J Cui

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. pmc The NH2 terminus of RCK1 domain regulates Ca2+-dependent BK(Ca) channel gating
    Gayathri Krishnamoorthy
    Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106, USA
    J Gen Physiol 126:227-41. 2005
  2. pmc Effects of multiple metal binding sites on calcium and magnesium-dependent activation of BK channels
    Lei Hu
    Department of Biomedical Engineering and Cardiac Bioelectricity and Arrhythmia Center, Washington University, St Louis, MO 63130, USA
    J Gen Physiol 127:35-49. 2006
  3. pmc Activation of Slo1 BK channels by Mg2+ coordinated between the voltage sensor and RCK1 domains
    Huanghe Yang
    Department of Biomedical Engineering, and Cardiac Bioelectricity and Arrhythmia Center, Washington University, 1 Brookings Drive, St Louis, Missouri 63130, USA
    Nat Struct Mol Biol 15:1152-9. 2008
  4. pmc State-dependent electrostatic interactions of S4 arginines with E1 in S2 during Kv7.1 activation
    Dick Wu
    Department of Biomedical Engineering and Cardiac Bioelectricity and Arrhythmia Center, Washington University, St Louis, MO 63130, USA
    J Gen Physiol 135:595-606. 2010
  5. pmc Molecular mechanisms of BK channel activation
    J Cui
    Department of Biomedical Engineering and Cardiac Bioelectricity and Arrhythmia Center, Washington University, 1 Brookings Drive, St Louis, Missouri 63130, USA
    Cell Mol Life Sci 66:852-75. 2009
  6. pmc BK-type calcium-activated potassium channels: coupling of metal ions and voltage sensing
    Jianmin Cui
    Department of Biomedical Engineering and Cardiac Bioelectricity and Arrhythmia Center, Washington University, St Louis, MO 63130, USA
    J Physiol 588:4651-8. 2010
  7. pmc Intracellular Mg(2+) enhances the function of BK-type Ca(2+)-activated K(+) channels
    J Shi
    Cardiac Bioelectricity Research and Training Center, Case Western Reserve University, Cleveland, OH 44106-7207, USA
    J Gen Physiol 118:589-606. 2001
  8. ncbi request reprint Allosteric linkage between voltage and Ca(2+)-dependent activation of BK-type mslo1 K(+) channels
    J Cui
    Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Biochemistry 39:15612-9. 2000
  9. pmc Controlled permeation of cell membrane by single bubble acoustic cavitation
    Y Zhou
    Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan 48109 2099, USA
    J Control Release 157:103-11. 2012

Research Grants

  1. Ca2+dependent K+Channels: Allosteric Gating
    Jianmin Cui; Fiscal Year: 2004
  2. Ca2+dependent K+Channels: Allosteric Gating
    Jianmin Cui; Fiscal Year: 2002
  3. Ca2+ Dependent K+ Channels: Allosteric Gating
    Jianmin Cui; Fiscal Year: 2009
  4. Ca2+ Dependent K+ Channels: Allosteric Gating
    Jianmin Cui; Fiscal Year: 2007
  5. Ca2+dependent K+Channels: Allosteric Gating
    Jianmin Cui; Fiscal Year: 2005
  6. Ca2+dependent K+Channels: Allosteric Gating
    Jianmin Cui; Fiscal Year: 2004
  7. Ca2+dependent K+Channels: Allosteric Gating
    Jianmin Cui; Fiscal Year: 2003
  8. Ca2+ Dependent K+ Channels: Allosteric Gating
    Jianmin Cui; Fiscal Year: 2010
  9. SUBUNITS INTERACTION IN THE FUNCTION OF BK CHANNELS
    Jianmin Cui; Fiscal Year: 2010
  10. Ca2+ Dependent K+ Channels: Allosteric Gating
    Jianmin Cui; Fiscal Year: 2009

Collaborators

  • Y Zhou
  • Ali Nekouzadeh
  • Huanghe Yang
  • Jingyi Shi
  • Dick Wu
  • Kelli Delaloye
  • Lei Hu
  • Gayathri Krishnamoorthy
  • J Shi
  • Yoram Rudy
  • Mark A Zaydman
  • Guohui Zhang
  • Junqiu Yang
  • David Sept

Detail Information

Publications9

  1. pmc The NH2 terminus of RCK1 domain regulates Ca2+-dependent BK(Ca) channel gating
    Gayathri Krishnamoorthy
    Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106, USA
    J Gen Physiol 126:227-41. 2005
    ....
  2. pmc Effects of multiple metal binding sites on calcium and magnesium-dependent activation of BK channels
    Lei Hu
    Department of Biomedical Engineering and Cardiac Bioelectricity and Arrhythmia Center, Washington University, St Louis, MO 63130, USA
    J Gen Physiol 127:35-49. 2006
    ..We provide an allosteric model for quantitative estimation of the contributions that each of these putative binding sites makes to channel activation at any [Ca2+]i and [Mg2+]i...
  3. pmc Activation of Slo1 BK channels by Mg2+ coordinated between the voltage sensor and RCK1 domains
    Huanghe Yang
    Department of Biomedical Engineering, and Cardiac Bioelectricity and Arrhythmia Center, Washington University, 1 Brookings Drive, St Louis, Missouri 63130, USA
    Nat Struct Mol Biol 15:1152-9. 2008
    ..These results suggest that the VSD and the cytoplasmic domains from different subunits may interact during channel gating, and the packing of VSD or the RCK1 domain to the pore in BK channels differ from that in Kv1.2 or MthK channels...
  4. pmc State-dependent electrostatic interactions of S4 arginines with E1 in S2 during Kv7.1 activation
    Dick Wu
    Department of Biomedical Engineering and Cardiac Bioelectricity and Arrhythmia Center, Washington University, St Louis, MO 63130, USA
    J Gen Physiol 135:595-606. 2010
    ..These electrostatic interactions contribute energetically to voltage-dependent gating and are important in setting the limits for S4 movement...
  5. pmc Molecular mechanisms of BK channel activation
    J Cui
    Department of Biomedical Engineering and Cardiac Bioelectricity and Arrhythmia Center, Washington University, 1 Brookings Drive, St Louis, Missouri 63130, USA
    Cell Mol Life Sci 66:852-75. 2009
    ..This review summarizes the current understanding of these structural domains and their mutual interactions in voltage-, Ca(2+)- and Mg(2+)-dependent activation of the channel...
  6. pmc BK-type calcium-activated potassium channels: coupling of metal ions and voltage sensing
    Jianmin Cui
    Department of Biomedical Engineering and Cardiac Bioelectricity and Arrhythmia Center, Washington University, St Louis, MO 63130, USA
    J Physiol 588:4651-8. 2010
    ....
  7. pmc Intracellular Mg(2+) enhances the function of BK-type Ca(2+)-activated K(+) channels
    J Shi
    Cardiac Bioelectricity Research and Training Center, Case Western Reserve University, Cleveland, OH 44106-7207, USA
    J Gen Physiol 118:589-606. 2001
    ..Quantitative computation of these effects reveals that the overall effect of Mg(2+) under physiological conditions is to enhance BK channel function...
  8. ncbi request reprint Allosteric linkage between voltage and Ca(2+)-dependent activation of BK-type mslo1 K(+) channels
    J Cui
    Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Biochemistry 39:15612-9. 2000
    ..The mutations changed the channel's voltage dependence with little effect on its Ca(2+) affinitiy...
  9. pmc Controlled permeation of cell membrane by single bubble acoustic cavitation
    Y Zhou
    Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan 48109 2099, USA
    J Control Release 157:103-11. 2012
    ..182±0.052μm (n=112) for a pulse duration of 40μs (1.5MPa). These results from controlled cell membrane permeation by cavitation of single bubbles revealed insights and key factors affecting sonoporation at the single cell level...

Research Grants11

  1. Ca2+dependent K+Channels: Allosteric Gating
    Jianmin Cui; Fiscal Year: 2004
    ..They will also contribute to our understanding of ion channel gating in general. ..
  2. Ca2+dependent K+Channels: Allosteric Gating
    Jianmin Cui; Fiscal Year: 2002
    ..They will also contribute to our understanding of ion channel gating in general. ..
  3. Ca2+ Dependent K+ Channels: Allosteric Gating
    Jianmin Cui; Fiscal Year: 2009
    ....
  4. Ca2+ Dependent K+ Channels: Allosteric Gating
    Jianmin Cui; Fiscal Year: 2007
    ....
  5. Ca2+dependent K+Channels: Allosteric Gating
    Jianmin Cui; Fiscal Year: 2005
    ..They will also contribute to our understanding of ion channel gating in general. ..
  6. Ca2+dependent K+Channels: Allosteric Gating
    Jianmin Cui; Fiscal Year: 2004
    ..They will also contribute to our understanding of ion channel gating in general. ..
  7. Ca2+dependent K+Channels: Allosteric Gating
    Jianmin Cui; Fiscal Year: 2003
    ..They will also contribute to our understanding of ion channel gating in general. ..
  8. Ca2+ Dependent K+ Channels: Allosteric Gating
    Jianmin Cui; Fiscal Year: 2010
    ....
  9. SUBUNITS INTERACTION IN THE FUNCTION OF BK CHANNELS
    Jianmin Cui; Fiscal Year: 2010
    ..It will lay the foundation for understanding the molecular basis of BK channel related pathological conditions, such as epilepsy and hypertension, and provide the target and rationale for their treatment. ..
  10. Ca2+ Dependent K+ Channels: Allosteric Gating
    Jianmin Cui; Fiscal Year: 2009
    ....