D B Clifford

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. pmc A study of mefloquine treatment for progressive multifocal leukoencephalopathy: results and exploration of predictors of PML outcomes
    David B Clifford
    Department of Neurology, Washington University in St Louis, Box 8111, 660 South Euclid Avenue, St Louis, MO 63110, USA
    J Neurovirol 19:351-8. 2013
  2. doi request reprint A randomized, double-blind, controlled study of NGX-4010, a capsaicin 8% dermal patch, for the treatment of painful HIV-associated distal sensory polyneuropathy
    David B Clifford
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Acquir Immune Defic Syndr 59:126-33. 2012
  3. pmc Depression symptoms and cognitive function among individuals with advanced HIV infection initiating HAART in Uganda
    Noeline Nakasujja
    Department of Public Health Sciences, Karolinska Institute, Stockholm, Sweden
    BMC Psychiatry 10:44. 2010
  4. ncbi request reprint Neurologic consequences of hepatitis C and human immunodeficiency virus coinfection
    David B Clifford
    Washington University School of Medicine, St Louis, MI 63110, USA
    J Neurovirol 11:67-71. 2005
  5. ncbi request reprint AIDS dementia
    David B Clifford
    Department of Neurology, Washington University School of Medicine, Box 8111, 660 South Euclid Street, St Louis, MO 63110, USA
    Med Clin North Am 86:537-50, vi. 2002
  6. ncbi request reprint Natalizumab and PML: a risky business?
    David B Clifford
    Department of Neurology, Box 8111, 660 South Euclid Avenue, Saint Louis, MO 63110, USA
    Gut 57:1347-9. 2008
  7. pmc Effects of active HCV replication on neurologic status in HIV RNA virally suppressed patients
    D B Clifford
    Washington University, St Louis, MO 63110, USA
    Neurology 73:309-14. 2009
  8. pmc CSF biomarkers of Alzheimer disease in HIV-associated neurologic disease
    D B Clifford
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Neurology 73:1982-7. 2009
  9. pmc Long-term impact of efavirenz on neuropsychological performance and symptoms in HIV-infected individuals (ACTG 5097s)
    David B Clifford
    Washington University School of Medicine, St Louis, MO 63110, USA
    HIV Clin Trials 10:343-55. 2009
  10. doi request reprint Natalizumab-associated progressive multifocal leukoencephalopathy in patients with multiple sclerosis: lessons from 28 cases
    David B Clifford
    Department of Neurology, Washington University in St Louis, Saint Louis, MO 63110, USA
    Lancet Neurol 9:438-46. 2010

Collaborators

Detail Information

Publications54

  1. pmc A study of mefloquine treatment for progressive multifocal leukoencephalopathy: results and exploration of predictors of PML outcomes
    David B Clifford
    Department of Neurology, Washington University in St Louis, Box 8111, 660 South Euclid Avenue, St Louis, MO 63110, USA
    J Neurovirol 19:351-8. 2013
    ..This study found no evidence of anti-JCV activity by mefloquine. An early decrease of CSF JCV DNA load appears to be associated with a better clinical outcome...
  2. doi request reprint A randomized, double-blind, controlled study of NGX-4010, a capsaicin 8% dermal patch, for the treatment of painful HIV-associated distal sensory polyneuropathy
    David B Clifford
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Acquir Immune Defic Syndr 59:126-33. 2012
    ..Effective treatment of HIV-associated distal sensory polyneuropathy remains a significant unmet therapeutic need...
  3. pmc Depression symptoms and cognitive function among individuals with advanced HIV infection initiating HAART in Uganda
    Noeline Nakasujja
    Department of Public Health Sciences, Karolinska Institute, Stockholm, Sweden
    BMC Psychiatry 10:44. 2010
    ..Initiation of highly active antiretroviral therapy (HAART) may have an effect on the prevalence and the change over time of depression symptoms and cognitive impairment among HIV-positive individuals...
  4. ncbi request reprint Neurologic consequences of hepatitis C and human immunodeficiency virus coinfection
    David B Clifford
    Washington University School of Medicine, St Louis, MI 63110, USA
    J Neurovirol 11:67-71. 2005
    ..Current evidence supports independent contributions of HCV and HIV to neurological impairment. Preliminary evidence suggests that coinfection-related impairment does not appear to accelerate HIV-1-associated cognitive disease...
  5. ncbi request reprint AIDS dementia
    David B Clifford
    Department of Neurology, Washington University School of Medicine, Box 8111, 660 South Euclid Street, St Louis, MO 63110, USA
    Med Clin North Am 86:537-50, vi. 2002
    ..With current therapy, infection is never completely eradicated, and significant portions of toxicity seem mediated by indirect mechanisms that may continue even during antiretroviral therapy...
  6. ncbi request reprint Natalizumab and PML: a risky business?
    David B Clifford
    Department of Neurology, Box 8111, 660 South Euclid Avenue, Saint Louis, MO 63110, USA
    Gut 57:1347-9. 2008
  7. pmc Effects of active HCV replication on neurologic status in HIV RNA virally suppressed patients
    D B Clifford
    Washington University, St Louis, MO 63110, USA
    Neurology 73:309-14. 2009
    ..Interaction of the viruses is likely to be complicated and better understanding of the contributions of each virus will be necessary to make evidence-based therapeutic decisions...
  8. pmc CSF biomarkers of Alzheimer disease in HIV-associated neurologic disease
    D B Clifford
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Neurology 73:1982-7. 2009
    ..CSF amyloid measurements in HAND have been reported to be similar to those in dementia of the Alzheimer type (DAT). Confirmatory evaluation of this finding in carefully evaluated subjects is needed...
  9. pmc Long-term impact of efavirenz on neuropsychological performance and symptoms in HIV-infected individuals (ACTG 5097s)
    David B Clifford
    Washington University School of Medicine, St Louis, MO 63110, USA
    HIV Clin Trials 10:343-55. 2009
    ..Efavirenz (EFV) is an antiretroviral (ARV) drug associated with neuropsychological effects. Limited data describing the long-term impact of EFV-based regimens on neuropsychological performance over more than 3 years are available...
  10. doi request reprint Natalizumab-associated progressive multifocal leukoencephalopathy in patients with multiple sclerosis: lessons from 28 cases
    David B Clifford
    Department of Neurology, Washington University in St Louis, Saint Louis, MO 63110, USA
    Lancet Neurol 9:438-46. 2010
    ..Assessment of these clinical cases will help to inform future therapeutic judgments and improve the outcomes for patients...
  11. pmc Rituximab-associated progressive multifocal leukoencephalopathy in rheumatoid arthritis
    David B Clifford
    Department of Neurology, Washington University, St Louis, MO 63110, USA
    Arch Neurol 68:1156-64. 2011
    ..To describe the development of progressive multifocal leukoencephalopathy (PML) in patients with rheumatoid arthritis (RA) treated with rituximab...
  12. ncbi request reprint The neuropsychological and neurological impact of hepatitis C virus co-infection in HIV-infected subjects
    David B Clifford
    Washington University School of Medicine, St Louis, MO 63110, USA
    AIDS 19:S64-71. 2005
    ....
  13. ncbi request reprint Human immunodeficiency virus-associated dementia
    D B Clifford
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Arch Neurol 57:321-4. 2000
    ..Therapy for HIV in the central nervous system compartment remains potentially the most challenging therapeutic frontier for HIV control...
  14. ncbi request reprint HAART improves prognosis in HIV-associated progressive multifocal leukoencephalopathy
    D B Clifford
    Department of Neurology, Washington University School of Medicine, St Louis, MO, USA
    Neurology 52:623-5. 1999
    ..This is an improvement in prognosis compared with recent historic experience and correlated with HIV RNA viral load reductions. We conclude that current HIV therapy is important in improving the outlook of PML in the setting of HIV...
  15. ncbi request reprint Challenges for clinical trials to treat progressive multifocal leukoencephalopathy
    David B Clifford
    Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurovirol 9:68-72. 2003
    ..A controlled trial of therapy utilizing an international group of trial groups is proposed...
  16. ncbi request reprint A phase II trial of nerve growth factor for sensory neuropathy associated with HIV infection. AIDS Clinical Trials Group Team 291
    J C McArthur
    Department of Neurology, Johns Hopkins University, Baltimore, MD, USA
    Neurology 54:1080-8. 2000
    ..To evaluate the safety and efficacy of recombinant human nerve growth factor (rhNGF) in HIV-associated sensory neuropathy (SN) within a multicenter, placebo-controlled, randomized trial (ACTG 291)...
  17. ncbi request reprint Long-term treatment with recombinant nerve growth factor for HIV-associated sensory neuropathy
    G Schifitto
    Department of Neurology, University of Rochester, NY 14642, USA
    Neurology 57:1313-6. 2001
    ..However, there was no improvement of neuropathy severity as assessed by neurologic examination, quantitative sensory testing, and epidermal nerve fiber density...
  18. ncbi request reprint A randomized clinical trial of CPI-1189 for HIV-associated cognitive-motor impairment
    D B Clifford
    Department of Neurology, Washington University, St Louis, MO 63110, USA
    Neurology 59:1568-73. 2002
    ..It has neuroprotective properties in model systems for HIV-associated neurotoxicity and thus is a candidate for neuroprotective therapy in humans with HIV-associated CNS disease...
  19. ncbi request reprint Correlates of epidermal nerve fiber densities in HIV-associated distal sensory polyneuropathy
    L Zhou
    Department of Neurology, Johns Hopkins University, Baltimore, MD 21287 7609, USA
    Neurology 68:2113-9. 2007
    ..To demonstrate the relationship between epidermal nerve fiber density (ENFD) in the leg and the phenotype of HIV-associated distal sensory polyneuropathy (HIV-DSP) in a multicenter prospective study (ACTG A5117)...
  20. pmc Benefits and risks of stavudine therapy for HIV-associated neurologic complications in Uganda
    N Sacktor
    Department of Neurology, Johns Hopkins Bayview Medical Center, Baltimore, MD 21224, USA
    Neurology 72:165-70. 2009
    ..Coformulated generic drugs, which include stavudine, are the most common regimens to treat HIV infection in Uganda and many other parts of Africa...
  21. pmc Cognitively unimpaired HIV-positive subjects do not have increased 11C-PiB: a case-control study
    B M Ances
    Department of Neurology, Washington University, St Louis, MO 63110, USA
    Neurology 75:111-5. 2010
    ..We evaluated the amyloid-binding agent (11)C-Pittsburgh compound B ((11)C-PiB), a biomarker for Alphabeta42 deposition, in cognitively unimpaired HIV+ (n = 10) participants and matched community controls without dementia (n = 20)...
  22. pmc Minocycline treatment for HIV-associated cognitive impairment: results from a randomized trial
    N Sacktor
    Department of Neurology, Johns Hopkins Bayview Medical Center, 4940 Eastern Ave, 301 Building, Suite 2100, Baltimore, MD 21224, USA
    Neurology 77:1135-42. 2011
    ..We conducted a study of minocycline to assess its safety, tolerability, and efficacy for the treatment of HIV-associated cognitive impairment...
  23. ncbi request reprint Reduced intraepidermal nerve fiber density in HIV-associated sensory neuropathy
    M Polydefkis
    Department of Neurology, Johns Hopkins University, Baltimore, MD, USA
    Neurology 58:115-9. 2002
    ..To explore the relationship between intraepidermal nerve fiber (IENF) density in HIV-associated sensory neuropathy (HIV-SN) to measurements of neuropathy severity and progression of HIV disease...
  24. ncbi request reprint A multicenter trial of selegiline transdermal system for HIV-associated cognitive impairment
    G Schifitto
    Department of Neurology, Movement and Inherited Neurologic Disorders, Clinical Trials Coordination Center, 1351 Mount Hope Avenue, Suite 223, Rochester, NY 14620, USA
    Neurology 69:1314-21. 2007
    ..This rationale has led to the design and implementation of this Selegiline Transdermal System (STS) study with the primary aims of assessing safety and tolerability of STS as well as improvement in cognitive performance...
  25. pmc Clinical outcome of long-term survivors of progressive multifocal leukoencephalopathy
    M A Lima
    Department of Neurology, Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, MA 02215, USA
    J Neurol Neurosurg Psychiatry 81:1288-91. 2010
    ..In absence of a specific treatment, immunotherapies aiming at boosting the cellular immune response against JCV may improve the prognosis of PML...
  26. ncbi request reprint Effects of fructose-1,6-bisphosphate on morphological and functional neuronal integrity in rat hippocampal slices during energy deprivation
    Y Izumi
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63310, USA
    Neuroscience 116:465-75. 2003
    ....
  27. pmc Role of metabolic syndrome components in HIV-associated sensory neuropathy
    Beau M Ances
    Department of Neurology, Washington University, St Louis, 660 South Euclid Avenue, Box 8111, St Louis, MO 63110, USA
    AIDS 23:2317-22. 2009
    ..We examined whether MetS or its components predispose individuals to HIV-associated sensory neuropathy (HIV-SN)...
  28. ncbi request reprint Rapid onset mitoxantrone-induced cardiotoxicity in secondary progressive multiple sclerosis
    Jagannadha R Avasarala
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Mult Scler 9:59-62. 2003
    ..It is suggested that more stringent cardiac monitoring guidelines than current Food and Drug Administration (FDA) recommendations be used to avert potential cardiac complications in SPMS patients on Mitoxantrone...
  29. ncbi request reprint Neurological evaluation of untreated human immunodeficiency virus infected adults in Ethiopia
    David B Clifford
    Department of Neurology, Washington University in St Louis, St Louis, Missouri 63110, USA
    J Neurovirol 13:67-72. 2007
    ..The unanticipated minor evidence of HIV-associated neurocognitive and peripheral nerve deficits in this untreated HIV-positive population invite further investigation...
  30. ncbi request reprint HIV-associated neurocognitive disease continues in the antiretroviral era
    David B Clifford
    Washington University School of Medicine, Saint Louis, MO, USA
    Top HIV Med 16:94-8. 2008
    ..This article summarizes a presentation on HIV-associated neurocognitive disorder made by David B. Clifford, MD, at an International AIDS Society-USA Continuing Medical Education course in New York in October 2007...
  31. pmc Immune reconstitution inflammatory syndrome in natalizumab-associated PML
    I L Tan
    Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Neurology 77:1061-7. 2011
    ..To study the outcome of patients with multiple sclerosis (MS) and with natalizumab-associated progressive multifocal leukoencephalopathy (PML) and immune reconstitution inflammatory syndrome (IRIS)...
  32. ncbi request reprint Bk virus: a clinical review
    M D Reploeg
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Clin Infect Dis 33:191-202. 2001
    ....
  33. ncbi request reprint HIV-associated neurocognitive disorders and the impact of combination antiretroviral therapies
    Beau M Ances
    Department of Neurology, University of Washington, St Louis, MO 63130, USA
    Curr Neurol Neurosci Rep 8:455-61. 2008
    ..Because viral control generally has been successful without eliminating cognitive dysfunction, further clinical studies that assess adjunctive neuroprotective drugs are likely to be required...
  34. ncbi request reprint HIV-associated cognitive impairment in sub-Saharan Africa--the potential effect of clade diversity
    Ned Sacktor
    Department of Neurology, Johns Hopkins University School of Medicine, Johns Hopkins Bayview Medical Center, Baltimore, MD 21224, USA
    Nat Clin Pract Neurol 3:436-43. 2007
    ..Further studies are needed to determine the true prevalence of HIV dementia in sub-Saharan Africa and to establish whether specific clade subtypes might influence the presentation of neurological complications...
  35. ncbi request reprint Atypical PML leading to a diagnosis of common variable immunodeficiency
    Michael D Snyder
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Neurology 64:1661. 2005
  36. pmc Impact of combination antiretroviral therapy on cerebrospinal fluid HIV RNA and neurocognitive performance
    Christina M Marra
    Department of Neurology, University of Washington School of Medicine, Seattle, USA
    AIDS 23:1359-66. 2009
    ..To determine whether antiretroviral regimens with good central nervous system (CNS) penetration control HIV in cerebrospinal fluid (CSF) and improve cognition...
  37. pmc Genotyping of Toxoplasma gondii strains from immunocompromised patients reveals high prevalence of type I strains
    A Khan
    Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Clin Microbiol 43:5881-7. 2005
    ..The multiplex nested PCR analysis described here will be useful for analyzing the contribution of parasite genotype to toxoplasmosis...
  38. ncbi request reprint Impact of efavirenz on neuropsychological performance and symptoms in HIV-infected individuals
    David B Clifford
    Washington University School of Medicine, Neurology Department, St Louis, Missouri 63110, USA
    Ann Intern Med 143:714-21. 2005
    ..Efavirenz is a commonly used antiretroviral drug that causes neurologic side effects in more than 50% of patients...
  39. pmc Frequency and phenotype of JC virus-specific CD8+ T lymphocytes in the peripheral blood of patients with progressive multifocal leukoencephalopathy
    Marco A Lima
    Department of Neurology, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215, USA
    J Virol 81:3361-8. 2007
    ..Immunotherapies aiming at increasing the cellular immune response against JCV may be valuable in the treatment of HIV+ individuals with PML...
  40. ncbi request reprint Clinical validation of the NeuroScreen
    Ronald J Ellis
    Department of Neurosciences, UCSD AntiViral Research Center and HIV Neurobehavioral Research Center, University of California, San Diego, California 92103, USA
    J Neurovirol 11:503-11. 2005
    ..However, because it yields substantial numbers of false positives and negatives, the NeuroScreen may be less useful in evaluating individual patients...
  41. pmc Evaluation of patients treated with natalizumab for progressive multifocal leukoencephalopathy
    Tarek A Yousry
    Institute of Neurology, Queen Square, London
    N Engl J Med 354:924-33. 2006
    ..Progressive multifocal leukoencephalopathy (PML) was reported to have developed in three patients treated with natalizumab. We conducted an evaluation to determine whether PML had developed in any other treated patients...
  42. doi request reprint Cidofovir in addition to antiretroviral treatment is not effective for AIDS-associated progressive multifocal leukoencephalopathy: a multicohort analysis
    Andrea De Luca
    Institute of Clinical Infectious Diseases, Catholic University of Sacred Heart, Lazio Region, Rome, Italy
    AIDS 22:1759-67. 2008
    ..To establish the effectiveness of cidofovir for AIDS-related progressive multifocal leukoencephalopathy (PML) in patients concomitantly receiving combination antiretroviral therapy...
  43. ncbi request reprint Selegiline transdermal system (STS) for HIV-associated cognitive impairment: open-label report of ACTG 5090
    Scott R Evans
    Harvard School of Public Health, Boston, Massachusetts, USA
    HIV Clin Trials 8:437-46. 2007
    ..To assess the long-term safety (primary aim) and efficacy (secondary aim) of the MAO-B inhibitor Selegiline Transdermal System (STS) for the treatment of HIV-associated cognitive impairment...
  44. ncbi request reprint Natalizumab treatment for multiple sclerosis: recommendations for patient selection and monitoring
    Ludwig Kappos
    University Hospital, Basel, Switzerland
    Lancet Neurol 6:431-41. 2007
    ..Maintaining clinical vigilance allows for early suspension of natalizumab in potential cases of PML, thereby increasing the opportunity for immune reconstitution, which may improve prognosis if PML is confirmed...
  45. ncbi request reprint Undetectable cerebrospinal fluid HIV RNA and beta-2 microglobulin do not indicate inactive AIDS dementia complex in highly active antiretroviral therapy-treated patients
    Lucette A Cysique
    St Vincent s Hospital Clinical School, University of New South Wales, Darlinghurst, Sydney, Australia
    J Acquir Immune Defic Syndr 39:426-9. 2005
    ....
  46. ncbi request reprint Mitochondrial haplogroups and peripheral neuropathy during antiretroviral therapy: an adult AIDS clinical trials group study
    Todd Hulgan
    Division of Infectious Diseases, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37203, USA
    AIDS 19:1341-9. 2005
    ..The objective of this study was to determine if NRTI-associated peripheral neuropathy is associated with European mitochondrial haplogroups...
  47. ncbi request reprint Pharmacogenetics of efavirenz and central nervous system side effects: an Adult AIDS Clinical Trials Group study
    David W Haas
    Program for Human Genetics, Vanderbilt University School of Medicine, 345 24th Avenue North, Nashville, TN 37203, USA
    AIDS 18:2391-400. 2004
    ..Efavirenz is metabolized by cytochrome P4502B6 (CYP2B6). We investigated whether polymorphisms in CYP2B6, CYP3A4, CYP3A5, and MDR1 were associated with efavirenz central nervous system side effects and pharmacokinetics...
  48. ncbi request reprint Pharmacogenetics of long-term responses to antiretroviral regimens containing Efavirenz and/or Nelfinavir: an Adult Aids Clinical Trials Group Study
    David W Haas
    Vanderbilt University School of Medicine, Nashville, TN 37203, USA
    J Infect Dis 192:1931-42. 2005
    ..Nelfinavir is a substrate for P-glycoprotein, which is encoded by MDR1. The present study examined associations between genetic variants and long-term responses to treatment...
  49. ncbi request reprint The evolving face of human immunodeficiency virus-related progressive multifocal leukoencephalopathy: defining a consensus terminology
    Paola Cinque
    Clinic of Infectious Diseases, San Raffaele Hospital, Milano, Italy
    J Neurovirol 9:88-92. 2003
    ..A standard patient classification would be helpful for clinical management of PML patients, for their inclusion in clinical studies, and also will increase our current knowledge of PML and its evolution in relation with HAART...
  50. ncbi request reprint Part 2: history of 20th century neurology: decade by decade
    Kenneth Tyler
    Ann Neurol 53:S27-45. 2003
  51. ncbi request reprint Oxidant stress and peripheral neuropathy during antiretroviral therapy: an AIDS clinical trials group study
    Todd Hulgan
    Vanderbilt University School of Medicine, Nashville, TN 37203, USA
    J Acquir Immune Defic Syndr 42:450-4. 2006
    ..Mitochondria play a central role in regulating oxidant stress. We explored the relationships between oxidant stress and NRTI-induced peripheral neuropathy...
  52. ncbi request reprint Hemochromatosis (HFE) gene mutations and peripheral neuropathy during antiretroviral therapy
    Asha R Kallianpur
    Department of Medicine, Divisions of General Internal Medicine and Public Health, Nashville, TN, USA
    AIDS 20:1503-13. 2006
    ..Since iron deficiency is associated with some types of PN, and iron is essential for mitochondrial function, we tested the hypothesis that hemochromatosis (HFE) gene mutations influence susceptibility to NRTI-induced PN...
  53. ncbi request reprint Multilocus genetic interactions and response to efavirenz-containing regimens: an adult AIDS clinical trials group study
    Alison A Motsinger
    Vanderbilt University School of Medicine, Nashville, Tennessee 37203, USA
    Pharmacogenet Genomics 16:837-45. 2006
    ..We examined whether long-term responses to efavirenz, and/or plasma efavirenz exposure, are better predicted by multilocus genetic interactions than by individual polymorphisms...
  54. ncbi request reprint The role of cohort studies in drug development: clinical evidence of antiviral activity of serotonin reuptake inhibitors and HMG-CoA reductase inhibitors in the central nervous system
    Scott L Letendre
    University of California, 150 W Washington St, San Diego, CA 92103, USA
    J Neuroimmune Pharmacol 2:120-7. 2007
    ..Some of these drugs, such as serotonin reuptake inhibitors (SRIs) and HMG-CoA reductase inhibitors (statins), may do so by reducing HIV replication in the CNS and are already widely used by HIV-infected individuals...