Li Shiun Chen

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. pmc Incorporating age at onset of smoking into genetic models for nicotine dependence: evidence for interaction with multiple genes
    Richard A Grucza
    Department of Psychiatry, Washington University School of Medicine, 660 South Euclid Ave, St Louis, MO 63110, USA
    Addict Biol 15:346-57. 2010
  2. pmc Interplay of genetic risk factors (CHRNA5-CHRNA3-CHRNB4) and cessation treatments in smoking cessation success
    Li Shiun Chen
    Department of Psychiatry and the Department of Genetics, Washington University School of Medicine, St Louis, MO, USA
    Am J Psychiatry 169:735-42. 2012
  3. pmc Nicotine dependence and comorbid psychiatric disorders: examination of specific genetic variants in the CHRNA5-A3-B4 nicotinic receptor genes
    Li Shiun Chen
    Department of Psychiatry, Washington University, St Louis, MO 63110, USA
    Drug Alcohol Depend 123:S42-51. 2012
  4. pmc Smoking and genetic risk variation across populations of European, Asian, and African American ancestry--a meta-analysis of chromosome 15q25
    Li Shiun Chen
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Genet Epidemiol 36:340-51. 2012
  5. pmc Dissection of the phenotypic and genotypic associations with nicotinic dependence
    Li Shiun Chen
    Department of Psychiatry Box 8134, Washington University School of Medicine, 660S Euclid Ave, St Louis, MO 63110, USA
    Nicotine Tob Res 14:425-33. 2012
  6. pmc Familial aggregation of clinical and neurocognitive features in sibling pairs with and without schizophrenia
    Li Shiun Chen
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Schizophr Res 111:159-66. 2009
  7. doi request reprint Pharmacotherapy effects on smoking cessation vary with nicotine metabolism gene (CYP2A6)
    Li Shiun Chen
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA
    Addiction 109:128-37. 2014
  8. pmc Variants in two adjacent genes, EGLN2 and CYP2A6, influence smoking behavior related to disease risk via different mechanisms
    A Joseph Bloom
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA
    Hum Mol Genet 23:555-61. 2014
  9. pmc CYP2B6 non-coding variation associated with smoking cessation is also associated with differences in allelic expression, splicing, and nicotine metabolism independent of common amino-acid changes
    A Joseph Bloom
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS ONE 8:e79700. 2013

Detail Information

Publications9

  1. pmc Incorporating age at onset of smoking into genetic models for nicotine dependence: evidence for interaction with multiple genes
    Richard A Grucza
    Department of Psychiatry, Washington University School of Medicine, 660 South Euclid Ave, St Louis, MO 63110, USA
    Addict Biol 15:346-57. 2010
    ..Incorporation of logically chosen interaction parameters, such as AOS, into genetic models of substance use disorders may increase the degree of explained phenotypic variation and constitutes a promising avenue for gene discovery...
  2. pmc Interplay of genetic risk factors (CHRNA5-CHRNA3-CHRNB4) and cessation treatments in smoking cessation success
    Li Shiun Chen
    Department of Psychiatry and the Department of Genetics, Washington University School of Medicine, St Louis, MO, USA
    Am J Psychiatry 169:735-42. 2012
    ....
  3. pmc Nicotine dependence and comorbid psychiatric disorders: examination of specific genetic variants in the CHRNA5-A3-B4 nicotinic receptor genes
    Li Shiun Chen
    Department of Psychiatry, Washington University, St Louis, MO 63110, USA
    Drug Alcohol Depend 123:S42-51. 2012
    ..We examined whether these genetic variants were associated with comorbid disorders and whether comorbid psychiatric disorders modified the genetic risk of nicotine dependence...
  4. pmc Smoking and genetic risk variation across populations of European, Asian, and African American ancestry--a meta-analysis of chromosome 15q25
    Li Shiun Chen
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Genet Epidemiol 36:340-51. 2012
    ..Using the cross-population study paradigm provides valuable insights to narrow regions of interest and inform future biological experiments...
  5. pmc Dissection of the phenotypic and genotypic associations with nicotinic dependence
    Li Shiun Chen
    Department of Psychiatry Box 8134, Washington University School of Medicine, 660S Euclid Ave, St Louis, MO 63110, USA
    Nicotine Tob Res 14:425-33. 2012
    ..We examined how these identified genetic variants relate to nicotine dependence defined by different categorical and dimensional measures...
  6. pmc Familial aggregation of clinical and neurocognitive features in sibling pairs with and without schizophrenia
    Li Shiun Chen
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Schizophr Res 111:159-66. 2009
    ....
  7. doi request reprint Pharmacotherapy effects on smoking cessation vary with nicotine metabolism gene (CYP2A6)
    Li Shiun Chen
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA
    Addiction 109:128-37. 2014
    ..We examine the effect of CYP2A6 genotype on smoking cessation success and response to cessation pharmacotherapy, and combine these effects with those of CHRNA5 genotypes...
  8. pmc Variants in two adjacent genes, EGLN2 and CYP2A6, influence smoking behavior related to disease risk via different mechanisms
    A Joseph Bloom
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA
    Hum Mol Genet 23:555-61. 2014
    ..These results indicate a previously unappreciated novel mechanism behind genome-wide significant associations with cigarette consumption and disease risk unrelated to nicotine metabolism. ..
  9. pmc CYP2B6 non-coding variation associated with smoking cessation is also associated with differences in allelic expression, splicing, and nicotine metabolism independent of common amino-acid changes
    A Joseph Bloom
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS ONE 8:e79700. 2013
    ..These results indicate differences in mRNA expression and splicing as potential molecular mechanisms by which non-coding variation in CYP2B6 may affect enzymatic activity leading to differences in metabolism and smoking cessation. ..