E Crouch

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. ncbi request reprint Surfactant protein D binds to human immunodeficiency virus (HIV) envelope protein gp120 and inhibits HIV replication
    Joseph Meschi
    Department of Medicine, Sections of Hematology Oncology, Boston University School of Medicine, EBRC 414, 650 Albany Street, Boston, MA 02118, USA
    J Gen Virol 86:3097-107. 2005
  2. ncbi request reprint Structure, biologic properties, and expression of surfactant protein D (SP-D)
    E C Crouch
    Department of Pathology, Barnes Jewish Hospital at Washington University Medical Center, 216 S Kingshighway, St Louis, MO 63110, USA
    Biochim Biophys Acta 1408:278-89. 1998
  3. ncbi request reprint Ligand specificity of human surfactant protein D: expression of a mutant trimeric collectin that shows enhanced interactions with influenza A virus
    Erika Crouch
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 280:17046-56. 2005
  4. ncbi request reprint Contributions of phenylalanine 335 to ligand recognition by human surfactant protein D: ring interactions with SP-D ligands
    Erika Crouch
    Department of Pathology and Immunology, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
    J Biol Chem 281:18008-14. 2006
  5. pmc Species differences in the carbohydrate binding preferences of surfactant protein D
    Erika C Crouch
    Dept of Pathology and Immunology, Campus Box 8118, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Am J Respir Cell Mol Biol 35:84-94. 2006
  6. ncbi request reprint Critical role of Arg/Lys343 in the species-dependent recognition of phosphatidylinositol by pulmonary surfactant protein D
    Erika Crouch
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Biochemistry 46:5160-9. 2007
  7. pmc Recognition of mannosylated ligands and influenza A virus by human surfactant protein D: contributions of an extended site and residue 343
    Erika Crouch
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Biochemistry 48:3335-45. 2009
  8. pmc Myeloperoxidase-dependent inactivation of surfactant protein D in vitro and in vivo
    Erika C Crouch
    Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, Missouri 63110, USA
    J Biol Chem 285:16757-70. 2010
  9. pmc Surfactant protein-D and pulmonary host defense
    E C Crouch
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri, USA
    Respir Res 1:93-108. 2000
  10. ncbi request reprint Surfactant proteins a and d and pulmonary host defense
    E Crouch
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Annu Rev Physiol 63:521-54. 2001

Research Grants

  1. STRUCTURE/FUNCTION OF SURFACTANT PROTEIN D
    Erika Crouch; Fiscal Year: 2005
  2. STRUCTURE/FUNCTION OF SURFACTANT PROTEIN D
    Erika Crouch; Fiscal Year: 2004
  3. STRUCTURE/FUNCTION OF SURFACTANT PROTEIN D
    Erika Crouch; Fiscal Year: 2003
  4. STRUCTURE/FUNCTION OF SURFACTANT PROTEIN D
    Erika Crouch; Fiscal Year: 2002
  5. STRUCTURE/FUNCTION OF SURFACTANT PROTEIN D
    Erika Crouch; Fiscal Year: 2001
  6. STRUCTURE/FUNCTION OF SURFACTANT PROTEIN D
    Erika Crouch; Fiscal Year: 2000
  7. STRUCTURE/FUNCTION OF SURFACTANT PROTEIN D
    Erika Crouch; Fiscal Year: 1999
  8. STRUCTURE/FUNCTION OF SURFACTANT PROTEIN D
    Erika Crouch; Fiscal Year: 2006

Collaborators

Detail Information

Publications50

  1. ncbi request reprint Surfactant protein D binds to human immunodeficiency virus (HIV) envelope protein gp120 and inhibits HIV replication
    Joseph Meschi
    Department of Medicine, Sections of Hematology Oncology, Boston University School of Medicine, EBRC 414, 650 Albany Street, Boston, MA 02118, USA
    J Gen Virol 86:3097-107. 2005
    ..SP-D is present in lung and airway fluids, as well as in blood and various mucosal locations, and could, like MBL, play a role in restricting HIV transmission or replication in vivo...
  2. ncbi request reprint Structure, biologic properties, and expression of surfactant protein D (SP-D)
    E C Crouch
    Department of Pathology, Barnes Jewish Hospital at Washington University Medical Center, 216 S Kingshighway, St Louis, MO 63110, USA
    Biochim Biophys Acta 1408:278-89. 1998
    ....
  3. ncbi request reprint Ligand specificity of human surfactant protein D: expression of a mutant trimeric collectin that shows enhanced interactions with influenza A virus
    Erika Crouch
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 280:17046-56. 2005
    ..In addition, RAK resembled CL-43 in its greater capacity to inhibit the infectivity of influenza A virus and to increase uptake of influenza by neutrophils...
  4. ncbi request reprint Contributions of phenylalanine 335 to ligand recognition by human surfactant protein D: ring interactions with SP-D ligands
    Erika Crouch
    Department of Pathology and Immunology, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
    J Biol Chem 281:18008-14. 2006
    ..Our studies indicate that Phe-335, which is evolutionarily conserved in all known SP-Ds, plays important, if not critical, roles in SP-D function...
  5. pmc Species differences in the carbohydrate binding preferences of surfactant protein D
    Erika C Crouch
    Dept of Pathology and Immunology, Campus Box 8118, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Am J Respir Cell Mol Biol 35:84-94. 2006
    ..Thus, ligand recognition by human SP-D involves a complex interplay between saccharide presentation, the valency of trimeric subunits, and species-specific residues that flank the primary carbohydrate binding site...
  6. ncbi request reprint Critical role of Arg/Lys343 in the species-dependent recognition of phosphatidylinositol by pulmonary surfactant protein D
    Erika Crouch
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Biochemistry 46:5160-9. 2007
    ..In addition, the studies indicate that oligomerization of trimeric subunits is an important determinant of recognition of PI by human SP-D...
  7. pmc Recognition of mannosylated ligands and influenza A virus by human surfactant protein D: contributions of an extended site and residue 343
    Erika Crouch
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Biochemistry 48:3335-45. 2009
    ..Our findings demonstrate an extended ligand binding site for mannosylated ligands and the significant contribution of the 343 side chain to specific recognition of multivalent microbial ligands, including high-mannose viral glycans...
  8. pmc Myeloperoxidase-dependent inactivation of surfactant protein D in vitro and in vivo
    Erika C Crouch
    Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, Missouri 63110, USA
    J Biol Chem 285:16757-70. 2010
    ..Thus, MPO-derived oxidants can lead to modifications of SP-D structure with associated alterations in its characteristic aggregating activity...
  9. pmc Surfactant protein-D and pulmonary host defense
    E C Crouch
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri, USA
    Respir Res 1:93-108. 2000
    ..The expression of SP-D is increased in response to many forms of lung injury, and deficient accumulation of appropriately oligomerized SP-D might contribute to the pathogenesis of a variety of human lung diseases...
  10. ncbi request reprint Surfactant proteins a and d and pulmonary host defense
    E Crouch
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Annu Rev Physiol 63:521-54. 2001
    ....
  11. ncbi request reprint Collectins and pulmonary innate immunity
    E Crouch
    Department of Pathology, Washington University School of Medicine, St Louis, MO 63110, USA
    Immunol Rev 173:52-65. 2000
    ....
  12. ncbi request reprint Collectins and pulmonary host defense
    E C Crouch
    Department of Pathology, Washington University School of Medicine, St Louis, Missouri, USA
    Am J Respir Cell Mol Biol 19:177-201. 1998
    ..Acquired or genetic alterations in the levels of active proteins within the airspaces and distal airways may increase susceptibility to infection...
  13. pmc Mutagenesis of surfactant protein D informed by evolution and x-ray crystallography enhances defenses against influenza A virus in vivo
    Erika Crouch
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 286:40681-92. 2011
    ..These studies demonstrate the potential utility of homology modeling and protein structure analysis for engineering effective collectin antivirals as in vivo therapeutics...
  14. ncbi request reprint Molecular structure of pulmonary surfactant protein D (SP-D)
    E Crouch
    Department of Pathology, Washington University School of Medicine, St Louis, Missouri 63110
    J Biol Chem 269:17311-9. 1994
    ....
  15. ncbi request reprint Purification and biochemical characterization of CP4 (SP-D), a collagenous surfactant-associated protein
    A Persson
    Department of Pathology, Jewish Hospital, Washington University Medical Center, St Louis, Missouri 63110
    Biochemistry 28:6361-7. 1989
    ..We propose that CP4 be designated "surfactant protein D" (SP-D) in accordance with an accepted nomenclature for surfactant-associated proteins...
  16. pmc Accumulation of surfactant protein D in human pulmonary alveolar proteinosis
    E Crouch
    Department of Pathology, Jewish Hospital, St Louis, MO 63110
    Am J Pathol 142:241-8. 1993
    ..These studies describe the isolation and biochemical characterization of human SP-D and demonstrate the abnormal accumulation of this protein in the air spaces of patients with alveolar proteinosis...
  17. ncbi request reprint Genomic organization of human surfactant protein D (SP-D). SP-D is encoded on chromosome 10q22.2-23.1
    E Crouch
    Department of Pathology, Jewish Hospital, Washington University Medical Center, St Louis, Missouri 63110
    J Biol Chem 268:2976-83. 1993
    ..Fluorescence in situ hybridization of metaphase chromosomes using genomic probes gave selective labeling of 10q22.2-23.1. We speculate that SP-D is encoded at a locus on 10q that includes the genes for surfactant protein A...
  18. ncbi request reprint The amino-terminal heptad repeats of the coiled-coil neck domain of pulmonary surfactant protein d are necessary for the assembly of trimeric subunits and dodecamers
    P Zhang
    Department of Pathology, Washington University School of Medicine, St. Louis, Missouri 63110, USA
    J Biol Chem 276:19862-70. 2001
    ..These studies provide strong evidence that the amino-terminal heptad repeats of the neck domain are necessary for the intracellular, trimeric association of SP-D monomers and for the assembly and secretion of functional dodecamers...
  19. ncbi request reprint Human surfactant protein D: SP-D contains a C-type lectin carbohydrate recognition domain
    K Rust
    Department of Pathology, Jewish Hospital, Washington University Medical Center, St Louis, Missouri 63110
    Arch Biochem Biophys 290:116-26. 1991
    ..The studies demonstrate that SP-D is a member of the C-type lectin family, and confirm predicted structural similarities to conglutinin, SP-D, and the serum mannose binding proteins...
  20. ncbi request reprint Surfactant protein D gene regulation. Interactions among the conserved CCAAT/enhancer-binding protein elements
    Yanchun He
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 277:19530-7. 2002
    ..Thus, interactions among C/EBP elements in the near-distal promoter can modulate the promoter activity of SP-D...
  21. ncbi request reprint Processing of type II procollagen amino propeptide by matrix metalloproteinases
    Naoshi Fukui
    Department of Orthopaedic Surgery, Barnes Jewish Hospital at Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 277:2193-201. 2002
    ....
  22. ncbi request reprint IL-4 and IL-13 form a negative feedback circuit with surfactant protein-D in the allergic airway response
    Angela Haczku
    Pulmonary, Allergy and Critical Care Division, Department of Medicine, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, USA
    J Immunol 176:3557-65. 2006
    ..This negative feedback regulatory circuit could be essential in protecting the airways from inflammatory damage after allergen inhalation...
  23. ncbi request reprint Identification and characterization of endogenous Langerin ligands in murine extracellular matrix
    Yayoi Tada
    Dermatology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Massachusetts, USA
    J Invest Dermatol 126:1549-58. 2006
    ..Langerin may have an unanticipated role in cell-matrix interactions that modulate LC development, localization, or function...
  24. doi request reprint Patterns of neutrophil serine protease-dependent cleavage of surfactant protein D in inflammatory lung disease
    Jessica Cooley
    Immune Disease Institute, Harvard Medical School, Boston, MA 02115, USA
    J Leukoc Biol 83:946-55. 2008
    ..The findings support a pre-eminent role for neutrophil elastase as the critical protease responsible for SP-D depletion in inflammatory lung disease...
  25. ncbi request reprint Innate defense against influenza A virus: activity of human neutrophil defensins and interactions of defensins with surfactant protein D
    Kevan L Hartshorn
    Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    J Immunol 176:6962-72. 2006
    ..These results are relevant to the early phase of host defense against IAV, and suggest a complex interplay between SP-D and HNPs at sites of active inflammation...
  26. pmc Reduced influenza viral neutralizing activity of natural human trimers of surfactant protein D
    Kevan L Hartshorn
    Boston University School of Medicine, Department of Medicine, Boston, MA, USA
    Respir Res 8:9. 2007
    ..We recently reported that the Thr/Thr 11 form of SP-D is associated with low serum levels and assembles predominantly as trimers as opposed to the more common multimeric forms of SP-D...
  27. doi request reprint Critical role for cross-linking of trimeric lectin domains of surfactant protein D in antiviral activity against influenza A virus
    Tesfaldet Tecle
    Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    Biochem J 412:323-9. 2008
    ..These results show that antiviral activities of SP-D can be reproduced without the N-terminal and collagen domains and that cross-linking of NCRDs is essential for antiviral activity of SP-D with respect to IAV...
  28. ncbi request reprint Antiviral activity of the long chain pentraxin PTX3 against influenza viruses
    Patrick C Reading
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria, Australia
    J Immunol 180:3391-8. 2008
    ....
  29. ncbi request reprint Surfactant protein D decreases pollen-induced IgE-dependent mast cell degranulation
    Delphine C Malherbe
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Am J Physiol Lung Cell Mol Physiol 289:L856-66. 2005
    ..This study is the first to demonstrate that SP-D modulates IgE-mediated mast cell functions, which are important in asthma and allergic inflammation...
  30. ncbi request reprint Interactions of surfactant protein D with fatty acids
    Nihal S DeSilva
    Dept of Pathology and Immunology, Barnes Jewish Hospital, North Campus, Box 8118 216 S Kingshighway, St Louis, MO 63110, USA
    Am J Respir Cell Mol Biol 29:757-70. 2003
    ..We speculate that the binding of SP-D to the fatty acyl chains of surfactant lipids, microbial ligands, or other complex lipids contributes to the diverse biological functions of SP-D in vivo...
  31. ncbi request reprint Porcine pulmonary collectins show distinct interactions with influenza A viruses: role of the N-linked oligosaccharides in the carbohydrate recognition domain
    Martin van Eijk
    Departments of Biochemistry and Cell Biology, Graduate School of Animal Health, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands
    J Immunol 171:1431-40. 2003
    ..A more efficient lung collectin-mediated immune response against IAV in pigs may play a role in providing conditions by which pigs can act as "mixing vessel" hosts that can lead to the production of reassortant, pandemic strains of IAV...
  32. ncbi request reprint Neutrophil serine proteinases inactivate surfactant protein D by cleaving within a conserved subregion of the carbohydrate recognition domain
    Tim O Hirche
    Department of Medicine, Washington University School of Medicine, Saint Louis, Missouri 63110, USA
    J Biol Chem 279:27688-98. 2004
    ..Together, our data suggest that neutrophil-derived serine proteinases cleave SP-D at sites of inflammation with potential deleterious effects on its biological functions...
  33. pmc Contributions of the N- and C-terminal domains of surfactant protein d to the binding, aggregation, and phagocytic uptake of bacteria
    Kevan L Hartshorn
    Department of Medicine, Boston University School of Medicine, Boston, Massachussets 02118, USA
    Infect Immun 70:6129-39. 2002
    ....
  34. ncbi request reprint Impact of neutrophils on antiviral activity of human bronchoalveolar lavage fluid
    Mitchell R White
    Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Am J Physiol Lung Cell Mol Physiol 293:L1293-9. 2007
    ..g., as in chronic smoking or cystic fibrosis) may reduce SP-D levels and predispose to IAV infection. In contrast, acute inflammation, as occurs in the early phase of IAV infection, may promote neutrophil-mediated viral clearance...
  35. pmc Distinctive anti-influenza properties of recombinant collectin 43
    Kevan L Hartshorn
    Department of Medicine, Boston University School of Medicine, EBRC 414, 650 Albany Street, Boston, MA 02118, U S A
    Biochem J 366:87-96. 2002
    ..These findings could facilitate the development of recombinant collectins with novel antimicrobial properties...
  36. ncbi request reprint Complementation of pulmonary abnormalities in SP-D(-/-) mice with an SP-D/conglutinin fusion protein
    Liqian Zhang
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    J Biol Chem 277:22453-9. 2002
    ..Our findings also strongly suggest that the molecular mechanisms underlying impaired pulmonary host defense and abnormal lipid metabolism are distinct from those that promote ongoing inflammation and the development of emphysema...
  37. ncbi request reprint Trimerization of the amino propeptide of type IIA procollagen using a 14-amino acid sequence derived from the coiled-coil neck domain of surfactant protein D
    Audrey McAlinden
    Department of Orthopaedic Surgery, Washington University School of Medicine at Barnes Jewish Hospital, 660 South Euclid Avenue, St Louis, MO 63110, USA
    J Biol Chem 277:41274-81. 2002
    ....
  38. ncbi request reprint Intramuscular gene transfer of interleukin-10 reduces neutrophil recruitment and ameliorates lung graft ischemia-reperfusion injury
    Benjamin D Kozower
    Division of Cardiothoracic Surgery, Washington University School of Medicine, Barnes Jewish Hospital, St Louis, MO, USA
    Am J Transplant 2:837-42. 2002
    ..This is associated with a reduction in I/R injury with improved isograft oxygenation and reduced tissue edema. Intramuscular gene transfer may be a useful strategy to reduce clinical l/R injury...
  39. ncbi request reprint Surfactant protein D expression in normal and pneumonic ovine lung
    Branka Grubor
    Department of Veterinary Pathology, College of Veterinary Medicine, Iowa State University, Veterinary Medicine, Ames, IA 50011 1250, USA
    Vet Immunol Immunopathol 101:235-42. 2004
    ....
  40. ncbi request reprint Human neutrophil defensins increase neutrophil uptake of influenza A virus and bacteria and modify virus-induced respiratory burst responses
    Tesfaldet Tecle
    Department of Medicine, Boston University School of Medicine, 650 Albany Street, Boston, MA 02118, USA
    J Immunol 178:8046-52. 2007
    ....
  41. ncbi request reprint A role for surfactant protein D in innate immunity of the human prostate
    Rebecca E Oberley
    Department of Anatomy and Cell Biology, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    Prostate 65:241-51. 2005
    ..In the present study, we found that SP-D is produced in the human prostate where it may play a role in innate immunity...
  42. ncbi request reprint Surfactant protein A and D differently regulate the immune response to nonmucoid Pseudomonas aeruginosa and its lipopolysaccharide
    Philip Bufler
    Dr von Haunersches Kinderspital, University of Munich, Munich, Germany
    Am J Respir Cell Mol Biol 28:249-56. 2003
    ..aeruginosa of diverse LPS phenotypes, and preferentially augments the cellular response to rough P. aeruginosa endotoxin...
  43. pmc Surfactant protein D increases fusion of Mycobacterium tuberculosis-containing phagosomes with lysosomes in human macrophages
    J Scott Ferguson
    Division of Infectious Diseases, Department of Internal Medicine, The Ohio State University, N 1147 Doan Hall, 410 W 10th Avenue, Columbus, OH 43210, USA
    Infect Immun 74:7005-9. 2006
    ..Here we show that SP-D limits the intracellular growth of bacilli in macrophages by increasing phagosome-lysosome fusion but not by generating a respiratory burst...
  44. pmc Effect of lung surfactant collectins on bronchoalveolar macrophage interaction with Blastomyces dermatitidis: inhibition of tumor necrosis factor alpha production by surfactant protein D
    Madhavi Lekkala
    Division of Infectious Diseases, Department of Medicine, Santa Clara Valley Medical Center, 751 South Bascom Ave, San Jose, California 95128 2699, USA
    Infect Immun 74:4549-56. 2006
    ..dermatitidis may utilize BALF constituents, such as SP-D, to blunt the host defensive reaction; this effect could reduce inflammation and tissue destruction but could also promote disease...
  45. ncbi request reprint Surfactant proteins A and D enhance the phagocytosis of Chlamydia into THP-1 cells
    Rebecca E Oberley
    Department of Anatomy and Cell Biology, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Am J Physiol Lung Cell Mol Physiol 287:L296-306. 2004
    ..In addition, the chlamydial pathogens internalized in the presence of collectins are able to grow and replicate in the THP-1 cells after phagocytosis...
  46. pmc Enhanced surfactant protein and defensin mRNA levels and reduced viral replication during parainfluenza virus type 3 pneumonia in neonatal lambs
    Branka Grubor
    Department of Veterinary Pathology, 2740 Veterinary Medicine, Iowa State University, Ames, IA 50011 1250, USA
    Clin Diagn Lab Immunol 11:599-607. 2004
    ....
  47. ncbi request reprint Cutting edge: B and T lymphocyte attenuator and programmed death receptor-1 inhibitory receptors are required for termination of acute allergic airway inflammation
    Christine Deppong
    Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 176:3909-13. 2006
    ..Thus, these receptors are critical determinants of the duration of allergic airway inflammation...
  48. pmc Surfactant protein D-mediated aggregation of Pneumocystis carinii impairs phagocytosis by alveolar macrophages
    Suk Joong Yong
    Thoracic Diseases Research Unit, Division of Pulmonary, Critical Care, and Internal Medicine, 8 24 Stabile Building, Mayo Clinic, Rochester, MN 55905, USA
    Infect Immun 71:1662-71. 2003
    ..Thus, SP-D-mediated aggregation of P. carinii may represent one means by which the organism avoids elimination by the host...
  49. ncbi request reprint Surfactant protein D is present in the human female reproductive tract and inhibits Chlamydia trachomatis infection
    Rebecca E Oberley
    Department of Anatomy and Cell Biology, University of Iowa, Carver College of Medicine, Iowa City, IA 52242, USA
    Mol Hum Reprod 10:861-70. 2004
    ..In conclusion, we detected SP-D in the female reproductive tract and determined that one of the functions of the SP-D protein may be to protect cervical epithelial cells from infection by C. trachomatis...
  50. pmc Mycobacterium tuberculosis binding to human surfactant proteins A and D, fibronectin, and small airway epithelial cells under shear conditions
    Luanne Hall-Stoodley
    Center for Genomic Sciences, Allegheny Singer Research Institute, 320 East North Avenue, 11th Floor, South Tower, Pittsburgh, PA 15212 4772, USA
    Infect Immun 74:3587-96. 2006
    ..tuberculosis and host innate immune determinants...

Research Grants13

  1. STRUCTURE/FUNCTION OF SURFACTANT PROTEIN D
    Erika Crouch; Fiscal Year: 2005
    ..As in the past, secreted recombinant proteins with novel structural attributes will be characterized and utilized for collaborative studies of SP-D function. ..
  2. STRUCTURE/FUNCTION OF SURFACTANT PROTEIN D
    Erika Crouch; Fiscal Year: 2004
    ..As in the past, secreted recombinant proteins with novel structural attributes will be characterized and utilized for collaborative studies of SP-D function. ..
  3. STRUCTURE/FUNCTION OF SURFACTANT PROTEIN D
    Erika Crouch; Fiscal Year: 2003
    ..As in the past, secreted recombinant proteins with novel structural attributes will be characterized and utilized for collaborative studies of SP-D function. ..
  4. STRUCTURE/FUNCTION OF SURFACTANT PROTEIN D
    Erika Crouch; Fiscal Year: 2002
    ..abstract_text> ..
  5. STRUCTURE/FUNCTION OF SURFACTANT PROTEIN D
    Erika Crouch; Fiscal Year: 2001
    ..abstract_text> ..
  6. STRUCTURE/FUNCTION OF SURFACTANT PROTEIN D
    Erika Crouch; Fiscal Year: 2000
    ..abstract_text> ..
  7. STRUCTURE/FUNCTION OF SURFACTANT PROTEIN D
    Erika Crouch; Fiscal Year: 1999
    ..abstract_text> ..
  8. STRUCTURE/FUNCTION OF SURFACTANT PROTEIN D
    Erika Crouch; Fiscal Year: 2006
    ..As in the past, secreted recombinant proteins with novel structural attributes will be characterized and utilized for collaborative studies of SP-D function. ..