Rebecca D Chernock

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. ncbi request reprint Extensive HPV-Related Carcinoma In Situ of the Upper Aerodigestive Tract with 'Nonkeratinizing' Histologic Features
    Rebecca D Chernock
    Department of Pathology and Immunology, Washington University, St Louis, MO, USA
    Head Neck Pathol 8:322-8. 2014
  2. ncbi request reprint Napsin A expression in anaplastic, poorly differentiated, and micropapillary pattern thyroid carcinomas
    Rebecca D Chernock
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA
    Am J Surg Pathol 37:1215-22. 2013
  3. doi request reprint Absence of Merkel cell polyomavirus in primary parotid high-grade neuroendocrine carcinomas regardless of cytokeratin 20 immunophenotype
    Rebecca D Chernock
    Departments of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA
    Am J Surg Pathol 35:1806-11. 2011
  4. pmc Morphologic features of conventional squamous cell carcinoma of the oropharynx: 'keratinizing' and 'nonkeratinizing' histologic types as the basis for a consistent classification system
    Rebecca D Chernock
    Department of Pathology and Immunology, Washington University School of Medicine, 660 S Euclid Ave, Campus Box 8118, St Louis, MO, USA
    Head Neck Pathol 6:S41-7. 2012
  5. pmc Human papillomavirus-related squamous cell carcinoma of the oropharynx: a comparative study in whites and African Americans
    Rebecca D Chernock
    Department of Pathology and Immunology, Washington University School of Medicine, 660 S Euclid Ave, Campus Box 8118, St Louis, MO 63110, USA
    Arch Otolaryngol Head Neck Surg 137:163-9. 2011
  6. pmc A novel RT-PCR method for quantification of human papillomavirus transcripts in archived tissues and its application in oropharyngeal cancer prognosis
    Ge Gao
    Department of Radiation Oncology, Washington University School of Medicine, St Louis, MO 63108, USA
    Int J Cancer 132:882-90. 2013
  7. doi request reprint Verrucous carcinomas of the head and neck, including those with associated squamous cell carcinoma, lack transcriptionally active high-risk human papillomavirus
    Kalyani R Patel
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Hum Pathol 44:2385-92. 2013
  8. pmc Papillary squamous cell carcinoma of the head and neck: clinicopathologic and molecular features with special reference to human papillomavirus
    Mitra Mehrad
    Departments of Pathology and Immunology Department of Otolaryngology Head and Neck Surgery Division of Biostatistics, Washington University School of Medicine, St Louis, MO Advanced Cell Diagnostics Inc, Hayward, CA
    Am J Surg Pathol 37:1349-56. 2013
  9. doi request reprint Transcriptionally-active high-risk human papillomavirus is rare in oral cavity and laryngeal/hypopharyngeal squamous cell carcinomas--a tissue microarray study utilizing E6/E7 mRNA in situ hybridization
    James S Lewis
    Department of Pathology and Immunology, Washington University, St Louis, MO 63110, USA
    Histopathology 60:982-91. 2012
  10. pmc Detection and significance of human papillomavirus, CDKN2A(p16) and CDKN1A(p21) expression in squamous cell carcinoma of the larynx
    Rebecca D Chernock
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Mod Pathol 26:223-31. 2013

Collaborators

Detail Information

Publications23

  1. ncbi request reprint Extensive HPV-Related Carcinoma In Situ of the Upper Aerodigestive Tract with 'Nonkeratinizing' Histologic Features
    Rebecca D Chernock
    Department of Pathology and Immunology, Washington University, St Louis, MO, USA
    Head Neck Pathol 8:322-8. 2014
    ..This case was strongly p16 positive by immunohistochemistry and harbored transcriptionally active HPV as demonstrated by E6/E7 RNA in situ hybridization. Furthermore, the patient had an excellent response to radiation treatment. ..
  2. ncbi request reprint Napsin A expression in anaplastic, poorly differentiated, and micropapillary pattern thyroid carcinomas
    Rebecca D Chernock
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA
    Am J Surg Pathol 37:1215-22. 2013
    ..PAX8 may be diagnostically useful to distinguish these napsin A-positive thyroid carcinomas from lung adenocarcinomas, which are PAX8 negative. ..
  3. doi request reprint Absence of Merkel cell polyomavirus in primary parotid high-grade neuroendocrine carcinomas regardless of cytokeratin 20 immunophenotype
    Rebecca D Chernock
    Departments of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA
    Am J Surg Pathol 35:1806-11. 2011
    ..Furthermore, viral testing may aid in distinguishing the 2 tumor types, as a positive result would favor a metastasis...
  4. pmc Morphologic features of conventional squamous cell carcinoma of the oropharynx: 'keratinizing' and 'nonkeratinizing' histologic types as the basis for a consistent classification system
    Rebecca D Chernock
    Department of Pathology and Immunology, Washington University School of Medicine, 660 S Euclid Ave, Campus Box 8118, St Louis, MO, USA
    Head Neck Pathol 6:S41-7. 2012
    ..This review will discuss this classification system and its utility in routine clinical practice...
  5. pmc Human papillomavirus-related squamous cell carcinoma of the oropharynx: a comparative study in whites and African Americans
    Rebecca D Chernock
    Department of Pathology and Immunology, Washington University School of Medicine, 660 S Euclid Ave, Campus Box 8118, St Louis, MO 63110, USA
    Arch Otolaryngol Head Neck Surg 137:163-9. 2011
    ..To evaluate the frequency of human papillomavirus-related oropharyngeal squamous cell carcinoma in African Americans and whites and to examine patient outcomes in these 2 groups...
  6. pmc A novel RT-PCR method for quantification of human papillomavirus transcripts in archived tissues and its application in oropharyngeal cancer prognosis
    Ge Gao
    Department of Radiation Oncology, Washington University School of Medicine, St Louis, MO 63108, USA
    Int J Cancer 132:882-90. 2013
    ..Thus, p16 mRNA or protein expression signature is a sensitive and specific surrogate marker for HPV transcriptional activity (all genotypes combined)...
  7. doi request reprint Verrucous carcinomas of the head and neck, including those with associated squamous cell carcinoma, lack transcriptionally active high-risk human papillomavirus
    Kalyani R Patel
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Hum Pathol 44:2385-92. 2013
    ..These findings argue that verrucous carcinoma and its related squamous cell carcinomas are not HPV-driven tumors. ..
  8. pmc Papillary squamous cell carcinoma of the head and neck: clinicopathologic and molecular features with special reference to human papillomavirus
    Mitra Mehrad
    Departments of Pathology and Immunology Department of Otolaryngology Head and Neck Surgery Division of Biostatistics, Washington University School of Medicine, St Louis, MO Advanced Cell Diagnostics Inc, Hayward, CA
    Am J Surg Pathol 37:1349-56. 2013
    ..Overall survival, disease-specific survival, and disease-free survival were favorable and did not significantly differ by anatomic subsite. However, HPV-related tumors showed a trend toward better survival. ..
  9. doi request reprint Transcriptionally-active high-risk human papillomavirus is rare in oral cavity and laryngeal/hypopharyngeal squamous cell carcinomas--a tissue microarray study utilizing E6/E7 mRNA in situ hybridization
    James S Lewis
    Department of Pathology and Immunology, Washington University, St Louis, MO 63110, USA
    Histopathology 60:982-91. 2012
    ..In particular, the significance of finding viral DNA is not known. We sought to evaluate nonoropharyngeal squamous cell carcinomas for transcriptionally-active human papillomavirus and to compare this with the presence of viral DNA...
  10. pmc Detection and significance of human papillomavirus, CDKN2A(p16) and CDKN1A(p21) expression in squamous cell carcinoma of the larynx
    Rebecca D Chernock
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Mod Pathol 26:223-31. 2013
    ..Because of this, CDKN2A(p16) should not be used as a definitive surrogate marker of HPV-driven tumors in the larynx...
  11. ncbi request reprint Partial p16 staining in oropharyngeal squamous cell carcinoma: extent and pattern correlate with human papillomavirus RNA status
    James S Lewis
    Department of Pathology and Immunology, Washington University, St Louis, MO 63110, USA
    Mod Pathol 25:1212-20. 2012
    ..These results support that greater than 75% p16 staining or, alternatively, >50% staining combined with >25% confluent areas, are suitable cutoffs for defining positivity...
  12. pmc A microRNA expression signature for the prognosis of oropharyngeal squamous cell carcinoma
    Ge Gao
    Department of Radiation Oncology, Washington University School of Medicine, St Louis, Missouri, USA
    Cancer 119:72-80. 2013
    ..One important goal is to identify those patients who are likely to fail standard therapy and who could potentially benefit from alternative or targeted treatments...
  13. pmc Human papillomavirus-positive basaloid squamous cell carcinomas of the upper aerodigestive tract: a distinct clinicopathologic and molecular subtype of basaloid squamous cell carcinoma
    Rebecca D Chernock
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Hum Pathol 41:1016-23. 2010
    ..These tumors occur almost exclusively in the oropharynx, are molecularly distinct from their human papillomavirus-negative counterparts, and have a more favorable clinical outcome...
  14. doi request reprint Radiotherapeutic management of cervical lymph node metastases from an unknown primary site
    Stephanie M Perkins
    Department of Radiation Oncology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Arch Otolaryngol Head Neck Surg 138:656-61. 2012
    ..To determine whether ipsilateral radiotherapy affects overall survival, cause-specific survival, or local control in patients with a cancer from an unknown primary of the head and neck compared with comprehensive radiotherapy...
  15. ncbi request reprint Keratinizing-type squamous cell carcinoma of the oropharynx: p16 overexpression is associated with positive high-risk HPV status and improved survival
    Chunyu Cai
    Departments of Pathology and Immunology Otolaryngology Head and Neck Surgery Radiation Oncology, Washington University School of Medicine, St Louis, MO
    Am J Surg Pathol 38:809-15. 2014
    ..046, respectively). These data, although with relatively small patient numbers, suggest that HPV-related SCC in the oropharynx is associated with highly favorable outcomes, regardless of the keratinizing or nonkeratinizing phenotype. ..
  16. pmc p16 positive oropharyngeal squamous cell carcinoma:an entity with a favorable prognosis regardless of tumor HPV status
    James S Lewis
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Surg Pathol 34:1088-96. 2010
    ..Many recommend use of both p16 immunohistochemistry and HPV in situ hybridization (ISH). A significant minority of tumors are p16 positive and HPV ISH negative, the significance of which is unclear...
  17. pmc HPV-related nonkeratinizing squamous cell carcinoma of the oropharynx: utility of microscopic features in predicting patient outcome
    Rebecca D Chernock
    Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid, Campus Box 8118, St Louis, MO 63110, USA
    Head Neck Pathol 3:186-94. 2009
    ..NK SCC histology strongly predicts HPV-association and better patient survival compared to K SCC. Hybrid SCC appears to have an intermediate frequency of HPV-association and patient survival...
  18. doi request reprint Mammaglobin and S-100 immunoreactivity in salivary gland carcinomas other than mammary analogue secretory carcinoma
    Kalyani R Patel
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Hum Pathol 44:2501-8. 2013
    ..This indicates a need for caution in the use of immunohistochemistry for diagnosing MASC, especially in the absence of cytogenetic confirmation. ..
  19. doi request reprint Prognostic significance of β-human chorionic gonadotropin and PAX8 expression in anaplastic thyroid carcinoma
    Nils Becker
    1 Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri
    Thyroid 24:319-26. 2014
    ..The objectives of this study were to report a case of β-hCG-secreting ATC and to study the expression and significance of β-hCG and PAX8 in an institutional cohort of ATC...
  20. pmc Recognition of nonkeratinizing morphology in oropharyngeal squamous cell carcinoma - a prospective cohort and interobserver variability study
    James S Lewis
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Histopathology 60:427-36. 2012
    ....
  21. pmc Overexpression of miR-10a and miR-375 and downregulation of YAP1 in medullary thyroid carcinoma
    Jena Hudson
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, United States
    Exp Mol Pathol 95:62-7. 2013
    ..Furthermore, the growth inhibitor YAP1 is identified as a potential important downstream target of miR-375. ..
  22. pmc Human papillomavirus and Epstein Barr virus in head and neck carcinomas: suggestions for the new WHO classification
    James S Lewis
    Division of Anatomic and Molecular Pathology, Department of Pathology and Immunology, Washington University School of Medicine, Campus Box 8118, 660 S Euclid Ave, St Louis, MO, 63110, USA
    Head Neck Pathol 8:50-8. 2014
    ....
  23. ncbi request reprint Receptor tyrosine kinases in sinonasal undifferentiated carcinomas--evaluation for EGFR, c-KIT, and HER2/neu expression
    Rebecca D Chernock
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri, USA
    Head Neck 31:919-27. 2009
    ..Our objective was to identify the expression of epidermal growth factor receptor (EGFR), c-KIT (CD117), and HER2/neu in sinonasal undifferentiated carcinoma (SNUC)...