C Cloninger

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. ncbi request reprint A practical way to diagnosis personality disorder: a proposal
    C R Cloninger
    Department of Psychiatry, Washington University, St Louis, MO 63130, USA
    J Pers Disord 14:99-108. 2000
  2. ncbi request reprint Spirituality and the science of feeling good
    C Robert Cloninger
    Washington University School of Medicine, Department of Psychiatry, Campus Box 8134, 660 South Euclid Avenue, St Louis, MO 63110, USA
    South Med J 100:740-3. 2007
  3. ncbi request reprint Can personality assessment predict future depression? A twelve-month follow-up of 631 subjects
    C Robert Cloninger
    Department of Psychiatry and the Sansone Center for Well Being, Washington University School of Medicine, St Louis, MO 63110, USA
    J Affect Disord 92:35-44. 2006
  4. pmc The discovery of susceptibility genes for mental disorders
    C Robert Cloninger
    Departments of Psychiatry and Genetics, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 99:13365-7. 2002
  5. ncbi request reprint Family-based study of the association of the dopamine D2 receptor gene (DRD2) with habitual smoking
    L J Bierut
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Med Genet 90:299-302. 2000
  6. ncbi request reprint Anxiety proneness linked to epistatic loci in genome scan of human personality traits
    C R Cloninger
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Med Genet 81:313-7. 1998
  7. ncbi request reprint Measurement of temperament and character in mood disorders: a model of fundamental states as personality types
    C R Cloninger
    Washington University Department of Psychiatry and the Center for Psychobiology of Personality, St Louis, MO 63110, USA
    J Affect Disord 51:21-32. 1998
  8. ncbi request reprint Temperament, character, and personality disorders: etiologic, diagnostic, treatment issues
    D M Svrakic
    Department of Psychiatry and Center for Psychobiology of Personality, Washington University School of Medicine, St Louis, MO 63110, USA
    Acta Psychiatr Scand 106:189-95. 2002
  9. ncbi request reprint Visual P300 and the self-directedness scale of the Temperament and Character Inventory
    A B Vedeniapin
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63108, USA
    Psychiatry Res 101:145-56. 2001
  10. ncbi request reprint Personality antecedents of alcoholism in a national area probability sample
    C R Cloninger
    Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA
    Eur Arch Psychiatry Clin Neurosci 245:239-44. 1995

Research Grants

  1. MOLECULAR GENETICS OF SCHIZOPHRENIA
    C Cloninger; Fiscal Year: 2002
  2. MOLECULAR GENETICS OF SCHIZOPHRENIA
    C Cloninger; Fiscal Year: 2006

Detail Information

Publications46

  1. ncbi request reprint A practical way to diagnosis personality disorder: a proposal
    C R Cloninger
    Department of Psychiatry, Washington University, St Louis, MO 63130, USA
    J Pers Disord 14:99-108. 2000
    ....
  2. ncbi request reprint Spirituality and the science of feeling good
    C Robert Cloninger
    Washington University School of Medicine, Department of Psychiatry, Campus Box 8134, 660 South Euclid Avenue, St Louis, MO 63110, USA
    South Med J 100:740-3. 2007
  3. ncbi request reprint Can personality assessment predict future depression? A twelve-month follow-up of 631 subjects
    C Robert Cloninger
    Department of Psychiatry and the Sansone Center for Well Being, Washington University School of Medicine, St Louis, MO 63110, USA
    J Affect Disord 92:35-44. 2006
    ..Prior studies by us examined personality and mood at the same time. Assessing personality may allow prediction of mood changes over time in a longitudinal study, as described in earlier prospective studies by Paula Clayton and others...
  4. pmc The discovery of susceptibility genes for mental disorders
    C Robert Cloninger
    Departments of Psychiatry and Genetics, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 99:13365-7. 2002
  5. ncbi request reprint Family-based study of the association of the dopamine D2 receptor gene (DRD2) with habitual smoking
    L J Bierut
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Med Genet 90:299-302. 2000
    ..There also was no evidence for unequal transmission of DRD2 alleles for the phenotypes "ever smoker" or comorbid alcohol dependence and habitual smoking. This study does not support linkage of the DRD2 with smoking...
  6. ncbi request reprint Anxiety proneness linked to epistatic loci in genome scan of human personality traits
    C R Cloninger
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Med Genet 81:313-7. 1998
    ..There was suggestive evidence of epistasis in other personality traits. These results confirm the important influence of epistasis on human personality suggested by twin and adoption studies...
  7. ncbi request reprint Measurement of temperament and character in mood disorders: a model of fundamental states as personality types
    C R Cloninger
    Washington University Department of Psychiatry and the Center for Psychobiology of Personality, St Louis, MO 63110, USA
    J Affect Disord 51:21-32. 1998
    ..Personality assessment may allow reliable measurement of risk of mood disorders...
  8. ncbi request reprint Temperament, character, and personality disorders: etiologic, diagnostic, treatment issues
    D M Svrakic
    Department of Psychiatry and Center for Psychobiology of Personality, Washington University School of Medicine, St Louis, MO 63110, USA
    Acta Psychiatr Scand 106:189-95. 2002
    ....
  9. ncbi request reprint Visual P300 and the self-directedness scale of the Temperament and Character Inventory
    A B Vedeniapin
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63108, USA
    Psychiatry Res 101:145-56. 2001
    ....
  10. ncbi request reprint Personality antecedents of alcoholism in a national area probability sample
    C R Cloninger
    Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA
    Eur Arch Psychiatry Clin Neurosci 245:239-44. 1995
    ..This supports Kraepelin's description of the etiology and course of alcoholism as a symptom complex related to individual differences in emotional predisposition...
  11. ncbi request reprint Personality characteristics in obesity and relationship with successful weight loss
    S Sullivan
    Department of Internal Medicine, Center for Human Nutrition, Washington University School of Medicine, St Louis, MO 63110, USA
    Int J Obes (Lond) 31:669-74. 2007
    ..Personality influences lifestyle behaviors. Therefore, certain personality traits could contribute to obesity and the response to behaviorally based weight loss therapy...
  12. ncbi request reprint Age of onset as a discriminator between alcoholic subtypes in a treatment-seeking outpatient population
    B A Johnson
    Department of Psychiatry, University of Texas, San Antonio 78284 7792, USA
    Am J Addict 9:17-27. 2000
    ..Yet, this clinical characterization would be clinically important if specific age of onset levels were found to be differentially sensitive to pharmacological and/or psychological treatments...
  13. ncbi request reprint Genome scan of European-American schizophrenia pedigrees: results of the NIMH Genetics Initiative and Millennium Consortium
    S V Faraone
    Department of Psychiatry, Harvard Medical School at Massachusetts Mental Health Center, Boston, USA
    Am J Med Genet 81:290-5. 1998
    ..4, P = .0004) and its neighbor, D10S582 (NPL Z = 3.2, P = .0006)...
  14. ncbi request reprint Evidence for the multigenic inheritance of schizophrenia
    R Freedman
    Department of Psychiatry, Denver VA Medical Center and University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Am J Med Genet 105:794-800. 2001
    ....
  15. ncbi request reprint Ondansetron for reduction of drinking among biologically predisposed alcoholic patients: A randomized controlled trial
    B A Johnson
    Department of Psychiatry, University of Texas Health Science Center, 7703 Floyd Curl Dr, Mail Stop 7792, San Antonio, TX 78229 3900, USA
    JAMA 284:963-71. 2000
    ..Thus, individuals with early-onset alcoholism may be responsive to treatment with a selective serotonergic agent...
  16. ncbi request reprint The impact of ADHD and autism spectrum disorders on temperament, character, and personality development
    Henrik Anckarsater
    Malmo University Hospital, Forensic Psychiatric Clinic, Sege Park 8A, S 205 02 Malmo, Sweden
    Am J Psychiatry 163:1239-44. 2006
    ..The authors describe personality development and disorders in relation to symptoms of attention deficit hyperactivity disorder (ADHD) and autism spectrum disorders...
  17. pmc Prevalence and correlates of binge eating disorder in a community sample
    Richard A Grucza
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Compr Psychiatry 48:124-31. 2007
    ..quot; Few epidemiological studies of BED have been conducted. Our aim was to describe the prevalence and correlates of BED, as assessed by the Patient Health Questionnaire (PHQ) in a community sample...
  18. ncbi request reprint Reliability and validity of the Italian version of the Temperament and Character Inventory-Revised in an outpatient sample
    Andrea Fossati
    School of Psychology, Vita Salute San Raffaele University, 20127 Milan, Italy
    Compr Psychiatry 48:380-7. 2007
    ..The aim of this study was to evaluate the reliability and validity of the Temperament and Character Inventory-Revised (TCI-R) in an outpatient sample...
  19. ncbi request reprint Marital status, alcohol dependence, and GABRA2: evidence for gene-environment correlation and interaction
    Danielle M Dick
    Department of Psychiatry, Washington University in St Louis, Box 8134, 660 South Euclid Ave, St Louis, MO 63130, USA
    J Stud Alcohol 67:185-94. 2006
    ..This article explores how this genetic risk factor interacts with marital status, another factor previously shown to be associated with the risk for alcohol dependence...
  20. pmc Temperament and character traits in patients with bipolar disorder and associations with comorbid alcoholism or anxiety disorders
    Fabiano G Nery
    Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
    J Psychiatr Res 42:569-77. 2008
    ..These findings suggest that personality, at least to some extent, mediates the comorbidity phenomena in bipolar disorder...
  21. pmc Linkage scan for quantitative traits identifies new regions of interest for substance dependence in the Collaborative Study on the Genetics of Alcoholism (COGA) sample
    Arpana Agrawal
    Washington University School of Medicine, St Louis, MO 63110, USA
    Drug Alcohol Depend 93:12-20. 2008
    ..0 on chromosome 2 (3.2, 234 cM), 10 (2.4 and 2.6 at 60 cM and 116 cM) and 13 (2.1 at 64 cM). These regions may harbor genes that contribute to the biological basis of alcohol and drug dependence...
  22. doi request reprint No significant association of 14 candidate genes with schizophrenia in a large European ancestry sample: implications for psychiatric genetics
    Alan R Sanders
    Department of Psychiatry and Behavioural Sciences, Evanston Northwestern Healthcare Research Institute, Evanston, IL 60201 3137, USA
    Am J Psychiatry 165:497-506. 2008
    ....
  23. pmc Screening for alcohol problems: an epidemiological perspective and implications for primary care
    Richard A Grucza
    Department of Psychiatry, Washington University School of Medicine, USA
    Mo Med 105:67-71. 2008
    ....
  24. pmc Whole-genome association study of bipolar disorder
    P Sklar
    Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA
    Mol Psychiatry 13:558-69. 2008
    ..Given the heritability of BP disorder, the lack of agreement between studies emphasizes that susceptibility alleles are likely to be modest in effect size and require even larger samples for detection...
  25. doi request reprint Genomewide association for schizophrenia in the CATIE study: results of stage 1
    P F Sullivan
    Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7264, USA
    Mol Psychiatry 13:570-84. 2008
    ....
  26. doi request reprint Psychometric characteristic of the Italian version of the Temperament and Character Inventory--revised, personality, psychopathology, and attachment styles
    Giovanni Martinotti
    Department of Psychiatry, Catholic University Medical School, 00168 Rome, Italy
    Compr Psychiatry 49:514-22. 2008
    ..Personality features are also confirmed as risk factors for specific psychopathologic domains, impulsivity, anger, and hostility. Furthermore, we found attachment styles of nonclinical subjects correlated with personality features...
  27. doi request reprint The psychobiological theory of temperament and character: comment on Farmer and Goldberg (2008)
    C Robert Cloninger
    Washington University, Department of Psychiatry, School of Medicine, St Louis, MO 63110, USA
    Psychol Assess 20:292-9; discussion 300-4. 2008
    ....
  28. pmc Variants in nicotinic receptors and risk for nicotine dependence
    Laura Jean Bierut
    Department of Psychiatry, Washington University School of Medicine, Box 8134, 660 South Euclid Ave, St Louis, MO 63110, USA
    Am J Psychiatry 165:1163-71. 2008
    ....
  29. pmc Genomewide linkage scan of 409 European-ancestry and African American families with schizophrenia: suggestive evidence of linkage at 8p23.3-p21.2 and 11p13.1-q14.1 in the combined sample
    Brian K Suarez
    Department of Psychiatry and Genetics, Washington University, St Louis, MO, USA
    Am J Hum Genet 78:315-33. 2006
    ..3-p15.2, 5p15.2-q13.3, 10p15.3-p14, 10q25.3-q26.3, and 11p13-q23.3. The highest increase in Z(lr) scores was observed for 5p14.1-q12.1, where the maximum Z(lr) increased from 2.77 initially to 3.80 after fine mapping in the EA families...
  30. ncbi request reprint Application of the seven-factor model of personality to early childhood
    John N Constantino
    Department of Psychiatry, Washington University School of Medicine, Campus Box 8134, 660 South Euclid Ave, Saint Louis, MO 63110, USA
    Psychiatry Res 109:229-43. 2002
    ..Future studies are warranted to test the extent to which early childhood measurements of the seven factors might predict the development of personality disorders...
  31. pmc Persistence and brain circuitry
    Debra A Gusnard
    Department of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 100:3479-84. 2003
    ..These findings represent a fresh approach to linking normal individual differences in personality and behavior to specific neuronal structures and subsystems...
  32. ncbi request reprint Personality and depressive symptoms: a multi-dimensional analysis
    Richard A Grucza
    Department of Psychiatry, Washington University School of Medicine, Campus Box 8134, 660 S Euclid Ave, St Louis, MO 63110, USA
    J Affect Disord 74:123-30. 2003
    ..The relationship of temperamental aspects of personality to symptoms of depression in a community-based sample of 804 individuals was examined using a multi-dimensional approach to account for heterogeneity in symptom patterns...
  33. ncbi request reprint Temperament, childhood environment and psychopathology as risk factors for avoidant and borderline personality disorders
    Peter R Joyce
    Department of Psychological Medicine, Christchurch School of Medicine and Health Sciences, New Zealand
    Aust N Z J Psychiatry 37:756-64. 2003
    ..To evaluate childhood experiences (neglect and abuse), temperament and childhood and adolescent psychopathology as risk factors for avoidant and borderline personality disorders in depressed outpatients...
  34. ncbi request reprint A genomic scan for habitual smoking in families of alcoholics: common and specific genetic factors in substance dependence
    Laura Jean Bierut
    School of Medicine, Washington University School of Medicine, 4940 Children s Place, St Louis, MO 63110, USA
    Am J Med Genet A 124:19-27. 2004
    ..Finally, there is also evidence of an area on chromosome 2 that may reflect a common genetic vulnerability locus to both habitual smoking and alcohol dependence...
  35. ncbi request reprint Bipolar disorder. III: Harm avoidance a risk factor for suicide attempts
    Christer Engström
    Department of Neuroscience and Locomotion, University of Linkoping, Linkoping, Sweden
    Bipolar Disord 6:130-8. 2004
    ..The aim of the study was to examine whether personality, i.e. temperament and character influence suicide attempts in bipolar patients...
  36. ncbi request reprint Atypical depression, atypical temperament and a differential antidepressant response to fluoxetine and nortriptyline
    Peter R Joyce
    Department of Psychological Medicine, Christchurch School of Medicine and Health Sciences, Christchurch, New Zealand
    Depress Anxiety 19:180-6. 2004
    ..A temperament derived measure of "rejection sensitivity" defines a group of depressed patients with a differential antidepressant response, regardless of reversed vegetative symptoms...
  37. pmc Prevalence and predictors of pathological gambling: results from the St. Louis personality, health and lifestyle (SLPHL) study
    Renee M Cunningham-Williams
    Department of Psychiatry, Washington University School of Medicine, 40 N Kingshighway, St Louis, MO 63108, USA
    J Psychiatr Res 39:377-90. 2005
    ..We report the prevalence of and risk and protective factors for DSM-IV sub-threshold gambling (1-4 criteria) and pathological gambling disorder (PGD; 5-10 criteria) in a non-clinical household sample of St. Louis area gamblers...
  38. ncbi request reprint Personality as a mediator of demographic risk factors for suicide attempts in a community sample
    Richard A Grucza
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Compr Psychiatry 46:214-22. 2005
    ..We conclude that risk associated with certain nonmodifiable demographic factors is often mediated by potentially modifiable intrapersonal factors, such as SD...
  39. ncbi request reprint Psychometric properties of the temperament and character inventory-revised (TCI-R) in a Belgian sample
    Michel Hansenne
    Department of Cognitive Sciences, University of Liege, Belgium
    J Pers Assess 85:40-9. 2005
    ..The TCI-R inventory had good test-retest reliabilities as well as good alpha coefficients. The addition of 3 new subscales to the original scale for Persistence has produced a very reliable dimension in the TCI-R...
  40. ncbi request reprint How does personality influence mortality in the elderly?
    C Robert Cloninger
    Psychosom Med 67:839-40. 2005
  41. ncbi request reprint Relationship between specialty choice and medical student temperament and character assessed with Cloninger Inventory
    Nutan Atre Vaidya
    Department of Psychiatry and Behavioral Sciences, Rosalind Franklin University of Medicine and Science The Chicago Medical School, Illinois, USA
    Teach Learn Med 16:150-6. 2004
    ..Many studies address specific variables for specific specialties, but few assess the relative impact of each factor...
  42. ncbi request reprint Functional variation in promoter region of monoamine oxidase A and subtypes of alcoholism: haplotype analysis
    Abbas Parsian
    Birth Defects Center, Department of Molecular and Cellular Biology, University of Louisville Health Sciences Center, Louisville, Kentucky, USA
    Am J Med Genet B Neuropsychiatr Genet 117:46-50. 2003
    ..After Bonferroni's correction for multiple tests none of the results remained significant at P < 0.05. Our results indicate that MAO-A may play a role in the development of alcoholism but the gene effect is very small...
  43. ncbi request reprint Temperament traits associated with risk of schizophrenia in an indigenous population of Argentina
    María Calvó de Padilla
    Schizophr Res 83:299-302. 2006
  44. pmc Genome scan meta-analysis of schizophrenia and bipolar disorder, part II: Schizophrenia
    Cathryn M Lewis
    Division of Genetics and Development, Guy s, King s and St Thomas School of Medicine, London, UK
    Am J Hum Genet 73:34-48. 2003
    ..There is greater consistency of linkage results across studies than has been previously recognized. The results suggest that some or all of these regions contain loci that increase susceptibility to schizophrenia in diverse populations...
  45. ncbi request reprint Linkage disequilibrium and haplotype analysis between serotonin receptor 1B gene variations and subtypes of alcoholism
    Rashmi Sinha
    Birth Defects Center, Department of Molecular and Cellular Biology, University of Louisville Health Sciences Center, Louisville, Kentucky 40202, USA
    Am J Med Genet B Neuropsychiatr Genet 121:83-8. 2003
    ..The pattern of distribution of haplotypes was similar in patients and controls. It is concluded that these SNPs are not playing any direct role in the development of susceptibility to alcoholism in our patient sample...
  46. ncbi request reprint Temperament and character in mood disorders: influence of DRD4, SERTPR, TPH and MAO-A polymorphisms
    Alessandro Serretti
    Department of Psychiatry, Vita Salute University, San Raffaele Institute, Milan, Italy
    Neuropsychobiology 53:9-16. 2006
    ....

Research Grants8

  1. MOLECULAR GENETICS OF SCHIZOPHRENIA
    C Cloninger; Fiscal Year: 2002
    ..Power analyses suggest that this study would have excellent power to detect loci associated with lambda sibs of 1.4, and moderate power for a value of 1.3, i.e., loci with relatively small etiologic effects. ..
  2. MOLECULAR GENETICS OF SCHIZOPHRENIA
    C Cloninger; Fiscal Year: 2006
    ..The goal of the study is to identify one or more SZ susceptibility genes whose subsequent characterization inmolecular and functional studies will elucidate the pathophysiology and treatment of SZ. ..