Research Topics
| MARIO contact CASTROSummaryAffiliation: Washington University School of Medicine Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Reslizumab for poorly controlled, eosinophilic asthma: a randomized, placebo-controlled studyMario Castro
Washington University School of Medicine, St Louis, MO 63110, USA
Am J Respir Crit Care Med 184:1125-32. 2011..Eosinophilic asthma is a phenotype of asthma characterized by the persistence of eosinophils in the airways. IL-5 is involved in the activation and survival of eosinophils...
Lung imaging in asthmatic patients: the picture is clearerMario Castro
Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, St Louis, MO 63110 1093, USA
J Allergy Clin Immunol 128:467-78. 2011....- Bronchial thermoplasty: a novel technique in the treatment of severe asthmaMario Castro
Washington University School of Medicine, St Louis, MO 63110 1093, USA
Ther Adv Respir Dis 4:101-16. 2010.... - Effectiveness and safety of bronchial thermoplasty in the treatment of severe asthma: a multicenter, randomized, double-blind, sham-controlled clinical trialMario Castro
Washington University School of Medicine, Campus Box 8052, 660 S Euclid, St Louis, MO 63110 1093, USA
Am J Respir Crit Care Med 181:116-24. 2010..Bronchial thermoplasty (BT) is a bronchoscopic procedure in which controlled thermal energy is applied to the airway wall to decrease smooth muscle... 
Asthma exacerbations after glucocorticoid withdrawal reflects T cell recruitment to the airwayMario Castro
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110 1093, USA
Am J Respir Crit Care Med 169:842-9. 2004....- Cytokine response after severe respiratory syncytial virus bronchiolitis in early lifeMario Castro
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110 1093, USA
J Allergy Clin Immunol 122:726-733.e3. 2008..Immune response after viral infection usually involves T(H)1-mediated response; however, severe respiratory syncytial virus (RSV) infection appears to be associated with the development of asthma, a T(H)2-predominant phenotype... - Placebo versus best-available-therapy control group in clinical trials for pharmacologic therapies: which is better?Mario Castro
Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, Campus Box 8052, 660 South Euclid Avenue, St Louis, MO 63110 1093, USA
Proc Am Thorac Soc 4:570-3. 2007..The pros and cons of using placebo versus best-available-therapy control groups are discussed... - Severity of respiratory syncytial virus bronchiolitis is affected by cigarette smoke exposure and atopyJoseph P Bradley
Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110-1093, USA
Pediatrics 115:e7-14. 2005..CONCLUSION: The severity of RSV bronchiolitis early in life seems modified by postnatal maternal cigarette smoke exposure and atopy and age of the infant, not by levels of allergens in the home environment... - Immunity, inflammation, and remodeling in the airway epithelial barrier: epithelial-viral-allergic paradigmMichael J Holtzman
Department of Medicine, Washington University School of Medicine, St Louis, Missouri, USA
Physiol Rev 82:19-46. 2002.... - Asthma intervention program prevents readmissions in high healthcare usersMario Castro
Departments of Medicine and Biostatistics, Washington University School of Medicine, St Louis, MO 63110 1093, USA
Am J Respir Crit Care Med 168:1095-9. 2003..03). A brief intervention program focusing on high healthcare users with asthma can result in improved asthma control and reduced hospital use with substantial cost savings... - Molecular phenotyping of severe asthma using pattern recognition of bronchoalveolar lavage-derived cytokinesAllan R Brasier
Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX 77555 1060, USA
J Allergy Clin Immunol 121:30-37.e6. 2008..Asthma is a heterogeneous clinical disorder. Methods for objective identification of disease subtypes will focus on clinical interventions and help identify causative pathways. Few studies have explored phenotypes at a molecular level... - Epithelial cell proliferation contributes to airway remodeling in severe asthmaLance Cohen
Department of Medicine, Washington University School of Medicine, Campus Box 8052, 660 South Euclid Avenue, St Louis, MO 63110 1093, USA
Am J Respir Crit Care Med 176:138-45. 2007..Despite long-term therapy with corticosteroids, patients with severe asthma develop irreversible airway obstruction... - Lower levels of plasmacytoid dendritic cells in peripheral blood are associated with a diagnosis of asthma 6 yr after severe respiratory syncytial virus bronchiolitisEli Silver
Washington University School of Medicine, St Louis, MO 63110 1093, USA
Pediatr Allergy Immunol 20:471-6. 2009..Children who are diagnosed with asthma after severe RSV bronchiolitis appear to have a relative deficiency of plasmacytoid DC in peripheral blood... - Airway lipoxin A4 generation and lipoxin A4 receptor expression are decreased in severe asthmaAnna Planagumà
Pulmonary and Critical Care Medicine Division, Department of Internal Medicine, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
Am J Respir Crit Care Med 178:574-82. 2008..Airway inflammation is common in severe asthma despite antiinflammatory therapy with corticosteroids. Lipoxin A(4) (LXA(4)) is an arachidonic acid-derived mediator that serves as an agonist for resolution of inflammation... - Airway remodeling measured by multidetector CT is increased in severe asthma and correlates with pathologyRavi S Aysola
Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, St Louis, MO 63110 1093, USA
Chest 134:1183-91. 2008..To prospectively apply an automated, quantitative three-dimensional approach to imaging and airway analysis to assess airway remodeling in asthma patients... - The role of viral respiratory infections in the pathogenesis and exacerbation of asthmaLance Cohen
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA
Semin Respir Infect 18:3-8. 2003..Insights into the mechanism of viral respiratory tract infections will provide therapeutic targets for treatment and possibly the prevention of virus-induced asthma... - Community Asthma Program improves appropriate prescribing in moderate to severe asthmaSheniz A Moonie
Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, Campus Box 8052, 660 S. Euclid Ave, St. Louis, MO 63110-1093, USA
J Asthma 42:281-9. 2005..Use of the CAP over time aided PCPs in appropriately medicating patients with moderate to severe asthma in accordance with guidelines... - Randomized trial of the effect of drug presentation on asthma outcomes: the American Lung Association Asthma Clinical Research CentersRobert A Wise
Division of Pulmonary and Critical Care Medicine, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
J Allergy Clin Immunol 124:436-44, 444e1-8. 2009..Although asthma symptoms often improve with placebo, it is not known whether the response to placebo or active treatment can be augmented by increasing expectation of benefit... - Strategic plan for pediatric respiratory diseases research: an NHLBI working group reportSteve Abman
Washington University School of Medicine, Medicine and Pediatrics, St Louis, Missouri
Pediatr Pulmonol 44:2-13. 2009.... - Severe asthma: what makes it so hard to manage?Luke Carlstrom
Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, St Louis, MO 63110 1093, USA
Curr Allergy Asthma Rep 9:393-400. 2009..New therapeutic approaches to these distinct phenotypes will improve our understanding and treatment of this difficult-to-manage disease... - Blocking airway mucous cell metaplasia by inhibiting EGFR antiapoptosis and IL-13 transdifferentiation signalsJeffrey W Tyner
Pulmonary and Critical Care Medicine, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Clin Invest 116:309-21. 2006.... - Influenza vaccine in patients with asthmaNicola A Hanania
Division of Pulmonary and Critical Care Medicine, Baylor College of Medicine, Houston, TX 77030, USA
Expert Rev Vaccines 5:111-8. 2006..In this review, the risk-versus-benefit of influenza vaccination in children and adults with asthma is evaluated, based on the current evidence... - Randomized comparison of strategies for reducing treatment in mild persistent asthmaStephen P Peters
Wake Forest University, Winston Salem, NC, USA
N Engl J Med 356:2027-39. 2007.... - Immune response to influenza vaccination in children and adults with asthma: effect of corticosteroid therapyNicola A Hanania
Pulmonary and Critical Care Medicine, Baylor College of Medicine, 1504 Taub Loop, Houston, TX 77030, USA
J Allergy Clin Immunol 113:717-24. 2004..However, the effect of maintenance corticosteroid therapy on the immune response to influenza vaccine has received limited evaluation... - Near-fatal asthma: what have we learned?Mario Castro
Chest 121:1394-5. 2002 - Alterations of the arginine metabolome in asthmaAbigail Lara
Department of Pathobiology, The Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
Am J Respir Crit Care Med 178:673-81. 2008..As the sole nitrogen donor in nitric oxide (NO) synthesis and key intermediate in the urea cycle, arginine and its metabolic pathways are integrally linked to cellular respiration, metabolism, and inflammation... - Major depression and allergy: does neuroticism explain the relationship?Renee D Goodwin
Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
Psychosom Med 68:94-8. 2006..To determine the association between major depression, neuroticism, and self-reported allergy among adults in the community... - Asthma exacerbations in African Americans treated for 1 year with combination fluticasone propionate and salmeterol or fluticasone propionate aloneWilliam Bailey
University of Alabama, Birmingham, AL, USA
Curr Med Res Opin 24:1669-82. 2008.... - The relationship between school absence, academic performance, and asthma statusSheniz Moonie
Department of Environmental and Occupational Health, Division of Epidemiology and Biostatistics, University of Nevada, Las Vegas, School of Public Health, 4505 Maryland Parkway Box 453064, Las Vegas, NV 89154 3064, USA
J Sch Health 78:140-8. 2008..The goal of this study was to investigate the relationships between absenteeism, presence of asthma, and asthma severity level with standardized test level performance in a predominantly African American urban school district... - Asthma status and severity affects missed school daysSheniz A Moonie
Clark County Health District, Office of Epidemiology, Las Vegas, NV 89127, USA
J Sch Health 76:18-24. 2006..Children with asthma are absent from school more often compared to their healthy peers and this appears to be driven by the underlying severity of symptoms. (J Sch Health. 2006;76(1):18-24)... - The C523A beta2 adrenergic receptor polymorphism associates with markers of asthma severity in African AmericansJohn J Lima
The American Lung Association Asthma Clinical Research Centers, Jacksonville, Florida, USA
J Asthma 43:185-91. 2006..018). Symptom scores, pulmonary function, and rescue inhaler use paralleled exacerbation prevalence. We conclude the 523 A allele modifies asthma severity in African Americans... - Asthma education for the frequent emergency department visitor: does it work?Mario Castro
Ann Allergy Asthma Immunol 97:4-6. 2006 - Volumetric measurements of lung nodules with multi-detector row CT: effect of changes in lung volumeJin Mo Goo
Department of Radiology, Seoul National University College of Medicine, and the Institute of Radiation Medicine, SNUMRC, Jongno gu, Seoul, Korea
Korean J Radiol 7:243-8. 2006..To evaluate how changes in lung volume affect volumetric measurements of lung nodules using a multi-detector row CT... - Predicting episodes of poor asthma control in treated patients with asthmaKaren McCoy
Ohio State University, USA
J Allergy Clin Immunol 118:1226-33. 2006..CLINICAL IMPLICATIONS: Simple assessments may be helpful in identifying patients most at risk for future asthma episodes... - IL4R alpha mutations are associated with asthma exacerbations and mast cell/IgE expressionSally E Wenzel
University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
Am J Respir Crit Care Med 175:570-6. 2007..However, an effect on exacerbations and tissue inflammation has not been shown... - Characterization of the severe asthma phenotype by the National Heart, Lung, and Blood Institute's Severe Asthma Research ProgramWendy C Moore
Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
J Allergy Clin Immunol 119:405-13. 2007..Severe asthma causes the majority of asthma morbidity. Understanding mechanisms that contribute to the development of severe disease is important... - Severe asthma in adults: what are the important questions?Pascal Chanez
INSERM U454 and Clinique des Maladies Respiratoires, Montpellier, France
J Allergy Clin Immunol 119:1337-48. 2007..Inhaled corticosteroids and bronchodilators are the mainstay of treatment, but patients with SRA remain uncontrolled, indicating a need for new therapies... - Investigative bronchoprovocation and bronchoscopy in airway diseasesWilliam W Busse
University of Wisconsin-Madison, USA
Am J Respir Crit Care Med 172:807-16. 2005..CONCLUSION: This review of investigative bronchoscopy and bronchoprovocation could serve as the basis for future guidelines for the use of these procedures in the United States... - Lung function in adults with stable but severe asthma: air trapping and incomplete reversal of obstruction with bronchodilationRonald L Sorkness
Univ of Wisconsin, 777 Highland Ave, Madison, WI 53705, USA
J Appl Physiol 104:394-403. 2008..We conclude that air trapping is a characteristic feature of the severe asthma population, suggesting that there is a pathological process associated with severe asthma that makes airways more vulnerable to this component... - Evaluation and management of severe asthmaMina Gaga
Asthma Centre and 7th Respiratory Medicine Department, Sotiria Hospital, Athens, Greece
Curr Med Chem 14:1049-59. 2007..In this report, the authors review the various issues of guideline based therapy but also new approaches that include anti-IgE antibodies, anti-cytokines (anti-IL-5, anti-IL9, anti-TNF)...
Research Grants
- Airway Remodeling in Severe AsthmaMario Castro; Fiscal Year: 2005..The identification of the potential variables associated with remodeling and severe asthma will help identify individuals at risk who would benefit from specific targeted therapy. ..
- GENETIC, BIOLOGIC, & IMMUNOLOGIC DETERMINANTS OF ASTHMAMario Castro; Fiscal Year: 2006..abstract_text> ..
- Asthma Clinical Research Network-Washington UniversityMario Castro; Fiscal Year: 2007..We propose that it is only through such a collaboration that important questions regarding current and novel therapies and management of asthma can be answered. ..
- SEVERE ASTHMA RESEARCH PROGRAM (SARPII) IMAGING COREMario Castro; Fiscal Year: 2010..This measure of airway remodeling may help identify individuals with asthma who are likely to develop severe disease and who may benefit from early targeted, aggressive therapy. (End of Abstract) ..
- GENETIC, BIOLOGIC, & IMMUNOLOGIC DETERMINANTS OF ASTHMAMario Castro; Fiscal Year: 2001..Therefore, this proposal will lead to a better understanding of the interaction of genetic, biologic, and immunologic factors following RSV infection which lead to the development of asthma in early life. ..
- Determinants of Asthma Following RSV Bronchiolitis in Early LifeMARIO contact CASTRO; Fiscal Year: 2010..This study will be the largest to date, consisting of over 600 children with severe RSV bronchiolitis, and will enable us to test new hypotheses on the causation of asthma and allergic disorders early in life. ..