MARIO contact CASTRO

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. doi request reprint Reslizumab for poorly controlled, eosinophilic asthma: a randomized, placebo-controlled study
    Mario Castro
    Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Respir Crit Care Med 184:1125-32. 2011
  2. pmc Lung imaging in asthmatic patients: the picture is clearer
    Mario Castro
    Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, St Louis, MO 63110 1093, USA
    J Allergy Clin Immunol 128:467-78. 2011
  3. doi request reprint Bronchial thermoplasty: a novel technique in the treatment of severe asthma
    Mario Castro
    Washington University School of Medicine, St Louis, MO 63110 1093, USA
    Ther Adv Respir Dis 4:101-16. 2010
  4. pmc Effectiveness and safety of bronchial thermoplasty in the treatment of severe asthma: a multicenter, randomized, double-blind, sham-controlled clinical trial
    Mario Castro
    Washington University School of Medicine, Campus Box 8052, 660 S Euclid, St Louis, MO 63110 1093, USA
    Am J Respir Crit Care Med 181:116-24. 2010
  5. ncbi request reprint Asthma exacerbations after glucocorticoid withdrawal reflects T cell recruitment to the airway
    Mario Castro
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110 1093, USA
    Am J Respir Crit Care Med 169:842-9. 2004
  6. pmc Cytokine response after severe respiratory syncytial virus bronchiolitis in early life
    Mario Castro
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110 1093, USA
    J Allergy Clin Immunol 122:726-733.e3. 2008
  7. pmc Placebo versus best-available-therapy control group in clinical trials for pharmacologic therapies: which is better?
    Mario Castro
    Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, Campus Box 8052, 660 South Euclid Avenue, St Louis, MO 63110 1093, USA
    Proc Am Thorac Soc 4:570-3. 2007
  8. ncbi request reprint Severity of respiratory syncytial virus bronchiolitis is affected by cigarette smoke exposure and atopy
    Joseph P Bradley
    Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110 1093, USA
    Pediatrics 115:e7-14. 2005
  9. ncbi request reprint Immunity, inflammation, and remodeling in the airway epithelial barrier: epithelial-viral-allergic paradigm
    Michael J Holtzman
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    Physiol Rev 82:19-46. 2002
  10. ncbi request reprint Asthma intervention program prevents readmissions in high healthcare users
    Mario Castro
    Departments of Medicine and Biostatistics, Washington University School of Medicine, St Louis, MO 63110 1093, USA
    Am J Respir Crit Care Med 168:1095-9. 2003

Detail Information

Publications40

  1. doi request reprint Reslizumab for poorly controlled, eosinophilic asthma: a randomized, placebo-controlled study
    Mario Castro
    Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Respir Crit Care Med 184:1125-32. 2011
    ..Eosinophilic asthma is a phenotype of asthma characterized by the persistence of eosinophils in the airways. IL-5 is involved in the activation and survival of eosinophils...
  2. pmc Lung imaging in asthmatic patients: the picture is clearer
    Mario Castro
    Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, St Louis, MO 63110 1093, USA
    J Allergy Clin Immunol 128:467-78. 2011
    ....
  3. doi request reprint Bronchial thermoplasty: a novel technique in the treatment of severe asthma
    Mario Castro
    Washington University School of Medicine, St Louis, MO 63110 1093, USA
    Ther Adv Respir Dis 4:101-16. 2010
    ....
  4. pmc Effectiveness and safety of bronchial thermoplasty in the treatment of severe asthma: a multicenter, randomized, double-blind, sham-controlled clinical trial
    Mario Castro
    Washington University School of Medicine, Campus Box 8052, 660 S Euclid, St Louis, MO 63110 1093, USA
    Am J Respir Crit Care Med 181:116-24. 2010
    ..Bronchial thermoplasty (BT) is a bronchoscopic procedure in which controlled thermal energy is applied to the airway wall to decrease smooth muscle...
  5. ncbi request reprint Asthma exacerbations after glucocorticoid withdrawal reflects T cell recruitment to the airway
    Mario Castro
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110 1093, USA
    Am J Respir Crit Care Med 169:842-9. 2004
    ....
  6. pmc Cytokine response after severe respiratory syncytial virus bronchiolitis in early life
    Mario Castro
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110 1093, USA
    J Allergy Clin Immunol 122:726-733.e3. 2008
    ..Immune response after viral infection usually involves T(H)1-mediated response; however, severe respiratory syncytial virus (RSV) infection appears to be associated with the development of asthma, a T(H)2-predominant phenotype...
  7. pmc Placebo versus best-available-therapy control group in clinical trials for pharmacologic therapies: which is better?
    Mario Castro
    Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, Campus Box 8052, 660 South Euclid Avenue, St Louis, MO 63110 1093, USA
    Proc Am Thorac Soc 4:570-3. 2007
    ..The pros and cons of using placebo versus best-available-therapy control groups are discussed...
  8. ncbi request reprint Severity of respiratory syncytial virus bronchiolitis is affected by cigarette smoke exposure and atopy
    Joseph P Bradley
    Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110 1093, USA
    Pediatrics 115:e7-14. 2005
    ..Little is known about what determines the severity of RSV bronchiolitis, which may be helpful in the initial assessment of these children...
  9. ncbi request reprint Immunity, inflammation, and remodeling in the airway epithelial barrier: epithelial-viral-allergic paradigm
    Michael J Holtzman
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    Physiol Rev 82:19-46. 2002
    ....
  10. ncbi request reprint Asthma intervention program prevents readmissions in high healthcare users
    Mario Castro
    Departments of Medicine and Biostatistics, Washington University School of Medicine, St Louis, MO 63110 1093, USA
    Am J Respir Crit Care Med 168:1095-9. 2003
    ..03). A brief intervention program focusing on high healthcare users with asthma can result in improved asthma control and reduced hospital use with substantial cost savings...
  11. pmc Molecular phenotyping of severe asthma using pattern recognition of bronchoalveolar lavage-derived cytokines
    Allan R Brasier
    Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX 77555 1060, USA
    J Allergy Clin Immunol 121:30-37.e6. 2008
    ..Asthma is a heterogeneous clinical disorder. Methods for objective identification of disease subtypes will focus on clinical interventions and help identify causative pathways. Few studies have explored phenotypes at a molecular level...
  12. pmc Epithelial cell proliferation contributes to airway remodeling in severe asthma
    Lance Cohen
    Department of Medicine, Washington University School of Medicine, Campus Box 8052, 660 South Euclid Avenue, St Louis, MO 63110 1093, USA
    Am J Respir Crit Care Med 176:138-45. 2007
    ..Despite long-term therapy with corticosteroids, patients with severe asthma develop irreversible airway obstruction...
  13. pmc Lower levels of plasmacytoid dendritic cells in peripheral blood are associated with a diagnosis of asthma 6 yr after severe respiratory syncytial virus bronchiolitis
    Eli Silver
    Washington University School of Medicine, St Louis, MO 63110 1093, USA
    Pediatr Allergy Immunol 20:471-6. 2009
    ..Children who are diagnosed with asthma after severe RSV bronchiolitis appear to have a relative deficiency of plasmacytoid DC in peripheral blood...
  14. pmc Airway lipoxin A4 generation and lipoxin A4 receptor expression are decreased in severe asthma
    Anna Planagumà
    Pulmonary and Critical Care Medicine Division, Department of Internal Medicine, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Am J Respir Crit Care Med 178:574-82. 2008
    ..Airway inflammation is common in severe asthma despite antiinflammatory therapy with corticosteroids. Lipoxin A(4) (LXA(4)) is an arachidonic acid-derived mediator that serves as an agonist for resolution of inflammation...
  15. pmc Airway remodeling measured by multidetector CT is increased in severe asthma and correlates with pathology
    Ravi S Aysola
    Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, St Louis, MO 63110 1093, USA
    Chest 134:1183-91. 2008
    ..To prospectively apply an automated, quantitative three-dimensional approach to imaging and airway analysis to assess airway remodeling in asthma patients...
  16. ncbi request reprint The role of viral respiratory infections in the pathogenesis and exacerbation of asthma
    Lance Cohen
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Semin Respir Infect 18:3-8. 2003
    ..Insights into the mechanism of viral respiratory tract infections will provide therapeutic targets for treatment and possibly the prevention of virus-induced asthma...
  17. ncbi request reprint Community Asthma Program improves appropriate prescribing in moderate to severe asthma
    Sheniz A Moonie
    Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, Campus Box 8052, 660 S Euclid Ave, St Louis, MO 63110 1093, USA
    J Asthma 42:281-9. 2005
    ..Use of the CAP over time aided PCPs in appropriately medicating patients with moderate to severe asthma in accordance with guidelines...
  18. pmc Randomized trial of the effect of drug presentation on asthma outcomes: the American Lung Association Asthma Clinical Research Centers
    Robert A Wise
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    J Allergy Clin Immunol 124:436-44, 444e1-8. 2009
    ..Although asthma symptoms often improve with placebo, it is not known whether the response to placebo or active treatment can be augmented by increasing expectation of benefit...
  19. pmc Strategic plan for pediatric respiratory diseases research: an NHLBI working group report
    Steve Abman
    Washington University School of Medicine, Medicine and Pediatrics, St Louis, Missouri
    Pediatr Pulmonol 44:2-13. 2009
    ....
  20. ncbi request reprint Severe asthma: what makes it so hard to manage?
    Luke Carlstrom
    Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, St Louis, MO 63110 1093, USA
    Curr Allergy Asthma Rep 9:393-400. 2009
    ..New therapeutic approaches to these distinct phenotypes will improve our understanding and treatment of this difficult-to-manage disease...
  21. pmc Blocking airway mucous cell metaplasia by inhibiting EGFR antiapoptosis and IL-13 transdifferentiation signals
    Jeffrey W Tyner
    Pulmonary and Critical Care Medicine, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 116:309-21. 2006
    ....
  22. ncbi request reprint Influenza vaccine in patients with asthma
    Nicola A Hanania
    Division of Pulmonary and Critical Care Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    Expert Rev Vaccines 5:111-8. 2006
    ..In this review, the risk-versus-benefit of influenza vaccination in children and adults with asthma is evaluated, based on the current evidence...
  23. ncbi request reprint Randomized comparison of strategies for reducing treatment in mild persistent asthma
    Stephen P Peters
    Wake Forest University, Winston Salem, NC, USA
    N Engl J Med 356:2027-39. 2007
    ....
  24. ncbi request reprint Immune response to influenza vaccination in children and adults with asthma: effect of corticosteroid therapy
    Nicola A Hanania
    Pulmonary and Critical Care Medicine, Baylor College of Medicine, 1504 Taub Loop, Houston, TX 77030, USA
    J Allergy Clin Immunol 113:717-24. 2004
    ..However, the effect of maintenance corticosteroid therapy on the immune response to influenza vaccine has received limited evaluation...
  25. ncbi request reprint Near-fatal asthma: what have we learned?
    Mario Castro
    Chest 121:1394-5. 2002
  26. pmc Alterations of the arginine metabolome in asthma
    Abigail Lara
    Department of Pathobiology, The Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Am J Respir Crit Care Med 178:673-81. 2008
    ..As the sole nitrogen donor in nitric oxide (NO) synthesis and key intermediate in the urea cycle, arginine and its metabolic pathways are integrally linked to cellular respiration, metabolism, and inflammation...
  27. ncbi request reprint Major depression and allergy: does neuroticism explain the relationship?
    Renee D Goodwin
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
    Psychosom Med 68:94-8. 2006
    ..To determine the association between major depression, neuroticism, and self-reported allergy among adults in the community...
  28. doi request reprint Asthma exacerbations in African Americans treated for 1 year with combination fluticasone propionate and salmeterol or fluticasone propionate alone
    William Bailey
    University of Alabama, Birmingham, AL, USA
    Curr Med Res Opin 24:1669-82. 2008
    ....
  29. doi request reprint The relationship between school absence, academic performance, and asthma status
    Sheniz Moonie
    Department of Environmental and Occupational Health, Division of Epidemiology and Biostatistics, University of Nevada, Las Vegas, School of Public Health, 4505 Maryland Parkway Box 453064, Las Vegas, NV 89154 3064, USA
    J Sch Health 78:140-8. 2008
    ..The goal of this study was to investigate the relationships between absenteeism, presence of asthma, and asthma severity level with standardized test level performance in a predominantly African American urban school district...
  30. ncbi request reprint Asthma status and severity affects missed school days
    Sheniz A Moonie
    Clark County Health District, Office of Epidemiology, Las Vegas, NV 89127, USA
    J Sch Health 76:18-24. 2006
    ..Children with asthma are absent from school more often compared to their healthy peers and this appears to be driven by the underlying severity of symptoms. (J Sch Health. 2006;76(1):18-24)...
  31. ncbi request reprint The C523A beta2 adrenergic receptor polymorphism associates with markers of asthma severity in African Americans
    John J Lima
    The American Lung Association Asthma Clinical Research Centers, Jacksonville, Florida, USA
    J Asthma 43:185-91. 2006
    ..018). Symptom scores, pulmonary function, and rescue inhaler use paralleled exacerbation prevalence. We conclude the 523 A allele modifies asthma severity in African Americans...
  32. ncbi request reprint Asthma education for the frequent emergency department visitor: does it work?
    Mario Castro
    Ann Allergy Asthma Immunol 97:4-6. 2006
  33. pmc Volumetric measurements of lung nodules with multi-detector row CT: effect of changes in lung volume
    Jin Mo Goo
    Department of Radiology, Seoul National University College of Medicine, and the Institute of Radiation Medicine, SNUMRC, Jongno gu, Seoul, Korea
    Korean J Radiol 7:243-8. 2006
    ..To evaluate how changes in lung volume affect volumetric measurements of lung nodules using a multi-detector row CT...
  34. ncbi request reprint Predicting episodes of poor asthma control in treated patients with asthma
    Karen McCoy
    Ohio State University, USA
    J Allergy Clin Immunol 118:1226-33. 2006
    ..Asthma exacerbations are dangerous, expensive, and difficult to anticipate...
  35. pmc IL4R alpha mutations are associated with asthma exacerbations and mast cell/IgE expression
    Sally E Wenzel
    University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Am J Respir Crit Care Med 175:570-6. 2007
    ..However, an effect on exacerbations and tissue inflammation has not been shown...
  36. pmc Characterization of the severe asthma phenotype by the National Heart, Lung, and Blood Institute's Severe Asthma Research Program
    Wendy C Moore
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Allergy Clin Immunol 119:405-13. 2007
    ..Severe asthma causes the majority of asthma morbidity. Understanding mechanisms that contribute to the development of severe disease is important...
  37. ncbi request reprint Severe asthma in adults: what are the important questions?
    Pascal Chanez
    INSERM U454 and Clinique des Maladies Respiratoires, Montpellier, France
    J Allergy Clin Immunol 119:1337-48. 2007
    ..Inhaled corticosteroids and bronchodilators are the mainstay of treatment, but patients with SRA remain uncontrolled, indicating a need for new therapies...
  38. pmc Investigative bronchoprovocation and bronchoscopy in airway diseases
    William W Busse
    University of Wisconsin Madison, USA
    Am J Respir Crit Care Med 172:807-16. 2005
    ..Since the last critical review more than a decade ago, some of the techniques and applications have changed, and untoward events have occurred, raising safety concerns and increasing institutional review scrutiny...
  39. ncbi request reprint Lung function in adults with stable but severe asthma: air trapping and incomplete reversal of obstruction with bronchodilation
    Ronald L Sorkness
    Univ of Wisconsin, 777 Highland Ave, Madison, WI 53705, USA
    J Appl Physiol 104:394-403. 2008
    ..We conclude that air trapping is a characteristic feature of the severe asthma population, suggesting that there is a pathological process associated with severe asthma that makes airways more vulnerable to this component...
  40. ncbi request reprint Evaluation and management of severe asthma
    Mina Gaga
    Asthma Centre and 7th Respiratory Medicine Department, Sotiria Hospital, Athens, Greece
    Curr Med Chem 14:1049-59. 2007
    ..In this report, the authors review the various issues of guideline based therapy but also new approaches that include anti-IgE antibodies, anti-cytokines (anti-IL-5, anti-IL9, anti-TNF)...

Research Grants21

  1. Airway Remodeling in Severe Asthma
    Mario Castro; Fiscal Year: 2005
    ..The identification of the potential variables associated with remodeling and severe asthma will help identify individuals at risk who would benefit from specific targeted therapy. ..
  2. GENETIC, BIOLOGIC, & IMMUNOLOGIC DETERMINANTS OF ASTHMA
    Mario Castro; Fiscal Year: 2006
    ..abstract_text> ..
  3. Asthma Clinical Research Network-Washington University
    Mario Castro; Fiscal Year: 2007
    ..We propose that it is only through such a collaboration that important questions regarding current and novel therapies and management of asthma can be answered. ..
  4. SEVERE ASTHMA RESEARCH PROGRAM (SARPII) IMAGING CORE
    Mario Castro; Fiscal Year: 2010
    ..This measure of airway remodeling may help identify individuals with asthma who are likely to develop severe disease and who may benefit from early targeted, aggressive therapy. (End of Abstract) ..
  5. GENETIC, BIOLOGIC, & IMMUNOLOGIC DETERMINANTS OF ASTHMA
    Mario Castro; Fiscal Year: 2001
    ..Therefore, this proposal will lead to a better understanding of the interaction of genetic, biologic, and immunologic factors following RSV infection which lead to the development of asthma in early life. ..
  6. Determinants of Asthma Following RSV Bronchiolitis in Early Life
    MARIO contact CASTRO; Fiscal Year: 2010
    ..This study will be the largest to date, consisting of over 600 children with severe RSV bronchiolitis, and will enable us to test new hypotheses on the causation of asthma and allergic disorders early in life. ..