Gautam Dantas

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. pmc Functional metagenomic investigations of the human intestinal microbiota
    Aimee M Moore
    Center for Genome Sciences and Systems Biology, Washington University School of Medicine St Louis, MO, USA
    Front Microbiol 2:188. 2011
  2. pmc Novel resistance functions uncovered using functional metagenomic investigations of resistance reservoirs
    Erica C Pehrsson
    Center for Genome Sciences and Systems Biology, Washington University School of Medicine St Louis, MO, USA
    Front Microbiol 4:145. 2013
  3. pmc Experimental approaches for defining functional roles of microbes in the human gut
    Gautam Dantas
    Center for Genome Sciences and Systems Biology and Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63108 email
    Annu Rev Microbiol 67:459-75. 2013
  4. doi Context matters - the complex interplay between resistome genotypes and resistance phenotypes
    Gautam Dantas
    Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, MO, USA
    Curr Opin Microbiol 15:577-82. 2012
  5. pmc Bacterial phylogeny structures soil resistomes across habitats
    Kevin J Forsberg
    1 Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, Missouri 63108, USA 2
    Nature 509:612-6. 2014
  6. pmc The shared antibiotic resistome of soil bacteria and human pathogens
    Kevin J Forsberg
    Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, MO 63108, USA
    Science 337:1107-11. 2012
  7. doi Identification of Genes Conferring Tolerance to Lignocellulose-Derived Inhibitors by Functional Selections in Soil Metagenomes
    Kevin J Forsberg
    Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, Missouri, USA
    Appl Environ Microbiol 82:528-37. 2015
  8. pmc Pediatric fecal microbiota harbor diverse and novel antibiotic resistance genes
    Aimee M Moore
    Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, Missouri, United States of America Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS ONE 8:e78822. 2013
  9. doi Comparative transcriptomics elucidates adaptive phenol tolerance and utilization in lipid-accumulating Rhodococcus opacus PD630
    Aki Yoneda
    Department of Pathology and Immunology, Washington University in St Louis School of Medicine, St Louis, MO 63108, USA Center for Genome Sciences and Systems Biology, Washington University in St Louis School of Medicine, St Louis, MO 63108, USA
    Nucleic Acids Res 44:2240-54. 2016
  10. doi The Tetracycline Destructases: A Novel Family of Tetracycline-Inactivating Enzymes
    Kevin J Forsberg
    Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, MO 63108, USA
    Chem Biol 22:888-97. 2015

Collaborators

  • Morten O A Sommer
  • Christian L Lauber
  • Rob Knight
  • Patrick H Degnan
  • Jeffrey I Gordon
  • Noah Fierer
  • Kevin J Forsberg
  • Molly K Gibson
  • Sanket Patel
  • Aimee M Moore
  • Bin Wang
  • Aki Yoneda
  • Mitchell W Pesesky
  • Erica C Pehrsson
  • Alejandro Reyes
  • Andrew L Goodman
  • Marcus Foston
  • Soo Ji Kim
  • Nicholas K Goldner
  • Tae Seok Moon
  • William R Henson
  • Kun Joo Park
  • Terence S Crofts
  • Timothy A Wencewicz
  • Evan Witt
  • Tyler D Ellison
  • Phillip I Tarr
  • Yasmin Razia
  • Xuan Qin
  • Gayle Bentley
  • Sara Ahmadi
  • Elizabeth M Selleck
  • George Kallstrom
  • Jeremiah J Faith
  • Christian Munck
  • Aimee Moore

Detail Information

Publications14

  1. pmc Functional metagenomic investigations of the human intestinal microbiota
    Aimee M Moore
    Center for Genome Sciences and Systems Biology, Washington University School of Medicine St Louis, MO, USA
    Front Microbiol 2:188. 2011
    ....
  2. pmc Novel resistance functions uncovered using functional metagenomic investigations of resistance reservoirs
    Erica C Pehrsson
    Center for Genome Sciences and Systems Biology, Washington University School of Medicine St Louis, MO, USA
    Front Microbiol 4:145. 2013
    ....
  3. pmc Experimental approaches for defining functional roles of microbes in the human gut
    Gautam Dantas
    Center for Genome Sciences and Systems Biology and Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63108 email
    Annu Rev Microbiol 67:459-75. 2013
    ..These developments promise to deepen our understanding of human gut host-microbiota relationships and are readily applicable to other host-associated and free-living microbial communities. ..
  4. doi Context matters - the complex interplay between resistome genotypes and resistance phenotypes
    Gautam Dantas
    Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, MO, USA
    Curr Opin Microbiol 15:577-82. 2012
    ....
  5. pmc Bacterial phylogeny structures soil resistomes across habitats
    Kevin J Forsberg
    1 Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, Missouri 63108, USA 2
    Nature 509:612-6. 2014
    ..Together, our results indicate that bacterial community composition is the primary determinant of soil ARG content, challenging previous hypotheses that horizontal gene transfer effectively decouples resistomes from phylogeny. ..
  6. pmc The shared antibiotic resistome of soil bacteria and human pathogens
    Kevin J Forsberg
    Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, MO 63108, USA
    Science 337:1107-11. 2012
    ..This identity encompasses noncoding regions as well as multiple mobilization sequences, offering not only evidence of lateral exchange but also a mechanism by which antibiotic resistance disseminates...
  7. doi Identification of Genes Conferring Tolerance to Lignocellulose-Derived Inhibitors by Functional Selections in Soil Metagenomes
    Kevin J Forsberg
    Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, Missouri, USA
    Appl Environ Microbiol 82:528-37. 2015
    ..These metagenomic tolerance genes can enable the flexible design of hardy microbial catalysts, customized to withstand inhibitors abundant in specific bioprocessing applications. ..
  8. pmc Pediatric fecal microbiota harbor diverse and novel antibiotic resistance genes
    Aimee M Moore
    Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, Missouri, United States of America Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS ONE 8:e78822. 2013
    ..coli) host also suggests that the potential for gut-associated resistomes to threaten human health by mediating antibiotic resistance in pathogens warrants further investigation. ..
  9. doi Comparative transcriptomics elucidates adaptive phenol tolerance and utilization in lipid-accumulating Rhodococcus opacus PD630
    Aki Yoneda
    Department of Pathology and Immunology, Washington University in St Louis School of Medicine, St Louis, MO 63108, USA Center for Genome Sciences and Systems Biology, Washington University in St Louis School of Medicine, St Louis, MO 63108, USA
    Nucleic Acids Res 44:2240-54. 2016
    ..The identified tolerance genes and pathways are promising candidates for future metabolic engineering in R. opacus for improved lignin conversion to lipid-based products. ..
  10. doi The Tetracycline Destructases: A Novel Family of Tetracycline-Inactivating Enzymes
    Kevin J Forsberg
    Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, MO 63108, USA
    Chem Biol 22:888-97. 2015
    ..Because tetracycline inactivation is scarcely observed in hospitals, these enzymes may fill an empty niche in pathogenic organisms, and should therefore be monitored for their dissemination potential into the clinic...
  11. pmc Improved annotation of antibiotic resistance determinants reveals microbial resistomes cluster by ecology
    Molly K Gibson
    Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, MO, USA
    ISME J 9:207-16. 2015
    ..Together, our results indicate that environmental and human-associated microbial communities harbor distinct resistance genes, suggesting that antibiotic resistance functions are largely constrained by ecology. ..
  12. pmc Extensive personal human gut microbiota culture collections characterized and manipulated in gnotobiotic mice
    Andrew L Goodman
    Center for Genome Science and Systems Biology, Washington University School of Medicine, St Louis, MO 63108, USA
    Proc Natl Acad Sci U S A 108:6252-7. 2011
    ....
  13. doi Antibiotics and the developing infant gut microbiota and resistome
    Molly K Gibson
    Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, MO, USA
    Curr Opin Microbiol 27:51-6. 2015
    ..Here we review the current understanding of the developmental progression of the IGM and the impact of antibiotic therapies on its composition and encoded reservoir of antibiotic resistance genes. ..
  14. pmc The yin and yang of bacterial resilience in the human gut microbiota
    Molly K Gibson
    Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Mol Biol 426:3866-76. 2014
    ....