T J Cicero

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. ncbi request reprint Role of steroids in sex differences in morphine-induced analgesia: activational and organizational effects
    Theodore J Cicero
    Washington University School of Medicine, Department of Psychiatry, St Louis, Missouri 63110, USA
    J Pharmacol Exp Ther 300:695-701. 2002
  2. ncbi request reprint Gender differences in the intravenous self-administration of mu opiate agonists
    Theodore J Cicero
    Department of Psychiatry, Washington University School of Medicine, Campus Box 8134, St Louis, MO 63110, USA
    Pharmacol Biochem Behav 74:541-9. 2003
  3. ncbi request reprint Gender-linked differences in the expression of physical dependence in the rat
    Theodore J Cicero
    Department of Psychiatry, Washington University School of Medicine, Campus Box 8134, St Louis, MO 63110, USA
    Pharmacol Biochem Behav 72:691-7. 2002
  4. ncbi request reprint Chronic opiate exposure in the male rat adversely affects fertility
    Theodore J Cicero
    Department of Psychiatry, Washington University School of Medicine, Box 8027, 660 South Euclid Avenue, St Louis, MO 63110 1093, USA
    Pharmacol Biochem Behav 72:157-63. 2002
  5. ncbi request reprint A postmarketing surveillance program to monitor Ultram (tramadol hydrochloride) abuse in the United States
    T J Cicero
    Washington University School of Medicine, St Louis, MO 63110 1093, USA
    Drug Alcohol Depend 57:7-22. 1999
  6. ncbi request reprint Chronic exposure to morphine decreases physiologically active corticosterone in both male and female rats but by different mechanisms
    B Nock
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    J Pharmacol Exp Ther 286:875-82. 1998
  7. ncbi request reprint Affinity of drugs and peptides for U-69,593-sensitive and -insensitive kappa opiate binding sites: the U-69,593-insensitive site appears to be the beta endorphin-specific epsilon receptor
    B Nock
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri
    J Pharmacol Exp Ther 254:412-9. 1990
  8. ncbi request reprint Use and misuse of buprenorphine in the management of opioid addiction
    Theodore J Cicero
    Washington University School of Medicine, St Louis, Missouri, USA
    J Opioid Manag 3:302-8. 2007
  9. ncbi request reprint Alcohol intoxication and withdrawal: the role of nitric oxide
    M L Adams
    Washington University School of Medicine, St Louis, MO 63110 1093, USA
    Alcohol 16:153-8. 1998
  10. doi request reprint Source of drugs for prescription opioid analgesic abusers: a role for the Internet?
    Theodore J Cicero
    Departmentof Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Pain Med 9:718-23. 2008

Research Grants

  1. EXTRAMURAL RESEARCH FACILITIES CONSTRUCTION
    Samuel Stanley; Fiscal Year: 2004

Detail Information

Publications23

  1. ncbi request reprint Role of steroids in sex differences in morphine-induced analgesia: activational and organizational effects
    Theodore J Cicero
    Washington University School of Medicine, Department of Psychiatry, St Louis, Missouri 63110, USA
    J Pharmacol Exp Ther 300:695-701. 2002
    ....
  2. ncbi request reprint Gender differences in the intravenous self-administration of mu opiate agonists
    Theodore J Cicero
    Department of Psychiatry, Washington University School of Medicine, Campus Box 8134, St Louis, MO 63110, USA
    Pharmacol Biochem Behav 74:541-9. 2003
    ..Finally, we conclude that they will also expend much greater effort in an operant conditioning task to obtain opiate reinforcement...
  3. ncbi request reprint Gender-linked differences in the expression of physical dependence in the rat
    Theodore J Cicero
    Department of Psychiatry, Washington University School of Medicine, Campus Box 8134, St Louis, MO 63110, USA
    Pharmacol Biochem Behav 72:691-7. 2002
    ....
  4. ncbi request reprint Chronic opiate exposure in the male rat adversely affects fertility
    Theodore J Cicero
    Department of Psychiatry, Washington University School of Medicine, Box 8027, 660 South Euclid Avenue, St Louis, MO 63110 1093, USA
    Pharmacol Biochem Behav 72:157-63. 2002
    ..This potentially important effect of paternal morphine administration on conception and/or preimplementation loss of embryos has not been previously noted and deserves more systematic study...
  5. ncbi request reprint A postmarketing surveillance program to monitor Ultram (tramadol hydrochloride) abuse in the United States
    T J Cicero
    Washington University School of Medicine, St Louis, MO 63110 1093, USA
    Drug Alcohol Depend 57:7-22. 1999
    ..Thus, the data support the decision not to schedule tramadol and, furthermore, suggest that a proactive post-marketing surveillance program can be successfully developed to effectively monitor abuse of new medications...
  6. ncbi request reprint Chronic exposure to morphine decreases physiologically active corticosterone in both male and female rats but by different mechanisms
    B Nock
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    J Pharmacol Exp Ther 286:875-82. 1998
    ..Thus, morphine appears to cause a deficit in physiologically active corticosterone in both sexes but by different mechanisms...
  7. ncbi request reprint Affinity of drugs and peptides for U-69,593-sensitive and -insensitive kappa opiate binding sites: the U-69,593-insensitive site appears to be the beta endorphin-specific epsilon receptor
    B Nock
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri
    J Pharmacol Exp Ther 254:412-9. 1990
    ..We could not identify any compound that is selective for the putative epsilon site. Of the more than 50 compounds tested, all were either equally potent at the [3H]U-69,593 and [3H]EKC sites or were more potent at the [3H]U-69,593 site...
  8. ncbi request reprint Use and misuse of buprenorphine in the management of opioid addiction
    Theodore J Cicero
    Washington University School of Medicine, St Louis, Missouri, USA
    J Opioid Manag 3:302-8. 2007
    ..Thus, the results indicate that it is unlikely that buprenorphine abuse will ever reach the epidemic that was feared by some regulatory groups and that its use in opioid detoxification and maintenance should continue...
  9. ncbi request reprint Alcohol intoxication and withdrawal: the role of nitric oxide
    M L Adams
    Washington University School of Medicine, St Louis, MO 63110 1093, USA
    Alcohol 16:153-8. 1998
    ....
  10. doi request reprint Source of drugs for prescription opioid analgesic abusers: a role for the Internet?
    Theodore J Cicero
    Departmentof Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Pain Med 9:718-23. 2008
    ..We have studied whether this is correct...
  11. pmc Co-morbidity and utilization of medical services by pain patients receiving opioid medications: data from an insurance claims database
    Theodore J Cicero
    Department of Psychiatry, Washington University School of Medicine, Campus Box 8134, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Pain 144:20-7. 2009
    ..g. morphine and oxycodone) seemed to be driven by numerous factors not necessarily related to the intensity or duration of pain...
  12. pmc Determinants of fentanyl and other potent ยต opioid agonist misuse in opioid-dependent individuals
    Theodore J Cicero
    Department of Psychiatry, Washington University, St Louis, MO 63110, USA
    Pharmacoepidemiol Drug Saf 19:1057-63. 2010
    ..Since the latter is seldom true, we postulated that there would be a significant mismatch between actual and predicted rates of misuse...
  13. doi request reprint Co-morbid pain and psychopathology in males and females admitted to treatment for opioid analgesic abuse
    Theodore J Cicero
    Department of Psychiatry, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8134, St Louis, MO 63110 1093, USA
    Pain 139:127-35. 2008
    ....
  14. ncbi request reprint Relationship between therapeutic use and abuse of opioid analgesics in rural, suburban, and urban locations in the United States
    Theodore J Cicero
    Washington University School of Medicine, MO, USA
    Pharmacoepidemiol Drug Saf 16:827-40. 2007
    ..The goal of these studies was to determine the relationship between prescribed use of opioid analgesics and their non-medically related use (abuse) at a regional level across the country...
  15. ncbi request reprint Trends in the use and abuse of branded and generic extended release oxycodone and fentanyl products in the United States
    Theodore J Cicero
    Washington University School of Medicine, Department of Psychiatry, 660 South Euclid Avenue, Campus Box 8134, St Louis, MO 63110 1093, USA
    Drug Alcohol Depend 91:115-20. 2007
    ..In this paper we assessed whether the introduction of generic products in the U.S. increased the therapeutic use and illicit abuse of extended release oxycodone products and the fentanyl patch...
  16. ncbi request reprint The development of a comprehensive risk-management program for prescription opioid analgesics: researched abuse, diversion and addiction-related surveillance (RADARS)
    Theodore J Cicero
    Washington University School of Medicine, St Louis, Missouri 63110, USA
    Pain Med 8:157-70. 2007
    ..Thus, its major focus was the detection of abuse of OxyContin and other commonly prescribed opioid analgesics at the three-digit ZIP code level across the country utilizing a number of different detection systems...
  17. ncbi request reprint Trends in abuse of Oxycontin and other opioid analgesics in the United States: 2002-2004
    Theodore J Cicero
    Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Pain 6:662-72. 2005
    ..These results indicate that OxyContin abuse is a pervasive problem in this country, but that it needs to be considered in the context of a general pattern of increasing prescription drug abuse...
  18. ncbi request reprint Rates of abuse of tramadol remain unchanged with the introduction of new branded and generic products: results of an abuse monitoring system, 1994-2004
    Theodore J Cicero
    Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Pharmacoepidemiol Drug Saf 14:851-9. 2005
    ..This provided a unique opportunity to study the potential changes in abuse as the generic and combination products became available...
  19. ncbi request reprint Chronic morphine increases the pituitary-adrenocortical response of juvenile rats to mild stress
    Bruce Nock
    Washington University School of Medicine, Department of Psychiatry, St Louis, MO 63110, USA
    Pharmacol Biochem Behav 80:77-85. 2005
    ..Either way, there is a striking shift in morphine's effects on the pituitary-adrenocortical axis across development...
  20. pmc Role of key informants and direct patient interviews in epidemiological studies of substance abuse
    Theodore J Cicero
    Washington University in St Louis, Department of Psychiatry, St Louis, MO, USA
    Pharmacoepidemiol Drug Saf 20:308-12. 2011
    ..The present study was undertaken to assess the degree to which key informants' perceptions of relative abuse liability of opioids in their communities correspond to actual drug use in their patients...
  21. ncbi request reprint Imidazoles suppress rat testosterone secretion and testicular interstitial fluid formation In vivo
    M L Adams
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110 1093
    Biol Reprod 59:248-54. 1998
    ..These results support the hypothesis that imidazoles inhibit testicular function and male reproductive function through inhibition of testosterone secretion, TIF formation, and LH secretion regulatory systems...
  22. ncbi request reprint Testosterone is required for corticosteroid-binding globulin upregulation by morphine to be fully manifested
    B Nock
    Department of Psychiatry, Anatomy, and Neurobiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Pharmacol Biochem Behav 67:193-8. 2000
    ..Thus, testosterone appears necessary for morphine effects on CBG to be fully manifested...
  23. ncbi request reprint Properties of the putative epsilon opioid receptor: identification in rat, guinea pig, cow, pig and chicken brain
    B Nock
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri
    J Pharmacol Exp Ther 264:349-59. 1993
    ....

Research Grants1

  1. EXTRAMURAL RESEARCH FACILITIES CONSTRUCTION
    Samuel Stanley; Fiscal Year: 2004
    ..The CNRU will bring together a wide group of researchers providing a synergistic environment to enhance translational and clinical neuroscience research at Washington University in St. Louis. ..