P E Cryer

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. ncbi request reprint Glycemic goals in diabetes: trade-off between glycemic control and iatrogenic hypoglycemia
    Philip E Cryer
    Washington University School of Medicine, St Louis, MO
    Diabetes 63:2188-95. 2014
  2. pmc Beta-cell-mediated signaling predominates over direct alpha-cell signaling in the regulation of glucagon secretion in humans
    Benjamin A Cooperberg
    Division of Endocrinology, Metabolism and Lipid Research, Washington University School of Medicine, St Louis, Missouri, USA
    Diabetes Care 32:2275-80. 2009
  3. pmc Glucagon supports postabsorptive plasma glucose concentrations in humans with biologically optimal insulin levels
    Benjamin A Cooperberg
    Division of Endocrinology, Metabolism and Lipid Research, Washington University School of Medicine, St Louis, Missouri, USA
    Diabetes 59:2941-4. 2010
  4. pmc Insulin reciprocally regulates glucagon secretion in humans
    Benjamin A Cooperberg
    Division of Endocrinology, Metabolism and Lipid Research, Washington University School of Medicine, St Louis, Missouri, USA
    Diabetes 59:2936-40. 2010
  5. pmc Adrenergic mediation of hypoglycemia-associated autonomic failure
    Ranjani Ramanathan
    Division of Endocrinology, Metabolism and Lipid Research, Washington University School of Medicine, St Louis, Missouri, USA
    Diabetes 60:602-6. 2011
  6. pmc Partial inhibition of insulin secretion results in glucose intolerance but not hyperglucagonemia
    Ranjani P Ramanathan
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    Diabetes 60:1324-8. 2011
  7. doi request reprint Hypoglycemia-associated autonomic failure in diabetes
    Philip E Cryer
    Department of Medicine, Washington University in St Louis and Barnes Jewish Hospital, St Louis, Missouri, USA Electronic address
    Handb Clin Neurol 117:295-307. 2013
  8. pmc Minireview: Glucagon in the pathogenesis of hypoglycemia and hyperglycemia in diabetes
    Philip E Cryer
    Division of Endocrinology, Metabolism, and Lipid Research, Washington University, St Louis, Missouri 63110, USA
    Endocrinology 153:1039-48. 2012
  9. ncbi request reprint Hypoglycemia in diabetes: pathophysiological mechanisms and diurnal variation
    Philip E Cryer
    Division of Endocrinology, Metabolism and Lipid Research, and the General Clinical Research Center and the Diabetes Research and Training Center, Washington University School of Medicine, St Louis, MO, USA
    Prog Brain Res 153:361-5. 2006
  10. doi request reprint Glucagon and hyperglycaemia in diabetes
    Philip E Cryer
    Division of Endocrinology, Metabolism and Lipid Research, Washington University School of Medicine, St Louis, 660 South Euclid Ave, MO 63110, USA
    Clin Sci (Lond) 114:589-90. 2008

Research Grants

Collaborators

Detail Information

Publications58

  1. ncbi request reprint Glycemic goals in diabetes: trade-off between glycemic control and iatrogenic hypoglycemia
    Philip E Cryer
    Washington University School of Medicine, St Louis, MO
    Diabetes 63:2188-95. 2014
    ....
  2. pmc Beta-cell-mediated signaling predominates over direct alpha-cell signaling in the regulation of glucagon secretion in humans
    Benjamin A Cooperberg
    Division of Endocrinology, Metabolism and Lipid Research, Washington University School of Medicine, St Louis, Missouri, USA
    Diabetes Care 32:2275-80. 2009
    ..Given evidence of both indirect and direct signaling, we tested the hypothesis that increased beta-cell-mediated signaling of alpha-cells negates direct alpha-cell signaling in the regulation of glucagon secretion in humans...
  3. pmc Glucagon supports postabsorptive plasma glucose concentrations in humans with biologically optimal insulin levels
    Benjamin A Cooperberg
    Division of Endocrinology, Metabolism and Lipid Research, Washington University School of Medicine, St Louis, Missouri, USA
    Diabetes 59:2941-4. 2010
    ....
  4. pmc Insulin reciprocally regulates glucagon secretion in humans
    Benjamin A Cooperberg
    Division of Endocrinology, Metabolism and Lipid Research, Washington University School of Medicine, St Louis, Missouri, USA
    Diabetes 59:2936-40. 2010
    ..We tested the hypothesis that an increase in insulin per se, i.e., in the absence of zinc, suppresses glucagon secretion during euglycemia and that a decrease in insulin per se stimulates glucagon secretion during hypoglycemia in humans...
  5. pmc Adrenergic mediation of hypoglycemia-associated autonomic failure
    Ranjani Ramanathan
    Division of Endocrinology, Metabolism and Lipid Research, Washington University School of Medicine, St Louis, Missouri, USA
    Diabetes 60:602-6. 2011
    ....
  6. pmc Partial inhibition of insulin secretion results in glucose intolerance but not hyperglucagonemia
    Ranjani P Ramanathan
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    Diabetes 60:1324-8. 2011
    ....
  7. doi request reprint Hypoglycemia-associated autonomic failure in diabetes
    Philip E Cryer
    Department of Medicine, Washington University in St Louis and Barnes Jewish Hospital, St Louis, Missouri, USA Electronic address
    Handb Clin Neurol 117:295-307. 2013
    ....
  8. pmc Minireview: Glucagon in the pathogenesis of hypoglycemia and hyperglycemia in diabetes
    Philip E Cryer
    Division of Endocrinology, Metabolism, and Lipid Research, Washington University, St Louis, Missouri 63110, USA
    Endocrinology 153:1039-48. 2012
    ..If so, abnormal glucagon secretion is involved in the pathogenesis of both hypoglycemia and hyperglycemia in diabetes...
  9. ncbi request reprint Hypoglycemia in diabetes: pathophysiological mechanisms and diurnal variation
    Philip E Cryer
    Division of Endocrinology, Metabolism and Lipid Research, and the General Clinical Research Center and the Diabetes Research and Training Center, Washington University School of Medicine, St Louis, MO, USA
    Prog Brain Res 153:361-5. 2006
    ..Finally, a unifying mechanism of HAAF would need to incorporate the effects of sleep and antecedent exercise which produce a phenomenon similar to hypoglycemia induced HAAF...
  10. doi request reprint Glucagon and hyperglycaemia in diabetes
    Philip E Cryer
    Division of Endocrinology, Metabolism and Lipid Research, Washington University School of Medicine, St Louis, 660 South Euclid Ave, MO 63110, USA
    Clin Sci (Lond) 114:589-90. 2008
    ..Nonetheless, compelling evidence that glucagon contributes to the pathogenesis of hyperglycaemia in diabetes awaits long-term selective reduction of glucagon secretion or action in humans...
  11. pmc Hypoglycemia, functional brain failure, and brain death
    Philip E Cryer
    Division of Endocrinology, Metabolism and Lipid Research, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 117:868-70. 2007
    ..This finding suggests that, at least in the setting of profound hypoglycemia, therapeutic hyperglycemia should be avoided...
  12. ncbi request reprint Severe iatrogenic hypoglycemia in type 2 diabetes mellitus
    Philip E Cryer
    Washington University School of Medicine, St Louis, MO 63109, USA
    Nat Clin Pract Endocrinol Metab 3:4-5. 2007
  13. ncbi request reprint Mechanisms of hypoglycemia-associated autonomic failure and its component syndromes in diabetes
    Philip E Cryer
    Division of Endocrinology, Metabolism and Lipid Research and General Clinical Research Center, Campus Box 8127, Washington University School of Medicine, 660 South Euclid Ave, St Louis, Missouri 63110, USA
    Diabetes 54:3592-601. 2005
    ..Pending the prevention and cure of diabetes, critical fundamental, translational, and outcomes research is needed if we are to eliminate hypoglycemia from the lives of people affected by diabetes...
  14. ncbi request reprint Hypoglycaemia: the limiting factor in the glycaemic management of the critically ill?
    P E Cryer
    Division of Endocrinology, Metabolism and Lipid Research Campus Box 8127, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Diabetologia 49:1722-5. 2006
  15. pmc Hypoglycemia in type 1 diabetes mellitus
    Philip E Cryer
    Department of Medicine, Washington University School of Medicine, Campus Box 8127, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Endocrinol Metab Clin North Am 39:641-54. 2010
    ..Elimination of hypoglycemia from the lives of people with T1DM will likely be accomplished by new treatment methods that provide plasma glucose-regulated insulin replacement or secretion...
  16. pmc Mechanisms of sympathoadrenal failure and hypoglycemia in diabetes
    Philip E Cryer
    Division of Endocrinology, Metabolism and Lipid Research, General Clinical Research Center, and Diabetes Research and Training Center, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 116:1470-3. 2006
    ..Thus, hypothalamic urocortin I release during antecedent hypoglycemia is, among other possibilities, a potential mechanism of HAAF...
  17. ncbi request reprint Diverse causes of hypoglycemia-associated autonomic failure in diabetes
    Philip E Cryer
    Division of Endocrinology, Metabolism, and Lipid Research, the General Clinical Research Center, Washington University School of Medicine, St Louis, MO 63110, USA
    N Engl J Med 350:2272-9. 2004
  18. ncbi request reprint Forearm norepinephrine spillover during standing, hyperinsulinemia, and hypoglycemia
    D S Paramore
    Division of Endocrinology, Diabetes, and Metabolism, General Clinical Research Center and the Diabetes Research and Training Center, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Physiol 275:E872-81. 1998
    ..Thus these data do not provide direct support for the concept that hypoglycemia per se also stimulates sympathetic neural activity...
  19. ncbi request reprint Blood-to-brain glucose transport, cerebral glucose metabolism, and cerebral blood flow are not increased after hypoglycemia
    S A Segel
    Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, USA
    Diabetes 50:1911-7. 2001
    ..They do not exclude regional increments in blood-to-brain glucose transport. Alternatively, the fundamental alteration might lie beyond the blood-brain barrier...
  20. pmc Direct muscarinic cholinergic inhibition of hepatic glucose production in humans
    P J Boyle
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110
    J Clin Invest 82:445-9. 1988
    ..Thus, particularly if regional neuronal firing occurs, the parasympathetic nervous system may play an important role in human glucoregulatory physiology...
  21. ncbi request reprint Hypoglycaemia: the limiting factor in the glycaemic management of Type I and Type II diabetes
    P E Cryer
    Division of Endocrinology, Diabetes and Metabolism, Washington University School of Medicine, St Louis, MO 63110, USA
    Diabetologia 45:937-48. 2002
    ....
  22. ncbi request reprint The pathophysiology of hypoglycaemia in diabetes
    P E Cryer
    Division of Endocrinology, Diabetes and Metabolism, and General Clinical Research Center, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Diabetes Nutr Metab 15:330-3; discussion 362. 2002
  23. ncbi request reprint Hierarchy of physiological responses to hypoglycemia: relevance to clinical hypoglycemia in type I (insulin dependent) diabetes mellitus
    P E Cryer
    Division of Endocrinology, Diabetes and Metabolism, and General Clinical Research Center, Washington University School of Medicine, St. Louis, Missouri, USA
    Horm Metab Res 29:92-6. 1997
    ....
  24. pmc Direct relationship between mononuclear leukocyte and lung beta-adrenergic receptors and apparent reciprocal regulation of extravascular, but not intravascular, alpha- and beta-adrenergic receptors by the sympathochromaffin system in humans
    S B Liggett
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110
    J Clin Invest 82:48-56. 1988
    ..These data provide further support for the concept of up regulation, as well as down regulation, of some adrenergic receptor populations during short-term activation of the sympathochromaffin system in humans...
  25. ncbi request reprint Hypoglycemia-associated autonomic failure in diabetes
    P E Cryer
    Division of Endocrinology, Diabetes and Metabolism, General Clinical Research Center, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Physiol Endocrinol Metab 281:E1115-21. 2001
    ....
  26. ncbi request reprint Renal compensation for impaired hepatic glucose release during hypoglycemia in type 2 diabetes: further evidence for hepatorenal reciprocity
    Hans J Woerle
    Department of Medicine, University of Rochester School of Medicine, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Diabetes 52:1386-92. 2003
    ....
  27. ncbi request reprint Sleep-related hypoglycemia-associated autonomic failure in type 1 diabetes: reduced awakening from sleep during hypoglycemia
    Salomon Banarer
    Division of Endocrinology, Metabolism, and Lipid Research, General Clinical Research Center, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Diabetes 52:1195-203. 2003
    ..This sleep-related hypoglycemia-associated autonomic failure, in the context of imperfect insulin replacement, likely explains the high frequency of nocturnal hypoglycemia in type 1 diabetes...
  28. ncbi request reprint Hypoglycemia in type 2 diabetes
    Salomon Banarer
    Department of Medicine, University of Louisville, ACB 3rd Floor, Suite 83G11, 550 Jackson Street, Louisville, KY 40209, USA
    Med Clin North Am 88:1107-16, xii-xiii. 2004
    ..Nonetheless, people with diabetes need better treatment regimens...
  29. ncbi request reprint Hypoglycemia in diabetes
    Philip E Cryer
    Division of Endocrinology, Diabetes and Metabolism, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Diabetes Care 26:1902-12. 2003
    ....
  30. ncbi request reprint Effects of glimepiride and glyburide on glucose counterregulation and recovery from hypoglycemia
    Ervin Szoke
    Department of Medicine, University of Rochester School of Medicine, Rochester, NY 14642, USA
    Metabolism 55:78-83. 2006
    ..This differential effect on insulin secretion may be an important factor in explaining why glyburide causes severe hypoglycemia more frequently than glimepiride...
  31. ncbi request reprint Hypoglycemia-associated autonomic failure in advanced type 2 diabetes
    Scott A Segel
    Division of Endocrinology, Diabetes and Metabolism, and the General Clinical Research Center and the Diabetes Research and Training Center, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Diabetes 51:724-33. 2002
    ....
  32. pmc Insulin resistance in HIV protease inhibitor-associated diabetes
    K E Yarasheski
    Division of Endocrinology, Diabetes, and Metabolism, Washington University Medical School, St Louis, Missouri 63110, USA
    J Acquir Immune Defic Syndr 21:209-16. 1999
    ..Fasting hyperglycemia has been associated with HIV protease inhibitor (PI) therapy...
  33. ncbi request reprint Glucagon, in concert with insulin, supports the postabsorptive plasma glucose concentration in humans
    Suzanne M Breckenridge
    Division of Endocrinology, Metabolism, and Lipid Research, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Diabetes 56:2442-8. 2007
    ..Given the interest in glucagon antagonism as a potential treatment of diabetes, we tested the hypothesis that glucagon, in concert with insulin, supports the postabsorptive plasma glucose concentration in humans...
  34. ncbi request reprint Nocturnal hypoglycemia in type 1 diabetes: an assessment of preventive bedtime treatments
    Bharathi Raju
    Campus Box 8127, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
    J Clin Endocrinol Metab 91:2087-92. 2006
    ..We assessed four putative bedtime treatments in the prevention of nocturnal hypoglycemia in type 1 diabetes...
  35. pmc Attenuation of counterregulatory responses to recurrent hypoglycemia by active thalamic inhibition: a mechanism for hypoglycemia-associated autonomic failure
    Ana Maria Arbelaez
    Campus Box 8127, Washington University School of Medicine, 660 South Euclid Ave, St Louis, MO 63110, USA
    Diabetes 57:470-5. 2008
    ..We investigated the role of cerebral mechanisms in HAAF by measuring regional brain activation during recurrent hypoglycemia with attenuated counterregulatory responses and comparing it with initial hypoglycemia in healthy individuals...
  36. ncbi request reprint Maintenance of the postabsorptive plasma glucose concentration: insulin or insulin plus glucagon?
    Bharathi Raju
    Division of Endocrinology, Metabolism and Lipid Research, Washington Univ School of Medicine, 660 South Euclid Ave, St Louis, MO 63110, USA
    Am J Physiol Endocrinol Metab 289:E181-6. 2005
    ..Although the balance of evidence suggests that glucagon is involved in the maintenance of euglycemia, more definitive evidence is needed, particularly in humans...
  37. ncbi request reprint Hypoglycemia risk reduction in type 1 diabetes
    P E Cryer
    Division of Endocrinology, Diabetes and Metabolism, General Clinical Research Center, Diabetes Research and Training Center, Washington University School of Medicine, St Louis, Missouri, USA
    Exp Clin Endocrinol Diabetes 109:S412-23. 2001
    ..With this approach the goals of improving glycemic control and minimizing hypoglycemia are not incompatible...
  38. ncbi request reprint Symptoms of hypoglycemia, thresholds for their occurrence, and hypoglycemia unawareness
    P E Cryer
    Division of Endocrinology, Diabetes, and Metabolism, Washington University School of Medicine, St Louis, Missouri, USA
    Endocrinol Metab Clin North Am 28:495-500, v-vi. 1999
    ..Thus, patients with recurrent hypoglycemia (e.g., those with tightly controlled diabetes or with an insulinoma) often tolerate abnormally low plasma glucose concentrations without symptoms...
  39. ncbi request reprint Elevated endogenous cortisol reduces autonomic neuroendocrine and symptom responses to subsequent hypoglycemia
    Veronica P McGregor
    Division of Endocrinology, Diabetes and Metabolism, General Clinical Research Center, and Diabetes Research and Training Center, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Physiol Endocrinol Metab 282:E770-7. 2002
    ....
  40. ncbi request reprint Intraislet hyperinsulinemia prevents the glucagon response to hypoglycemia despite an intact autonomic response
    Salomon Banarer
    Division of Endocrinology, Diabetes and Metabolism and the General Clinical Research Center and the Diabetes Research and Training Center, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Diabetes 51:958-65. 2002
    ..We conclude that intraislet hyperinsulinemia prevents the glucagon response to hypoglycemia despite an intact autonomic response and a low alpha-cell glucose concentration...
  41. ncbi request reprint Hypoglycemia: still the limiting factor in the glycemic management of diabetes
    Philip E Cryer
    Division of Endocrinology, Metabolism and Lipid Research, Washington University School of Medicine, St Louis, MO 63110, USA
    Endocr Pract 14:750-6. 2008
    ..To review the prevalence of, risk factors for, and prevention of hypoglycemia from the perspective of the pathophysiologic aspects of glucose counterregulation in diabetes...
  42. ncbi request reprint Basal insulin, glucagon, and growth hormone replacement
    Suzanne M Breckenridge
    Division of Endocrinology, Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Physiol Endocrinol Metab 293:E1303-10. 2007
    ..Thus, insulin "replacement" doses of 0.20 and even 0.15 mU.kg(-1).min(-1) are excessive, and conclusions drawn from the pancreatic clamp technique using such doses may need to be reassessed...
  43. ncbi request reprint Loss of the decrement in intraislet insulin plausibly explains loss of the glucagon response to hypoglycemia in insulin-deficient diabetes: documentation of the intraislet insulin hypothesis in humans
    Bharathi Raju
    Division of Endocrinology, Metabolism and Lipid Research, General Clinical Research Center, Washington University School of Medicine, 660 South Euclid Ave, St Louis, MO 63110, USA
    Diabetes 54:757-64. 2005
    ....
  44. ncbi request reprint Mechanism, temporal patterns, and magnitudes of the metabolic responses to the KATP channel agonist diazoxide
    Bharathi Raju
    Division of Endocrinology, Metabolism, and Lipid Research, the General Clinical Research Center, Washington University School of Medicine, St Louis, Missouri, USA
    Am J Physiol Endocrinol Metab 288:E80-5. 2005
    ....
  45. ncbi request reprint Hypoglycemia and the sympathoadrenal system: neurogenic symptoms are largely the result of sympathetic neural, rather than adrenomedullary, activation
    Michael A DeRosa
    Campus Box 8127, Washington Univ School of Medicine, 660 South Euclid Ave, St Louis, MO 63110, USA
    Am J Physiol Endocrinol Metab 287:E32-41. 2004
    ..They also suggest that the plasma NE and hemodynamic responses to hypoglycemia are largely the result of adrenomedullary, rather that sympathetic neural, activation...
  46. ncbi request reprint Evaluation and management of adult hypoglycemic disorders: an Endocrine Society Clinical Practice Guideline
    Philip E Cryer
    Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Endocrinol Metab 94:709-28. 2009
    ..The aim is to provide guidelines for the evaluation and management of adults with hypoglycemic disorders, including those with diabetes mellitus...
  47. pmc Terbutaline and the prevention of nocturnal hypoglycemia in type 1 diabetes
    Benjamin A Cooperberg
    Division of Endocrinology, Metabolism and Lipid Research, Washington University School of Medicine, St Louis, Missouri, USA
    Diabetes Care 31:2271-2. 2008
    ..We tested the hypothesis that 2.5 mg terbutaline prevents nocturnal hypoglycemia without causing morning hyperglycemia...
  48. ncbi request reprint Cortisol elevations comparable to those that occur during hypoglycemia do not cause hypoglycemia-associated autonomic failure
    Bharathi Raju
    Division of Endocrinology, Metabolism and Lipid Research, Washington University School of Medicine, St Louis, Missouri, USA
    Diabetes 52:2083-9. 2003
    ..304 +/- 26 pg/ml) or neurogenic symptom (e.g., final scores of 9.3 +/- 1.1 vs. 13.2 +/- 1.3) responses to subsequent hypoglycemia. Thus, these data do not support the suggestion that cortisol mediates HAAF...
  49. ncbi request reprint Limited impact of vigorous exercise on defenses against hypoglycemia: relevance to hypoglycemia-associated autonomic failure
    Veronica P McGregor
    Division of Endocrinology Diabetes and Metabolism, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Diabetes 51:1485-92. 2002
    ..These data do not support the hypothesis that the cortisol response to hypoglycemia mediates the reduced neurogenic symptom response to subsequent hypoglycemia, another key component of HAAF in type 1 diabetes...
  50. pmc Activation of human medial prefrontal cortex during autonomic responses to hypoglycemia
    Denise Teves
    Division of Endocrinology, Metabolism, and Lipid Research of the Department of Internal Medicine, Washington University School of Medicine, Campus Box 8127, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 101:6217-21. 2004
    ..These results provide evidence that the MPFC participates in the autonomic responses to simple physiological stimuli in humans...
  51. ncbi request reprint Management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes
    Philip E Cryer
    Diabetes Care 30:190-2; author reply 194-6. 2007
  52. ncbi request reprint Multiple defects in counterregulation of hypoglycemia in modestly advanced type 2 diabetes mellitus
    Zarmen Israelian
    Department of Endocrinology, Carl T Hayden VA Medical Center, Phoenix, AZ 85012, and Department of Medicine, University of Rochester School of Medicine, NY 14642, USA
    Metabolism 55:593-8. 2006
    ..These include delayed and reduced decreases in insulin secretion, and impaired increases of plasma glucagon and growth hormone...
  53. ncbi request reprint Role of the decrement in intraislet insulin for the glucagon response to hypoglycemia in humans
    Niyaz R Gosmanov
    Carl T Hayden VA Medical Center, 650 E Indian School Road, Phoenix, AZ 85012, USA
    Diabetes Care 28:1124-31. 2005
    ..However, in humans this role of decreased intraislet insulin is still unclear...
  54. ncbi request reprint Increasing the decrement in insulin secretion improves glucagon responses to hypoglycemia in advanced type 2 diabetes
    Zarmen Israelian
    Department of Endocrinology, Carl T Hayden VA Medical Center, Phoenix, AZ 85012, USA
    Diabetes Care 28:2691-6. 2005
    ..The present studies were therefore undertaken to test the hypothesis that these may be improved by increasing this decrement in insulin secretion...

Research Grants2

  1. ADRENERGIC MECHANISMS IN METABOLIC PATHOPHYSIOLOGY
    PHILIP CRYER; Fiscal Year: 2007
    ..abstract_text> ..
  2. ADRENERGIC MECHANISMS IN METABOLIC PATHOPHYSIOLOGY
    PHILIP CRYER; Fiscal Year: 2008
    ..abstract_text> ..