Genomes and Genes
Peter A Crawford
Affiliation: Washington University School of Medicine
- Regulation of myocardial ketone body metabolism by the gut microbiota during nutrient deprivationPeter A Crawford
Center for Genome Sciences and Department of Medicine, Washington University School of Medicine, St Louis, MO 63108, USA
Proc Natl Acad Sci U S A 106:11276-81. 2009..Together, these results illustrate benefits provided by the gut microbiota during periods of nutrient deprivation, and emphasize the importance of further exploring the relationship between gut microbes and cardiovascular health...
- Low-carbohydrate ketogenic diets, glucose homeostasis, and nonalcoholic fatty liver diseaseRebecca C Schugar
Department of Medicine, Center for Cardiovascular Research, Washington University School of Medicine, St Louis, Missouri, USA
Curr Opin Clin Nutr Metab Care 15:374-80. 2012..This review focuses on the most recent findings that reveal the relationship between low-carbohydrate diets and NAFLD in rodent models and humans...
- Adaptation of myocardial substrate metabolism to a ketogenic nutrient environmentAnna E Wentz
Department of Medicine, Washington University, St Louis, Missouri 63108, USA
J Biol Chem 285:24447-56. 2010..These results indicate that ketotic nutrient environments engage mechanisms that curtail ketolytic capacity, controlling the utilization of ketone bodies in ketotic states...
- Hepatic steatosis, inflammation, and ER stress in mice maintained long term on a very low-carbohydrate ketogenic dietJoel R Garbow
Department of 1Medicine, Washington University, St Louis, Missouri 63110, USA
Am J Physiol Gastrointest Liver Physiol 300:G956-67. 2011..The distinctive nutrient milieu created by long-term administration of this low-carbohydrate, low-protein ketogenic diet in mice evokes unique signatures of nonalcoholic fatty liver disease and whole-body glucose homeostasis...
- Postnatal lymphatic partitioning from the blood vasculature in the small intestine requires fasting-induced adipose factorFredrik Backhed
Center for Genome Sciences, Washington University School of Medicine, St Louis, MO 63108, USA
Proc Natl Acad Sci U S A 104:606-11. 2007..This organ-specific lymphovascular abnormality can be rescued by allowing embryonic Fiaf-/- intestinal isografts to develop in Fiaf+/+ recipients...
- Altered systemic ketone body metabolism in advanced heart failureAjit Janardhan
Division of Cardiovascular Medicine, Department of Medicine, Washington University, St Louis, Missouri 63110, USA
Tex Heart Inst J 38:533-8. 2011..Future studies are needed to determine whether ketone body metabolism serves as a dynamic quantitative biomarker of skeletal myopathy and fatigue in heart failure...
- Microbial regulation of intestinal radiosensitivityPeter A Crawford
Center for Genome Sciences and Department of Molecular Biology, Washington University School of Medicine, St. Louis, MO 63108, USA
Proc Natl Acad Sci U S A 102:13254-9. 2005..Together, these findings provide insights about the cellular and molecular targets involved in microbial regulation of intestinal radiosensitivity...
- Akt2 deficiency promotes cardiac induction of Rab4a and myocardial β-adrenergic hypersensitivitySharon Etzion
Center for Cardiovascular Research, John Milliken Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
J Mol Cell Cardiol 49:931-40. 2010..This maladaptive response is associated with hypersensitivity of akt2(-/-) myocardium to β-adrenergic stimulation...
- Obligate role for ketone body oxidation in neonatal metabolic homeostasisDavid G Cotter
Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Biol Chem 286:6902-10. 2011..These results indicate the critical metabolic roles of ketone bodies in neonatal metabolism and suggest that distinct tissues exhibit specific metabolic responses to loss of ketone body oxidation...