James Cheverud

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. ncbi request reprint Independent quantitative trait loci influence ventral and dorsal hippocampal volume in recombinant inbred strains of mice
    Maureen V Martin
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Genes Brain Behav 5:614-23. 2006
  2. pmc Healing quantitative trait loci in a combined cross analysis using related mouse strain crosses
    J M Cheverud
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Heredity (Edinb) 108:441-6. 2012
  3. pmc Sex dependent imprinting effects on complex traits in mice
    Reinmar Hager
    Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK
    BMC Evol Biol 8:303. 2008
  4. ncbi request reprint Genetic architecture of adiposity in the cross of LG/J and SM/J inbred mice
    J M Cheverud
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Mamm Genome 12:3-12. 2001
  5. ncbi request reprint Genetic evidence for discordance between obesity- and diabetes-related traits in the LGXSM recombinant inbred mouse strains
    James M Cheverud
    Department of Anatomy and Neurobiology, Washington University School of Medicine, 660 S Euclid Ave, St Louis, MO 63110, USA
    Diabetes 53:2700-8. 2004
  6. ncbi request reprint Quantitative trait loci for obesity- and diabetes-related traits and their dietary responses to high-fat feeding in LGXSM recombinant inbred mouse strains
    James M Cheverud
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, MO, 63110, USA
    Diabetes 53:3328-36. 2004
  7. pmc Fine-mapping of obesity-related quantitative trait loci in an F9/10 advanced intercross line
    Gloria L Fawcett
    Department of Anatomy and Neurobiology, Washington University in St Louis, St Louis, Missouri, USA
    Obesity (Silver Spring) 18:1383-92. 2010
  8. pmc Evolution in a genetically heritable social environment
    James M Cheverud
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 100:4357-9. 2003
  9. ncbi request reprint Pleiotropic effects on mandibular morphology II: differential epistasis and genetic variation in morphological integration
    James M Cheverud
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Exp Zool B Mol Dev Evol 302:424-35. 2004
  10. ncbi request reprint A simple correction for multiple comparisons in interval mapping genome scans
    J M Cheverud
    Department of Anatomy and Neurobiology, Washington University School of Medicine, 660 S Euclid Ave, St Louis, MO, 63110, USA
    Heredity (Edinb) 87:52-8. 2001

Collaborators

Detail Information

Publications71

  1. ncbi request reprint Independent quantitative trait loci influence ventral and dorsal hippocampal volume in recombinant inbred strains of mice
    Maureen V Martin
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Genes Brain Behav 5:614-23. 2006
    ..These findings suggest that the development of the ventral and dorsal components of the hippocampus is influenced by separate genetic loci...
  2. pmc Healing quantitative trait loci in a combined cross analysis using related mouse strain crosses
    J M Cheverud
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Heredity (Edinb) 108:441-6. 2012
    ..QTL support intervals are 40% smaller in the combined cross analysis than in either of the single crosses. Combined cross analysis was successful in enhancing the interpretation of earlier QTL results for these strains...
  3. pmc Sex dependent imprinting effects on complex traits in mice
    Reinmar Hager
    Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK
    BMC Evol Biol 8:303. 2008
    ..Moreover, theoretical work on the evolution of sex-dependent genomic imprinting effects makes specific predictions about the phenotypic patterns of such effects, which, however, have not been assessed empirically to date...
  4. ncbi request reprint Genetic architecture of adiposity in the cross of LG/J and SM/J inbred mice
    J M Cheverud
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Mamm Genome 12:3-12. 2001
    ..Body size and obesity QTLs in the same locations as those discovered here are commonly found in mapping experiments with other mouse strains...
  5. ncbi request reprint Genetic evidence for discordance between obesity- and diabetes-related traits in the LGXSM recombinant inbred mouse strains
    James M Cheverud
    Department of Anatomy and Neurobiology, Washington University School of Medicine, 660 S Euclid Ave, St Louis, MO 63110, USA
    Diabetes 53:2700-8. 2004
    ..These recombinant inbred strains represent potentially valuable new models for dissecting the complex physiological relationships among obesity and diabetes...
  6. ncbi request reprint Quantitative trait loci for obesity- and diabetes-related traits and their dietary responses to high-fat feeding in LGXSM recombinant inbred mouse strains
    James M Cheverud
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, MO, 63110, USA
    Diabetes 53:3328-36. 2004
    ..These QTL locations form a panel for further research and fine mapping of loci affecting obesity- and diabetes-related traits and their responses to high-fat feeding...
  7. pmc Fine-mapping of obesity-related quantitative trait loci in an F9/10 advanced intercross line
    Gloria L Fawcett
    Department of Anatomy and Neurobiology, Washington University in St Louis, St Louis, Missouri, USA
    Obesity (Silver Spring) 18:1383-92. 2010
    ..We also present further characterization of the pleiotropic and epistatic interactions underlying these obesity-related traits...
  8. pmc Evolution in a genetically heritable social environment
    James M Cheverud
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 100:4357-9. 2003
  9. ncbi request reprint Pleiotropic effects on mandibular morphology II: differential epistasis and genetic variation in morphological integration
    James M Cheverud
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Exp Zool B Mol Dev Evol 302:424-35. 2004
    ..These results comprise examples of genetic variation necessary for an evolutionary response to selection on the range of pleiotropic effects...
  10. ncbi request reprint A simple correction for multiple comparisons in interval mapping genome scans
    J M Cheverud
    Department of Anatomy and Neurobiology, Washington University School of Medicine, 660 S Euclid Ave, St Louis, MO, 63110, USA
    Heredity (Edinb) 87:52-8. 2001
    ..The method introduced here provides a relatively simple correction for multiple comparisons that can be easily calculated using standard statistics packages...
  11. pmc Calpain-10 is a component of the obesity-related quantitative trait locus Adip1
    James M Cheverud
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, MO, USA
    J Lipid Res 51:907-13. 2010
    ..Differences between the LG/J and SM/J Capn10 alleles are the likely source of some of the QTL effects mapped to Adip1 in the LG/J-by-SM/J cross. Capn10 plays an important role in regulating obesity and diabetes in mice...
  12. ncbi request reprint Fine-mapping gene-by-diet interactions on chromosome 13 in a LG/J x SM/J murine model of obesity
    Thomas H Ehrich
    Department of Anatomy and Neurobiology, Washington University School of Medicine, 660 S Euclid Ave, St Louis, MO 63110, USA
    Diabetes 54:1863-72. 2005
    ..The phosphofructokinase (PFK) C (Pfkp) and the pitrilysin metalloprotease 1 (Pitrm1) genes are compelling positional candidate genes in this region that show coding sequence differences between the parental strains in functional domains...
  13. pmc Genetic relationships between obesity and osteoporosis in LGXSM recombinant inbred mice
    Michael S Reich
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Genet Res (Camb) 90:433-44. 2008
    ..Our results support the use of the LG/J-by-SM/J mouse intercross populations as models for normal, complex genetic variation in obesity, bone properties and their interrelationship...
  14. pmc Genetic influences on hippocampal structure and function in recombinant inbred mice
    Maureen V Martin
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA
    Behav Brain Res 196:78-83. 2009
    ....
  15. ncbi request reprint Genetic variation and correlation of dietary response in an advanced intercross mouse line produced from two divergent growth lines
    Thomas H Ehrich
    Department of Anatomy and Neurobiology, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Genet Res 85:211-22. 2005
    ..Therefore, genetic effects for these traits are different depending on the environment an animal is exposed to...
  16. ncbi request reprint The relationship between development and evolution through heritable variation
    James M Cheverud
    Department of Anatomy and Neurobiology, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Novartis Found Symp 284:55-65; discussion 65-70, 110-5. 2007
    ..We hypothesize that modular pleiotropic patterns are sculpted by natural selection so that functionally-and developmentally-related traits are affected by module-specific genes...
  17. doi request reprint Differential dominance of pleiotropic loci for mouse skeletal traits
    Jane P Kenney-Hunt
    Washington University School of Medicine, Department of Anatomy and Neurobiology, Saint Louis, Missouri 63110, USA
    Evolution 63:1845-51. 2009
    ..We conclude that multivariate overdominance is common and should be considered in models and in empirical studies of the role of genetic variation in evolvability...
  18. ncbi request reprint Genetic characterization of a new set of recombinant inbred lines (LGXSM) formed from the inter-cross of SM/J and LG/J inbred mouse strains
    Tomas Hrbek
    Department of Anatomy and Neurobiology, Washington University School of Medicine, 660 S Euclid Ave, St Louis, Missouri 63110, USA
    Mamm Genome 17:417-29. 2006
    ..The LGxSM RI strain panel provides a powerful new resource for mapping the genetic bases of complex traits and should prove to be of great biomedical utility in modeling complex human diseases such as obesity and diabetes...
  19. pmc A high-resolution map of segmental DNA copy number variation in the mouse genome
    Timothy A Graubert
    Department of Medicine, Division of Oncology, Stem Cell Biology Section, Washington University, St Louis, Missouri, United States of America
    PLoS Genet 3:e3. 2007
    ..Annotation of CNVs in the mouse genome combined with sequence-based analysis provides an important resource that will help define the genetic basis of complex traits...
  20. ncbi request reprint Genetic variation in pleiotropy: differential epistasis as a source of variation in the allometric relationship between long bone lengths and body weight
    Mihaela Pavlicev
    Department of Anatomy and Neurobiology, Washington University, St Louis, MO 63110, USA
    Evolution 62:199-213. 2008
    ..Variation in pleiotropy maintains evolvability of the genetic architecture, in particular the evolvability of its modular organization...
  21. pmc Replication of long-bone length QTL in the F9-F10 LG,SM advanced intercross
    Elizabeth A Norgard
    Department of Anatomy and Neurobiology, Washington University School of Medicine, Box 8108, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Mamm Genome 20:224-35. 2009
    ..Further characterization of the biological bases of these QTL will help provide a better understanding of the genetics of small variations in long-bone length...
  22. ncbi request reprint The evolution of genetic architecture. I. Diversification of genetic backgrounds by genetic drift
    Reinaldo A De Brito
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Evolution 59:2333-42. 2005
    ..Further analysis indicates that this differentiation results in changes in the order of tester strain effects so that common patterns of selection in these differentiated populations could result in the fixation of different alleles...
  23. ncbi request reprint Trends in metabolic syndrome and gene networks in human and rodent models
    Aldi T Kraja
    Division of Statistical Genomics, Washington University School of Medicine, 4444 Forest Park Blvd, Campus Box 8506, Saint Louis, MO 63110, USA
    Endocr Metab Immune Disord Drug Targets 8:198-207. 2008
    ..Our results justify the existence of MetS as a meaningful syndrome and suggest that a better understanding of its etiology can benefit the health of human kind...
  24. ncbi request reprint Quantitative trait loci for body size components in mice
    Jane P Kenney-Hunt
    Department of Anatomy and Neurobiology, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Mamm Genome 17:526-37. 2006
    ..Antagonistic pleiotropy, in which a locus has opposite effects on different characteristics, is uncommon...
  25. ncbi request reprint Pleiotropic effects on mandibular morphology I. Developmental morphological integration and differential dominance
    Thomas H Ehrich
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Exp Zool B Mol Dev Evol 296:58-79. 2003
    ..We find that multivariate overdominance is a common and substantial phenomenon, and may potentially provide an explanation for the persistence of heterozygosity in natural populations...
  26. pmc Quantitative trait loci associated with susceptibility to therapy-related acute murine promyelocytic leukemia in hCG-PML/RARA transgenic mice
    Ryan K Funk
    Department of Internal Medicine, Division of Oncology, Stem Cell Biology Section, Washington University School of Medicine, St Louis, MO 63110, USA
    Blood 112:1434-42. 2008
    ..Improved understanding of genetic risk factors should lead to tailored treatment regimens that reduce risk for patients predisposed to t-AML...
  27. pmc Identification of quantitative trait loci affecting murine long bone length in a two-generation intercross of LG/J and SM/J Mice
    Elizabeth A Norgard
    Department of Anatomy and Neurobiology, Washington University, St Louis, Missouri 63110, USA
    J Bone Miner Res 23:887-95. 2008
    ..However, the molecular nature of variation in large, phenotypically normal populations tends to be characterized by smaller phenotypic effects that remain undefined...
  28. ncbi request reprint Diet, obesity, and hyperglycemia in LG/J and SM/J mice
    Thomas H Ehrich
    Department of Anatomy and Neurobiology, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Obes Res 11:1400-10. 2003
    ..To examine the differential response of obesity- and diabetes-related traits to a high- or low-fat diet in LG/J and SM/J mice. We also examined food consumption in these strains...
  29. doi request reprint Genetic architecture of adiposity and organ weight using combined generation QTL analysis
    Gloria L Fawcett
    Department of Anatomy and Neurobiology, Washington University in St Louis, St Louis, Missouri, USA
    Obesity (Silver Spring) 16:1861-8. 2008
    ..Analysis of the complex genetic architecture underlying fatpad and organ weights in this model may eventually help to elucidate not only heritable contributions to obesity but also common gene sets for obesity and its comorbidities...
  30. pmc Metabolic syndrome components in murine models
    Heather A Lawson
    The Department of Anatomy and Neurobiology, Washington University School of Medicine in St Louis, MO, USA
    Endocr Metab Immune Disord Drug Targets 10:25-40. 2010
    ..Finally we discuss how knowledge gained from mouse models can be used in conjunction with comparative genomic methods and bioinformatic resources to inform human MetS research...
  31. pmc The importance of context to the genetic architecture of diabetes-related traits is revealed in a genome-wide scan of a LG/J × SM/J murine model
    Heather A Lawson
    Department of Anatomy and Neurobiology, Washington University School of Medicine, 3820 North Building, Campus Box 8108, St Louis, MO 63110, USA
    Mamm Genome 22:197-208. 2011
    ..Our results have important implications for studies of complex traits in humans...
  32. ncbi request reprint Maternal genotype affects adult offspring lipid, obesity, and diabetes phenotypes in LGXSM recombinant inbred strains
    Joseph P Jarvis
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Lipid Res 46:1692-702. 2005
    ..We also found an interaction affecting adult phenotype between the effects of maternal care between RI strain mothers and C57BL/6J mothers and a later environmental factor (dietary fat intake) for some age-specific weights...
  33. ncbi request reprint Convergence and the multidimensional niche
    Luke J Harmon
    Department of Biology, Washington University, St Louis, Missouri 63130, USA
    Evolution 59:409-21. 2005
    ..This suggests that the habitat specialist niches into which these anoles have evolved are multidimensional, involving several distinct and independent aspects of morphology...
  34. pmc Genetic factors and diet affect long-bone length in the F34 LG,SM advanced intercross
    Elizabeth A Norgard
    Department of Anatomy and Neurobiology, Washington University School of Medicine, Campus Box 8108, 660 South Euclid Avenue, Saint Louis, MO 63110, USA
    Mamm Genome 22:178-96. 2011
    ..Additional experimentation is required to understand how changes in gene regulation or protein function can alter the genetic architecture and interact with the environment to produce phenotypic variation...
  35. pmc Diet-dependent genetic and genomic imprinting effects on obesity in mice
    James M Cheverud
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri, USA
    Obesity (Silver Spring) 19:160-70. 2011
    ..Nearly every locus interacted with sex and/or diet in important ways demonstrating that gene effects are primarily context dependent, changing depending on sex and/or diet...
  36. pmc Genetic, epigenetic, and gene-by-diet interaction effects underlie variation in serum lipids in a LG/JxSM/J murine model
    Heather A Lawson
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, MO, USA
    J Lipid Res 51:2976-84. 2010
    ..Here we examine genetic, environmental, and genetic-by-environmental interactions of QTL overlapping previously identified loci associated with CVD risk factors, and we add to the serum lipid QTL landscape by identifying new loci...
  37. pmc Obesity-insulin targeted genes in the 3p26-25 region in human studies and LG/J and SM/J mice
    Aldi T Kraja
    Division of Statistical Genomics, Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, MO 63110, USA
    Metabolism 61:1129-41. 2012
    ..Several of the candidate genes have functions in the brain. Their interaction with MetS and the brain warrants further investigation...
  38. pmc Evidence for nucleolus organizer regions as the units of regulation in nucleolar dominance in Arabidopsis thaliana interecotype hybrids
    Michelle S Lewis
    Biology Department, Washington University, St Louis, Missouri 63130, USA
    Genetics 167:931-9. 2004
    ..NOR2. Collectively, the data indicate that nucleolar dominance is a complex trait in which NORs, rather than individual rRNA genes, are the likely units of regulation...
  39. pmc Genomic imprinting effects on adult body composition in mice
    James M Cheverud
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 105:4253-8. 2008
    ..These results indicate that genomic imprinting has small, but detectable, effects on the normal variation of complex traits in adults and is likely to be more common than usually thought...
  40. pmc Pleiotropic patterns of quantitative trait loci for 70 murine skeletal traits
    Jane P Kenney-Hunt
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Genetics 178:2275-88. 2008
    ..Evaluating the pleiotropic relationships of skeletal traits is important in understanding the role of genetic variation in the growth and development of the skeleton...
  41. ncbi request reprint Helicobacter pylori tissue tropism: mouse-colonizing strains can target different gastric niches
    Junko K Akada
    Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Microbiology 149:1901-9. 2003
    ..Differences among gastric regions and the mixed infections that these allow may contribute to H. pylori diversity and genome evolution...
  42. ncbi request reprint Discerning evolutionary processes in patterns of tamarin (genus Saguinus) craniofacial variation
    Rebecca Rogers Ackermann
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Phys Anthropol 117:260-71. 2002
    ..midas and S. bicolor. Morphological similarity is not a good guide to phylogenetic affinity in the tamarins, especially with regard to deeper nodes in the phylogenetic tree...
  43. ncbi request reprint Identification of candidate alkylator-induced cancer susceptibility genes by whole genome scanning in mice
    Timothy S Fenske
    Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cancer Res 66:5029-38. 2006
    ....
  44. doi request reprint Pleiotropic scaling of gene effects and the 'cost of complexity'
    Gunter P Wagner
    Department of Ecology and Evolutionary Biology, Yale University, New Haven, Connecticut 06520 8106, USA
    Nature 452:470-2. 2008
    ..This suggests that evolution of higher organisms does not suffer a 'cost of complexity' because most mutations affect few traits and the size of the effects does not decrease with pleiotropy...
  45. pmc Genome-wide analysis reveals a complex pattern of genomic imprinting in mice
    Jason B Wolf
    Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom
    PLoS Genet 4:e1000091. 2008
    ..Our findings also show that the imprinting pattern of a locus can be variable over ontogenetic time and, in contrast to current views, may often be stronger at later stages in life...
  46. ncbi request reprint Pleiotropy of quantitative trait loci for organ weights and limb bone lengths in mice
    Larry J Leamy
    Department of Biology, University of North Carolina at Charlotte, Charlotte, North Carolina 28223, USA
    Physiol Genomics 10:21-9. 2002
    ..The direction of the effect of these QTLs was almost always consistent within and between characters, with little evidence for antagonistic pleiotropy...
  47. ncbi request reprint An epistatic genetic basis for fluctuating asymmetry of mandible size in mice
    Larry J Leamy
    Department of Biology, University of North Carolina, Charlotte 28223, USA
    Evolution 56:642-53. 2002
    ....
  48. pmc Analysis of quantitative trait locus effects on the size and shape of mandibular molars in mice
    Michael Scott Workman
    Department of Biology, University of North Carolina, Charlotte, North Carolina 28223, USA
    Genetics 160:1573-86. 2002
    ....
  49. pmc Quantitative trait loci for maternal performance for offspring survival in mice
    Andréa C Peripato
    Department of Biology Genetics, IB, Universidade de Sao Paulo, Brazil
    Genetics 162:1341-53. 2002
    ....
  50. pmc Maternal effects as the cause of parent-of-origin effects that mimic genomic imprinting
    Reinmar Hager
    Faculty of Life Sciences, University of Manchester, Manchester, UK
    Genetics 178:1755-62. 2008
    ....
  51. ncbi request reprint A unifying statistical model for QTL mapping of genotype x sex interaction for developmental trajectories
    Wei Zhao
    Department of Statistics, University of Florida, Gainesville, Florida 32611, USA
    Physiol Genomics 19:218-27. 2004
    ..The implications of our model for studying the genetic architecture of growth trajectories and its extensions to some more general situations are discussed...
  52. ncbi request reprint The Collaborative Cross, a community resource for the genetic analysis of complex traits
    Gary A Churchill
    The Jackson Laboratory, 600 Main Street Bar Harbor, Maine 04609, USA
    Nat Genet 36:1133-7. 2004
    ..The Collaborative Cross will provide a common reference panel specifically designed for the integrative analysis of complex systems and will change the way we approach human health and disease...
  53. ncbi request reprint A non-stationary model for functional mapping of complex traits
    Wei Zhao
    Department of Statistics, University of Florida, Gainesville, FL 32611, USA
    Bioinformatics 21:2469-77. 2005
    ..Based on results from computer simulation studies, we suggest that these two models are alternative to one another and should be used simultaneously for the same dataset...
  54. pmc Integration and modularity of quantitative trait locus effects on geometric shape in the mouse mandible
    Christian Peter Klingenberg
    School of Biological Sciences, University of Manchester, Manchester M13 9PT, United Kingdom
    Genetics 166:1909-21. 2004
    ....
  55. pmc Epistatic pleiotropy and the genetic architecture of covariation within early and late-developing skull trait complexes in mice
    Jason B Wolf
    Faculty of Life Sciences, University of Manchester, UK
    Genetics 171:683-94. 2005
    ..Nearly all single-locus and epistatic pleiotropic effects contributed positive components to covariances between traits, suggesting that genetic integration in the skull is achieved by a complex combination of pleiotropic effects...
  56. ncbi request reprint Size as a line of least evolutionary resistance: diet and adaptive morphological radiation in New World monkeys
    Gabriel Marroig
    Departamento de Genética e Biologia Evolutiva, Instituto de Biociencias, Universidade de Sao Paulo, CP 11 461, CEP 05422 970, Sao Paulo, SP, Brazil
    Evolution 59:1128-42. 2005
    ....
  57. ncbi request reprint Mechanistic mapping of ontogenetic growth based on biological principles
    Min Lin
    Department of Statistics, University of Florida, Gainesville, Florida 32611, USA
    Growth Dev Aging 69:31-7. 2005
    ..The model provides the basis for deciphering genetic relationships for growth rates and the timing of life history events for any kind of organisms...
  58. ncbi request reprint Model for mapping imprinted quantitative trait loci in an inbred F2 design
    Yuehua Cui
    Department of Statistics, University of Florida, Gainesville, FL 32611, USA
    Genomics 87:543-51. 2006
    ..Our approach provides a standard procedure for testing the statistical significance of iQTL involved in the genetic control of complex traits...
  59. ncbi request reprint Systematics and evolution of the Jacchus group of marmosets (Platyrrhini)
    Gabriel Marroig
    Departamento de Biologia Celular e Genetica, Instituto de Biologia, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil 20550 013
    Am J Phys Anthropol 123:11-22. 2004
    ..This result, together with the lack of clinal variation in skull traits, suggests that an allopatric model of speciation might best explain eastern marmoset diversification...
  60. ncbi request reprint Fine mapping of mouse QTLs for fatness using SNP data
    Armin O Schmitt
    Institute for Animal Sciences, Humboldt Universitat zu Berlin, Berlin, Germany
    OMICS 11:341-50. 2007
    ..Viewing the genomic region of fatness-related QTLs under several different aspects is appropriate to assess the many thousands of genes that reside in such QTLs and to produce lists of more robust candidate genes...
  61. pmc Antagonistic pleiotropic effects reduce the potential adaptive value of the FRIGIDA locus
    Nora Scarcelli
    Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester, United Kingdom
    Proc Natl Acad Sci U S A 104:16986-91. 2007
    ..We propose that these antagonistic pleiotropic effects reduce the adaptive value of FRI, and helps explain the maintenance of alternative life history strategies across natural populations of A. thaliana...
  62. ncbi request reprint Perspective: Evolution and detection of genetic robustness
    J Arjan G M de Visser
    Department of Genetics, Wageningen University, Arboretumlaan 4, 6703 BD Wageningen, The Netherlands
    Evolution 57:1959-72. 2003
    ....
  63. ncbi request reprint Identifying the morphological signatures of hybridization in primate and human evolution
    Rebecca Rogers Ackermann
    Department of Archaeology, University of Cape Town, Rondebosch 7701, South Africa
    J Hum Evol 51:632-45. 2006
    ..Similar variation is also observed in museum samples drawn from natural hybrid zones. The results offer a strategy for detecting hybrid zones in the fossil record; implications for interpreting the hominin fossil record are discussed...
  64. ncbi request reprint A statistical model for dissecting genomic imprinting through genetic mapping
    Yuehua Cui
    Department of Statistics and Probability, Michigan State University, A 411 Wells Hall, East Lansing, MI 48824, USA
    Genetica 130:227-39. 2007
    ..Two partially maternal imprinting iQTL are identified which regulate the growth of body weight. Our approach provides a testable framework for identifying and estimating iQTL involved in the genetic control of complex traits...
  65. ncbi request reprint The contribution of epistatic pleiotropy to the genetic architecture of covariation among polygenic traits in mice
    Jason B Wolf
    Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK
    Evol Dev 8:468-76. 2006
    ..Thus, although epistatic pleiotropy made a smaller contribution than single-locus pleiotropy, it clearly made a significant contribution to the genetic architecture of variation/covariation...
  66. ncbi request reprint Genetic mapping of allometric scaling laws
    Fei Long
    Department of Statistics, University of Florida, Gainesville, FL 32611, USA
    Genet Res 87:207-16. 2006
    ..This model has been validated by a real example for a mouse F2 progeny, in which two QTLs were detected on different chromosomes that determine the allometric relationship between growth rate and body weight...
  67. pmc A mechanistic model for genetic machinery of ontogenetic growth
    Rongling Wu
    Department of Statistics, University of Florida, Gainesville, Florida 32611, USA
    Genetics 168:2383-94. 2004
    ..The estimates of QTL positions and effects from our model are broadly in agreement with those by traditional interval-mapping approaches. The implications of this model for biological and biomedical research are discussed...
  68. pmc Detecting genetic drift versus selection in human evolution
    Rebecca Rogers Ackermann
    Department of Archaeology, University of Cape Town, Private Bag, Rondebosch 7701, South Africa
    Proc Natl Acad Sci U S A 101:17946-51. 2004
    ....
  69. pmc The nature and identification of quantitative trait loci: a community's view
    Oduola Abiola
    Nat Rev Genet 4:911-6. 2003
    ..Quantitative trait loci (QTLs) can be identified in several ways, but is there a definitive test of whether a candidate locus actually corresponds to a specific QTL?..
  70. ncbi request reprint Cranial evolution in sakis (Pithecia, Platyrrhini) I: interspecific differentiation and allometric patterns
    Gabriel Marroig
    Departamento de Biologia Celular e Genetica, Instituto de Biologia, Universidade do Estado do Rio de Janeiro, 20550 900 Rio de Janeiro, Brazil
    Am J Phys Anthropol 125:266-78. 2004
    ..D2 distances obtained from these scale-corrected data are similar in magnitude and pattern to the original D2, but show a closer similarity of P. monacha with the Pithecia group. P. monacha is a scaled-up version of the smaller sakis...
  71. ncbi request reprint Epistatic effects between two genes in the renin-angiotensin system and systolic blood pressure and coronary artery calcification
    Sharon L R Kardia
    Department of Epidemiology, University of Michigan, Ann Arbor, MI 48104 3028, USA
    Med Sci Monit 12:CR150-8. 2006
    ..Since elevated blood pressure (BP) is an important predictor of CAC, genetic polymorphisms in the renin-angiotensin system and their interaction may play a role in explaining CAC quantity variation...

Research Grants33

  1. Genetic Environmental Relationship Between Bone, Obesity and Leptin in Mice
    James Cheverud; Fiscal Year: 2007
    ..This project will identify novel genes and physiological pathways affecting osteoporosis and examine how genetic and environmentally-based obesity affects bone mass, morphology and biomechanical function. ..
  2. A Mouse Model for Complex Human Diseases
    James Cheverud; Fiscal Year: 2007
    ..Backcrossing with SM/J will be used to narrow the QTL interval for strain loss and to produce a new strain, carrying the unusual phenotypes of SM/J without requiring enforced heterozygosity at the agouti locus. ..
  3. GENETIC VARIATION IN MURINE LONG BONE GROWTH AND DEVELOPMENT
    James Cheverud; Fiscal Year: 2007
    ..The outcome of these experiments will be a better understanding of the genetic, molecular, and cellular processes responsible for variation in limb growth with consequences for our understanding of pathologies of growth. ..
  4. Genetics Basis of Dietary Obesity in Mice
    James Cheverud; Fiscal Year: 2009
    ..These studies will increase our knowledge of the important physiological effects of dietary fat, including the genetic variants responsible for individual variations in response to a high fat diet. ..
  5. Genetic Environmental Relationship Between Bone Obesity and Leptin in Mice
    James Cheverud; Fiscal Year: 2009
    ..This project will identify novel genes and physiological pathways affecting osteoporosis and examine how genetic and environmentally-based obesity affects bone mass, morphology and biomechanical function. ..
  6. GENETIC VARIATION IN MURINE LONG BONE GROWTH AND DEVELOPMENT
    James Cheverud; Fiscal Year: 2009
    ..The outcome of these experiments will be a better understanding of the genetic, molecular, and cellular processes responsible for variation in limb growth with consequences for our understanding of pathologies of growth. ..
  7. A Mouse Model for Complex Human Diseases
    James Cheverud; Fiscal Year: 2009
    ..Backcrossing with SM/J will be used to narrow the QTL interval for strain loss and to produce a new strain, carrying the unusual phenotypes of SM/J without requiring enforced heterozygosity at the agouti locus. ..
  8. Genetic Environmental Relationship Between Bone Obesity and Leptin in Mice
    James M Cheverud; Fiscal Year: 2010
    ..This project will identify novel genes and physiological pathways affecting osteoporosis and examine how genetic and environmentally-based obesity affects bone mass, morphology and biomechanical function. ..
  9. GENETIC VARIATION IN MURINE LONG BONE GROWTH AND DEVELOPMENT
    James M Cheverud; Fiscal Year: 2010
    ..The outcome of these experiments will be a better understanding of the genetic, molecular, and cellular processes responsible for variation in limb growth with consequences for our understanding of pathologies of growth. ..
  10. A Mouse Model for Complex Human Diseases
    James Cheverud; Fiscal Year: 2009
    ..Backcrossing with SM/J will be used to narrow the QTL interval for strain loss and to produce a new strain, carrying the unusual phenotypes of SM/J without requiring enforced heterozygosity at the agouti locus. ..
  11. GENETIC BASIS OF DIETARY OBESITY IN MICE
    James Cheverud; Fiscal Year: 2007
    ..These studies will increase our knowledge of the important physiological effects of dietary fat, including the genetic variants responsible for individual variations in response to a high fat diet. ..
  12. GENETIC VARIATION IN MURINE LONG BONE GROWTH AND DEVELOPMENT
    James Cheverud; Fiscal Year: 2006
    ..The outcome of these experiments will be a better understanding of the genetic, molecular, and cellular processes responsible for variation in limb growth with consequences for our understanding of pathologies of growth. ..
  13. A Mouse Model for Complex Human Diseases
    James Cheverud; Fiscal Year: 2006
    ..Backcrossing with SM/J will be used to narrow the QTL interval for strain loss and to produce a new strain, carrying the unusual phenotypes of SM/J without requiring enforced heterozygosity at the agouti locus. ..
  14. GENE INTERACTION FOR BODY WEIGHT COMPONENTS IN MICE
    James Cheverud; Fiscal Year: 1999
    ....
  15. GENE INTERACTION FOR BODY WEIGHT COMPONENTS IN MICE
    James Cheverud; Fiscal Year: 2000
    ..In addition to positional cloning of the QTLs, congenic strains will be formed for each QTL and will be tested, along with the LGxSM recombinant inbred strains for a variety of obesity-related traits. ..
  16. A Mouse Model for Complex Human Diseases
    James Cheverud; Fiscal Year: 2001
    ..We will test whether animals subjected to relatively poor pre- and neonatal environments respond more strongly to the high fat diet. We will map quantitative trait loci for these genetic maternal effects and their interaction with diet. ..
  17. GENETIC BASIS OF DIETARY OBESITY IN MICE
    James Cheverud; Fiscal Year: 2001
    ..This project will be the first to detect and map genes specifically affecting response to a high fat diet. ..
  18. GENE INTERACTION FOR BODY WEIGHT COMPONENTS IN MICE
    James Cheverud; Fiscal Year: 2001
    ..In addition to positional cloning of the QTLs, congenic strains will be formed for each QTL and will be tested, along with the LGxSM recombinant inbred strains for a variety of obesity-related traits. ..
  19. GENETIC BASIS OF DIETARY OBESITY IN MICE
    James Cheverud; Fiscal Year: 2002
    ..This project will be the first to detect and map genes specifically affecting response to a high fat diet. ..
  20. GENE INTERACTION FOR BODY WEIGHT COMPONENTS IN MICE
    James Cheverud; Fiscal Year: 2002
    ..In addition to positional cloning of the QTLs, congenic strains will be formed for each QTL and will be tested, along with the LGxSM recombinant inbred strains for a variety of obesity-related traits. ..
  21. A Mouse Model for Complex Human Diseases
    James Cheverud; Fiscal Year: 2002
    ..We will test whether animals subjected to relatively poor pre- and neonatal environments respond more strongly to the high fat diet. We will map quantitative trait loci for these genetic maternal effects and their interaction with diet. ..
  22. A Mouse Model for Complex Human Diseases
    James Cheverud; Fiscal Year: 2003
    ..We will test whether animals subjected to relatively poor pre- and neonatal environments respond more strongly to the high fat diet. We will map quantitative trait loci for these genetic maternal effects and their interaction with diet. ..
  23. Gene Environment Relationship Btwn Bone, Obesity, Leptin
    James Cheverud; Fiscal Year: 2006
    ..This project will identify novel genes and physiological pathways affecting osteoporosis and examine how genetic and environmentally-based obesity affects bone mass, morphology and biomechanical function. ..
  24. GENETIC BASIS OF DIETARY OBESITY IN MICE
    James Cheverud; Fiscal Year: 2006
    ..These studies will increase our knowledge of the important physiological effects of dietary fat, including the genetic variants responsible for individual variations in response to a high fat diet. ..
  25. GENETIC BASIS OF DIETARY OBESITY IN MICE
    James Cheverud; Fiscal Year: 2005
    ..This project will be the first to detect and map genes specifically affecting response to a high fat diet. ..
  26. Genetic Environmental Relationship Between Bone Obesity and Leptin in Mice
    James M Cheverud; Fiscal Year: 2010
    ..This project will identify novel genes and physiological pathways affecting osteoporosis and examine how genetic and environmentally-based obesity affects bone mass, morphology and biomechanical function. ..