Craig M Coopersmith

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. ncbi Overexpression of Bcl-2 in the intestinal epithelium improves survival in septic mice
    Craig M Coopersmith
    Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Crit Care Med 30:195-201. 2002
  2. ncbi Effect of an education program on decreasing catheter-related bloodstream infections in the surgical intensive care unit
    Craig M Coopersmith
    Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Crit Care Med 30:59-64. 2002
  3. ncbi Inhibition of intestinal epithelial apoptosis and survival in a murine model of pneumonia-induced sepsis
    Craig M Coopersmith
    Department of Surgery, Washington University School of Medicine, 660 S Euclid Ave, Campus Box 8109, St Louis, MO 63110, USA
    JAMA 287:1716-21. 2002
  4. ncbi The impact of bedside behavior on catheter-related bacteremia in the intensive care unit
    Craig M Coopersmith
    Department of Surgery, Washington University School of Medicine, St Louis, MO, USA
    Arch Surg 139:131-6. 2004
  5. ncbi High-dose exogenous iron following cecal ligation and puncture increases mortality rate in mice and is associated with an increase in gut epithelial and splenic apoptosis
    Pardis Javadi
    Department of Surgery, Washington University School of Medicine, St Louis, MO, USA
    Crit Care Med 32:1178-85. 2004
  6. pmc IL-15 prevents apoptosis, reverses innate and adaptive immune dysfunction, and improves survival in sepsis
    Shigeaki Inoue
    Department of Anesthesiology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 184:1401-9. 2010
  7. pmc Streptococcus pneumoniae and Pseudomonas aeruginosa pneumonia induce distinct host responses
    Kevin W McConnell
    Departments of Surgery, Washington University School of Medicine, St Louis, MO, USA
    Crit Care Med 38:223-41. 2010
  8. pmc Mechanisms of methicillin-resistant Staphylococcus aureus pneumonia-induced intestinal epithelial apoptosis
    Erin E Perrone
    Department of Surgery, Washington University School of Medicine, St Louis, Missouri, USA
    Shock 38:68-75. 2012
  9. pmc CD4+ lymphocytes control gut epithelial apoptosis and mediate survival in sepsis
    Paul E Stromberg
    Department of Surgery, Washington University School of Medicine, 660 South Euclid Ave, St Louis, MO 63110, USA
    FASEB J 23:1817-25. 2009
  10. pmc Characterization and modulation of the immunosuppressive phase of sepsis
    Jared T Muenzer
    Department of Pediatrics, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
    Infect Immun 78:1582-92. 2010

Collaborators

Detail Information

Publications76

  1. ncbi Overexpression of Bcl-2 in the intestinal epithelium improves survival in septic mice
    Craig M Coopersmith
    Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Crit Care Med 30:195-201. 2002
    ..The roles of the antiapoptotic protein Bcl-2 and the "executioner" protease caspase-3 in sepsis-induced gut cell death also were evaluated...
  2. ncbi Effect of an education program on decreasing catheter-related bloodstream infections in the surgical intensive care unit
    Craig M Coopersmith
    Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Crit Care Med 30:59-64. 2002
    ..The purpose of the study was to determine whether an education initiative aimed at improving central venous catheter insertion and care could decrease the rate of primary bloodstream infections...
  3. ncbi Inhibition of intestinal epithelial apoptosis and survival in a murine model of pneumonia-induced sepsis
    Craig M Coopersmith
    Department of Surgery, Washington University School of Medicine, 660 S Euclid Ave, Campus Box 8109, St Louis, MO 63110, USA
    JAMA 287:1716-21. 2002
    ..Increased intestinal epithelial apoptosis is present in both human autopsy studies and animal models of sepsis. Whether altering gut apoptosis decreases mortality in sepsis induced by pathogenic bacteria outside the gut is unknown...
  4. ncbi The impact of bedside behavior on catheter-related bacteremia in the intensive care unit
    Craig M Coopersmith
    Department of Surgery, Washington University School of Medicine, St Louis, MO, USA
    Arch Surg 139:131-6. 2004
    ..The success of an educational program in July 1999 that lowered the catheter-related bloodstream infection (CRBSI) rate in our intensive care unit (ICU) 3-fold is correlated with compliance with "best-practice" behaviors...
  5. ncbi High-dose exogenous iron following cecal ligation and puncture increases mortality rate in mice and is associated with an increase in gut epithelial and splenic apoptosis
    Pardis Javadi
    Department of Surgery, Washington University School of Medicine, St Louis, MO, USA
    Crit Care Med 32:1178-85. 2004
    ....
  6. pmc IL-15 prevents apoptosis, reverses innate and adaptive immune dysfunction, and improves survival in sepsis
    Shigeaki Inoue
    Department of Anesthesiology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 184:1401-9. 2010
    ..IL-15 represents a potentially novel therapy of this highly lethal disorder...
  7. pmc Streptococcus pneumoniae and Pseudomonas aeruginosa pneumonia induce distinct host responses
    Kevin W McConnell
    Departments of Surgery, Washington University School of Medicine, St Louis, MO, USA
    Crit Care Med 38:223-41. 2010
    ..The purpose of this study was to determine whether host response is similar after disparate infections with similar mortalities...
  8. pmc Mechanisms of methicillin-resistant Staphylococcus aureus pneumonia-induced intestinal epithelial apoptosis
    Erin E Perrone
    Department of Surgery, Washington University School of Medicine, St Louis, Missouri, USA
    Shock 38:68-75. 2012
    ..Methicillin-resistant S. aureus pneumonia thus induces organism-specific changes in intestinal apoptosis via changes in both the mitochondrial and receptor-mediated pathways, although the former may be more functionally significant...
  9. pmc CD4+ lymphocytes control gut epithelial apoptosis and mediate survival in sepsis
    Paul E Stromberg
    Department of Surgery, Washington University School of Medicine, 660 South Euclid Ave, St Louis, MO 63110, USA
    FASEB J 23:1817-25. 2009
    ..Thus, sepsis unmasks CD4(+) lymphocyte control of gut apoptosis that is not present under homeostatic conditions, which acts as a key determinant of both cellular survival and host mortality...
  10. pmc Characterization and modulation of the immunosuppressive phase of sepsis
    Jared T Muenzer
    Department of Pediatrics, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
    Infect Immun 78:1582-92. 2010
    ..However, by 7 days post-CLP, the host's immune system has recovered sufficiently to mount an effective immune response. Modulation of the immunosuppressive phase of sepsis may aid in the development of new therapeutic strategies...
  11. pmc Cancer causes increased mortality and is associated with altered apoptosis in murine sepsis
    Amy C Fox
    Departments of Surgery, Washington University School of Medicine, St Louis, MO, USA
    Crit Care Med 38:886-93. 2010
    ..Malignancy is the most common comorbidity associated with sepsis. The purpose of this study was to determine whether mice with cancer have a different response to sepsis than healthy animals...
  12. pmc Intestine-specific overexpression of IL-10 improves survival in polymicrobial sepsis
    Saju Rajan
    Department of Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Shock 29:483-9. 2008
    ....
  13. pmc Mechanisms of decreased intestinal epithelial proliferation and increased apoptosis in murine acute lung injury
    Kareem D Husain
    Departments of Surgery, Washington University School of Medicine, St Louis, MO, USA
    Crit Care Med 33:2350-7. 2005
    ..The relationship between severity and timing of lung injury to intestinal pathology was also examined...
  14. doi Implementation of a mandatory checklist of protocols and objectives improves compliance with a wide range of evidence-based intensive care unit practices
    Matthew C Byrnes
    Department of Surgery, Washington University School of Medicine, St Louis, MO, USA
    Crit Care Med 37:2775-81. 2009
    ..To determine a) if a checklist covering a diverse group of intensive care unit protocols and objectives would improve clinician consideration of these domains and b) if improved consideration would change practice patterns...
  15. ncbi Antibiotics improve survival and alter the inflammatory profile in a murine model of sepsis from Pseudomonas aeruginosa pneumonia
    Craig M Coopersmith
    Department of Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Shock 19:408-14. 2003
    ..These results indicate that both gentamicin and imipenem increase survival at least 10-fold in a model of pneumonia-induced monomicrobial sepsis, and this is predominantly associated with a down-regulation of proinflammatory cytokines...
  16. pmc Prevention of lymphocyte apoptosis in septic mice with cancer increases mortality
    Amy C Fox
    Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 187:1950-6. 2011
    ..These data demonstrate that, despite overwhelming evidence that prevention of lymphocyte apoptosis is beneficial in septic hosts without comorbidities, the same strategy worsens survival in mice with cancer that are given pneumonia...
  17. pmc Cecal ligation and puncture followed by methicillin-resistant Staphylococcus aureus pneumonia increases mortality in mice and blunts production of local and systemic cytokines
    Enjae Jung
    Department of Surgery, Washington University School of Medicine, St Louis, Missouri, USA
    Shock 37:85-94. 2012
    ....
  18. ncbi Age disproportionately increases sepsis-induced apoptosis in the spleen and gut epithelium
    Isaiah R Turnbull
    Department of Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Shock 22:364-8. 2004
    ....
  19. pmc The role of heat shock protein 70 in mediating age-dependent mortality in sepsis
    Kevin W McConnell
    Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 186:3718-25. 2011
    ..HSP70 may play a protective role in an age-dependent response to sepsis by preventing excessive gut apoptosis and both pulmonary and systemic inflammation...
  20. ncbi Sepsis from Pseudomonas aeruginosa pneumonia decreases intestinal proliferation and induces gut epithelial cell cycle arrest
    Craig M Coopersmith
    Department of Surgery, Washiongton University School of Medicine, St Louis, MO, USA
    Crit Care Med 31:1630-7. 2003
    ..To evaluate whether the up-regulation in sepsis-induced gut epithelial apoptosis is balanced by an increase in intestinal proliferation and to assess mechanisms affecting the gut's regenerative response to overwhelming infection...
  21. doi Staphylococcus aureus nasal colonization and subsequent infection in intensive care unit patients: does methicillin resistance matter?
    Hitoshi Honda
    Division of Infectious Diseases, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Infect Control Hosp Epidemiol 31:584-91. 2010
    ..aureus infection. However, MRSA-colonized patients may have more comorbidities than methicillin-susceptible S. aureus (MSSA)-colonized or noncolonized patients and therefore may be more susceptible to infection on that basis...
  22. pmc The endogenous bacteria alter gut epithelial apoptosis and decrease mortality following Pseudomonas aeruginosa pneumonia
    Amy C Fox
    Department of Surgery, Washington University School of Medicine, St Louis, MO, USA
    Shock 38:508-14. 2012
    ..In addition, sepsis-induced lymphocyte-dependent increases in gut epithelial apoptosis appear to be mediated by the endogenous bacteria...
  23. ncbi Bcl-2 inhibits gut epithelial apoptosis induced by acute lung injury in mice but has no effect on survival
    Kareem D Husain
    Department of Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Shock 20:437-43. 2003
    ....
  24. pmc Effects of aging on the immunopathologic response to sepsis
    Isaiah R Turnbull
    Department of Surgery, Washington University School of Medicine, St Louis, MO, USA
    Crit Care Med 37:1018-23. 2009
    ..The purpose of this study was to determine whether this represents a fundamental age-based difference in the host response or is secondary to the increased mortality seen in aged hosts...
  25. doi The impact of a simple, low-cost oral care protocol on ventilator-associated pneumonia rates in a surgical intensive care unit
    Carrie S Sona
    Departments of Nursing, Barnes Jewish Hospital, St Louis, Missouri, USA
    J Intensive Care Med 24:54-62. 2009
    ..The purpose of this study was to determine the effects of a simple low-cost oral care protocol on ventilator-associated pneumonia rates in a surgical intensive care unit...
  26. doi Tracheostomy protocol: experience with development and potential utility
    Bradley D Freeman
    Department of Surgery, Washington University School of Medicine, St Louis, MO, USA
    Crit Care Med 36:1742-8. 2008
    ..To examine the feasibility and potential utility of a tracheostomy protocol based on a standardized approach to ventilator weaning...
  27. pmc Epidermal growth factor treatment decreases mortality and is associated with improved gut integrity in sepsis
    Jessica A Clark
    Department of Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Shock 30:36-42. 2008
    ..Mortality decreased from 60% to 30% in mice treated with EGF after the onset of sepsis (P < 0.05). Thus, EGF may be a potential therapeutic agent for the treatment of sepsis in part due to its ability to protect intestinal integrity...
  28. pmc Inhibition of IKKβ in enterocytes exacerbates sepsis-induced intestinal injury and worsens mortality
    Jessica A Dominguez
    1Department of Anesthesiology, University of Colorado Anschutz Medical Campus, Aurora, CO 2Department of Surgery, Washington University School of Medicine, St Louis, MO 3Emory Center for Critical Care and Department of Surgery, Emory Healthcare and Emory University School of Medicine, Atlanta, GA 4Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA
    Crit Care Med 41:e275-85. 2013
    ..Nuclear factor-κB is a critical regulator of cell-survival genes and the host inflammatory response. The purpose of this study was to investigate the role of enterocyte-specific NF-kB in sepsis through selective ablation of IkB kinase...
  29. ncbi Antibiotics improve survival in sepsis independent of injury severity but do not change mortality in mice with markedly elevated interleukin 6 levels
    Isaiah R Turnbull
    Department of Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Shock 21:121-5. 2004
    ..Furthermore, there is a threshold IL-6 level that can be identified 6 h after sepsis above which animals are destined to die, and antibiotic treatment does not alter their outcome...
  30. ncbi Effect of chlorhexidine/silver sulfadiazine-impregnated central venous catheters in an intensive care unit with a low blood stream infection rate after implementation of an educational program: a before-after trial
    Douglas J E Schuerer
    Department of Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Surg Infect (Larchmt) 8:445-54. 2007
    ..The purpose of this study was to determine if chlorhexidine/silver sulfadiazine-impregnated CVCs could decrease the CR-BSI rate in an intensive care unit (ICU) with a low baseline infection rate...
  31. doi Lymphocyte phenotyping to distinguish septic from nonseptic critical illness
    Steven J Schwulst
    Department of Surgery, Washington University School of Medicine, St Louis, MO, USA
    J Am Coll Surg 206:335-42. 2008
    ..In this study, we hypothesized that lymphocyte phenotype can distinguish between septic and nonseptic critical illness...
  32. ncbi Patient safety event reporting in critical care: a study of three intensive care units
    Carolyn B Harris
    Department of Internal Medicine, Division of Infectious Diseases, Washington University School of Medicine, St Louis, MO, USA
    Crit Care Med 35:1068-76. 2007
    ..To increase patient safety event reporting in three intensive care units (ICUs) using a new voluntary card-based event reporting system and to compare and evaluate observed differences in reporting among healthcare workers across ICUs...
  33. pmc Early antibiotic administration but not antibody therapy directed against IL-6 improves survival in septic mice predicted to die on basis of high IL-6 levels
    Dinesh Vyas
    Washington University School of Medicine, 660 South Euclid Ave, Campus Box 8109, St Louis, MO 63110, USA
    Am J Physiol Regul Integr Comp Physiol 289:R1048-53. 2005
    ..These results demonstrate that earlier systemic therapy can improve outcome in a subset of mice predicted to die in sepsis, but we are unable to demonstrate any benefit in similar animals using targeted therapy directed at IL-6...
  34. ncbi Impact of a methicillin-resistant Staphylococcus aureus active surveillance program on contact precaution utilization in a surgical intensive care unit
    David K Warren
    Division of Infectious Diseases, Department of Surgery, Washington University School of Medicine, St Louis, and Barnes Jewish Hospital, St Louis, MO 63110, USA
    Crit Care Med 35:430-4. 2007
    ....
  35. pmc Enterocyte-specific epidermal growth factor prevents barrier dysfunction and improves mortality in murine peritonitis
    Jessica A Clark
    Department of Surgery, Washington University School of Medicine, St Louis, Missouri, USA
    Am J Physiol Gastrointest Liver Physiol 297:G471-9. 2009
    ....
  36. doi Myocardial transcriptional profiles in a murine model of sepsis: evidence for the importance of age
    Paul A Checchia
    Center for Critical Illness and Health Engineering and the Departments of Pediatrics and Surgery, Washington University School of Medicine, St Louis, MO, USA
    Pediatr Crit Care Med 9:530-5. 2008
    ..We hypothesized that analysis of cardiac RNA expression profiles may differentiate between the myocardial response to sepsis in young and old mice...
  37. pmc Neutrophil depletion causes a fatal defect in murine pulmonary Staphylococcus aureus clearance
    Charles M Robertson
    Department of Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Surg Res 150:278-85. 2008
    ..Staphylococcus aureus is the most common cause of healthcare-associated pneumonia. Despite the significant morbidity and mortality associated with the disease, animal models of S. aureus pneumonia are rare...
  38. pmc Inhibition of intestinal epithelial apoptosis improves survival in a murine model of radiation combined injury
    Enjae Jung
    Department of Surgery, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS ONE 8:e77203. 2013
    ....
  39. ncbi Mupirocin resistance in patients colonized with methicillin-resistant Staphylococcus aureus in a surgical intensive care unit
    Jeffrey C Jones
    Division of Infectious Diseases, Washington University School of Medicine, St Louis, MO 63110, USA
    Clin Infect Dis 45:541-7. 2007
    ..Mupirocin resistance in patients with MRSA has been reported, usually in the context of widespread mupirocin use...
  40. ncbi Sequence makes a difference: paradoxical effects of stress in vivo
    Joseph J Wizorek
    Cellular Injury and Adaptation Laboratory, Department of Surgery, Washington University, St Louis, Missouri 63130, USA
    Shock 22:229-33. 2004
    ..The cellular mechanisms responsible for these "stressor" paradoxes in vivo are not known, but do not involve altered sepsis-induced apoptosis...
  41. pmc Iron dysregulation combined with aging prevents sepsis-induced apoptosis
    Pardis Javadi
    Department of Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Surg Res 128:37-44. 2005
    ..Sepsis, iron loading, and aging cause independent increases in gut epithelial and splenic apoptosis. It is unknown how their combination will affect apoptosis and systemic cytokine levels...
  42. pmc Intestine-specific Mttp deletion decreases mortality and prevents sepsis-induced intestinal injury in a murine model of Pseudomonas aeruginosa pneumonia
    Jessica A Dominguez
    Department of Surgery, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS ONE 7:e49159. 2012
    ..Here we studied the outcome of sepsis in mice with conditional, intestine-specific deletion of microsomal triglyceride transfer protein (Mttp-IKO), which exhibit a block in chylomicron assembly together with lipid malabsorption...
  43. ncbi Accelerated lymphocyte death in sepsis occurs by both the death receptor and mitochondrial pathways
    Richard S Hotchkiss
    Department of Anesthesiology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 174:5110-8. 2005
    ..Lymphocyte loss occurs by both death receptor and mitochondrial-mediated apoptosis, suggesting that there may be multiple triggers for lymphocyte apoptosis...
  44. ncbi Anti-apoptotic peptides protect against radiation-induced cell death
    Kevin W McConnell
    Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Biochem Biophys Res Commun 355:501-7. 2007
    ..Thus, by targeting steps within the apoptosis signaling pathway it is possible to develop post-exposure treatments to protect radio-sensitive tissues...
  45. pmc Adoptive transfer of dying cells causes bystander-induced apoptosis
    Steven J Schwulst
    Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Biochem Biophys Res Commun 353:780-5. 2007
    ..05). Therefore, this data suggests that dying cells emit signals triggering cell death in neighboring non-Bcl-2 overexpressing cells, i.e., a "trans" destructive effect...
  46. ncbi TAT-BH4 and TAT-Bcl-xL peptides protect against sepsis-induced lymphocyte apoptosis in vivo
    Richard S Hotchkiss
    Department of Anesthesiology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    J Immunol 176:5471-7. 2006
    ..In conclusion, TAT-conjugated antiapoptotic Bcl-2-like peptides may offer a novel therapy to prevent apoptosis in sepsis and improve survival...
  47. doi Examination of non-clinical factors affecting tracheostomy practice in an academic surgical intensive care unit
    Bradley D Freeman
    Departmentsof Surgery, Washington University School of Medicine, St Louis, MO, USA
    Crit Care Med 37:3070-8. 2009
    ..To gain insight into nonclinical factors potentially influencing tracheostomy practice and determine whether a specialized consultation form impacts tracheostomy utilization...
  48. ncbi Efficacy and safety of an insulin infusion protocol in a surgical ICU
    Beth E Taylor
    Department of Food and Nutrition, Barnes Jewish Hospital, St Louis, MO, USA
    J Am Coll Surg 202:1-9. 2006
    ..The purpose of this study was to determine the efficacy and safety of nurse-driven insulin infusion protocols in lowering blood glucose (BG) in critical illness...
  49. pmc Pharmacoepidemiology of QT-interval prolonging drug administration in critically ill patients
    Bradley D Freeman
    Department of Surgery, School of Medicine, Washington University, St Louis, MO 63110, USA
    Pharmacoepidemiol Drug Saf 17:971-81. 2008
    ..Commonly prescribed medications produce QT-prolongation and are associated with torsades de pointes in non-acutely ill patients. We examined patterns of QT-prolonging drug use in critically ill individuals...
  50. ncbi Prevention of lymphocyte apoptosis--a potential treatment of sepsis?
    Richard S Hotchkiss
    Department of Anesthesiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Clin Infect Dis 41:S465-9. 2005
    ..A variety of strategies to inhibit apoptosis may ultimately provide an effective therapy for this highly lethal disorder...
  51. pmc Prevalence and cost of full-time research fellowships during general surgery residency: a national survey
    Charles M Robertson
    Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Ann Surg 249:155-61. 2009
    ..To quantify the prevalence, outcomes, and cost of surgical resident research...
  52. doi Catheter-related bloodstream infection
    Matthew R Goede
    Surgical Critical Care, Barnes Jewish Hospital Washington University School of Medicine, St Louis, MO 63110, USA
    Surg Clin North Am 89:463-74, ix. 2009
    ..The diagnosis of CR-BSI is made largely based on culture results. CR-BSIs should always be treated with antibiotics, and except in rare circumstances the infected catheter needs to be removed...
  53. pmc Neutrophil-mediated oxidative burst and host defense are controlled by a Vav-PLCgamma2 signaling axis in mice
    Daniel B Graham
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri, USA
    J Clin Invest 117:3445-52. 2007
    ..Taken together, our data indicate that integrin-dependent signals generated during neutrophil adhesion contribute to the activation of NADPH oxidase by a variety of distinct effector pathways, all of which require Vav...
  54. ncbi Treatment of hypophosphatemia using a protocol based on patient weight and serum phosphorus level in a surgical intensive care unit
    Beth E Taylor
    Department of Food and Nutrition, Barnes Jewish Hospital, 660 S Euclid Avenue, St Louis, MO 63110, USA
    J Am Coll Surg 198:198-204. 2004
    ..Hypophosphatemia may cause organ derangements in the surgical intensive care unit. The purpose of this study was to determine the impact of a repletion protocol for hypophosphatemia based on admission weight and phosphorus level...
  55. ncbi Effect of an education program aimed at reducing the occurrence of ventilator-associated pneumonia
    Jeanne E Zack
    Department of Hospital Epidemiology, Barnes Jewish Hospital, St Louis, MO, USA
    Crit Care Med 30:2407-12. 2002
    ..The purpose of the study was to determine whether an education initiative could decrease the hospital rate of ventilator-associated pneumonia...
  56. ncbi Genetic research and testing in critical care: surrogates' perspective
    Bradley D Freeman
    Department of Surgery, Washington University School of Medicine, St Louis, MO, USA
    Crit Care Med 34:986-94. 2006
    ..This study explored the perspectives of surrogate decision-makers (SDMs) for acutely ill patients with respect to social, legal, and ethical aspects of genetic testing...
  57. ncbi Role of intestinal epithelial apoptosis in survival
    Kareem D Husain
    Department of Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Curr Opin Crit Care 9:159-63. 2003
    ..To outline evidence that suggests increased intestinal epithelial apoptosis (programmed cell death) plays an important role in critical illness of infectious and noninfectious origin...
  58. pmc Targeted delivery of siRNA to cell death proteins in sepsis
    Pavan Brahmamdam
    Department of Surgery, Washington University in St Louis, School of Medicine, St Louis, Missouri 63110, USA
    Shock 32:131-9. 2009
    ....
  59. ncbi A new safety event reporting system improves physician reporting in the surgical intensive care unit
    Douglas J E Schuerer
    Department of Surgery, Division of General Surgery, Washington University in St Louis School of Medicine, St Louis, MO, USA
    J Am Coll Surg 202:881-7. 2006
    ..In the SICU, reporting was generally poor and reporting by physicians was virtually nonexistent. This study was designed to observe changes in error reporting in an SICU when a new card-based system (SAFE) was introduced...
  60. ncbi Epidemiology of methicillin-resistant Staphylococcus aureus colonization in a surgical intensive care unit
    David K Warren
    Division of Infectious Diseases, Washington University School of Medicine, Barnes Jewish Hospital, Saint Louis, MO 63110, USA
    Infect Control Hosp Epidemiol 27:1032-40. 2006
    ..Methicillin-resistant Staphylococcus aureus (MRSA) is a cause of healthcare-associated infections among surgical intensive care unit (ICU) patients, though transmission dynamics are unclear...
  61. doi Improved extubation rates and earlier liberation from mechanical ventilation with implementation of a daily spontaneous-breathing trial protocol
    T Elizabeth Robertson
    Department of Surgery, Washington University School of Medicine, St Louis, MO, USA
    J Am Coll Surg 206:489-95. 2008
    ..Here we determine whether implementation of a mandatory, protocol-driven daily SBT on all ventilated patients in the ICU improves extubation rates and accelerates liberation from mechanical ventilation...
  62. ncbi Epithelial cells
    Kevin W McConnell
    Department of Surgery, Washington University School of Medicine, St Louis, MO, USA
    Crit Care Med 33:S520-2. 2005
  63. ncbi Use of hypochlorite solution to decrease rates of Clostridium difficile-associated diarrhea
    Kathleen M McMullen
    Barnes Jewish Hospital, St Louis, MO 63108, USA
    Infect Control Hosp Epidemiol 28:205-7. 2007
    ..One unit instituted enhanced environmental cleaning with a hypochlorite solution in all rooms, whereas the other unit used hypochlorite solution only in rooms of patients with CDAD. The CDAD rates decreased in both units...
  64. ncbi Effects of age on mortality and antibiotic efficacy in cecal ligation and puncture
    Isaiah R Turnbull
    Department of Surgery, Washington University School of Medicine, St Louis, Missouri 63110 1093, USA
    Shock 19:310-3. 2003
    ..However, high IL-6 was predictive of mortality at any age. Mice appear to have age-dependent responses to intra-abdominal sepsis and to appropriate therapy...
  65. pmc Plasticity of the systemic inflammatory response to acute infection during critical illness: development of the riboleukogram
    Jonathan E McDunn
    Center for Critical Illness and Health Engineering, Department of Surgery, Washington University in St Louis, St Louis, Missouri, USA
    PLoS ONE 3:e1564. 2008
    ..We hypothesized that circulating leukocyte transcriptional profiles can be used to monitor the host response to and recovery from infection complicating critical illness...
  66. ncbi Vasoactive drugs and the gut: is there anything new?
    Cheryl A Woolsey
    Department of Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Curr Opin Crit Care 12:155-9. 2006
    ..This review will highlight recent studies examining secondary effects of vasoactive agents on intestinal perfusion, metabolism, and barrier function...
  67. ncbi Relationship between tracheostomy timing and duration of mechanical ventilation in critically ill patients
    Bradley D Freeman
    Department of Surgery, Washington University School of Medicine, St Louis, MO, USA
    Crit Care Med 33:2513-20. 2005
    ....
  68. doi Extracorporeal membrane oxygenation: current clinical practice, coding, and reimbursement
    Douglas J E Schuerer
    Department of Surgery, Washington University School of Medicine, 660 South Euclid Ave, Campus Box 8109, St Louis, MO 63110, USA
    Chest 134:179-84. 2008
    ..In addition, current practice management related to coding and reimbursement for this intensive therapy will be discussed...
  69. pmc Intestinal crosstalk: a new paradigm for understanding the gut as the "motor" of critical illness
    Jessica A Clark
    Department of Surgery, Washington University School of Medicine, St Louis, Missouri, USA
    Shock 28:384-93. 2007
    ....
  70. ncbi The systemic inflammatory response syndrome
    Charles M Robertson
    Department of Surgery, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8109, St Louis, MO 63110, USA
    Microbes Infect 8:1382-9. 2006
    ..This review outlines the pathophysiology of SIRS and highlights potential targets for future therapeutic intervention in patients with this complex entity...
  71. pmc Long-term outcomes of performing a postdoctoral research fellowship during general surgery residency
    Charles M Robertson
    Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Ann Surg 245:516-23. 2007
    ..To determine whether dedicated research time during surgical residency leads to funding following postgraduate training...
  72. ncbi Prevention of catheter-related blood stream infection
    Matthew C Byrnes
    Department of Surgery, Washington University School of Medicine, St Louis, Missouri, USA
    Curr Opin Crit Care 13:411-5. 2007
    ..Catheter-related blood stream infections are a morbid complication of central venous catheters. This review will highlight a comprehensive approach demonstrated to prevent catheter-related blood stream infections...
  73. ncbi Mitochondrial membrane dysfunction in endotoxemia: the difference between what's in and what's out
    Craig M Coopersmith
    Crit Care Med 32:607-9. 2004
  74. ncbi Mitochondrial resuscitation with exogenous cytochrome c in the septic heart
    David A Piel
    Department of Anesthesiology and Critical Care Medicine, The Children s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA, USA
    Crit Care Med 35:2120-7. 2007
    ..In the septic heart, cytochrome oxidase is competitively inhibited. We hypothesized that cytochrome oxidase inhibition coupled with reduced substrate availability is a reversible cause of sepsis-associated myocardial depression...
  75. pmc Just the right amount of JNK: How nuclear factor-kappaB and downstream mediators prevent burn-induced intestinal injury
    Jessica A Clark
    Crit Care Med 35:1433-4. 2007
  76. pmc Intestinal dysplasia induced by simian virus 40 T antigen is independent of p53
    Jennifer A Markovics
    Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA
    J Virol 79:7492-502. 2005
    ..These data indicate that loss of p53 function does not play a role in T antigen-induced dysplasia in the intestine. Rather, some unknown function of T antigen is essential for progression beyond hyperplasia...