Marco Colonna

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. ncbi request reprint TREMs in the immune system and beyond
    Marco Colonna
    Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
    Nat Rev Immunol 3:445-53. 2003
  2. ncbi request reprint Inhibitory receptors: friend or foe?
    Marco Colonna
    Washington University School of Medicine, St Louis, MO 63110, USA
    Lancet 361:1067-8. 2003
  3. pmc Macrophage colony-stimulating factor induces the proliferation and survival of macrophages via a pathway involving DAP12 and beta-catenin
    Karel Otero
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri, USA
    Nat Immunol 10:734-43. 2009
  4. ncbi request reprint Cutting edge: TREM-2 attenuates macrophage activation
    Isaiah R Turnbull
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 177:3520-4. 2006
  5. ncbi request reprint Dendritic cells respond to influenza virus through TLR7- and PKR-independent pathways
    Winfried Barchet
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Eur J Immunol 35:236-42. 2005
  6. pmc IL-34 is a tissue-restricted ligand of CSF1R required for the development of Langerhans cells and microglia
    Yaming Wang
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri, USA
    Nat Immunol 13:753-60. 2012
  7. ncbi request reprint TLR9-dependent recognition of MCMV by IPC and DC generates coordinated cytokine responses that activate antiviral NK cell function
    Anne Krug
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Immunity 21:107-19. 2004
  8. ncbi request reprint Vav1 controls DAP10-mediated natural cytotoxicity by regulating actin and microtubule dynamics
    Daniel B Graham
    Department of Pathology and Immunology, Washington University School of Medicine and Siteman Cancer Center, 660 South Euclid Avenue, St Louis, MO 63110, USA
    J Immunol 177:2349-55. 2006
  9. pmc Distinct and complementary functions of MDA5 and TLR3 in poly(I:C)-mediated activation of mouse NK cells
    Stephen McCartney
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Exp Med 206:2967-76. 2009
  10. pmc CRTAM controls residency of gut CD4+CD8+ T cells in the steady state and maintenance of gut CD4+ Th17 during parasitic infection
    Victor S Cortez
    Department of Pathology and Immunology, 2 Department of Internal Medicine, 3 Department of Molecular Microbiology, and 4 Howard Hughes Medical Institute, Washington University School of Medicine, St Louis, MO 63110
    J Exp Med 211:623-33. 2014

Research Grants

  1. Nectins in Tumor Immunosurveillance
    Marco Colonna; Fiscal Year: 2007
  2. The Functional of TREM-1 in Sepsis
    Marco Colonna; Fiscal Year: 2007

Detail Information

Publications114 found, 100 shown here

  1. ncbi request reprint TREMs in the immune system and beyond
    Marco Colonna
    Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
    Nat Rev Immunol 3:445-53. 2003
    ..Remarkably, TREM2 deficiency leads to a severe disease that is characterized by bone cysts and demyelination of the central nervous system, which results in dementia, implying that the function of TREM2 extends beyond the immune system...
  2. ncbi request reprint Inhibitory receptors: friend or foe?
    Marco Colonna
    Washington University School of Medicine, St Louis, MO 63110, USA
    Lancet 361:1067-8. 2003
  3. pmc Macrophage colony-stimulating factor induces the proliferation and survival of macrophages via a pathway involving DAP12 and beta-catenin
    Karel Otero
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri, USA
    Nat Immunol 10:734-43. 2009
    ..DAP12 was essential for phosphorylation and nuclear accumulation of beta-catenin. Our results provide a mechanistic explanation for the many defects of DAP12-deficient mononuclear phagocytes...
  4. ncbi request reprint Cutting edge: TREM-2 attenuates macrophage activation
    Isaiah R Turnbull
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 177:3520-4. 2006
    ..Taken together, these data show that TREM-2 is expressed on newly differentiated and alternatively activated macrophages and functions to restrain macrophage activation...
  5. ncbi request reprint Dendritic cells respond to influenza virus through TLR7- and PKR-independent pathways
    Winfried Barchet
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Eur J Immunol 35:236-42. 2005
    ..We conclude that DC and IPC are hard-wired to secrete IFN-alpha via different pathways, reflecting their complementary but distinct roles in anti-viral immunity...
  6. pmc IL-34 is a tissue-restricted ligand of CSF1R required for the development of Langerhans cells and microglia
    Yaming Wang
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri, USA
    Nat Immunol 13:753-60. 2012
    ..Il34(LacZ/LacZ) mice selectively lacked LCs and microglia and responded poorly to skin antigens and viral infection of the CNS. Thus, IL-34 specifically directs the differentiation of myeloid cells in the skin epidermis and CNS...
  7. ncbi request reprint TLR9-dependent recognition of MCMV by IPC and DC generates coordinated cytokine responses that activate antiviral NK cell function
    Anne Krug
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Immunity 21:107-19. 2004
    ..We conclude that the TLR9/MyD88 pathway mediates antiviral cytokine responses by IPC, DC, and possibly other cell types, which are coordinated to promote effective NK cell function and MCMV clearance...
  8. ncbi request reprint Vav1 controls DAP10-mediated natural cytotoxicity by regulating actin and microtubule dynamics
    Daniel B Graham
    Department of Pathology and Immunology, Washington University School of Medicine and Siteman Cancer Center, 660 South Euclid Avenue, St Louis, MO 63110, USA
    J Immunol 177:2349-55. 2006
    ..Based on these findings, we propose a novel model of ITAM-independent signaling by Vav downstream of DAP10 in NK cells...
  9. pmc Distinct and complementary functions of MDA5 and TLR3 in poly(I:C)-mediated activation of mouse NK cells
    Stephen McCartney
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Exp Med 206:2967-76. 2009
    ..These results demonstrate distinct yet complementary roles for MDA5 and TLR3 in poly(I:C)-mediated NK cell activation...
  10. pmc CRTAM controls residency of gut CD4+CD8+ T cells in the steady state and maintenance of gut CD4+ Th17 during parasitic infection
    Victor S Cortez
    Department of Pathology and Immunology, 2 Department of Internal Medicine, 3 Department of Molecular Microbiology, and 4 Howard Hughes Medical Institute, Washington University School of Medicine, St Louis, MO 63110
    J Exp Med 211:623-33. 2014
    ....
  11. pmc Cell depletion in mice that express diphtheria toxin receptor under the control of SiglecH encompasses more than plasmacytoid dendritic cells
    Melissa Swiecki
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110
    J Immunol 192:4409-16. 2014
    ....
  12. pmc DAP10 associates with Ly49 receptors but contributes minimally to their expression and function in vivo
    Ilaria Tassi
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Eur J Immunol 39:1129-35. 2009
    ..Thus, while many activating NK-cell receptors are promiscuous in terms of adaptor association, our data indicate that the functional consequences of such promiscuity may vary widely and may not be evident in all cases...
  13. ncbi request reprint Phospholipase C-gamma 2 is a critical signaling mediator for murine NK cell activating receptors
    Ilaria Tassi
    Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    J Immunol 175:749-54. 2005
    ..These results demonstrate that PLCgamma2 is crucial for development of the NK cell receptor repertoire and signaling of activating NK cell receptors, mediating optimal NK cell function in vivo...
  14. pmc Phosphatidylinositol 3-kinase activation is required to form the NKG2D immunological synapse
    Emanuele Giurisato
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Mol Cell Biol 27:8583-99. 2007
    ..These results provide new insights into the mechanism of immunological synapse formation and also demonstrate how multiple mechanisms can be used to recruit the same signaling proteins to the plasma membrane...
  15. pmc Development and function of murine B220+CD11c+NK1.1+ cells identify them as a subset of NK cells
    Amanda L Blasius
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Exp Med 204:2561-8. 2007
    ..In terms of function, expression of distinctive cell surface receptors, and location in lymphoid organs, NK1.1(+)B220(+)CD11c(+) appear to be the murine equivalent of human CD56(bright) NK cells...
  16. pmc DNAM-1 promotes activation of cytotoxic lymphocytes by nonprofessional antigen-presenting cells and tumors
    Susan Gilfillan
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Exp Med 205:2965-73. 2008
    ....
  17. pmc Plasmacytoid dendritic cell ablation impacts early interferon responses and antiviral NK and CD8(+) T cell accrual
    Melissa Swiecki
    Department of Pathology and Immunology, Washington University School of Medicine, 425 S Euclid, St Louis, MO 63110, USA
    Immunity 33:955-66. 2010
    ..We conclude that pDCs mediate early antiviral IFN-I responses and influence the accrual of virus-specific NK or CD8(+) T cells in a virus-dependent manner...
  18. pmc A novel molecular interaction for the adhesion of follicular CD4 T cells to follicular DC
    Kent S Boles
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Eur J Immunol 39:695-703. 2009
    ..These results reveal a novel molecular interaction that mediates adhesion of TFH to FDC and provide the first evidence that immune receptors for Nectins/Necl may be involved the generation of T cell-dependent antibody responses...
  19. ncbi request reprint p110gamma and p110delta phosphoinositide 3-kinase signaling pathways synergize to control development and functions of murine NK cells
    Ilaria Tassi
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Immunity 27:214-27. 2007
    ..Our data shed light on the multiple intersecting pathways through which PI3Ks control NK cell-mediated innate responses...
  20. pmc Intraepithelial type 1 innate lymphoid cells are a unique subset of IL-12- and IL-15-responsive IFN-γ-producing cells
    Anja Fuchs
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Immunity 38:769-81. 2013
    ..Thus, intraepithelial ILC1 may initiate IFN-γ responses against pathogens but contribute to pathology when dysregulated...
  21. pmc Type I interferon negatively controls plasmacytoid dendritic cell numbers in vivo
    Melissa Swiecki
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Exp Med 208:2367-74. 2011
    ..IFN-I-mediated control of pDCs may explain the loss of pDCs during human infections caused by HBV, HCV, or HIV and has important therapeutic implications for settings in which IFN-I is used to treat infections and autoimmune diseases...
  22. pmc Adhesive mechanisms governing interferon-producing cell recruitment into lymph nodes
    Thomas G Diacovo
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Exp Med 202:687-96. 2005
    ..Identification of the adhesive machinery required for IPC trafficking into PLNs may provide opportunities to regulate immune responses reliant on the activity of these cells...
  23. pmc A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity
    Marina Cella
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Nature 457:722-5. 2009
    ....
  24. pmc Loss of DNAM-1 contributes to CD8+ T-cell exhaustion in chronic HIV-1 infection
    Marina Cella
    Department of Pathology, Washington University School of Medicine, St Louis, MO 63110, USA
    Eur J Immunol 40:949-54. 2010
    ..Thus, DNAX-activating molecule-1 downregulation on CD8(+) T cells aggravates the impairment of CTL effector function in chronic HIV-1 infection...
  25. pmc MDA-5 recognition of a murine norovirus
    Stephen A McCartney
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS Pathog 4:e1000108. 2008
    ..Knowledge of the host response to MNV-1 may provide keys for prevention and treatment of the human disease...
  26. pmc Accumulation of plasmacytoid DC: Roles in disease pathogenesis and targets for immunotherapy
    Melissa Swiecki
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Eur J Immunol 40:2094-8. 2010
    ..In this Viewpoint, we discuss how the recruitment and accumulation of pDC may impact pathogenesis of several diseases and how pDC can be targeted for therapeutic interventions...
  27. pmc RNA sensor-induced type I IFN prevents diabetes caused by a β cell-tropic virus in mice
    Stephen A McCartney
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 121:1497-507. 2011
    ..We therefore conclude that optimal functioning of viral sensors and prompt IFN-I responses are required to prevent diabetes when caused by a virus that infects and damages the β cells of the pancreas...
  28. ncbi request reprint Adhesion of human T cells to antigen-presenting cells through SIRPbeta2-CD47 interaction costimulates T-cell proliferation
    Laura Piccio
    Department of Pathology and Immunology, Washington University School of Medicine, 660 S Euclid, St Louis, MO 63110, USA
    Blood 105:2421-7. 2005
    ..Consequently, engagement of SIRPbeta2 on T cells by CD47 on antigen-presenting cells results in enhanced antigen-specific T-cell proliferation...
  29. pmc Efficient colonic mucosal wound repair requires Trem2 signaling
    Hiroshi Seno
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 106:256-61. 2009
    ..These studies show that Trem2 signaling is an important pathway to promote healing of wounds in the colon where stem cell replacement is necessary...
  30. doi request reprint Requirement of phospholipase C-gamma2 (PLCgamma2) for Dectin-1-induced antigen presentation and induction of TH1/TH17 polarization
    Ilaria Tassi
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Eur J Immunol 39:1369-78. 2009
    ..We conclude that PLCgamma2 is a crucial signaling mediator that modifies DC gene expression program to activate DC responses to beta-glucan-containing pathogens...
  31. doi request reprint Cutting edge: polyinosinic:polycytidylic acid boosts the generation of memory CD8 T cells through melanoma differentiation-associated protein 5 expressed in stromal cells
    Yaming Wang
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 184:2751-5. 2010
    ..We conclude that MDA5 and TLR3 mediate substantially distinct yet complementary functions during poly I:C-mediated activation of Ag-specific CD8 T cell responses...
  32. pmc Unraveling the functions of plasmacytoid dendritic cells during viral infections, autoimmunity, and tolerance
    Melissa Swiecki
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Immunol Rev 234:142-62. 2010
    ..Finally, we discuss the emergent role of pDCs and one of their receptors, tetherin, in human immunodeficiency virus pathogenesis...
  33. ncbi request reprint Bone marrow stromal cell antigen 2 is a specific marker of type I IFN-producing cells in the naive mouse, but a promiscuous cell surface antigen following IFN stimulation
    Amanda L Blasius
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 177:3260-5. 2006
    ..Finally, we show that BST2 resides within an intracellular compartment corresponding to the Golgi apparatus, and may be involved in trafficking secreted cytokines in IPC...
  34. pmc L-Myc expression by dendritic cells is required for optimal T-cell priming
    Wumesh Kc
    Department of Pathology and Immunology, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, Missouri 63110, USA
    Nature 507:243-7. 2014
    ..The replacement of c-Myc by L-Myc in immature DCs may provide for Myc transcriptional activity in the setting of inflammation that is required for optimal T-cell priming...
  35. pmc Timing and magnitude of type I interferon responses by distinct sensors impact CD8 T cell exhaustion and chronic viral infection
    Yaming Wang
    Department of Pathology and Immunology, Washington University School of Medicine, 425 S Euclid, St Louis, MO 63110, USA
    Cell Host Microbe 11:631-42. 2012
    ..Thus, effective antiviral CD8(+)T cell responses depend on the timing and magnitude of IFN-I production...
  36. pmc TREM2 and β-catenin regulate bone homeostasis by controlling the rate of osteoclastogenesis
    Karel Otero
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 188:2612-21. 2012
    ..These results reveal that TREM2 regulates the rate of osteoclastogenesis and provide a mechanism for the bone pathology in NHD...
  37. ncbi request reprint Interferon-producing cells develop from murine CD31(high)/Ly6C(-) marrow progenitors
    Friederike H Kreisel
    Washington University School of Medicine, Department of Pathology and Immunology, Division of Anatomic Pathology, 660 South Euclid Ave, Campus Box 8118, St Louis, MO 63110, USA
    Cell Immunol 242:91-8. 2006
    ....
  38. ncbi request reprint FcRL6, a new ITIM-bearing receptor on cytolytic cells, is broadly expressed by lymphocytes following HIV-1 infection
    Timothy J Wilson
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA
    Blood 109:3786-93. 2007
    ....
  39. ncbi request reprint The tumor suppressor TSLC1/NECL-2 triggers NK-cell and CD8+ T-cell responses through the cell-surface receptor CRTAM
    Kent S Boles
    Washington University School of Medicine, 660 S Euclid, St Louis, MO 63110, USA
    Blood 106:779-86. 2005
    ..Furthermore, they reveal Necl-2 as one of the molecular targets that allows the immunosurveillance network to distinguish tumor cells from normal cells...
  40. pmc Melanoma differentiation-associated gene 5 (MDA5) is involved in the innate immune response to Paramyxoviridae infection in vivo
    Leonid Gitlin
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS Pathog 6:e1000734. 2010
    ....
  41. pmc Siglec-H is an IPC-specific receptor that modulates type I IFN secretion through DAP12
    Amanda L Blasius
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Blood 107:2474-6. 2006
    ..Moreover, it supports a model in which engagement of DNAX-activation protein 12 (DAP12)-associated receptors with antibodies or low avidity endogenous ligands interferes with TLR-mediated cellular activation...
  42. pmc NK cell-activating receptors require PKC-theta for sustained signaling, transcriptional activation, and IFN-gamma secretion
    Ilaria Tassi
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA
    Blood 112:4109-16. 2008
    ..These results indicate that NK cell-activating receptors require PKC- to generate sustained intracellular signals that reach the nucleus and promote transcriptional activation, ultimately inducing IFN-gamma production...
  43. pmc The mitogen-activated protein kinase scaffold KSR1 is required for recruitment of extracellular signal-regulated kinase to the immunological synapse
    Emanuele Giurisato
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Mol Cell Biol 29:1554-64. 2009
    ..Imaging studies showed that KSR1 is recruited to the immunological synapse during T-cell activation and that membrane recruitment of KSR1 is required for recruitment of active ERK to the synapse...
  44. ncbi request reprint The enigmatic function of TREM-2 in osteoclastogenesis
    Marco Colonna
    Washington University School of Medicine, St Louis, Department of Pathology and Immunology, MO, USA
    Adv Exp Med Biol 602:97-105. 2007
    ....
  45. ncbi request reprint Plasmacytoid dendritic cells: in search of their niche in immune responses
    Winfried Barchet
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Immunol Res 32:75-83. 2005
    ..This review highlights aspects in which pDCs are unique in comparison to other antigen-presenting cells in regulating innate and adaptive immune responses...
  46. pmc Expansion of human NK-22 cells with IL-7, IL-2, and IL-1beta reveals intrinsic functional plasticity
    Marina Cella
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 107:10961-6. 2010
    ..Finally, we found that NK-22 cells released the B-cell survival factor, B-cell activating factor belonging to the TNF family (BAFF), suggesting a potential role of NK-22 cells in promoting B-cell-mediated mucosal immunity...
  47. pmc dsRNA sensors and plasmacytoid dendritic cells in host defense and autoimmunity
    Yaming Wang
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Immunol Rev 243:74-90. 2011
    ....
  48. pmc Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus
    Leonid Gitlin
    Division of Infectious Diseases, Department of Medicine, Washington University School of Medicine, Campus Box 8118, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 103:8459-64. 2006
    ..Moreover, mda-5-/- mice exhibited a selectively impaired antiviral response to encephalomyocarditis picornavirus, indicating functional specialization of mda-5 in vivo...
  49. ncbi request reprint Splenic CD4+ T cells have a distinct transcriptional response six hours after the onset of sepsis
    Jonathan E McDunn
    Cellular Injury and Adaptation Laboratory, Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    J Am Coll Surg 203:365-75. 2006
    ..The molecular mechanism(s) for the phenotypic changes of splenic CD4+ T cells in sepsis are not well understood...
  50. ncbi request reprint Paradoxic inhibition of human natural interferon-producing cells by the activating receptor NKp44
    Anja Fuchs
    Department of Pathology and Immunology, Washington University School of Medicine, 660 S Euclid, St Louis, MO 63110, USA
    Blood 106:2076-82. 2005
    ..Therefore, IL-3-mediated induction of NKp44 on IPCs may be an important component of the ongoing crosstalk between the innate and adaptive immune response that allows memory CD8+ T cells to control the IPC response to virus...
  51. pmc Alerting dendritic cells to pathogens: the importance of Toll-like receptor signaling of stromal cells
    Marco Colonna
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 101:16083-4. 2004
  52. pmc Complement-induced regulatory T cells suppress T-cell responses but allow for dendritic-cell maturation
    Winfried Barchet
    Washington University School of Medicine, Department of Pathology and Immunology, St Louis, MO 63110, USA
    Blood 107:1497-504. 2006
    ....
  53. pmc Embryonic and Adult-Derived Resident Cardiac Macrophages Are Maintained through Distinct Mechanisms at Steady State and during Inflammation
    Slava Epelman
    Center for Cardiovascular Research, Division of Cardiology, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Immunity 40:91-104. 2014
    ..These data highlight the presence of multiple cardiac macrophage subsets, with different functions, origins, and strategies to regulate compartment size. ..
  54. pmc Cutting edge: paradoxical roles of BST2/tetherin in promoting type I IFN response and viral infection
    Melissa Swiecki
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 188:2488-92. 2012
    ..These findings suggest complex roles of BST2 beyond retroviral control in vivo, possibly reflecting the involvement of BST2 in endocytosis and intracellular trafficking of viruses, viral nucleic acids, and Ags...
  55. ncbi request reprint The role of NK cell recognition of nectin and nectin-like proteins in tumor immunosurveillance
    Anja Fuchs
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA
    Semin Cancer Biol 16:359-66. 2006
    ..We here review current knowledge on these receptors, CD226, CD96 and CRTAM, and their role in tumor immunosurveillance...
  56. pmc Differential requirements for Vav proteins in DAP10- and ITAM-mediated NK cell cytotoxicity
    Marina Cella
    Department of Pathology and Immunology, Washington University School of Medicine, 660 S Euclid Ave, St Louis, MO 63110, USA
    J Exp Med 200:817-23. 2004
    ..Our results provide evidence that these three Vav proteins function specifically in distinct pathways that trigger NK cell cytotoxicity...
  57. doi request reprint Fc receptor-like A associates with intracellular IgG and IgM but is dispensable for antigen-specific immune responses
    Timothy J Wilson
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 185:2960-7. 2010
    ..Cumulatively, our data suggest that FcRLA plays a role in Ig assembly that can be compensated for by other proteins...
  58. ncbi request reprint NKG2D recruits two distinct adapters to trigger NK cell activation and costimulation
    Susan Gilfillan
    Department of Pathology and Immunology, Washington University School of Medicine, 660 S Euclid, St Louis, MO 63110, USA
    Nat Immunol 3:1150-5. 2002
    ..Thus, NKG2D is a versatile receptor that, depending on the availability of adapter partners, mediates costimulation in T cells and/or activation in NK cells...
  59. ncbi request reprint Cutting edge: Salivary gland NK cells develop independently of Nfil3 in steady-state
    Victor S Cortez
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110
    J Immunol 192:4487-91. 2014
    ....
  60. pmc HLA alleles determine differences in human natural killer cell responsiveness and potency
    Sungjin Kim
    Howard Hughes Medical Institute, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 105:3053-8. 2008
    ....
  61. pmc Identification of soluble TREM-2 in the cerebrospinal fluid and its association with multiple sclerosis and CNS inflammation
    Laura Piccio
    Department of Neurology and Neurosurgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Brain 131:3081-91. 2008
    ..The elevated levels of sTREM-2 in CSF of multiple sclerosis patients may inhibit the anti-inflammatory function of the membrane-bound receptor suggesting sTREM-2 to be a possible target for future therapies...
  62. ncbi request reprint Murine vascular endothelium activates and induces the generation of allogeneic CD4+25+Foxp3+ regulatory T cells
    Alexander Sasha Krupnick
    Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 175:6265-70. 2005
    ..This process occurs independently of B7.1 costimulation but is dependent on programmed death ligand 1 (B7-H1). This finding may have important implications for tolerance induction in transplantation...
  63. pmc Interferon-producing cells fail to induce proliferation of naive T cells but can promote expansion and T helper 1 differentiation of antigen-experienced unpolarized T cells
    Anne Krug
    Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid, St Louis, MO 63108, USA
    J Exp Med 197:899-906. 2003
    ..Independent and coordinated control of T cell proliferation and differentiation would provide the immune system with greater flexibility in regulating immune responses...
  64. ncbi request reprint Running to stand still: BCR-like signaling suppresses type I IFN responses in pDC
    Melissa K Swiecki
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis MO 63110, USA
    Eur J Immunol 37:3327-9. 2007
    ..In this issue of the European Journal of Immunology, evidence for a B cell receptor (BCR)-like signaling cascade in pDC that suppresses type I IFN production is provided...
  65. pmc TLR7/9 versus TLR3/MDA5 signaling during virus infections and diabetes
    Melissa Swiecki
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Leukoc Biol 90:691-701. 2011
    ..This highlights the complexity of the host antiviral response and how multiple cellular and molecular components balance protective versus pathological responses...
  66. ncbi request reprint Herpes simplex virus type 1 activates murine natural interferon-producing cells through toll-like receptor 9
    Anne Krug
    Department of Pathology and Immunology, Washington University School of Medicine, 660 S Euclid Ave, St Louis, MO 63110, USA
    Blood 103:1433-7. 2004
    ....
  67. pmc Type I interferons: diversity of sources, production pathways and effects on immune responses
    Melissa Swiecki
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, United States
    Curr Opin Virol 1:463-75. 2011
    ..Finally, we discuss the effects of IFN-I on cells of the immune system with emphasis on dendritic cells...
  68. ncbi request reprint Human T regulatory cells can use the perforin pathway to cause autologous target cell death
    William J Grossman
    Department of Pediatrics, Division of Hematology Oncology, St Louis Children s Hospital, St Louis, MO 63110, USA
    Immunity 21:589-601. 2004
    ..This cytotoxicity is dependent on CD18 adhesive interactions but is independent of Fas/FasL. Our findings suggest that the perforin/granzyme pathway is one of the mechanisms that Treg cells can use to control immune responses...
  69. ncbi request reprint Costimulation through NKG2D enhances murine CD8+ CTL function: similarities and differences between NKG2D and CD28 costimulation
    Mary A Markiewicz
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 175:2825-33. 2005
    ..Understanding the outcomes of these differences may allow for a better understanding of T cell costimulation in general...
  70. pmc Gr1(+) inflammatory monocytes are required for mucosal resistance to the pathogen Toxoplasma gondii
    Ildiko R Dunay
    Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Immunity 29:306-17. 2008
    ..Collectively, these findings illustrate the critical importance of inflammatory monocytes as a first line of defense in controlling intestinal pathogens...
  71. ncbi request reprint Cutting edge: CD96 (tactile) promotes NK cell-target cell adhesion by interacting with the poliovirus receptor (CD155)
    Anja Fuchs
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 172:3994-8. 2004
    ..As PVR is highly expressed in certain tumors, this receptor system may be critical for NK cell recognition of tumors...
  72. ncbi request reprint A cell-surface molecule selectively expressed on murine natural interferon-producing cells that blocks secretion of interferon-alpha
    Amanda Blasius
    Department of Pathology and Immunology, Washington University School of Medicine, 660 S Euclid, Box 8118, St Louis, MO 63110, USA
    Blood 103:4201-6. 2004
    ..Thus, the antibody identifies an IPC-specific surface molecule that, when engaged, inhibits IFN-alpha secretion...
  73. ncbi request reprint A fresh look at an antiviral helicase
    Leonid Gitlin
    Department of Pathology and Immunology, Washington University School of Medicine, Campus Box 8118, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Cell Res 17:898-900. 2007
  74. ncbi request reprint The cytotoxicity receptor CRACC (CS-1) recruits EAT-2 and activates the PI3K and phospholipase Cgamma signaling pathways in human NK cells
    Ilaria Tassi
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 175:7996-8002. 2005
    ..These results outline a new signaling pathway that triggers CRACC-mediated cytotoxicity and modulates 2B4-mediated activation...
  75. pmc DAP12 (KARAP) amplifies inflammation and increases mortality from endotoxemia and septic peritonitis
    Isaiah R Turnbull
    Department of Pathology and Immunology, Department of Surgery, Washington University School of Medicine, St Louis, MO 63110
    J Exp Med 202:363-9. 2005
    ..These data demonstrate that, during sepsis, DAP12 signaling augments the response to microbial products, amplifying inflammation and contributing to mortality...
  76. ncbi request reprint Dendritic cells process and present antigens across a range of maturation states
    Ravi K Veeraswamy
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 170:5367-72. 2003
    ..Immature bone marrow-derived DC also processed exogenous HEL. We conclude that the DC sets normally found in tissue show a scale of maturation features but even the most immature process and present peptides by MHC class II molecules...
  77. pmc Toll-like receptors and IFN-alpha: partners in autoimmunity
    Marco Colonna
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 116:2319-22. 2006
    ..Activated cells then secrete IFN-alpha and TNF-alpha, which trigger tissue release of chemokines that attract self-reactive CD8+ T cells, ultimately leading to liver damage...
  78. pmc Impaired differentiation of osteoclasts in TREM-2-deficient individuals
    Marina Cella
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Exp Med 198:645-51. 2003
    ..These results demonstrate a critical role for TREM-2 in the differentiation of mononuclear myeloid precursors into functional multinucleated OCs...
  79. ncbi request reprint IFN-producing cells respond to CXCR3 ligands in the presence of CXCL12 and secrete inflammatory chemokines upon activation
    Anne Krug
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 169:6079-83. 2002
    ..Upon pathogen encounter, IPC positioning within the lymph node may be further directed by CCR7 and IPC secretion of inflammatory chemokines may attract other IPC, promoting cluster formation in lymph nodes...
  80. ncbi request reprint Plasmacytoid dendritic cells--virus experts of innate immunity
    Winfried Barchet
    Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8118, St Louis, MO 63110, USA
    Semin Immunol 17:253-61. 2005
    ..This review highlights the features that make pDC uniquely able to sense and respond to viral infection...
  81. pmc DAP12 signaling: from immune cells to bone modeling and brain myelination
    Marco Colonna
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 111:313-4. 2003
  82. pmc Cytolytic responses: cadherins put out the fire
    Marco Colonna
    Department of Pathology and Immunology, Washington University School of Medicine, MO 63110, USA
    J Exp Med 203:261-4. 2006
    ..But recent studies, including one in this issue, suggest that MHC class I-independent inhibitory signals can also result in inhibition of cytotoxic cells...
  83. ncbi request reprint Dendritic cells at the host-pathogen interface
    Marco Colonna
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Nat Immunol 7:117-20. 2006
    ..How DCs integrate information from pathogens, tissues, and innate leukocytes for the induction of immune responses was presented at the second International Conference on Dendritic Cells at the Host-Pathogen Interface...
  84. ncbi request reprint Interferon-producing cells: on the front line in immune responses against pathogens
    Marco Colonna
    Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid Avenue, Box 8118, St Louis, MO 63110, USA
    Curr Opin Immunol 14:373-9. 2002
    ..These breakthroughs have brought IPC to the attention of immunologists for their role in innate immunity and in shaping T cell responses. Here we review recent progress and outstanding questions in the field...
  85. ncbi request reprint TREM-1 (triggering receptor expressed on myeloid cells): a new player in acute inflammatory responses
    Marco Colonna
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Infect Dis 187:S397-401. 2003
    ..Whatever the ligands, targeted activation or blockade of TREM-1 and its ligands may help maximize the efficacy of existing treatments for sepsis...
  86. ncbi request reprint Skin function for human CD1a-reactive T cells
    Marco Colonna
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri, USA
    Nat Immunol 11:1079-80. 2010
    ..Human CD4+ T cells that produce interleukin 22 are an essential component of skin defense and repair. New evidence shows that these T cells recognize CD1a-lipid complexes on Langerhans cells...
  87. doi request reprint Interleukin-22-producing natural killer cells and lymphoid tissue inducer-like cells in mucosal immunity
    Marco Colonna
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Immunity 31:15-23. 2009
    ..Finally, we discuss the challenges faced in furthering our understanding of the developmental relationships and role of NK and LTi-like cells in mucosal immune responses...
  88. doi request reprint NK cells: new issues and challenges. Preface
    Marco Colonna
    Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA
    Eur J Immunol 38:2927-9. 2008
    ..This introduction to the series brings together some of the novel concepts emerging from the experts' discussions...
  89. ncbi request reprint Impaired mononuclear cell immune function in extreme obesity is corrected by weight loss
    Luigi Fontana
    Division of Geriatrics and Nutritional Sciences, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Rejuvenation Res 10:41-6. 2007
    ....
  90. ncbi request reprint TLR pathways and IFN-regulatory factors: to each its own
    Marco Colonna
    Washington University School of Medicine, St Louis, MO 63110, USA
    Eur J Immunol 37:306-9. 2007
    ..These distinct TLR-IRF pathways may allow the immune system to tailor its responses to viral pathogens...
  91. ncbi request reprint Granulocyte macrophage colony-stimulating factor ameliorates DSS-induced experimental colitis
    Satheesh K Sainathan
    Division of Gastroenterology, Washington University School of Medicine, St Louis, Missouri, USA
    Inflamm Bowel Dis 14:88-99. 2008
    ..To study the mechanism, we examined the effects of GM-CSF in the dextran sulfate sodium (DSS)-induced acute colitis model. We hypothesized that GM-CSF may work through effects on dendritic cells (DCs)...
  92. pmc Viral immunosuppression: disabling the guards
    Marco Colonna
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 113:660-2. 2004
    ..The discovery of these immunosuppressive mechanisms provides new perspectives for the therapy of chronic infections associated with immunosuppression...
  93. ncbi request reprint Crosspresentation: plasmacytoid dendritic cells are in the business
    Marco Colonna
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Immunity 27:419-21. 2007
    ..In this issue, Hoeffel et al. (2007) show that human plasmacytoid dendritic cells can crosspresent HIV-derived peptides conjugated to a lipopeptide or HIV-infected cells undergoing apoptosis...
  94. ncbi request reprint Plasmacytoid dendritic cells in immunity
    Marco Colonna
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri, USA
    Nat Immunol 5:1219-26. 2004
    ..Here we review recent progress on the characterization of plasmacytoid dendritic cell origin, development, migration and function in immunity and tolerance, as well as their effect on human diseases...
  95. pmc Characterization of DC-SIGN/R interaction with human immunodeficiency virus type 1 gp120 and ICAM molecules favors the receptor's role as an antigen-capturing rather than an adhesion receptor
    Greg A Snyder
    Laboratory of Immunogenetics, Structural Immunology Section, NIAID, NIH, Twinbrook II, 12441 Parklawn Dr, Rockville, MD 20852, USA
    J Virol 79:4589-98. 2005
    ..Our work contradicts the function of DC-SIGN as a Trojan horse to facilitate HIV-1 infection; rather, it supports the function of DC-SIGN/R (a designation referring to both DC-SIGN and DC-SIGNR) as an antigen-capturing receptor...
  96. ncbi request reprint Recombinant HLA-G5 and -G6 drive U937 myelomonocytic cell production of TGF-beta1
    Ramsey H McIntire
    Departments of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    J Leukoc Biol 76:1220-8. 2004
    ..Collectively, the results are consistent with the postulate that environmental programming of decidual macrophages may be dictated in part by their proximity to soluble HLA-G-producing fetal cytotrophoblast cells...
  97. ncbi request reprint Crystal structure of the human myeloid cell activating receptor TREM-1
    Sergei Radaev
    Structural Immunology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 12441 Parklawn Drive, Rockville, MD 20852, USA
    Structure 11:1527-35. 2003
    ..As a result, the dimeric TREM-1 most likely contains two distinct ligand binding sites...
  98. ncbi request reprint Monoclonal T-cell expansions in asymptomatic individuals and in patients with large granular leukemia consist of cytotoxic effector T cells expressing the activating CD94:NKG2C/E and NKD2D killer cell receptors
    Valerie Bigouret
    Division of Immunology and Allergology, University Hospital, Geneva, Switzerland
    Blood 101:3198-204. 2003
    ....
  99. ncbi request reprint CD56bright natural killer cells are present in human lymph nodes and are activated by T cell-derived IL-2: a potential new link between adaptive and innate immunity
    Todd A Fehniger
    Department of Internal Medicine, Division of Hematology Oncology, The Ohio State University, Columbus, OH 43210, USA
    Blood 101:3052-7. 2003
    ..These data show a dynamic interaction between innate and adaptive human lymphocytes and emphasize the importance of studying interactions between immune components to understand the immune response as a whole...
  100. pmc Human inhibitory receptors Ig-like transcript 2 (ILT2) and ILT4 compete with CD8 for MHC class I binding and bind preferentially to HLA-G
    Mitsunori Shiroishi
    Division of Structural Biology, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Proc Natl Acad Sci U S A 100:8856-61. 2003
    ....
  101. ncbi request reprint Distribution and signaling of TREM2/DAP12, the receptor system mutated in human polycystic lipomembraneous osteodysplasia with sclerosing leukoencephalopathy dementia
    Giuseppina Sessa
    Department of Neuroscience, DIBIT, Vita Salute San Raffaele University and San Raffaele Institute, Via Olgettina 58, 20132 Milan, Italy
    Eur J Neurosci 20:2617-28. 2004
    ....

Research Grants2

  1. Nectins in Tumor Immunosurveillance
    Marco Colonna; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  2. The Functional of TREM-1 in Sepsis
    Marco Colonna; Fiscal Year: 2007
    ..We also have detected a binding partner of TREM-1 (the TREM-1 ligand) and we propose to identify this molecule as it may serve as a novel target for the treatment of septic patients, ..