Marco Colonna


Affiliation: Washington University School of Medicine
Country: USA


  1. Colonna M, Facchetti F. TREM-1 (triggering receptor expressed on myeloid cells): a new player in acute inflammatory responses. J Infect Dis. 2003;187 Suppl 2:S397-401 pubmed
    ..Whatever the ligands, targeted activation or blockade of TREM-1 and its ligands may help maximize the efficacy of existing treatments for sepsis. ..
  2. Song C, Lee J, Gilfillan S, Robinette M, Newberry R, Stappenbeck T, et al. Unique and redundant functions of NKp46+ ILC3s in models of intestinal inflammation. J Exp Med. 2015;212:1869-82 pubmed publisher
    ..Thus, NKp46(+)ILC3s have a unique capacity to promote inflammation through GM-CSF-induced accumulation of inflammatory monocytes, but are superseded by LTi-like ILC3s and T cells in controlling intestinal bacterial infection. ..
  3. Colonna M. Cytolytic responses: cadherins put out the fire. J Exp Med. 2006;203:261-4 pubmed
    ..But recent studies, including one in this issue, suggest that MHC class I-independent inhibitory signals can also result in inhibition of cytotoxic cells. ..
  4. Colonna M, Trinchieri G, Liu Y. Plasmacytoid dendritic cells in immunity. Nat Immunol. 2004;5:1219-26 pubmed
    ..Here we review recent progress on the characterization of plasmacytoid dendritic cell origin, development, migration and function in immunity and tolerance, as well as their effect on human diseases. ..
  5. ULRICH J, Ulland T, Mahan T, Nyström S, Nilsson K, Song W, et al. ApoE facilitates the microglial response to amyloid plaque pathology. J Exp Med. 2018;215:1047-1058 pubmed publisher
    ..Our results suggest that apoE is critical in stimulating the innate immune response to amyloid pathology. ..
  6. Colonna M, Turnbull I, Klesney Tait J. The enigmatic function of TREM-2 in osteoclastogenesis. Adv Exp Med Biol. 2007;602:97-105 pubmed
  7. Cortez V, Robinette M, Colonna M. Innate lymphoid cells: new insights into function and development. Curr Opin Immunol. 2015;32:71-7 pubmed publisher
    ..Furthermore, we highlight recent insights into the development of ILCs, including the common pathways they share as well as points of divergence between ILC groups and subsets. ..
  8. Cella M, Colonna M. Aryl hydrocarbon receptor: Linking environment to immunity. Semin Immunol. 2015;27:310-4 pubmed publisher
    ..Here, we will review progresses in this field and discuss how targeting AHR activation may impact disease. ..
  9. Colonna M, Butovsky O. Microglia Function in the Central Nervous System During Health and Neurodegeneration. Annu Rev Immunol. 2017;35:441-468 pubmed publisher
    ..Moreover, we highlight the complexity of targeting microglia for therapeutic intervention in neurodegenerative diseases. ..

More Information


  1. Colonna M. Interleukin-22-producing natural killer cells and lymphoid tissue inducer-like cells in mucosal immunity. Immunity. 2009;31:15-23 pubmed publisher
    ..Finally, we discuss the challenges faced in furthering our understanding of the developmental relationships and role of NK and LTi-like cells in mucosal immune responses. ..
  2. Cortez V, Cervantes Barragan L, Robinette M, Bando J, Wang Y, Geiger T, et al. Transforming Growth Factor-? Signaling Guides the Differentiation of Innate Lymphoid Cells in Salivary Glands. Immunity. 2016;44:1127-39 pubmed publisher
    ..Finally, TGF-? imprinting of SG ILCs was synchronized with SG development, highlighting the impact of tissue microenvironment on ILC development. ..
  3. Koues O, Collins P, Cella M, Robinette M, Porter S, Pyfrom S, et al. Distinct Gene Regulatory Pathways for Human Innate versus Adaptive Lymphoid Cells. Cell. 2016;165:1134-1146 pubmed publisher
  4. Ulland T, Wang Y, Colonna M. Regulation of microglial survival and proliferation in health and diseases. Semin Immunol. 2015;27:410-5 pubmed publisher
    ..Here we review the current literature regarding the roles of these microglial pathways in both the normal and diseased brain and discuss areas that require further investigation. ..
  5. Rowland S, Riggs J, Gilfillan S, Bugatti M, Vermi W, Kolbeck R, et al. Early, transient depletion of plasmacytoid dendritic cells ameliorates autoimmunity in a lupus model. J Exp Med. 2014;211:1977-91 pubmed publisher
    ..Together, our findings demonstrate a critical function for pDCs during the IFN-α/β-dependent initiation of autoimmune lupus and point to pDCs as an attractive therapeutic target for the treatment of SLE. ..
  6. Wang Y, Ulland T, ULRICH J, Song W, Tzaferis J, Hole J, et al. TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques. J Exp Med. 2016;213:667-75 pubmed publisher
    ..Thus, TREM2 protects from AD by enabling microglia to surround and alter Aβ plaque structure, thereby limiting neuritic damage. ..
  7. Barrow A, Colonna M. Tailoring Natural Killer cell immunotherapy to the tumour microenvironment. Semin Immunol. 2017;31:30-36 pubmed publisher
  8. Robinette M, Colonna M. Immune modules shared by innate lymphoid cells and T cells. J Allergy Clin Immunol. 2016;138:1243-1251 pubmed publisher
    ..We review modules currently recognized to be shared between ILCs and T cells. ..
  9. Song W, Hooli B, Mullin K, Jin S, Cella M, Ulland T, et al. Alzheimer's disease-associated TREM2 variants exhibit either decreased or increased ligand-dependent activation. Alzheimers Dement. 2017;13:381-387 pubmed publisher
    ..Our results suggest that TREM2 signaling helps protect against AD but can cause harm in excess, supporting the idea that proper TREM2 function is important to counteract disease progression. ..
  10. Cortez V, Colonna M. Diversity and function of group 1 innate lymphoid cells. Immunol Lett. 2016;179:19-24 pubmed publisher
  11. Rapaport A, Schriewer J, Gilfillan S, Hembrador E, Crump R, Plougastel B, et al. The Inhibitory Receptor NKG2A Sustains Virus-Specific CD8⁺ T Cells in Response to a Lethal Poxvirus Infection. Immunity. 2015;43:1112-24 pubmed publisher
    ..Thus, although inhibitory receptors often cause T cell exhaustion and viral spreading during chronic viral infections, NKG2A optimizes CD8(+) T cell responses during an acute poxvirus infection. ..
  12. Colonna M. DAP12 signaling: from immune cells to bone modeling and brain myelination. J Clin Invest. 2003;111:313-4 pubmed
  13. Wang Y, Cella M, Mallinson K, ULRICH J, Young K, Robinette M, et al. TREM2 lipid sensing sustains the microglial response in an Alzheimer's disease model. Cell. 2015;160:1061-71 pubmed publisher
    ..Remarkably, the R47H mutation impairs TREM2 detection of lipid ligands. Thus, TREM2 detects damage-associated lipid patterns associated with neurodegeneration, sustaining the microglial response to Aβ accumulation. ..
  14. Barrow A, Palarasah Y, Bugatti M, Holehouse A, Byers D, Holtzman M, et al. OSCAR is a receptor for surfactant protein D that activates TNF-α release from human CCR2+ inflammatory monocytes. J Immunol. 2015;194:3317-26 pubmed publisher
  15. Allam A, Swiecki M, Vermi W, Ashwell J, Colonna M. Dual function of CD70 in viral infection: modulator of early cytokine responses and activator of adaptive responses. J Immunol. 2014;193:871-8 pubmed publisher