:7190-3. 2001..This superantigen-dependent phenotype may be relevant to immunopathogenesis mediated by certain microbial toxins. The size and N-terminal sequence of immunoprecipitated ACT3 indicate that ACT3 is the bovine orthologue of CD26... - Staphylococcus aureus associated with mammary glands of cows: genotyping to distinguish different strains among herdsY S Joo
Mastitis Research Laboratory, Bacteriology and Immunology Department, National Veterinary Research Institute, Kyunggi-do, South Korea
Vet Microbiol 80:131-8. 2001..aureus are more likely to be restricted to a single herd, than found in multiple herds... - Cloning, sequencing and expression of the bovine CD3 epsilon and TCR-zeta chains, two invariant components of the T-cell receptor complexG Hagens
Institute of Animal Pathology, University of Berne, Switzerland
Gene 169:165-71. 1996..coli, and were used in Western blot analysis to further characterise TCR zeta-chain expression in T-cells. The regents provide valuable tools for the study of signal transduction pathways in normal and transformed bovine T-cells... - Members of the novel WC1 gene family are differentially expressed on subsets of bovine CD4-CD8- gamma delta T lymphocytesP L Wijngaard
Department of Immunology, University Hospital, Utrecht, The Netherlands
J Immunol 152:3476-82. 1994..Although the function of WC1 remains unknown, it likely involves interaction with ligands that originate from a similarly complex genetic system... - Myocarditis associated with foot-and-mouth disease virus type O in lambsM Y Gulbahar
University of Ondokuz Mayis, Faculty of Veterinary Medicine, Department of Pathology, Kurupelit, 55139 Samsun, Turkey
Vet Pathol 44:589-99. 2007..These findings suggest that the iNOS expressed by inflammatory cells in lesions may have a deleterious effect on cardiac myocytes in these lesions...