ROBERT C CULVERHOUSE

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. pmc Uncovering hidden variance: pair-wise SNP analysis accounts for additional variance in nicotine dependence
    ROBERT C CULVERHOUSE
    Division of General Medical Sciences, Department of Medicine, Washington University, Saint Louis, MO 63110, USA
    Hum Genet 129:177-88. 2011
  2. pmc Protocol for a collaborative meta-analysis of 5-HTTLPR, stress, and depression
    ROBERT C CULVERHOUSE
    Department of Medicine, Washington University School of Medicine, St, Louis, MO, USA
    BMC Psychiatry 13:304. 2013
  3. pmc Identifying rare variants from exome scans: the GAW17 experience
    Saurabh Ghosh
    Human Genetics Unit, Indian Statistical Institute, Kolkata 700018, India
    BMC Proc 5:S1. 2011
  4. pmc A comparison of methods sensitive to interactions with small main effects
    ROBERT C CULVERHOUSE
    Department of Internal Medicine, Washington University in St Louis School of Medicine, St Louis, Missouri 63110, USA
    Genet Epidemiol 36:303-11. 2012
  5. doi request reprint The restricted partition method
    Robert Culverhouse
    Washington University in St Louis School of Medicine, St Louis, Missouri, USA
    Adv Genet 72:117-39. 2010
  6. pmc Power and false-positive rates for the restricted partition method (RPM) in a large candidate gene data set
    Robert Culverhouse
    Department of Medicine, Washington University School of Medicine, 660 South Euclid Avenue, St, Louis, Missouri 63110, USA
    BMC Proc 3:S74. 2009
  7. pmc Gene x gene and gene x environment interactions for complex disorders
    Robert Culverhouse
    Department of Medicine, Washington University, 660 South Euclid, GMS Box 8005, St, Louis, Missouri 63110, USA
    BMC Proc 1:S72. 2007
  8. ncbi request reprint The use of the restricted partition method with case-control data
    R Culverhouse
    Department of Internal Medicine, Washington University in St Louis School of Medicine, St Louis, MO 63110, USA
    Hum Hered 63:93-100. 2007
  9. pmc Smoking and genetic risk variation across populations of European, Asian, and African American ancestry--a meta-analysis of chromosome 15q25
    Li Shiun Chen
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Genet Epidemiol 36:340-51. 2012
  10. pmc The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans
    Nancy L Saccone
    Department of Genetics, Washington University, St Louis, Missouri 63110, UA
    Cancer Res 69:6848-56. 2009

Detail Information

Publications16

  1. pmc Uncovering hidden variance: pair-wise SNP analysis accounts for additional variance in nicotine dependence
    ROBERT C CULVERHOUSE
    Division of General Medical Sciences, Department of Medicine, Washington University, Saint Louis, MO 63110, USA
    Hum Genet 129:177-88. 2011
    ..Methodologies that limit analyses of joint effects to variants that demonstrate association in single SNP analyses, or require a significant interaction term, will likely miss important joint effects...
  2. pmc Protocol for a collaborative meta-analysis of 5-HTTLPR, stress, and depression
    ROBERT C CULVERHOUSE
    Department of Medicine, Washington University School of Medicine, St, Louis, MO, USA
    BMC Psychiatry 13:304. 2013
    ..Meta-analyses of multiple studies have also reached differing conclusions...
  3. pmc Identifying rare variants from exome scans: the GAW17 experience
    Saurabh Ghosh
    Human Genetics Unit, Indian Statistical Institute, Kolkata 700018, India
    BMC Proc 5:S1. 2011
    ....
  4. pmc A comparison of methods sensitive to interactions with small main effects
    ROBERT C CULVERHOUSE
    Department of Internal Medicine, Washington University in St Louis School of Medicine, St Louis, Missouri 63110, USA
    Genet Epidemiol 36:303-11. 2012
    ..The MDR outperformed the SVM when the true model had only a few, well-separated risk classes; while the SVM outperformed the MDR on more complicated models. Of these methods, only MDR has a well-developed user interface...
  5. doi request reprint The restricted partition method
    Robert Culverhouse
    Washington University in St Louis School of Medicine, St Louis, Missouri, USA
    Adv Genet 72:117-39. 2010
    ..Because the algorithm and software lend themselves to distributed processing, larger analyses can easily be split among multiple computers...
  6. pmc Power and false-positive rates for the restricted partition method (RPM) in a large candidate gene data set
    Robert Culverhouse
    Department of Medicine, Washington University School of Medicine, 660 South Euclid Avenue, St, Louis, Missouri 63110, USA
    BMC Proc 3:S74. 2009
    ..Power and false-positive rates were evaluated using the first 100 replicate datasets. This included an exploration of the utility of using of all genotyped family members compared with selecting one member per family...
  7. pmc Gene x gene and gene x environment interactions for complex disorders
    Robert Culverhouse
    Department of Medicine, Washington University, 660 South Euclid, GMS Box 8005, St, Louis, Missouri 63110, USA
    BMC Proc 1:S72. 2007
    ....
  8. ncbi request reprint The use of the restricted partition method with case-control data
    R Culverhouse
    Department of Internal Medicine, Washington University in St Louis School of Medicine, St Louis, MO 63110, USA
    Hum Hered 63:93-100. 2007
    ..The aim of this study is to evaluate the performance of the RPM on case-control data...
  9. pmc Smoking and genetic risk variation across populations of European, Asian, and African American ancestry--a meta-analysis of chromosome 15q25
    Li Shiun Chen
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Genet Epidemiol 36:340-51. 2012
    ..Using the cross-population study paradigm provides valuable insights to narrow regions of interest and inform future biological experiments...
  10. pmc The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans
    Nancy L Saccone
    Department of Genetics, Washington University, St Louis, Missouri 63110, UA
    Cancer Res 69:6848-56. 2009
    ..The nonsynonymous SNP rs16969968, a known risk variant in populations of European-descent, is also significantly associated with risk in African-Americans. Additional SNPs contribute to risk in distinct ways in these two populations...
  11. pmc Multiple distinct CHRNB3-CHRNA6 variants are genetic risk factors for nicotine dependence in African Americans and European Americans
    ROBERT C CULVERHOUSE
    Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA Division of Biostatistics, Washington University School of Medicine, Saint Louis, MO, USA
    Addiction 109:814-22. 2014
    ..We investigate whether this generalizes to African Americans, whether the association is specific to nicotine dependence and whether this region contains additional genetic contributors to nicotine dependence...
  12. pmc Linkage analysis merging replicate phenotypes: an application to three quantitative phenotypes in two African samples
    Anthony L Hinrichs
    Department of Psychiatry, Washington University School of Medicine, 660 South Euclid Ave, Campus Box 8134, St, Louis, MO 63110, USA
    BMC Proc 5:S81. 2011
    ..Using both methods, we found numerous significant linkage signals for Q1, although population colocalization was absent for most of these signals. The linkage analysis of Q2 and Q4 failed to reveal any strong linkage signals...
  13. pmc Stratify or adjust? Dealing with multiple populations when evaluating rare variants
    ROBERT C CULVERHOUSE
    Department of Medicine, Washington University School of Medicine, 660 South Euclid Avenue, Saint Louis, MO 63110, USA
    BMC Proc 5:S101. 2011
    ..However, including population as a covariate was not an effective substitute for analyzing the subpopulations separately when only one subpopulation contained a rare variant linked to the phenotype...
  14. pmc A genome-wide association study of alcohol dependence
    Laura J Bierut
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 107:5082-7. 2010
    ..11 and 1.16. Further dissection of the alcoholism phenotype, to disentangle the influence of comorbid substance-use disorders, will be a next step in identifying genetic variants associated with alcohol dependence...
  15. ncbi request reprint Gene by environment interactions
    ROBERT C CULVERHOUSE
    Department of Medicine, Washington University School of Medicine, 600 South Euclid, St Louis, MO 63110, USA
    Genet Epidemiol 31:S68-74. 2007
    ..A related but distinct goal is to characterize an interaction (e.g. to determine if the interaction is significant)...
  16. ncbi request reprint Exploiting linkage disequilibrium in population isolates
    R Culverhouse
    Department of Psychiatry, Washington University School of Medicine, Box 8134, Dept. of Psychiatry, 660 South Euclid, St. Louis, MO 63110, USA
    Genet Epidemiol 21:S429-34. 2001
    ..We describe two statistical methods to utilize D: a method appropriate for a single moderately sized sample and a sequential approach appropriate for multiple small independent samples...