Allison B Coffin

Summary

Affiliation: Washington State University
Country: USA

Publications

  1. pmc Bax, Bcl2, and p53 differentially regulate neomycin- and gentamicin-induced hair cell death in the zebrafish lateral line
    Allison B Coffin
    Virginia Merrill Bloedel Hearing Research Center, University of Washington, Box 357923, Seattle, WA, 98195, USA
    J Assoc Res Otolaryngol 14:645-59. 2013
  2. pmc Profiling drug-induced cell death pathways in the zebrafish lateral line
    Allison B Coffin
    Virginia Merrill Bloedel Hearing Research Center, University of Washington, Box 357923, Seattle, WA 98195, USA
    Apoptosis 18:393-408. 2013
  3. doi request reprint Extracellular divalent cations modulate aminoglycoside-induced hair cell death in the zebrafish lateral line
    Allison B Coffin
    Virginia Merrill Bloedel Hearing Research Center, Department of Otolaryngology Head and Neck Surgery, University of Washington, Box 357923, Seattle, WA 98195, USA
    Hear Res 253:42-51. 2009
  4. pmc Response of mechanosensory hair cells of the zebrafish lateral line to aminoglycosides reveals distinct cell death pathways
    Kelly N Owens
    Department of Biological Structure, V M Bloedel Hearing Research Center, University of Washington, Box 357420, Seattle, WA 98195 7420, USA
    Hear Res 253:32-41. 2009
  5. pmc Disruption of intracellular calcium regulation is integral to aminoglycoside-induced hair cell death
    Robert Esterberg
    Virginia Merrill Bloedel Hearing Research Center, University of Washington, Seattle, Washington 98195, USA
    J Neurosci 33:7513-25. 2013
  6. pmc Functional mechanotransduction is required for cisplatin-induced hair cell death in the zebrafish lateral line
    Andrew J Thomas
    Virginia Merrill Bloedel Hearing Research Center, Department of Otolaryngology Head and Neck Surgery, University of Washington, Seattle, Washington 98195, USA
    J Neurosci 33:4405-14. 2013
  7. pmc Chemical screening for hair cell loss and protection in the zebrafish lateral line
    Allison B Coffin
    Virginia Merrill Bloedel Hearing Research Center, University of Washington, Seattle, Washington 98195 7923, USA
    Zebrafish 7:3-11. 2010
  8. pmc Identification of genetic and chemical modulators of zebrafish mechanosensory hair cell death
    Kelly N Owens
    Department of Biological Structure, University of Washington, Seattle, Washington, United States of America
    PLoS Genet 4:e1000020. 2008
  9. pmc Saccular-specific hair cell addition correlates with reproductive state-dependent changes in the auditory saccular sensitivity of a vocal fish
    Allison B Coffin
    Virginia Merrill Bloedel Hearing Research Center, Department of Otolaryngology Head and Neck Surgery, University of Washington, Seattle, Washington 98195, USA
    J Neurosci 32:1366-76. 2012
  10. pmc Differences in lateral line morphology between hatchery- and wild-origin steelhead
    Andrew D Brown
    Department of Speech and Hearing Sciences, University of Washington, Seattle, WA, USA
    PLoS ONE 8:e59162. 2013

Collaborators

Detail Information

Publications10

  1. pmc Bax, Bcl2, and p53 differentially regulate neomycin- and gentamicin-induced hair cell death in the zebrafish lateral line
    Allison B Coffin
    Virginia Merrill Bloedel Hearing Research Center, University of Washington, Box 357923, Seattle, WA, 98195, USA
    J Assoc Res Otolaryngol 14:645-59. 2013
    ..These results suggest a role for mitochondrial p53 activity in promoting hair cell death due to aminoglycosides, likely upstream of Bax and Bcl2. ..
  2. pmc Profiling drug-induced cell death pathways in the zebrafish lateral line
    Allison B Coffin
    Virginia Merrill Bloedel Hearing Research Center, University of Washington, Box 357923, Seattle, WA 98195, USA
    Apoptosis 18:393-408. 2013
    ..Taken together, these results suggest that ototoxin-treated hair cells die via multiple processes that form an interactive network of cell death signaling cascades...
  3. doi request reprint Extracellular divalent cations modulate aminoglycoside-induced hair cell death in the zebrafish lateral line
    Allison B Coffin
    Virginia Merrill Bloedel Hearing Research Center, Department of Otolaryngology Head and Neck Surgery, University of Washington, Box 357923, Seattle, WA 98195, USA
    Hear Res 253:42-51. 2009
    ..These experiments lend further support to the hypothesis that aminoglycoside toxicity occurs via multiple pathways in a both a drug and time course-specific manner...
  4. pmc Response of mechanosensory hair cells of the zebrafish lateral line to aminoglycosides reveals distinct cell death pathways
    Kelly N Owens
    Department of Biological Structure, V M Bloedel Hearing Research Center, University of Washington, Box 357420, Seattle, WA 98195 7420, USA
    Hear Res 253:32-41. 2009
    ..The distinctions between the times of action of these aminoglycosides indicate that these drugs induce multiple cell death pathways...
  5. pmc Disruption of intracellular calcium regulation is integral to aminoglycoside-induced hair cell death
    Robert Esterberg
    Virginia Merrill Bloedel Hearing Research Center, University of Washington, Seattle, Washington 98195, USA
    J Neurosci 33:7513-25. 2013
    ..These data suggest that alterations in intracellular Ca(2+) homeostasis play an essential role in aminoglycoside-induced hair cell death, and indicate several potential therapeutic targets to stem ototoxicity...
  6. pmc Functional mechanotransduction is required for cisplatin-induced hair cell death in the zebrafish lateral line
    Andrew J Thomas
    Virginia Merrill Bloedel Hearing Research Center, Department of Otolaryngology Head and Neck Surgery, University of Washington, Seattle, Washington 98195, USA
    J Neurosci 33:4405-14. 2013
    ..These findings demonstrate that cisplatin-induced hair cell death is dependent on functional mechanotransduction in the zebrafish lateral line...
  7. pmc Chemical screening for hair cell loss and protection in the zebrafish lateral line
    Allison B Coffin
    Virginia Merrill Bloedel Hearing Research Center, University of Washington, Seattle, Washington 98195 7923, USA
    Zebrafish 7:3-11. 2010
    ..We discuss chemical screens to identify compounds that induce hair cell loss and others that protect hair cells from known toxins and the potential application of these screens to human medicine...
  8. pmc Identification of genetic and chemical modulators of zebrafish mechanosensory hair cell death
    Kelly N Owens
    Department of Biological Structure, University of Washington, Seattle, Washington, United States of America
    PLoS Genet 4:e1000020. 2008
    ..The combination of chemical screening with traditional genetic approaches is a new strategy for identifying drugs and drug targets to attenuate hearing and balance disorders...
  9. pmc Saccular-specific hair cell addition correlates with reproductive state-dependent changes in the auditory saccular sensitivity of a vocal fish
    Allison B Coffin
    Virginia Merrill Bloedel Hearing Research Center, Department of Otolaryngology Head and Neck Surgery, University of Washington, Seattle, Washington 98195, USA
    J Neurosci 32:1366-76. 2012
    ..This demonstration of correlated seasonal plasticity of hair cell addition and auditory sensitivity may in part facilitate the adaptive auditory plasticity of this species to enhance mate detection and localization during breeding...
  10. pmc Differences in lateral line morphology between hatchery- and wild-origin steelhead
    Andrew D Brown
    Department of Speech and Hearing Sciences, University of Washington, Seattle, WA, USA
    PLoS ONE 8:e59162. 2013
    ..Physiological and behavioral studies are required to establish the functional significance of these morphological differences...