Research Topics | Rodney B CroteauSummaryAffiliation: Washington State University Country: USA Research Grants BIOSYNTHESIS of TaxolRodney B Croteau; Fiscal Year: 2007 ENZYMATIC CYCLIZATION TO TERPENOID NATURAL PRODUCTSRodney B Croteau; Fiscal Year: 2007 BIOSYNTHESIS of TaxolRodney B Croteau; Fiscal Year: 2008 Publications Strategies for transgenic manipulation of monoterpene biosynthesis in plantsSoheil S Mahmoud Institute of Biological Chemistry, Washington State University, Pullman, WA 99164, USA Trends Plant Sci 7:366-73 A systems biology approach identifies the biochemical mechanisms regulating monoterpenoid essential oil composition in peppermintRigoberto Rios Estepa Institute of Biological Chemistry, M J Murdock Metabolomics Laboratory, Center for Integrated Biotechnology, and School of Chemical Engineering and Bioengineering, Washington State University, Pullman, WA 99164 6340, USA Proc Natl Acad Sci U S A 105:2818-23 Stable transformation and long-term maintenance of transgenic Taxus cell suspension culturesRaymond E B Ketchum Institute of Biological Chemistry, Washington State University, Pullman, WA 99164 6340, USA Plant Cell Rep 26:1025-33 Administering cultured Taxus cells with early precursors reveals bifurcations in the taxoid biosynthetic pathwayRaymond E B Ketchum Institute of Biological Chemistry, Washington State University, 299 Clark Hall, P O Box 646340, Pullman, WA 99164 6340, USA Phytochemistry 68:335-41 (-)-Menthol biosynthesis and molecular geneticsRodney B Croteau Institute of Biological Chemistry, Washington State University, Pullman, WA 99164 6340, USA Naturwissenschaften 92:562-77 Genetic engineering of peppermint for improved essential oil composition and yieldMark R Wildung Institute of Biological Chemistry, Washington State University, Pullman, WA 99164-6340, USA Transgenic Res 14:365-72 Genetic engineering of taxol biosynthetic genes in Saccharomyces cerevisiaeJinghong M DeJong eXegenics, Inc, 2110 Research Row, Dallas, Texas 75235, USA Biotechnol Bioeng 93:212-24 Taxus metabolomics: methyl jasmonate preferentially induces production of taxoids oxygenated at C-13 in Taxus x media cell culturesRaymond E B Ketchum Institute of Biological Chemistry, Washington State University, Pullman, WA 99164, USA Phytochemistry 62:901-9 Coexpression in yeast of Taxus cytochrome P450 reductase with cytochrome P450 oxygenases involved in Taxol biosynthesisStefan Jennewein Institute of Biological Chemistry, Washington State University, Pullman, Washington 99164-6340, USA Biotechnol Bioeng 89:588-98 Menthofuran regulates essential oil biosynthesis in peppermint by controlling a downstream monoterpene reductaseSoheil S Mahmoud Institute of Biological Chemistry, Washingston State University, Pullman, WA 99164-6340, USA Proc Natl Acad Sci U S A 100:14481-6 | Collaborators
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Detail Information
Research Grants
BIOSYNTHESIS of TaxolRodney B Croteau; Fiscal Year: 2007
..This abstract is not available...
ENZYMATIC CYCLIZATION TO TERPENOID NATURAL PRODUCTSRodney B Croteau; Fiscal Year: 2007
..This abstract is not available...
BIOSYNTHESIS of TaxolRodney B Croteau; Fiscal Year: 2008
..This abstract is not available.
Public Health Relevance: This Public Health Relevance is not available...
Publications
Strategies for transgenic manipulation of monoterpene biosynthesis in plantsSoheil S Mahmoud
Institute of Biological Chemistry, Washington State University, Pullman, WA 99164, USA
Trends Plant Sci 7:366-73
Institute of Biological Chemistry, Washington State University, Pullman, WA 99164, USA
Trends Plant Sci 7:366-73
....
A systems biology approach identifies the biochemical mechanisms regulating monoterpenoid essential oil composition in peppermintRigoberto Rios Estepa
Institute of Biological Chemistry, M J Murdock Metabolomics Laboratory, Center for Integrated Biotechnology, and School of Chemical Engineering and Bioengineering, Washington State University, Pullman, WA 99164 6340, USA
Proc Natl Acad Sci U S A 105:2818-23
Institute of Biological Chemistry, M J Murdock Metabolomics Laboratory, Center for Integrated Biotechnology, and School of Chemical Engineering and Bioengineering, Washington State University, Pullman, WA 99164 6340, USA
Proc Natl Acad Sci U S A 105:2818-23
..These results illustrate the utility of iterative cycles of mathematical modeling and experimental testing to elucidate the mechanisms controlling flux through metabolic pathways...
Stable transformation and long-term maintenance of transgenic Taxus cell suspension culturesRaymond E B Ketchum
Institute of Biological Chemistry, Washington State University, Pullman, WA 99164 6340, USA
Plant Cell Rep 26:1025-33
Institute of Biological Chemistry, Washington State University, Pullman, WA 99164 6340, USA
Plant Cell Rep 26:1025-33
..The introduced genes had no discernable effect on growth or Taxol production in the transgenic cell lines when compared to the parent control. The methods for transforming non-embryogenic Taxus suspension cultures are described...
Administering cultured Taxus cells with early precursors reveals bifurcations in the taxoid biosynthetic pathwayRaymond E B Ketchum
Institute of Biological Chemistry, Washington State University, 299 Clark Hall, P O Box 646340, Pullman, WA 99164 6340, USA
Phytochemistry 68:335-41
Institute of Biological Chemistry, Washington State University, 299 Clark Hall, P O Box 646340, Pullman, WA 99164 6340, USA
Phytochemistry 68:335-41
....
(-)-Menthol biosynthesis and molecular geneticsRodney B Croteau
Institute of Biological Chemistry, Washington State University, Pullman, WA 99164 6340, USA
Naturwissenschaften 92:562-77
Institute of Biological Chemistry, Washington State University, Pullman, WA 99164 6340, USA
Naturwissenschaften 92:562-77
..Genetic engineering to up-regulate a flux-limiting step and down-regulate a side route reaction has led to improvement in the composition and yield of peppermint oil...
Genetic engineering of peppermint for improved essential oil composition and yieldMark R Wildung
Institute of Biological Chemistry, Washington State University, Pullman, WA 99164-6340, USA
Transgenic Res 14:365-72
Institute of Biological Chemistry, Washington State University, Pullman, WA 99164-6340, USA
Transgenic Res 14:365-72
..These experiments, along with related studies on other pathway genes, have led to a systematic, stepwise approach for the creation of a 'super' peppermint...
Genetic engineering of taxol biosynthetic genes in Saccharomyces cerevisiaeJinghong M DeJong
eXegenics, Inc, 2110 Research Row, Dallas, Texas 75235, USA
Biotechnol Bioeng 93:212-24
eXegenics, Inc, 2110 Research Row, Dallas, Texas 75235, USA
Biotechnol Bioeng 93:212-24
..The means of overcoming this limitation are described in the context of further development of this novel approach for production of Taxol precursors and related taxoids in yeast...
Taxus metabolomics: methyl jasmonate preferentially induces production of taxoids oxygenated at C-13 in Taxus x media cell culturesRaymond E B Ketchum
Institute of Biological Chemistry, Washington State University, Pullman, WA 99164, USA
Phytochemistry 62:901-9
Institute of Biological Chemistry, Washington State University, Pullman, WA 99164, USA
Phytochemistry 62:901-9
..Hicksii cell suspension cultures induced with methyl jasmonate to produce paclitaxel (Taxol). The majority of the taxoid metabolites produced in these induced cultures were oxygenated at C-13, and not C-14...
Coexpression in yeast of Taxus cytochrome P450 reductase with cytochrome P450 oxygenases involved in Taxol biosynthesisStefan Jennewein
Institute of Biological Chemistry, Washington State University, Pullman, Washington 99164-6340, USA
Biotechnol Bioeng 89:588-98
Institute of Biological Chemistry, Washington State University, Pullman, Washington 99164-6340, USA
Biotechnol Bioeng 89:588-98
..Functional transgenic coupling of the Taxus reductase with a homologous cytochrome P450 taxoid hydroxylase represents an important initial step in reconstructing Taxol biosynthesis in a microbial host...
Menthofuran regulates essential oil biosynthesis in peppermint by controlling a downstream monoterpene reductaseSoheil S Mahmoud
Institute of Biological Chemistry, Washingston State University, Pullman, WA 99164-6340, USA
Proc Natl Acad Sci U S A 100:14481-6
Institute of Biological Chemistry, Washingston State University, Pullman, WA 99164-6340, USA
Proc Natl Acad Sci U S A 100:14481-6
..The ability to reduce both menthofuran and pulegone levels is of commercial significance in improving essential oil quality; however, the physiological rationale for such complex regulation is presently unclear...
Bifunctional abietadiene synthase: mutual structural dependence of the active sites for protonation-initiated and ionization-initiated cyclizationsReuben J Peters
Institute of Biological Chemistry, Washington State University, Pullman, Washington 99164-6340, USA
Biochemistry 42:2700-7
Institute of Biological Chemistry, Washington State University, Pullman, Washington 99164-6340, USA
Biochemistry 42:2700-7
..Thus, the two cyclization sites of abietadiene synthase cannot be dissected into catalytically distinct domains, and, therefore, abietadiene synthase is unlikely to have arisen by fusion of two previously independent genes...
Structure of limonene synthase, a simple model for terpenoid cyclase catalysisDavid C Hyatt
Institute of Biological Chemistry, Washingston State University, Pullman, WA 99164 6340, USA
Proc Natl Acad Sci U S A 104:5360-5
Institute of Biological Chemistry, Washingston State University, Pullman, WA 99164 6340, USA
Proc Natl Acad Sci U S A 104:5360-5
..The implications of these findings are described for domain interactions in the homodimer and for changes in diphosphate-metal ion coordination and substrate binding conformation in the course of the multistep reaction...
Inhibition of monoterpene cyclases by inert analogues of geranyl diphosphate and linalyl diphosphateFrank Karp
Institute of Biological Chemistry, Washington State University, Pullman, WA 99164 6340, USA
Arch Biochem Biophys 468:140-6
Institute of Biological Chemistry, Washington State University, Pullman, WA 99164 6340, USA
Arch Biochem Biophys 468:140-6
....
Bornyl diphosphate synthase: structure and strategy for carbocation manipulation by a terpenoid cyclaseDouglas A Whittington
Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia 19104-6323, USA
Proc Natl Acad Sci U S A 99:15375-80
Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia 19104-6323, USA
Proc Natl Acad Sci U S A 99:15375-80
..Structures of complexes with aza analogues of substrate and carbocation intermediates, as well as complexes with pyrophosphate and bornyl diphosphate, provide "snapshots" of the terpene cyclization cascade...
Specificity of the N-benzoyl transferase responsible for the last step of Taxol biosynthesisRobert M Long
Institute of Biological Chemistry, Washington State University, Clark Hall, Pullman, WA 99164 6340, USA
Arch Biochem Biophys 477:384-9
Institute of Biological Chemistry, Washington State University, Clark Hall, Pullman, WA 99164 6340, USA
Arch Biochem Biophys 477:384-9
..These results support the proposed sequence of reactions for C13-O-side chain assembly in Taxol biosynthesis, and suggest that other N-transferases are responsible for the formation of related, late pathway, N-acylated taxoids...