John C Clohisy

..See the Guidelines for Authors for a complete description of levels of evidence...

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..Level of Evidence: Level IV, therapeutic study. See Guidelines for Authors for a complete description of levels of evidence...

..Thus, PMMA particle activation of NF-kappaB is a secondary event resulting from enhanced TNF expression and is independent of LPS contamination...

..The purpose of this study was to evaluate patient compliance with early clinical follow-up after total hip arthroplasty or total knee arthroplasty...

..These data underscore the variety of surgical techniques needed to treat this patient population, and emphasize an expanding role for nonarthroplasty surgical interventions...

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..6 mm for hips with impingement versus 9.3 mm for control hips). The frog-leg lateral radiograph provides accurate visualization of the femoral head-neck offset in patients being evaluated for femoroacetabular impingement...

..We outline general guidelines for the assessment and treatment of hip pain in young adult patients...

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..This study demonstrates that in addition to optimizing femoral head coverage, a major and distinct advantage of the periacetabular osteotomy is reproducible and consistent medial translation of the hip joint center...

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..Again, this inhibitor efficiently blocked particle-induced osteoclastogenesis. Thus, we have shown that pharmaceutical and molecular blockade of NF-kB activation inhibits PMMA particle-directed osteoclastogenesis in vitro...

..The purpose of this study was to determine the interobserver and intraobserver reliability of various musculoskeletal physicians in performing selected measurements of adult structural hip anatomy...

..While cementless hemispherical components have been utilized to treat large acetabular defects, most reports have not focused specifically on patients with extensive deficiencies...

..Previous literature has focused on the amount of polyethylene wear comparing highly crosslinked polyethylene (HXPLE) with conventional liners but has not clarified the relative incidence of osteolysis with these two liners...

..Level of Evidence: Level IV, therapeutic study. See Guidelines for Authors for a complete description of levels of evidence...

..The patients were relatively active, yet demonstrated restrictions of function and overall health. These data may facilitate diagnosis of this disorder...

..Dosing algorithms have not been widely adopted because they require a fixed initial warfarin dose (eg, 5 mg) and are not tailored to other factors that may affect the international normalized ratio (INR)...

..Significant improvement in clinical and radiographic outcomes may be anticipated using these surgical techniques...

..Accordingly, a more clear set of definitions and measurements must be developed to allow for more reliable diagnosis of early hip disease...

..Nevertheless, the necessity and indications for surgical correction of associated acetabular dysplasia have not been established...

..Yet, the reliability of arthroscopic hip disease classification has not been well defined. Purpose/..

..To determine the activity level, represented by total daily strides (TDS), of young and middle-aged adults with hip disorders and asymptomatic controls and to assess the association between TDS and self-report functional measures...

..However, the degree to which function and radiographic deformity are corrected in patients with more severe deformities that have undergone previous reconstructive pelvic or femoral osteotomies is unclear...

..While intraoperative Gram stains are routinely performed during revision total knee arthroplasty, their value remains unclear...

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..Femoral neck fracture is an arthroplasty-related complication unique to surface replacement arthroplasty. However, it is unclear regarding whether patients are at lower risk for fracture after a certain postoperative time...

..These data indicate combined PAO/PFO is associated with improved hip function in most patients. These clinical results are comparable to those obtained with isolated PAO for lesser hip deformities...

..Thus, NF-kappaB appears to be the centerpiece of inflammatory-osteolytic arthritis and direct inhibition of this transcription factor by unique and novel I-kappaB mutant proteins blocks manifestation of the disease...

..These preliminary data suggest that patients with cam femoroacetabular impingement may have improved clinical outcomes when the impingement deformity is corrected...

..The optimal method of surgical correction for these challenging combined deformities remains controversial...

..Thus, our findings demonstrate that activation of the NFAT pathway in conjunction with MAP kinases is essential for basal and PMMA-stimulated osteoclastogenesis...

..Previous studies using plain radiographs report high rates of graft incorporation. However, given plain radiographs underestimate osteolysis, it is unclear whether plain radiographs adequately reflect graft fill or incorporation...

..FAI is now more commonly diagnosed and there is an increasing need for a thorough understanding of the broad spectrum of clinical presentation for the disease as well as more precise definition of the possible surgical options...

..Nevertheless, contemporary diagnostic tools have significant limitations in predicting severity of disease preoperatively...

..Fluoroscopy is used by some surgeons to assess intraoperative acetabular correction but it is unclear whether the features observed by fluoroscopy accurately reflect those on postoperative radiographs...

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..Although CL imaging provides acceptable assessment of general component position, it has limited use for precise analysis in research, outcome reporting, or determination of cause of implant failure...

..LEVEL OF EVIDENCE: Level II, prognostic study. See the Guidelines for Authors for a complete description of levels of evidence...

..001). Minimal incision surgery TKA accounted for a substantial percentage of revision TKA in recent years at these centers. The high prevalence of MIS failures occurring within 24 months is disturbing and warrants further investigation...

..LEVEL OF EVIDENCE: Level II, diagnostic study. See the Guidelines for Authors for a complete description of levels of evidence...

..Our hypothesis was that coxa profunda is a very common radiographic finding in females and is not a finding that is specifically associated with pincer-type femoroacetabular impingement...

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..The purpose of this study was to prospectively determine the early clinical presentation of symptomatic acetabular dysplasia in skeletally mature patients...

..TKA is commonly performed to treat advanced inflammatory and degenerative knee arthritis. With increasing use in younger patients, it is important to define the best practices to enhance clinical performance and implant longevity...

..All the 3 patients were subsequently diagnosed with and successfully treated for symptomatic acetabular labral damage. All patients were informed that data concerning their case would be submitted for publication...

..Level of Evidence: Level IV, therapeutic study. See Guidelines for Authors for a complete description of levels of evidence...

..It is unclear, however, whether the plain radiographs accurately reflect the findings on three-dimensional imaging...

..The purpose of this study was to investigate the prevalence of radiographic findings of femoroacetabular impingement (FAI) in elite football players with a history of hip pain or groin injury who underwent radiographs...

..At two-year follow-up, the patient had an excellent clinical and radiographic outcome...

..LEVEL OF EVIDENCE: Diagnostic Level IV. See Instructions to Authors for a complete description of levels of evidence...

..Surgical site complications requiring readmission or reoperation should be considered "major" complications...

..To determine whether posterior pelvic pain is associated with intra-articular hip abnormalities (labral tears and early degenerative changes) in patients with minimal-to-no radiographic abnormalities...

..The purpose of the present study was to determine the reliability and accuracy of the Shenton line in the diagnosis of acetabular dysplasia in the skeletally mature patient...

..Two of these patients became reinfected within a year. A single positive intraoperative culture after revision total knee arthroplasty does not mandate further treatment in the absence of any other signs of infection...

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..66, 77, 78, and 998.59) in 70% of cases. The findings of our study raise questions regarding the validity of accepting information obtained from larger databases without closer scrutiny...

..Although mid-term followup (4-10 years) has been performed to follow cohorts of patients, the benefit of observing individual patients regardless of symptoms has not been established...

..4%), with the vast majority returning to their preoperative occupation, and very few (2.3%) were limited in their ability to return to work because of their operative hip...

..Thus, NBD peptide is considered as a promising modality to regulate inflammatory osteolysis...

..Additionally, we will illustrate the use of MRI imaging to detect subtle anatomic abnormalities, as well as the use of biochemical imaging techniques such as dGEMRIC to guide clinical decision making...

..Improved understanding of intra-articular disease patterns associated with hip dysplasia will help delineate the role of arthroscopy as an adjunct to osteotomy surgery for dysplastic hips...

..The current evidence is primarily Level IV. LEVEL OF EVIDENCE: Level IV, therapeutic study. See Guidelines for Authors for a complete description of levels of evidence...

..The functional improvements in this group of patients are not well documented and whether the condition for which the surgery is performed influences function...

..Restoration of more normal proximal femoral morphology results in marked improvement in functional outcome. Effective orthopaedic management requires an understanding of the mechanisms of hip disease as well as surgical expertise...

..If validated, this model should provide a safer, more effective process for initiating warfarin therapy...

..Importantly, these effects are mediated via a mechanism requiring the TNF type-1 receptor...

..An appreciation of the complex network that leads to these cellular and inflammatory responses will form a foundation on which to develop therapeutic interventions to combat inflammatory periprosthetic bone loss...

..LEVEL OF EVIDENCE: Therapeutic study, Level III-1 (retrospective comparative study). See the Guidelines for Authors for a complete description of levels of evidence...

..The combination of short-duration warfarin and mechanical prophylaxis with predischarge ultrasound screening was safe and effective in limiting the occurrence of venous thromboembolism...

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..Successful treatment of periprosthetic femoral shaft nonunion yielded excellent pain relief, improved function, and patient satisfaction. However, complication and reoperation rates remain high...

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