J G Csernansky

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. ncbi request reprint Relapse and rehospitalisation rates in patients with schizophrenia: effects of second generation antipsychotics
    John G Csernansky
    Department of Psychiatry, Washington University School of Medicine and Metropolitan St Louis Psychiatric Center, St Louis, Missouri 63110, USA
    CNS Drugs 16:473-84. 2002
  2. ncbi request reprint A comparison of risperidone and haloperidol for the prevention of relapse in patients with schizophrenia
    John G Csernansky
    Washington University School of Medicine and Metropolitan St Louis Psychiatric Center, St Louis 63110 1081, USA
    N Engl J Med 346:16-22. 2002
  3. pmc Hippocampal morphometry in schizophrenia by high dimensional brain mapping
    J G Csernansky
    Department of Psychiatry, Washington University, St Louis, MO 63130, USA
    Proc Natl Acad Sci U S A 95:11406-11. 1998
  4. ncbi request reprint Kainic acid lesions enhance locomotor responses to novelty, saline, amphetamine, and MK-801
    M E Bardgett
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110 1093, USA
    Behav Brain Res 84:47-55. 1997
  5. ncbi request reprint Statistical analysis of hippocampal asymmetry in schizophrenia
    L Wang
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Neuroimage 14:531-45. 2001
  6. ncbi request reprint Preclinical detection of Alzheimer's disease: hippocampal shape and volume predict dementia onset in the elderly
    J G Csernansky
    Department of Psychiatry, Alzheimer s Disease Research Center, Washington University School of Medicine, St Louis, MO 63110, USA
    Neuroimage 25:783-92. 2005
  7. ncbi request reprint The effects of kainic acid lesions on locomotor responses to haloperidol and clozapine
    M E Bardgett
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110 1093, USA
    Psychopharmacology (Berl) 135:270-8. 1998
  8. ncbi request reprint Modulation of hippocampal cell proliferation, memory, and amyloid plaque deposition in APPsw (Tg2576) mutant mice by isolation stress
    H Dong
    Department of Psychiatry, Washington University School of Medicine, Campus Box 8134, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Neuroscience 127:601-9. 2004
  9. ncbi request reprint Predictive value of hippocampal MR imaging-based high-dimensional mapping in mesial temporal epilepsy: preliminary findings
    R E Hogan
    Department of Neurology, Saint Louis University, St Louis, MO, USA
    AJNR Am J Neuroradiol 27:2149-54. 2006
  10. pmc Corticosterone and related receptor expression are associated with increased beta-amyloid plaques in isolated Tg2576 mice
    H Dong
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Neuroscience 155:154-63. 2008

Collaborators

Detail Information

Publications71

  1. ncbi request reprint Relapse and rehospitalisation rates in patients with schizophrenia: effects of second generation antipsychotics
    John G Csernansky
    Department of Psychiatry, Washington University School of Medicine and Metropolitan St Louis Psychiatric Center, St Louis, Missouri 63110, USA
    CNS Drugs 16:473-84. 2002
    ..The societal costs of treating patients with schizophrenia can be lessened by employing strategies that decrease relapse and the need for rehospitalisation, the most costly treatment alternative...
  2. ncbi request reprint A comparison of risperidone and haloperidol for the prevention of relapse in patients with schizophrenia
    John G Csernansky
    Washington University School of Medicine and Metropolitan St Louis Psychiatric Center, St Louis 63110 1081, USA
    N Engl J Med 346:16-22. 2002
    ....
  3. pmc Hippocampal morphometry in schizophrenia by high dimensional brain mapping
    J G Csernansky
    Department of Psychiatry, Washington University, St Louis, MO 63130, USA
    Proc Natl Acad Sci U S A 95:11406-11. 1998
    ..These results also show that comparisons of neuroanatomical shapes can be more informative than volume comparisons for identifying individuals with neuropsychiatric diseases, such as schizophrenia...
  4. ncbi request reprint Kainic acid lesions enhance locomotor responses to novelty, saline, amphetamine, and MK-801
    M E Bardgett
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110 1093, USA
    Behav Brain Res 84:47-55. 1997
    ..The possibility that damage to the limbic system disrupts dopaminergic regulation of locomotor behavior is discussed, as well as implications for neuropathology in schizophrenia...
  5. ncbi request reprint Statistical analysis of hippocampal asymmetry in schizophrenia
    L Wang
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Neuroimage 14:531-45. 2001
    ....
  6. ncbi request reprint Preclinical detection of Alzheimer's disease: hippocampal shape and volume predict dementia onset in the elderly
    J G Csernansky
    Department of Psychiatry, Alzheimer s Disease Research Center, Washington University School of Medicine, St Louis, MO 63110, USA
    Neuroimage 25:783-92. 2005
    ..These results suggest that inward deformation of the left hippocampal surface in a zone corresponding to the CA1 subfield is an early predictor of the onset of DAT in nondemented elderly subjects...
  7. ncbi request reprint The effects of kainic acid lesions on locomotor responses to haloperidol and clozapine
    M E Bardgett
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110 1093, USA
    Psychopharmacology (Berl) 135:270-8. 1998
    ..These data indicate that the hyperactivity associated with limbic-cortical lesions may be insensitive to reversal by haloperidol, yet uniquely sensitive to suppression by clozapine...
  8. ncbi request reprint Modulation of hippocampal cell proliferation, memory, and amyloid plaque deposition in APPsw (Tg2576) mutant mice by isolation stress
    H Dong
    Department of Psychiatry, Washington University School of Medicine, Campus Box 8134, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Neuroscience 127:601-9. 2004
    ..These results suggest that stress may have an impact on the underlying disease process associated with Alzheimer's disease...
  9. ncbi request reprint Predictive value of hippocampal MR imaging-based high-dimensional mapping in mesial temporal epilepsy: preliminary findings
    R E Hogan
    Department of Neurology, Saint Louis University, St Louis, MO, USA
    AJNR Am J Neuroradiol 27:2149-54. 2006
    ....
  10. pmc Corticosterone and related receptor expression are associated with increased beta-amyloid plaques in isolated Tg2576 mice
    H Dong
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Neuroscience 155:154-63. 2008
    ..These results suggest that isolation stress increases corticosterone levels and GR and CRFR1 expression in conjunction with increases in brain tissue Abeta levels and Abeta plaque deposition in the Tg2576 mouse model of AD...
  11. ncbi request reprint Quantitative trait loci linked to thalamus and cortex gray matter volumes in BXD recombinant inbred mice
    H Dong
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Heredity (Edinb) 99:62-9. 2007
    ..71). These results suggest that there are separate and shared genetic influences on the development of the thalamus and cerebral cortex...
  12. ncbi request reprint Glucocorticoid interactions with memory function in schizophrenia
    J W Newcomer
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Psychoneuroendocrinology 23:65-72. 1998
    ....
  13. ncbi request reprint Methods for inducing neuronal loss in preweanling rats using intracerebroventricular infusion of kainic acid
    W M Humphrey
    Department of Psychiatry, Washington University School of Medicine, Washington University School of Medicine, 4940 Children's Place, 63110, St. Louis, MO, USA
    Brain Res Brain Res Protoc 7:1-10. 2001
    ..This developmental animal model of neuronal loss may be useful in studying neurodevelopmental disorders where the onset of symptoms or cognitive deficits is thought to follow an early developmental insult...
  14. ncbi request reprint Abnormalities of thalamic activation and cognition in schizophrenia
    Jessica Andrews
    Department of Anatomy and Neurobiology, Washington University, St Louis, MO 63130, USA
    Am J Psychiatry 163:463-9. 2006
    ....
  15. pmc Plasma cortisol and progression of dementia in subjects with Alzheimer-type dementia
    John G Csernansky
    Alzheimer s Disease Research Center and the Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Psychiatry 163:2164-9. 2006
    ....
  16. ncbi request reprint Levels-of-processing effects in first-degree relatives of individuals with schizophrenia
    Aaron Bonner-Jackson
    Washington University, Department of Psychology, St Louis, Missouri 63130, USA
    Biol Psychiatry 61:1141-7. 2007
    ..The current study used a similar paradigm to determine whether siblings of individuals with schizophrenia (SIBs) also show increases in brain activity when presented with beneficial encoding strategies...
  17. pmc Spatial relationship between synapse loss and beta-amyloid deposition in Tg2576 mice
    Hongxin Dong
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Comp Neurol 500:311-21. 2007
    ..These results provide the first quantitative morphological evidence at the ultrastructure level of a spatial relationship between beta-amyloid plaques and synapse loss within the hippocampus and the entorhinal cortex of Tg2576 mice...
  18. ncbi request reprint Inter-rater reliability of manual segmentation of the superior, inferior and middle frontal gyri
    John P John
    Department of Psychiatry, National Institute of Mental Health and Neurosciences NIMHANS, Hosur Road, Bangalore 560 029, Karnataka, India
    Psychiatry Res 148:151-63. 2006
    ..97, 0.94 and 0.93, respectively. Thus, we describe a reliable method of parcellating the SFG, IFG and MFG, which constitute the DLPFC, a brain region involved in a variety of neuropsychiatric conditions...
  19. ncbi request reprint Independent quantitative trait loci influence ventral and dorsal hippocampal volume in recombinant inbred strains of mice
    Maureen V Martin
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Genes Brain Behav 5:614-23. 2006
    ..These findings suggest that the development of the ventral and dorsal components of the hippocampus is influenced by separate genetic loci...
  20. pmc Structural analysis of the basal ganglia in schizophrenia
    Daniel Mamah
    Department of Psychiatry, Washington University Medical School, St Louis, MO 63110, USA
    Schizophr Res 89:59-71. 2007
    ..In conclusion, basal ganglia volumes relative to total brain volume were larger in schizophrenia subjects than healthy comparison subjects. Specific patterns of shape change accompanied these volume differences...
  21. ncbi request reprint Neural correlates of verbal and nonverbal working memory deficits in individuals with schizophrenia and their high-risk siblings
    Shefali B Brahmbhatt
    Washington University, Department of Psychology, One Brookings Drive, Box 1125, St Louis, MO 63130, USA
    Schizophr Res 87:191-204. 2006
    ....
  22. pmc Factors mediating cognitive deficits and psychopathology among siblings of individuals with schizophrenia
    Zainab Delawalla
    Department of Psychology, Washington University, USA
    Schizophr Bull 32:525-37. 2006
    ..Results suggest that there is a complex relationship between cognitive and clinical factors in this high-risk population...
  23. ncbi request reprint Neuroanatomical predictors of response to donepezil therapy in patients with dementia
    John G Csernansky
    Alzheimer s Disease Research Center, and Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Arch Neurol 62:1718-22. 2005
    ..Patients with dementia of the Alzheimer type (DAT) respond variably to treatment with acetylcholinesterase inhibitors...
  24. ncbi request reprint Neuroprotective effects of olanzapine in a rat model of neurodevelopmental injury
    John G Csernansky
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Pharmacol Biochem Behav 83:208-13. 2006
    ..These results suggest that olanzapine has neuroprotective effects in a rat model of neurodevelopmental insult, and may be relevant to the observed effects of atypical antipsychotic drugs on brain structure in patients with schizophrenia...
  25. ncbi request reprint Neurodegeneration in schizophrenia: evidence from in vivo neuroimaging studies
    John G Csernansky
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    ScientificWorldJournal 7:135-43. 2007
    ..The cellular mechanisms responsible for such gray matter losses are unknown, but have been hypothesized to involve abnormal increases in apoptosis...
  26. pmc Large deformation diffeomorphism and momentum based hippocampal shape discrimination in dementia of the Alzheimer type
    Lei Wang
    Department of Psychiatry, Washington University School of Medicine, Campus Box 8134, 660 S Euclid Ave, St Louis, MO 63110, USA
    IEEE Trans Med Imaging 26:462-70. 2007
    ..Further, PCA of the initial momentum leads to correct classification of 12 out of 18 DAT subjects and 22 out of 26 control subjects...
  27. doi request reprint Neural networks in schizophrenia
    John G Csernansky
    Am J Psychiatry 165:937-9. 2008
  28. pmc Subclinical expression of schizophrenia-like symptoms in non-psychotic siblings of individuals with schizophrenia
    Matthew J Smith
    Schizophr Res 103:324-5. 2008
  29. pmc Comparing surface-based and volume-based analyses of functional neuroimaging data in patients with schizophrenia
    Alan Anticevic
    Department of Psychology, Washington University in St Louis, MO 63130, USA
    Neuroimage 41:835-48. 2008
    ..These results indicate that SBR provides significant advantages over affine VBR when analyzing cortical fMRI activations. Furthermore, these improvements can be even greater in disorders that have associated structural abnormalities...
  30. pmc Basal ganglia shape abnormalities in the unaffected siblings of schizophrenia patients
    Daniel Mamah
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Biol Psychiatry 64:111-20. 2008
    ..Our aim was to test the hypothesis that abnormalities of basal ganglia structure are intrinsic features of schizophrenia by assessing basal ganglia volume and shape in the unaffected siblings of schizophrenia subjects...
  31. pmc Parallel transport in diffeomorphisms distinguishes the time-dependent pattern of hippocampal surface deformation due to healthy aging and the dementia of the Alzheimer's type
    Anqi Qiu
    Division of Bioengineering, National University of Singapore, 7 Engineering Drive 1, Singapore, Singapore
    Neuroimage 40:68-76. 2008
    ..77 and 0.87, which were obtained in the same training set using the leave-one-out cross validation approach...
  32. ncbi request reprint Thalamic shape abnormalities in individuals with schizophrenia and their nonpsychotic siblings
    Michael P Harms
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 27:13835-42. 2007
    ..Inward deformation of the anterior and posterior regions of the thalamus represents a potential neuroanatomical endophenotype of schizophrenia...
  33. ncbi request reprint A proposal for MRI-based parcellation of the frontal pole
    John P John
    Department of Psychiatry, National Institute of Mental Health and Neurosciences, P B No 2900, Dharmaram P O, Hosur Road, Bangalore, Karnataka, 560029, India
    Brain Struct Funct 212:245-53. 2007
    ..Therefore, in the absence of a naturally occurring sulcal boundary, the proposed method for parcellation of the FP can provide unbiased volume estimations for studies of healthy and disordered populations of subjects...
  34. pmc Anti-dementia drugs and hippocampal-dependent memory in rodents
    Carla M Yuede
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Behav Pharmacol 18:347-63. 2007
    ..Suggestions for future research are offered...
  35. ncbi request reprint Open Access Series of Imaging Studies (OASIS): cross-sectional MRI data in young, middle aged, nondemented, and demented older adults
    Daniel S Marcus
    Washington University, MO 63110, USA
    J Cogn Neurosci 19:1498-507. 2007
    ..Automated calculation of whole-brain volume and estimated total intracranial volume are presented to demonstrate use of the data for measuring differences associated with normal aging and Alzheimer's disease...
  36. pmc Prefrontal cortex function in nonpsychotic siblings of individuals with schizophrenia
    Zainab Delawalla
    Department of Psychology, Washington University, St Louis, Missouri 63130, USA
    Biol Psychiatry 63:490-7. 2008
    ..In individuals with schizophrenia, deficits in context processing have been associated with functional impairments of the dorsolateral prefrontal cortex (DLPFC)...
  37. ncbi request reprint Abnormal parietal cortex activation during working memory in schizophrenia: verbal phonological coding disturbances versus domain-general executive dysfunction
    Deanna M Barch
    Department of Psychology, Washington University, St Louis, MO 63130, USA
    Am J Psychiatry 164:1090-8. 2007
    ..e., ventral prefrontal and parietal cortices) or 2) domain-general executive processes engaged by verbal and nonverbal tasks (i.e., dorsal prefrontal and parietal cortices)...
  38. pmc Acute stress increases interstitial fluid amyloid-beta via corticotropin-releasing factor and neuronal activity
    Jae Eun Kang
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 104:10673-8. 2007
    ..Thus, behavioral stressors can rapidly increase ISF Abeta through neuronal activity in a CRF-dependent manner, and the results suggest a mechanism by which behavioral stress may affect Alzheimer's disease pathogenesis...
  39. pmc Abnormalities of cingulate gyrus neuroanatomy in schizophrenia
    Lei Wang
    Department of Psychiatry, Washington University School of Medicine, Box 8134, 660 S Euclid Ave, St Louis, MO 63110, United States
    Schizophr Res 93:66-78. 2007
    ....
  40. pmc Abnormalities of hippocampal surface structure in very mild dementia of the Alzheimer type
    Lei Wang
    Alzheimer s Disease Research Center and The Department of Psychiatry Box 8134, Washington University School of Medicine, 660 S Euclid, St Louis, MO 63110, USA
    Neuroimage 30:52-60. 2006
    ..Neurology 55, 1636--1643.] and suggest that inward deformities of the hippocampal surface in proximity to the CA1 subfield and subiculum can be used to distinguish subjects with very mild DAT from nondemented subjects...
  41. ncbi request reprint Low dose quetiapine reverses deficits in contextual and cued fear conditioning in rats with excitotoxin-induced hippocampal neuropathy
    Maureen V Martin
    Department of Psychiatry Box 8134, Washington University School of Medicine, 660 S Euclid, St Louis, MO 63110, United States
    Pharmacol Biochem Behav 82:263-9. 2005
    ..These results may be relevant to the effects of quetiapine and other antipsychotic drugs on memory deficits in patients with schizophrenia...
  42. ncbi request reprint Easier tasks can have better discriminating power: the case of verbal fluency
    Meredith R D Melinder
    Department of Psychology, Washington University, St Louis, MO 63130, USA
    J Abnorm Psychol 114:385-91. 2005
    ..In this article, the authors present data from 2 studies using phonologic and category fluency tasks to demonstrate that the critical factor for task selection and matching is discriminating power, not task difficulty...
  43. ncbi request reprint Intracerebroventricular kainic acid administration to neonatal rats alters interneuron development in the hippocampus
    Hongxin Dong
    Department of Psychiatry, Washington University School of Medicine, Campus Box 8134, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Brain Res Dev Brain Res 145:81-92. 2003
    ..The functional impact of these changes may be relevant to the pathogenesis of neuropsychiatric disorders, such as schizophrenia...
  44. ncbi request reprint Computer-assisted imaging to assess brain structure in healthy and diseased brains
    John Ashburner
    The Wellcome Department of Imaging Neuroscience, Institute of Neurology, London, UK
    Lancet Neurol 2:79-88. 2003
    ....
  45. ncbi request reprint Treatment of schizophrenia: preventing the progression of disease
    John G Csernansky
    Department of Psychiatry, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Psychiatr Clin North Am 26:367-79. 2003
    ..Despite increased pill costs for atypical antipsychotic drugs, the overall costs of providing care to patients with schizophrenia using these drugs do not appear to be substantially higher...
  46. ncbi request reprint NMDA receptor blockade and hippocampal neuronal loss impair fear conditioning and position habit reversal in C57Bl/6 mice
    Mark E Bardgett
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110 1093, USA
    Brain Res Bull 60:131-42. 2003
    ..Furthermore, they serve as a basis for a non-transgenic mouse model of the NMDA receptor or hippocampal dysfunction hypothesized to occur in human cognitive disorders...
  47. ncbi request reprint Hippocampal neurogenesis follows kainic acid-induced apoptosis in neonatal rats
    Hongxin Dong
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 23:1742-9. 2003
    ..KA administration resulted in both neuronal apoptosis and neurogenesis within the CA3 subfield, suggesting that the purpose of neurogenesis in the CA3 is to replace neurons lost to apoptosis...
  48. ncbi request reprint Working memory and prefrontal cortex dysfunction: specificity to schizophrenia compared with major depression
    Deanna M Barch
    Department of Psychology, Washington University, St Louis, Missouri, USA
    Biol Psychiatry 53:376-84. 2003
    ..It is not clear whether people with major depression also demonstrate impaired prefrontal activation during performance of working memory tasks...
  49. ncbi request reprint High-dimensional mapping of the hippocampus in depression
    Joel A Posener
    Department of Psychiatry, Washington University School of Medicine, Campus Box 8134, 660 South Euclid Ave, St Louis, MO 63110, USA
    Am J Psychiatry 160:83-9. 2003
    ..In this study, high-dimensional brain mapping was used to evaluate hippocampal shape and volume in patients with major depressive disorder and healthy comparison subjects...
  50. ncbi request reprint The effects of excitotoxic hippocampal lesions in rats on risperidone- and olanzapine-induced locomotor suppression
    Mark E Bardgett
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA
    Neuropsychopharmacology 27:930-8. 2002
    ....
  51. ncbi request reprint Hippocampal deformities in schizophrenia characterized by high dimensional brain mapping
    John G Csernansky
    Department of Psychiatry Box 8134, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Am J Psychiatry 159:2000-6. 2002
    ..High dimensional brain mapping, which utilizes probabilistic deformations of a neuroanatomical template, was used to characterize disease-related patterns of changes in hippocampal volume, shape, and asymmetry...
  52. ncbi request reprint Relationships among cerebrospinal fluid biomarkers in dementia of the Alzheimer type
    John G Csernansky
    Alzheimer Disease Research Center, St Louis, Missouri, USA
    Alzheimer Dis Assoc Disord 16:144-9. 2002
    ..Increased CSF concentrations of tau significantly discriminated DAT and control subjects, as did the ratios of tau to Abeta and tau to Abeta(1-42)...
  53. ncbi request reprint Working and long-term memory deficits in schizophrenia: is there a common prefrontal mechanism?
    Deanna M Barch
    Department of Psychology, Washington University, St Louis, Missouri 63130, USA
    J Abnorm Psychol 111:478-94. 2002
    ..Some evidence was found for more severe cognitive and functional deficits with verbal than nonverbal stimuli, although these results were mixed...
  54. ncbi request reprint Immediate and delayed hippocampal neuronal loss induced by kainic acid during early postnatal development in the rat
    William M Humphrey
    Department of Psychiatry, Washington University School of Medicine, Campus Box 8134, 660 South Euclid Ave, St Louis, MO 63110, USA
    Brain Res Dev Brain Res 137:1-12. 2002
    ..These findings may be relevant to the pathogenesis of some neuropsychiatric disorders, where early CNS injury is not apparent until the onset of clinical symptoms in young adulthood...
  55. ncbi request reprint Abnormalities of thalamic volume and shape detected in fetally irradiated rhesus monkeys with high dimensional brain mapping
    Matthew K Schindler
    Department of Psychiatry, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Biol Psychiatry 51:827-37. 2002
    ..Irradiated monkeys sacrificed as infants demonstrate neuronal losses in specific thalamic nuclei and decreases in cortical neuropil...
  56. ncbi request reprint Changes in hippocampal volume and shape across time distinguish dementia of the Alzheimer type from healthy aging
    Lei Wang
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Neuroimage 20:667-82. 2003
    ..These results suggest that different patterns of hippocampal shape change in time as well as different rates of hippocampal volume loss distinguish very mild DAT from healthy aging...
  57. ncbi request reprint Hemodynamic responses in visual, motor, and somatosensory cortices in schizophrenia
    Deanna M Barch
    Department of Psychology, Washington University, St Louis, MO 63130, USA
    Neuroimage 20:1884-93. 2003
    ..These results begin to validate the interpretation of functional neuroimaging studies of schizophrenia in terms of neuronal as opposed to vascular mechanisms...
  58. pmc The influence of encoding strategy on episodic memory and cortical activity in schizophrenia
    Aaron Bonner-Jackson
    Department of Psychology, Washington University, St Louis, Missouri 63130, USA
    Biol Psychiatry 58:47-55. 2005
    ..We tested the hypothesis that providing effective encoding strategies to schizophrenia patients enhances encoding-related brain activity and recognition performance...
  59. pmc Cholinesterase inhibitors ameliorate behavioral deficits induced by MK-801 in mice
    John G Csernansky
    Department of Psychiatry, Washington University School of Medicine, 660 S Euclid, St Louis, MO 63110, USA
    Neuropsychopharmacology 30:2135-43. 2005
    ....
  60. pmc Acetylcholinesterase inhibitors ameliorate behavioral deficits in the Tg2576 mouse model of Alzheimer's disease
    Hongxin Dong
    Department of Psychiatry, Washington University School of Medicine, Campus Box 8134, 660 South Euclid Ave, St Louis, MO 63110, USA
    Psychopharmacology (Berl) 181:145-52. 2005
    ..Transgenic mice that overexpress the human form of amyloid precursor protein and develop deposits of beta-amyloid (Abeta) and behavioral deficits during adulthood are useful for investigating this question...
  61. ncbi request reprint Direct and indirect effects of fetal irradiation on cortical gray and white matter volume in the macaque
    Lynn D Selemon
    Department of Neurobiology, Yale University School of Medicine, PO Box 208001, New Haven, CT 06520 8001, USA
    Biol Psychiatry 57:83-90. 2005
    ..Exposure of nonhuman primates to x-irradiation in early gestation has previously been shown to decrease thalamic volume and neuronal number. Here we examine whether early gestational irradiation also results in cortical volume reduction...
  62. ncbi request reprint Correlations between antemortem hippocampal volume and postmortem neuropathology in AD subjects
    John G Csernansky
    Alzheimer Disease Research Center, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Alzheimer Dis Assoc Disord 18:190-5. 2004
    ..The data suggest that hippocampal volume assessed in living subjects with probable AD is both a good marker of dementia severity and of an underlying element of the AD disease process...
  63. ncbi request reprint Computational anatomy and neuropsychiatric disease: probabilistic assessment of variation and statistical inference of group difference, hemispheric asymmetry, and time-dependent change
    John G Csernansky
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Neuroimage 23:S56-68. 2004
    ..g., asymmetry), and changes of shapes over time. Promising preliminary studies employing these approaches to studies of subjects with schizophrenia and very mild to mild Alzheimer's disease (AD) are presented...
  64. ncbi request reprint Feature selection for shape-based classification of biological objects
    Paul Yushkevich
    Medical Image Display and Analysis Group, University of North Carolina, Chapel Hill, NC, USA
    Inf Process Med Imaging 18:114-25. 2003
    ..Results on clinical data indicate that features describing the head of the right hippocampus are most relevant for discrimination...
  65. ncbi request reprint Abnormalities of thalamic volume and shape in schizophrenia
    John G Csernansky
    Department of Psychiatry Box 8134, Washington University School of Medicine, 660 S Euclid Ave, St Louis, MO 63110, USA
    Am J Psychiatry 161:896-902. 2004
    ..However, the pattern of shape change associated with such volume loss has not been investigated. In this study, alterations in thalamic volume, shape, and symmetry were compared in subjects with and without schizophrenia...
  66. ncbi request reprint Correlates of cognitive deficits in first episode schizophrenia
    Gitry Heydebrand
    Washington University School of Medicine, St Louis, MO, USA
    Schizophr Res 68:1-9. 2004
    ..If present, such relationships should be most clearly observable in patients with first episode schizophrenia; that is, before the effects of chronic illness, institutionalization, or treatment might confound them...
  67. ncbi request reprint Hippocampal deformities in the unaffected siblings of schizophrenia subjects
    Ralf Tepest
    Department of Psychiatry RT, University of Bonn Medical Center, Bonn, Germany
    Biol Psychiatry 54:1234-40. 2003
    ..The objective of this study was to further elucidate hippocampal deformities as a marker of genetic vulnerability for schizophrenia...
  68. ncbi request reprint Validation of semiautomated methods for quantifying cingulate cortical metrics in schizophrenia
    J Tilak Ratnanather
    Center for Imaging Science, The Johns Hopkins University, Clark 301, 3400 North Charles St, Baltimore, MD 21218, USA
    Psychiatry Res 132:53-68. 2004
    ..82. In addition, by repeating the entire procedure three times in one subject, we obtained a coefficient of variation of 0.0438 for surface area...
  69. ncbi request reprint MRI-based high-dimensional hippocampal mapping in mesial temporal lobe epilepsy
    R Edward Hogan
    Department of Neurology, Saint Louis University, 1221 S Grand, 1st Floor, Epilepsy Offices, St Louis, MO 63104, USA
    Brain 127:1731-40. 2004
    ..Contralateral hippocampi show different HDM-LD changes, suggesting that the underlying disease process in the contralateral hippocampi is different from MTS...
  70. ncbi request reprint Platelet serotonin content correlates inversely with life history of aggression in personality-disordered subjects
    Joseph S Goveas
    Clinical Neuroscience and Psychopharmacology Research Unit, Department of Psychiatry, MC 3077, Pritzker School of Medicine, University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60615, USA
    Psychiatry Res 126:23-32. 2004
    ..Similar to other studies of platelet 5-HT markers, these data suggest that platelet 5-HT content may also reflect central 5-HT alterations and may be used as a biological marker in appropriate patient samples...
  71. ncbi request reprint Kainic acid lesions disrupt fear-mediated memory processing
    Henry Yin
    Department of Psychology, Northern Kentucky University, BEP 359, Nunn Drive, Highland Heights, KY 41099, USA
    Neurobiol Learn Mem 77:389-401. 2002
    ..These data suggest that decreases in fear conditioning produced by hippocampal lesions reflect a memory deficit and not a lack of fear...