Research Topics
| Joseph CulverSummaryAffiliation: Washington University School of Medicine Country: USA Publications
Research Grants
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Detail Information
Publications
Quantitative diffuse optical tomography for small animals using an ultrafast gated image intensifierSachin V Patwardhan
Washington University School of Medicine, Department of Radiology, Mallinckrodt Institute of Radiology, St Louis, Missouri 63110, USA
J Biomed Opt 13:011009. 2008..Experiments with tissue simulating phantoms demonstrate the feasibility of reconstructing the absorption and scattering optical properties in a small animal imaging system...
Evidence that cerebral blood volume can provide brain activation maps with better spatial resolution than deoxygenated hemoglobinJoseph P Culver
Mallinckrodt Institute of Radiology, Washington University School of Medicine, 4525 Scott Avenue, St Louis, MO 63110, USA
Neuroimage 27:947-59. 2005..These results indicate that total hemoglobin and cerebral blood volume may have advantages as hemodynamic mapping contrasts, particularly for large amplitude, longer duration stimulus paradigms...- Quantitative small animal fluorescence tomography using an ultrafast gated image intensifierSachin V Patwardhan
Dept of Radiol, Washington Univ Sch of Med, St Louis, MO 63110, USA
Conf Proc IEEE Eng Med Biol Soc 1:2675-8. 2006..Here we present a time-resolved, charged coupled device (CCD) based system for quantitative small animal fluorescence tomography... - Topics in Biomedical Optics: introduction to the feature issueJoseph P Culver
Mallinckrodt Institute of Radiology, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8225, St Louis, Missouri 63110, USA
Appl Opt 48:TBO1-2. 2009..This Applied Optics feature issue on Topics in Biomedical Optics highlights papers presented at the 2008 Biomedical Topical meeting sponsored by the Optical Society... 
Quantitative evaluation of high-density diffuse optical tomography: in vivo resolution and mapping performanceBrian R White
Washington University School of Medicine, Department of Radiology and Department of Physics, St Louis, Missouri 63110, USA
J Biomed Opt 15:026006. 2010..In particular, we demonstrate that HD-DOT enables detailed phase-encoded retinotopic mapping, while sparse arrays are limited to imaging individual block-design visual stimuli...- Mapping the human brain at rest with diffuse optical tomographyBrian R White
Department of Physics, Washington University, St Louis, MO, USA
Conf Proc IEEE Eng Med Biol Soc 2009:4070-2. 2009.... - Phase-encoded retinotopy as an evaluation of diffuse optical neuroimagingBrian R White
Department of Radiology, Washington University School of Medicine, 4525 Scott Ave, St Louis, MO 63110, USA
Neuroimage 49:568-77. 2010..With these advances in techniques and validation paradigms, optical neuroimaging can be extended into studies of higher-order brain function and of clinical utility with greater performance and confidence... - In vivo fluorescence lifetime tomographyRalph E Nothdurft
Washington University School of Medicine, Department of Radiology, Mallinckrodt Institute of Radiology, St Louis, Missouri 63110, USA
J Biomed Opt 14:024004. 2009..Use in a common research scenario is ultimately demonstrated by imaging accumulation of a targeted near-infrared (NIR) fluorescent-labeled peptide probe (cypate-RGD) in a mouse with a subcutaneous tumor... - Resting-state functional connectivity in the human brain revealed with diffuse optical tomographyBrian R White
Department of Radiology, Washington University, St Louis, MO 63110, USA
Neuroimage 47:148-56. 2009..In addition, the comprehensive hemoglobin contrasts of fc-DOT enable innovative studies of the biophysical origin of the functional connectivity signal... - Neonatal hemodynamic response to visual cortex activity: high-density near-infrared spectroscopy studySteve M Liao
Washington University School of Medicine, Department of Pediatrics and Department of Neurology and Department of Radiology, St Louis, Missouri 63110, USA
J Biomed Opt 15:026010. 2010.... - Blind identification of evoked human brain activity with independent component analysis of optical dataJoanne Markham
Department of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
Hum Brain Mapp 30:2382-92. 2009..Our results suggest that ICA can extract the time courses and the corresponding spatial extent of functional responses in DOT imaging... - Retinotopic mapping of adult human visual cortex with high-density diffuse optical tomographyBenjamin W Zeff
Department of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
Proc Natl Acad Sci U S A 104:12169-74. 2007..These results demonstrate that high-density DOT is a practical and powerful tool for mapping function in the human cortex... - Activatable molecular systems using homologous near-infrared fluorescent probes for monitoring enzyme activities in vitro, in cellulo, and in vivoZongren Zhang
Department of Radiology, Washington University School of Medicine, 4525 Scott Avenue, St Louis, Missouri 63110, USA
Mol Pharm 6:416-27. 2009..The NIR activatable molecular probes provide an effective strategy to screen new drugs in vitro and monitor treatment response in living organisms... - Diffuse optical tomography of cerebral blood flow, oxygenation, and metabolism in rat during focal ischemiaJoseph P Culver
Department of Physics and Astronomy, Cerebrovascular Research Center, University of Pennsylvania, Philadelphia, Pennsylvania, U S A
J Cereb Blood Flow Metab 23:911-24. 2003.... - Reconstructing chromosphere concentration images directly by continuous-wave diffuse optical tomographyAng Li
Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
Opt Lett 29:256-8. 2004..We demonstrate this improvement with simulations and a dynamic blood phantom experiment... - Hemodynamic evoked response of the sensorimotor cortex measured noninvasively with near-infrared optical imagingMaria Angela Franceschini
NMR Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
Psychophysiology 40:548-60. 2003..Our findings based on optical imaging are in agreement with results in the literature obtained with positron emission tomography and functional magnetic resonance imaging... - Temporal comparison of functional brain imaging with diffuse optical tomography and fMRI during rat forepaw stimulationAndrew M Siegel
Tufts University Bioengineering Center, Medford, MA 02155, USA
Phys Med Biol 48:1391-403. 2003.... - Diffuse optical measurement of hemoglobin and cerebral blood flow in rat brain during hypercapnia, hypoxia and cardiac arrestJoseph P Culver
Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, PA 19104, USA
Adv Exp Med Biol 510:293-7. 2003..The new instrument and concept may also be applicable to human studies especially in infants and neonates permitting noninvasive monitoring of cerebral hemodynamics and oxygen (see [4] and [2] for examples of NIR spectroscopy)... - Optode positional calibration in diffuse optical tomographyJonathan J Stott
Harvard Medical School Massachusetts Institute of Technology Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 13th Street, Building 149, Charlestown, Massachusetts 02129, USA
Appl Opt 42:3154-62. 2003..We present a technique for simultaneously calibrating optode positions and reconstructing images that significantly improves image quality, as we demonstrate with simulations and phantom experiments... - Singular-value analysis and optimization of experimental parameters in fluorescence molecular tomographyEdward E Graves
Center for Molecular Imaging Research, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Room 5404, Charlestown, Massachusetts 02129, USA
J Opt Soc Am A Opt Image Sci Vis 21:231-41. 2004.... - Volumetric diffuse optical tomography of brain activityJoseph P Culver
Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
Opt Lett 28:2061-3. 2003..A combination of positional optode calibration and contrast-to-noise ratio weighting was found to improve imaging performance... - An integrated approach to measuring tumor oxygen status using human melanoma xenografts as a modelChandrakala Menon
Department of Surgery, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA
Cancer Res 63:7232-40. 2003..An integrated approach that yields a comprehensive and consistent profile of oxygen status in tumors could potentially provide critical information for prognosis and treatment... - A quantitative comparison of simultaneous BOLD fMRI and NIRS recordings during functional brain activationGary Strangman
Harvard U, Cambridge
Neuroimage 17:719-31. 2002..This may reflect, at least in part, the superior contrast-to-noise ratio for oxyhemoglobin relative to deoxyhemoglobin (from optical measurements), rather than physiology related to BOLD signal interpretation...
Research Grants
- Continuous DOT Imaging of Hemodynamics During StrokeJoseph Culver; Fiscal Year: 2006..abstract_text> ..
- Full Head, High Density Functional Diffuse Optical TomographyJoseph Culver; Fiscal Year: 2007....
- HIGH-SENSITIVITY DOT FOR MAPPING HUMAN BRAIN FUNCTIONJoseph Culver; Fiscal Year: 2009..These steps will enable application of DOT to studies of brain function in young children; a question not readily addressed with current neuroimaging techniques. ..
- HIGH-SENSITIVITY DOT FOR MAPPING HUMAN BRAIN FUNCTIONJoseph P Culver; Fiscal Year: 2010..These steps will enable application of DOT to studies of brain function in young children;a question not readily addressed with current neuroimaging techniques. ..