Hyelim Cho

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. pmc Immune responses to West Nile virus infection in the central nervous system
    Hyelim Cho
    Departments of Molecular Microbiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Viruses 4:3812-30. 2012
  2. pmc 2'-O methylation of the viral mRNA cap by West Nile virus evades ifit1-dependent and -independent mechanisms of host restriction in vivo
    Kristy J Szretter
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri, United Stated of America
    PLoS Pathog 8:e1002698. 2012
  3. pmc A role for Ifit2 in restricting West Nile virus infection in the brain
    Hyelim Cho
    Department of Molecular Microbiology, Washington University School of Medicine, St Louis, Missouri, USA
    J Virol 87:8363-71. 2013
  4. pmc Interferon regulatory factor-1 (IRF-1) shapes both innate and CD8(+) T cell immune responses against West Nile virus infection
    James D Brien
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS Pathog 7:e1002230. 2011
  5. pmc A short hairpin RNA screen of interferon-stimulated genes identifies a novel negative regulator of the cellular antiviral response
    Jianqing Li
    Department of Molecular Microbiology, Washington University School of Medicine, St Louis, Missouri, USA
    MBio 4:e00385-13. 2013
  6. pmc Differential innate immune response programs in neuronal subtypes determine susceptibility to infection in the brain by positive-stranded RNA viruses
    Hyelim Cho
    Department of Molecular Microbiology, Washington University School of Medicine, St Louis, Missouri, USA
    Nat Med 19:458-64. 2013
  7. pmc Viral MHC class I inhibition evades CD8+ T-cell effector responses in vivo but not CD8+ T-cell priming
    Maria D Gainey
    Rheumatology Division, Department of Medicine, Washington University School of Medicine in St Louis, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 109:E3260-7. 2012
  8. pmc A short N-terminal peptide motif on flavivirus nonstructural protein NS1 modulates cellular targeting and immune recognition
    Soonjeon Youn
    Department of Medicine, Washington University School of Medicine, 660 South Euclid Ave, Saint Louis, MO 63110, USA
    J Virol 84:9516-32. 2010

Collaborators

Detail Information

Publications8

  1. pmc Immune responses to West Nile virus infection in the central nervous system
    Hyelim Cho
    Departments of Molecular Microbiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Viruses 4:3812-30. 2012
    ..We will focus on defining the current state of knowledge of WNV entry, tropism, and host immune response in the CNS, all of which affect the balance between injury and successful clearance...
  2. pmc 2'-O methylation of the viral mRNA cap by West Nile virus evades ifit1-dependent and -independent mechanisms of host restriction in vivo
    Kristy J Szretter
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri, United Stated of America
    PLoS Pathog 8:e1002698. 2012
    ....
  3. pmc A role for Ifit2 in restricting West Nile virus infection in the brain
    Hyelim Cho
    Department of Molecular Microbiology, Washington University School of Medicine, St Louis, Missouri, USA
    J Virol 87:8363-71. 2013
    ..Our results suggest that Ifit2 restricts WNV infection and pathogenesis in different tissues in a cell type-specific manner. ..
  4. pmc Interferon regulatory factor-1 (IRF-1) shapes both innate and CD8(+) T cell immune responses against West Nile virus infection
    James D Brien
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS Pathog 7:e1002230. 2011
    ..Thus, IRF-1 restricts WNV infection by modulating the expression of innate antiviral effector molecules while shaping the antigen-specific CD8(+) T cell response...
  5. pmc A short hairpin RNA screen of interferon-stimulated genes identifies a novel negative regulator of the cellular antiviral response
    Jianqing Li
    Department of Molecular Microbiology, Washington University School of Medicine, St Louis, Missouri, USA
    MBio 4:e00385-13. 2013
    ..Compared to prior ectopic ISG expression studies, our shRNA screen identified novel ISGs that restrict infection of WNV and other viruses and defined a new counterregulatory ISG, ASCC3, which tempers cell-intrinsic immunity...
  6. pmc Differential innate immune response programs in neuronal subtypes determine susceptibility to infection in the brain by positive-stranded RNA viruses
    Hyelim Cho
    Department of Molecular Microbiology, Washington University School of Medicine, St Louis, Missouri, USA
    Nat Med 19:458-64. 2013
    ..Thus, neurons from evolutionarily distinct brain regions have unique innate immune signatures, which probably contribute to their relative permissiveness to infection...
  7. pmc Viral MHC class I inhibition evades CD8+ T-cell effector responses in vivo but not CD8+ T-cell priming
    Maria D Gainey
    Rheumatology Division, Department of Medicine, Washington University School of Medicine in St Louis, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 109:E3260-7. 2012
    ..Instead, we demonstrate that, during acute infection in vivo, MHC class I down-regulation prevents primed virus-specific CD8(+) T cells from recognizing infected cells and exerting effector responses to control the infection...
  8. pmc A short N-terminal peptide motif on flavivirus nonstructural protein NS1 modulates cellular targeting and immune recognition
    Soonjeon Youn
    Department of Medicine, Washington University School of Medicine, 660 South Euclid Ave, Saint Louis, MO 63110, USA
    J Virol 84:9516-32. 2010
    ..These studies also suggest a link between the effects of NS1 on viral replication and the levels of secreted or cell surface NS1...