John Constantino

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. ncbi request reprint Rapid quantitative assessment of autistic social impairment by classroom teachers
    John N Constantino
    Program of Occupational Therapy, Washington University in St Louis, 660 S Euclid, Campus Box 8134, St Louis, MO 63110, USA
    J Am Acad Child Adolesc Psychiatry 46:1668-76. 2007
  2. pmc Sibling recurrence and the genetic epidemiology of autism
    John N Constantino
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Psychiatry 167:1349-56. 2010
  3. ncbi request reprint Clarifying the associations between language and social development in autism: a study of non-native phoneme recognition
    John N Constantino
    Department of Psychiatry, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8134, St Louis, MO 63110, USA
    J Autism Dev Disord 37:1256-63. 2007
  4. ncbi request reprint Mental representations of attachment in identical female twins with and without conduct problems
    John N Constantino
    Department of Psychiatry, Washington University School of Medicine, 660 South Euclid Ave, Campus Box 8134, St Louis, MO 63110, USA
    Child Psychiatry Hum Dev 37:65-72. 2006
  5. ncbi request reprint Autistic social impairment in the siblings of children with pervasive developmental disorders
    John N Constantino
    Department of Psychiatry, Washington University School of Medicine, 660 S Euclid Ave, Campus Box 8134, St Louis, MO 63110, USA
    Am J Psychiatry 163:294-6. 2006
  6. ncbi request reprint Intergenerational transmission of subthreshold autistic traits in the general population
    John N Constantino
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Biol Psychiatry 57:655-60. 2005
  7. ncbi request reprint The factor structure of autistic traits
    John N Constantino
    Washington University School of Medicine, Missouri 63110, USA
    J Child Psychol Psychiatry 45:719-26. 2004
  8. pmc Developmental course of autistic social impairment in males
    John N Constantino
    Washington University School of Medicine, St Louis, MO 63110, USA
    Dev Psychopathol 21:127-38. 2009
  9. pmc The quantitative nature of autistic social impairment
    John N Constantino
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Pediatr Res 69:55R-62R. 2011
  10. ncbi request reprint Brief report: autistic traits in twins vs. non-twins--a preliminary study
    Alexander Ho
    Washington University School of Medicine, Saint Louis, MO 63110, USA
    J Autism Dev Disord 35:129-33. 2005

Research Grants

  1. A QUANTITATIVE GENETIC MEASURE OF AUTISTIC TRAITS
    John Constantino; Fiscal Year: 2002
  2. Autistic Traits: Life Course & Genetic Structure
    John Constantino; Fiscal Year: 2009
  3. Autistic Traits: Life Course and Genetic Structure
    John Constantino; Fiscal Year: 2007
  4. Autistic Traits: Life Course and Genetic Structure SUPPLEMENT
    John Constantino; Fiscal Year: 2006
  5. Autistic Traits: Life Course & Genetic Structure
    John N Constantino; Fiscal Year: 2010

Detail Information

Publications27

  1. ncbi request reprint Rapid quantitative assessment of autistic social impairment by classroom teachers
    John N Constantino
    Program of Occupational Therapy, Washington University in St Louis, 660 S Euclid, Campus Box 8134, St Louis, MO 63110, USA
    J Am Acad Child Adolesc Psychiatry 46:1668-76. 2007
    ..In this study, we compared teachers' ratings of autistic symptomatology with those derived from parents, expert clinicians, and trained raters...
  2. pmc Sibling recurrence and the genetic epidemiology of autism
    John N Constantino
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Psychiatry 167:1349-56. 2010
    ..Although the symptoms of autism exhibit quantitative distributions in nature, estimates of recurrence risk in families have never previously considered or incorporated quantitative characterization of the autistic phenotype among siblings...
  3. ncbi request reprint Clarifying the associations between language and social development in autism: a study of non-native phoneme recognition
    John N Constantino
    Department of Psychiatry, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8134, St Louis, MO 63110, USA
    J Autism Dev Disord 37:1256-63. 2007
    ..Although earlier in autistic development there may exist qualitative deficits in this specific aspect of AIP, they are not an enduring characteristic of verbal school-aged children with ASD...
  4. ncbi request reprint Mental representations of attachment in identical female twins with and without conduct problems
    John N Constantino
    Department of Psychiatry, Washington University School of Medicine, 660 South Euclid Ave, Campus Box 8134, St Louis, MO 63110, USA
    Child Psychiatry Hum Dev 37:65-72. 2006
    ..In this sample of twins with and without histories of Conduct Disorder, mental representations of attachment appear to be highly familial, i.e., strongly influenced by either shared environmental factors, genetic factors, or both...
  5. ncbi request reprint Autistic social impairment in the siblings of children with pervasive developmental disorders
    John N Constantino
    Department of Psychiatry, Washington University School of Medicine, 660 S Euclid Ave, Campus Box 8134, St Louis, MO 63110, USA
    Am J Psychiatry 163:294-6. 2006
    ..Sibling recurrence risk in autism has been estimated to be approximately 10%. This study investigated subsyndromal autistic impairments among siblings of probands with pervasive developmental disorders...
  6. ncbi request reprint Intergenerational transmission of subthreshold autistic traits in the general population
    John N Constantino
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Biol Psychiatry 57:655-60. 2005
    ..Subthreshold autistic social impairments are known to aggregate in the family members of autistic probands; therefore, we conducted this study to examine the intergenerational transmission of such traits in the general population...
  7. ncbi request reprint The factor structure of autistic traits
    John N Constantino
    Washington University School of Medicine, Missouri 63110, USA
    J Child Psychol Psychiatry 45:719-26. 2004
    ..The identification of 'endophenotypes' of the autistic syndrome may be very useful for genetic and neurobiologic studies of autism, but only if they represent truly independent sub domains of the disorder...
  8. pmc Developmental course of autistic social impairment in males
    John N Constantino
    Washington University School of Medicine, St Louis, MO 63110, USA
    Dev Psychopathol 21:127-38. 2009
    ..Such measurements can serve as reliable indices of phenotypic severity for genetic and neurobiologic studies, and have potential utility for ascertaining incremental response to intervention...
  9. pmc The quantitative nature of autistic social impairment
    John N Constantino
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Pediatr Res 69:55R-62R. 2011
    ....
  10. ncbi request reprint Brief report: autistic traits in twins vs. non-twins--a preliminary study
    Alexander Ho
    Washington University School of Medicine, Saint Louis, MO 63110, USA
    J Autism Dev Disord 35:129-33. 2005
    ..As has been suggested for autism, twin status may incur increased liability to subthreshold autistic symptomatology, particularly in males...
  11. pmc Familial aggregation of quantitative autistic traits in multiplex versus simplex autism
    Yamini V Virkud
    Departments of Psychiatry, Washington University, St Louis, Missouri, USA
    Am J Med Genet B Neuropsychiatr Genet 150:328-34. 2009
    ..Characterization of QAT and other endophenotypes among close relatives may be useful for reducing sample heterogeneity in future genetic and neurobiologic studies of autism...
  12. ncbi request reprint Autistic traits in a population-based ADHD twin sample
    Angela M Reiersen
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110 1093, USA
    J Child Psychol Psychiatry 48:464-72. 2007
    ..This study assesses whether children with ADHD selected from the general twin population have elevated levels of autistic traits...
  13. doi request reprint Co-occurrence of motor problems and autistic symptoms in attention-deficit/hyperactivity disorder
    Angela M Reiersen
    Department of Psychiatry Box 8134, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110 1093, USA
    J Am Acad Child Adolesc Psychiatry 47:662-72. 2008
    ..To investigate the relation between parent reports of motor problems and clinically significant autistic symptoms in children with and without attention-deficit/hyperactivity disorder (ADHD)...
  14. pmc Brief report: Under-representation of African americans in autism genetic research: a rationale for inclusion of subjects representing diverse family structures
    Claudia L Hilton
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    J Autism Dev Disord 40:633-9. 2010
    ..Comprehensive efforts-including expansion of eligibility to families of diverse structure-are warranted to facilitate the inclusion of African American children in biomedical research...
  15. ncbi request reprint Application of the seven-factor model of personality to early childhood
    John N Constantino
    Department of Psychiatry, Washington University School of Medicine, Campus Box 8134, 660 South Euclid Ave, Saint Louis, MO 63110, USA
    Psychiatry Res 109:229-43. 2002
    ..Future studies are warranted to test the extent to which early childhood measurements of the seven factors might predict the development of personality disorders...
  16. ncbi request reprint Novelty seeking as a moderator of familial risk for alcohol dependence
    Richard A Grucza
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Alcohol Clin Exp Res 30:1176-83. 2006
    ..We examined this possibility by analyzing the association between NS and alcohol dependence in individuals at intermediate and high levels of familial risk for alcohol dependence...
  17. ncbi request reprint Validation of a brief quantitative measure of autistic traits: comparison of the social responsiveness scale with the autism diagnostic interview-revised
    John N Constantino
    Department of Psychiatry, Washington University School of Medicine, Saint Louis, Missouri 63110, USA
    J Autism Dev Disord 33:427-33. 2003
    ..Q. and exhibited inter-rater reliability on the order of 0.8. The SRS is a valid quantitative measure of autistic traits, feasible for use in clinical settings and for large-scale research studies of autism spectrum conditions...
  18. ncbi request reprint Autistic traits in the general population: a twin study
    John N Constantino
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Arch Gen Psychiatry 60:524-30. 2003
    ....
  19. ncbi request reprint Deficits in reciprocal social behavior in male twins: evidence for a genetically independent domain of psychopathology
    John N Constantino
    Department of Psychiatry, Washington University School of Medicine, Campus Box 8134, 660 South Euclid Avenue, St Louis, MO 63110, USA
    J Am Acad Child Adolesc Psychiatry 42:458-67. 2003
    ....
  20. pmc Evidence for shared genetic influences on self-reported ADHD and autistic symptoms in young adult Australian twins
    Angela M Reiersen
    Department of Psychiatry, Washington University in St Louis School of Medicine, St Louis 63110, USA
    Twin Res Hum Genet 11:579-85. 2008
    ..72. Our results suggest that in young adults, a substantial proportion of the genetic influences on self-reported autistic and ADHD symptoms may be shared between the two disorders...
  21. doi request reprint Motor impairment in sibling pairs concordant and discordant for autism spectrum disorders
    Claudia List Hilton
    Washington University in St Louis, MO, USA
    Autism 16:430-41. 2012
    ..We used a standardized measure of motor proficiency to objectively examine quantitative variation in motor proficiency in sibling pairs concordant and discordant for ASD...
  22. ncbi request reprint Quantitative assessment of autistic symptomatology in preschoolers
    Elyse Pine
    Washington University School of Medicine, Department of Psychiatry, St Louis, MO 63110, USA
    Autism 10:344-52. 2006
    ..We conclude that it is possible to obtain reliable quantitative measurements of autistic social impairment in preschoolers, suitable for assessing treatment response...
  23. ncbi request reprint The National Health Service Corps: disparities in service to the mentally ill in Missouri and the United States
    Chris Loynd
    Department of Psychiatry, Washington University School of Medicine, USA
    Mo Med 105:90-2. 2008
    ..S. is far less than that for primary health care. Revisions to the method by which the program prioritizes support of HPSAs are strongly and urgently warranted...
  24. ncbi request reprint Lack of evidence for increased genetic loading for autism among families of affected females: a replication from family history data in two large samples
    Robin P Goin-Kochel
    Baylor College of Medicine, Houston, USA
    Autism 11:279-86. 2007
    ..Results from both samples did not suggest significant differences in the prevalence of ASD among relatives of affected males versus females...
  25. ncbi request reprint Mapping autism risk loci using genetic linkage and chromosomal rearrangements
    Peter Szatmari
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario L8N 3Z5, Canada
    Nat Genet 39:319-28. 2007
    ..Neurexins team with previously implicated neuroligins for glutamatergic synaptogenesis, highlighting glutamate-related genes as promising candidates for contributing to ASDs...
  26. ncbi request reprint A quantitative trait locus analysis of social responsiveness in multiplex autism families
    Jacqueline A Duvall
    Department of Neurology, University of California, Los Angeles, USA
    Am J Psychiatry 164:656-62. 2007
    ..The authors present the first genome-wide scan for a social endophenotype in autism using the Social Responsiveness Scale, which provides a quantitative measure of autistic-like behavior, primarily focused on social relatedness...

Research Grants10

  1. A QUANTITATIVE GENETIC MEASURE OF AUTISTIC TRAITS
    John Constantino; Fiscal Year: 2002
    ..If the SRS compares favorably with the ADI-R, the SRS could feasibly be used to study the genetics of autism by examining the genetic structure of autistic traits in whole populations. ..
  2. Autistic Traits: Life Course & Genetic Structure
    John Constantino; Fiscal Year: 2009
    ....
  3. Autistic Traits: Life Course and Genetic Structure
    John Constantino; Fiscal Year: 2007
    ..Q., SES, comorbid psychiatric conditions, and treatment conditions. The factor structure of sub threshold autistic traits, and the extent to which they aggregate in the family members of affected individuals, will also be explored. ..
  4. Autistic Traits: Life Course and Genetic Structure SUPPLEMENT
    John Constantino; Fiscal Year: 2006
    ..Furthermore, these quantitative methods could be applied to large collections of extended autism pedigrees and could greatly enhance the power to identify other genes of major effect in autism. ..
  5. Autistic Traits: Life Course & Genetic Structure
    John N Constantino; Fiscal Year: 2010
    ....