Peter A Crawford

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. pmc Regulation of myocardial ketone body metabolism by the gut microbiota during nutrient deprivation
    Peter A Crawford
    Center for Genome Sciences and Department of Medicine, Washington University School of Medicine, St Louis, MO 63108, USA
    Proc Natl Acad Sci U S A 106:11276-81. 2009
  2. pmc Successful adaptation to ketosis by mice with tissue-specific deficiency of ketone body oxidation
    David G Cotter
    Division of Cardiology, Dept of Medicine, Washington Univ School of Medicine, St Louis, MO 63110, USA
    Am J Physiol Endocrinol Metab 304:E363-74. 2013
  3. pmc Impact of peripheral ketolytic deficiency on hepatic ketogenesis and gluconeogenesis during the transition to birth
    David G Cotter
    Department of Medicine, Washington University, St Louis, Missouri 63110, USA
    J Biol Chem 288:19739-49. 2013
  4. pmc Low-carbohydrate ketogenic diets, glucose homeostasis, and nonalcoholic fatty liver disease
    Rebecca C Schugar
    Department of Medicine, Center for Cardiovascular Research, Washington University School of Medicine, St Louis, Missouri, USA
    Curr Opin Clin Nutr Metab Care 15:374-80. 2012
  5. pmc Hepatic steatosis, inflammation, and ER stress in mice maintained long term on a very low-carbohydrate ketogenic diet
    Joel R Garbow
    Department of 1Medicine, Washington University, St Louis, Missouri 63110, USA
    Am J Physiol Gastrointest Liver Physiol 300:G956-67. 2011
  6. pmc Adaptation of myocardial substrate metabolism to a ketogenic nutrient environment
    Anna E Wentz
    Department of Medicine, Washington University, St Louis, Missouri 63108, USA
    J Biol Chem 285:24447-56. 2010
  7. pmc Role of choline deficiency in the Fatty liver phenotype of mice fed a low protein, very low carbohydrate ketogenic diet
    Rebecca C Schugar
    Department of Medicine, Center for Cardiovascular Research, Washington University, St Louis, Missouri, USA
    PLoS ONE 8:e74806. 2013
  8. pmc Postnatal lymphatic partitioning from the blood vasculature in the small intestine requires fasting-induced adipose factor
    Fredrik Backhed
    Center for Genome Sciences, Washington University School of Medicine, St Louis, MO 63108, USA
    Proc Natl Acad Sci U S A 104:606-11. 2007
  9. pmc PGC-1β and ChREBP partner to cooperatively regulate hepatic lipogenesis in a glucose concentration-dependent manner
    Kari T Chambers
    Center for Human Nutrition, Washington University School of Medicine, St Louis, MO 63110, United States Center for Cardiovascular Research, Washington University School of Medicine, St Louis, MO 63110, United States
    Mol Metab 2:194-204. 2013
  10. pmc Liver-specific PGC-1beta deficiency leads to impaired mitochondrial function and lipogenic response to fasting-refeeding
    Kari T Chambers
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS ONE 7:e52645. 2012

Collaborators

Detail Information

Publications16

  1. pmc Regulation of myocardial ketone body metabolism by the gut microbiota during nutrient deprivation
    Peter A Crawford
    Center for Genome Sciences and Department of Medicine, Washington University School of Medicine, St Louis, MO 63108, USA
    Proc Natl Acad Sci U S A 106:11276-81. 2009
    ..Together, these results illustrate benefits provided by the gut microbiota during periods of nutrient deprivation, and emphasize the importance of further exploring the relationship between gut microbes and cardiovascular health...
  2. pmc Successful adaptation to ketosis by mice with tissue-specific deficiency of ketone body oxidation
    David G Cotter
    Division of Cardiology, Dept of Medicine, Washington Univ School of Medicine, St Louis, MO 63110, USA
    Am J Physiol Endocrinol Metab 304:E363-74. 2013
    ....
  3. pmc Impact of peripheral ketolytic deficiency on hepatic ketogenesis and gluconeogenesis during the transition to birth
    David G Cotter
    Department of Medicine, Washington University, St Louis, Missouri 63110, USA
    J Biol Chem 288:19739-49. 2013
    ..Together, these results indicate that peripheral ketone body oxidation prevents hypoglycemia and supports hepatic metabolic homeostasis, which is critical for the maintenance of glycemia during the adaptation to birth. ..
  4. pmc Low-carbohydrate ketogenic diets, glucose homeostasis, and nonalcoholic fatty liver disease
    Rebecca C Schugar
    Department of Medicine, Center for Cardiovascular Research, Washington University School of Medicine, St Louis, Missouri, USA
    Curr Opin Clin Nutr Metab Care 15:374-80. 2012
    ..This review focuses on the most recent findings that reveal the relationship between low-carbohydrate diets and NAFLD in rodent models and humans...
  5. pmc Hepatic steatosis, inflammation, and ER stress in mice maintained long term on a very low-carbohydrate ketogenic diet
    Joel R Garbow
    Department of 1Medicine, Washington University, St Louis, Missouri 63110, USA
    Am J Physiol Gastrointest Liver Physiol 300:G956-67. 2011
    ..The distinctive nutrient milieu created by long-term administration of this low-carbohydrate, low-protein ketogenic diet in mice evokes unique signatures of nonalcoholic fatty liver disease and whole-body glucose homeostasis...
  6. pmc Adaptation of myocardial substrate metabolism to a ketogenic nutrient environment
    Anna E Wentz
    Department of Medicine, Washington University, St Louis, Missouri 63108, USA
    J Biol Chem 285:24447-56. 2010
    ..These results indicate that ketotic nutrient environments engage mechanisms that curtail ketolytic capacity, controlling the utilization of ketone bodies in ketotic states...
  7. pmc Role of choline deficiency in the Fatty liver phenotype of mice fed a low protein, very low carbohydrate ketogenic diet
    Rebecca C Schugar
    Department of Medicine, Center for Cardiovascular Research, Washington University, St Louis, Missouri, USA
    PLoS ONE 8:e74806. 2013
    ....
  8. pmc Postnatal lymphatic partitioning from the blood vasculature in the small intestine requires fasting-induced adipose factor
    Fredrik Backhed
    Center for Genome Sciences, Washington University School of Medicine, St Louis, MO 63108, USA
    Proc Natl Acad Sci U S A 104:606-11. 2007
    ..This organ-specific lymphovascular abnormality can be rescued by allowing embryonic Fiaf-/- intestinal isografts to develop in Fiaf+/+ recipients...
  9. pmc PGC-1β and ChREBP partner to cooperatively regulate hepatic lipogenesis in a glucose concentration-dependent manner
    Kari T Chambers
    Center for Human Nutrition, Washington University School of Medicine, St Louis, MO 63110, United States Center for Cardiovascular Research, Washington University School of Medicine, St Louis, MO 63110, United States
    Mol Metab 2:194-204. 2013
    ..These data suggest that PGC-1β-mediated coactivation of ChREBP is involved in the lipogenic response to hyperglycemia. ..
  10. pmc Liver-specific PGC-1beta deficiency leads to impaired mitochondrial function and lipogenic response to fasting-refeeding
    Kari T Chambers
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS ONE 7:e52645. 2012
    ..These results suggest that PGC-1β plays dual roles in regulating hepatic fatty acid metabolism by controlling the expression of programs of genes involved in both fatty acid oxidation and de novo fatty acid synthesis...
  11. pmc Metabolic stress in the myocardium: adaptations of gene expression
    Peter A Crawford
    Diabetic Cardiovascular Disease Center, Cardiovascular Division, Washington University School of Medicine, USA
    J Mol Cell Cardiol 55:130-8. 2013
    ..This article is part of a Special Issue entitled "Focus on Cardiac Metabolism"...
  12. pmc Altered systemic ketone body metabolism in advanced heart failure
    Ajit Janardhan
    Division of Cardiovascular Medicine, Department of Medicine, Washington University, St Louis, Missouri 63110, USA
    Tex Heart Inst J 38:533-8. 2011
    ..Future studies are needed to determine whether ketone body metabolism serves as a dynamic quantitative biomarker of skeletal myopathy and fatigue in heart failure...
  13. pmc X13CMS: global tracking of isotopic labels in untargeted metabolomics
    Xiaojing Huang
    Departments of Genetics, Medicine, and Chemistry, Washington University School of Medicine, St Louis, MO 63110, United States
    Anal Chem 86:1632-9. 2014
    ..Like XCMS, X(13)CMS is implemented in R. It is available from our laboratory website at http://pattilab.wustl.edu/x13cms.php . ..
  14. pmc Obligate role for ketone body oxidation in neonatal metabolic homeostasis
    David G Cotter
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 286:6902-10. 2011
    ..These results indicate the critical metabolic roles of ketone bodies in neonatal metabolism and suggest that distinct tissues exhibit specific metabolic responses to loss of ketone body oxidation...
  15. pmc Akt2 deficiency promotes cardiac induction of Rab4a and myocardial β-adrenergic hypersensitivity
    Sharon Etzion
    Center for Cardiovascular Research, John Milliken Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    J Mol Cell Cardiol 49:931-40. 2010
    ..This maladaptive response is associated with hypersensitivity of akt2(-/-) myocardium to β-adrenergic stimulation...
  16. pmc Microbial regulation of intestinal radiosensitivity
    Peter A Crawford
    Center for Genome Sciences and Department of Molecular Biology, Washington University School of Medicine, St Louis, MO 63108, USA
    Proc Natl Acad Sci U S A 102:13254-9. 2005
    ..Together, these findings provide insights about the cellular and molecular targets involved in microbial regulation of intestinal radiosensitivity...