Joseph Culver

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. doi request reprint Quantitative diffuse optical tomography for small animals using an ultrafast gated image intensifier
    Sachin V Patwardhan
    Washington University School of Medicine, Department of Radiology, Mallinckrodt Institute of Radiology, St Louis, Missouri 63110, USA
    J Biomed Opt 13:011009. 2008
  2. ncbi request reprint Evidence that cerebral blood volume can provide brain activation maps with better spatial resolution than deoxygenated hemoglobin
    Joseph P Culver
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, 4525 Scott Avenue, St Louis, MO 63110, USA
    Neuroimage 27:947-59. 2005
  3. ncbi request reprint Quantitative small animal fluorescence tomography using an ultrafast gated image intensifier
    Sachin V Patwardhan
    Dept of Radiol, Washington Univ Sch of Med, St Louis, MO 63110, USA
    Conf Proc IEEE Eng Med Biol Soc 1:2675-8. 2006
  4. ncbi request reprint Topics in Biomedical Optics: introduction to the feature issue
    Joseph P Culver
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8225, St Louis, Missouri 63110, USA
    Appl Opt 48:TBO1-2. 2009
  5. pmc Quantitative evaluation of high-density diffuse optical tomography: in vivo resolution and mapping performance
    Brian R White
    Washington University School of Medicine, Department of Radiology and Department of Physics, St Louis, Missouri 63110, USA
    J Biomed Opt 15:026006. 2010
  6. doi request reprint Mapping the human brain at rest with diffuse optical tomography
    Brian R White
    Department of Physics, Washington University, St Louis, MO, USA
    Conf Proc IEEE Eng Med Biol Soc 2009:4070-2. 2009
  7. pmc Phase-encoded retinotopy as an evaluation of diffuse optical neuroimaging
    Brian R White
    Department of Radiology, Washington University School of Medicine, 4525 Scott Ave, St Louis, MO 63110, USA
    Neuroimage 49:568-77. 2010
  8. doi request reprint In vivo fluorescence lifetime tomography
    Ralph E Nothdurft
    Washington University School of Medicine, Department of Radiology, Mallinckrodt Institute of Radiology, St Louis, Missouri 63110, USA
    J Biomed Opt 14:024004. 2009
  9. pmc Resting-state functional connectivity in the human brain revealed with diffuse optical tomography
    Brian R White
    Department of Radiology, Washington University, St Louis, MO 63110, USA
    Neuroimage 47:148-56. 2009
  10. pmc Neonatal hemodynamic response to visual cortex activity: high-density near-infrared spectroscopy study
    Steve M Liao
    Washington University School of Medicine, Department of Pediatrics and Department of Neurology and Department of Radiology, St Louis, Missouri 63110, USA
    J Biomed Opt 15:026010. 2010

Collaborators

Detail Information

Publications23

  1. doi request reprint Quantitative diffuse optical tomography for small animals using an ultrafast gated image intensifier
    Sachin V Patwardhan
    Washington University School of Medicine, Department of Radiology, Mallinckrodt Institute of Radiology, St Louis, Missouri 63110, USA
    J Biomed Opt 13:011009. 2008
    ..Experiments with tissue simulating phantoms demonstrate the feasibility of reconstructing the absorption and scattering optical properties in a small animal imaging system...
  2. ncbi request reprint Evidence that cerebral blood volume can provide brain activation maps with better spatial resolution than deoxygenated hemoglobin
    Joseph P Culver
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, 4525 Scott Avenue, St Louis, MO 63110, USA
    Neuroimage 27:947-59. 2005
    ..These results indicate that total hemoglobin and cerebral blood volume may have advantages as hemodynamic mapping contrasts, particularly for large amplitude, longer duration stimulus paradigms...
  3. ncbi request reprint Quantitative small animal fluorescence tomography using an ultrafast gated image intensifier
    Sachin V Patwardhan
    Dept of Radiol, Washington Univ Sch of Med, St Louis, MO 63110, USA
    Conf Proc IEEE Eng Med Biol Soc 1:2675-8. 2006
    ..Here we present a time-resolved, charged coupled device (CCD) based system for quantitative small animal fluorescence tomography...
  4. ncbi request reprint Topics in Biomedical Optics: introduction to the feature issue
    Joseph P Culver
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8225, St Louis, Missouri 63110, USA
    Appl Opt 48:TBO1-2. 2009
    ..This Applied Optics feature issue on Topics in Biomedical Optics highlights papers presented at the 2008 Biomedical Topical meeting sponsored by the Optical Society...
  5. pmc Quantitative evaluation of high-density diffuse optical tomography: in vivo resolution and mapping performance
    Brian R White
    Washington University School of Medicine, Department of Radiology and Department of Physics, St Louis, Missouri 63110, USA
    J Biomed Opt 15:026006. 2010
    ..In particular, we demonstrate that HD-DOT enables detailed phase-encoded retinotopic mapping, while sparse arrays are limited to imaging individual block-design visual stimuli...
  6. doi request reprint Mapping the human brain at rest with diffuse optical tomography
    Brian R White
    Department of Physics, Washington University, St Louis, MO, USA
    Conf Proc IEEE Eng Med Biol Soc 2009:4070-2. 2009
    ....
  7. pmc Phase-encoded retinotopy as an evaluation of diffuse optical neuroimaging
    Brian R White
    Department of Radiology, Washington University School of Medicine, 4525 Scott Ave, St Louis, MO 63110, USA
    Neuroimage 49:568-77. 2010
    ..With these advances in techniques and validation paradigms, optical neuroimaging can be extended into studies of higher-order brain function and of clinical utility with greater performance and confidence...
  8. doi request reprint In vivo fluorescence lifetime tomography
    Ralph E Nothdurft
    Washington University School of Medicine, Department of Radiology, Mallinckrodt Institute of Radiology, St Louis, Missouri 63110, USA
    J Biomed Opt 14:024004. 2009
    ..Use in a common research scenario is ultimately demonstrated by imaging accumulation of a targeted near-infrared (NIR) fluorescent-labeled peptide probe (cypate-RGD) in a mouse with a subcutaneous tumor...
  9. pmc Resting-state functional connectivity in the human brain revealed with diffuse optical tomography
    Brian R White
    Department of Radiology, Washington University, St Louis, MO 63110, USA
    Neuroimage 47:148-56. 2009
    ..In addition, the comprehensive hemoglobin contrasts of fc-DOT enable innovative studies of the biophysical origin of the functional connectivity signal...
  10. pmc Neonatal hemodynamic response to visual cortex activity: high-density near-infrared spectroscopy study
    Steve M Liao
    Washington University School of Medicine, Department of Pediatrics and Department of Neurology and Department of Radiology, St Louis, Missouri 63110, USA
    J Biomed Opt 15:026010. 2010
    ....
  11. doi request reprint Blind identification of evoked human brain activity with independent component analysis of optical data
    Joanne Markham
    Department of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Hum Brain Mapp 30:2382-92. 2009
    ..Our results suggest that ICA can extract the time courses and the corresponding spatial extent of functional responses in DOT imaging...
  12. pmc Retinotopic mapping of adult human visual cortex with high-density diffuse optical tomography
    Benjamin W Zeff
    Department of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 104:12169-74. 2007
    ..These results demonstrate that high-density DOT is a practical and powerful tool for mapping function in the human cortex...
  13. pmc Activatable molecular systems using homologous near-infrared fluorescent probes for monitoring enzyme activities in vitro, in cellulo, and in vivo
    Zongren Zhang
    Department of Radiology, Washington University School of Medicine, 4525 Scott Avenue, St Louis, Missouri 63110, USA
    Mol Pharm 6:416-27. 2009
    ..The NIR activatable molecular probes provide an effective strategy to screen new drugs in vitro and monitor treatment response in living organisms...
  14. ncbi request reprint Diffuse optical tomography of cerebral blood flow, oxygenation, and metabolism in rat during focal ischemia
    Joseph P Culver
    Department of Physics and Astronomy, Cerebrovascular Research Center, University of Pennsylvania, Philadelphia, Pennsylvania, U S A
    J Cereb Blood Flow Metab 23:911-24. 2003
    ....
  15. ncbi request reprint Reconstructing chromosphere concentration images directly by continuous-wave diffuse optical tomography
    Ang Li
    Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Opt Lett 29:256-8. 2004
    ..We demonstrate this improvement with simulations and a dynamic blood phantom experiment...
  16. pmc Hemodynamic evoked response of the sensorimotor cortex measured noninvasively with near-infrared optical imaging
    Maria Angela Franceschini
    NMR Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Psychophysiology 40:548-60. 2003
    ..Our findings based on optical imaging are in agreement with results in the literature obtained with positron emission tomography and functional magnetic resonance imaging...
  17. ncbi request reprint Temporal comparison of functional brain imaging with diffuse optical tomography and fMRI during rat forepaw stimulation
    Andrew M Siegel
    Tufts University Bioengineering Center, Medford, MA 02155, USA
    Phys Med Biol 48:1391-403. 2003
    ....
  18. ncbi request reprint Diffuse optical measurement of hemoglobin and cerebral blood flow in rat brain during hypercapnia, hypoxia and cardiac arrest
    Joseph P Culver
    Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, PA 19104, USA
    Adv Exp Med Biol 510:293-7. 2003
    ..The new instrument and concept may also be applicable to human studies especially in infants and neonates permitting noninvasive monitoring of cerebral hemodynamics and oxygen (see [4] and [2] for examples of NIR spectroscopy)...
  19. ncbi request reprint Optode positional calibration in diffuse optical tomography
    Jonathan J Stott
    Harvard Medical School Massachusetts Institute of Technology Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 13th Street, Building 149, Charlestown, Massachusetts 02129, USA
    Appl Opt 42:3154-62. 2003
    ..We present a technique for simultaneously calibrating optode positions and reconstructing images that significantly improves image quality, as we demonstrate with simulations and phantom experiments...
  20. ncbi request reprint Singular-value analysis and optimization of experimental parameters in fluorescence molecular tomography
    Edward E Graves
    Center for Molecular Imaging Research, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Room 5404, Charlestown, Massachusetts 02129, USA
    J Opt Soc Am A Opt Image Sci Vis 21:231-41. 2004
    ....
  21. ncbi request reprint Volumetric diffuse optical tomography of brain activity
    Joseph P Culver
    Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Opt Lett 28:2061-3. 2003
    ..A combination of positional optode calibration and contrast-to-noise ratio weighting was found to improve imaging performance...
  22. ncbi request reprint An integrated approach to measuring tumor oxygen status using human melanoma xenografts as a model
    Chandrakala Menon
    Department of Surgery, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Cancer Res 63:7232-40. 2003
    ..An integrated approach that yields a comprehensive and consistent profile of oxygen status in tumors could potentially provide critical information for prognosis and treatment...
  23. ncbi request reprint A quantitative comparison of simultaneous BOLD fMRI and NIRS recordings during functional brain activation
    Gary Strangman
    Neural Systems Group, NMR Center, Massachusetts General Hospital Harvard Medical School, Harvard MIT Division of Health Sciences and Technology, Charlestown 02129, USA
    Neuroimage 17:719-31. 2002
    ..This may reflect, at least in part, the superior contrast-to-noise ratio for oxyhemoglobin relative to deoxyhemoglobin (from optical measurements), rather than physiology related to BOLD signal interpretation...

Research Grants6

  1. Continuous DOT Imaging of Hemodynamics During Stroke
    Joseph Culver; Fiscal Year: 2006
    ..abstract_text> ..
  2. Full Head, High Density Functional Diffuse Optical Tomography
    Joseph Culver; Fiscal Year: 2007
    ....
  3. HIGH-SENSITIVITY DOT FOR MAPPING HUMAN BRAIN FUNCTION
    Joseph Culver; Fiscal Year: 2009
    ..These steps will enable application of DOT to studies of brain function in young children; a question not readily addressed with current neuroimaging techniques. ..
  4. HIGH-SENSITIVITY DOT FOR MAPPING HUMAN BRAIN FUNCTION
    Joseph P Culver; Fiscal Year: 2010
    ..These steps will enable application of DOT to studies of brain function in young children;a question not readily addressed with current neuroimaging techniques. ..