Affiliation: Washington University School of Medicine
Burgers P, Gerik K. Structure and processivity of two forms of Saccharomyces cerevisiae DNA polymerase delta. J Biol Chem. 1998;273:19756-62 pubmed
..However, Poldelta*-mediated DNA synthesis proceeded inefficiently and was characterized by frequent pause sites. Reconstitution of Poldelta was achieved upon addition of Pol32p to Poldelta*. ..
Wanrooij P, Burgers P. Yet another job for Dna2: Checkpoint activation. DNA Repair (Amst). 2015;32:17-23 pubmed publisher
..A role for these checkpoint activators in channeling aberrant replication structures into checkpoint complexes is discussed. ..
Burgers P, Kunkel T. Eukaryotic DNA Replication Fork. Annu Rev Biochem. 2017;86:417-438 pubmed publisher
Stodola J, Burgers P. Mechanism of Lagging-Strand DNA Replication in Eukaryotes. Adv Exp Med Biol. 2017;1042:117-133 pubmed publisher
..Occasional long flaps are further processed by backup nucleases including Dna2. ..
Makarova A, Burgers P. Eukaryotic DNA polymerase Î¶. DNA Repair (Amst). 2015;29:47-55 pubmed publisher
..These interactions are modulated by posttranslational modifications such as ubiquitination and phosphorylation that enhance translesion synthesis (TLS) and mutagenesis. ..
Sawicka M, Wanrooij P, Darbari V, Tannous E, Hailemariam S, Bose D, et al
. The Dimeric Architecture of Checkpoint Kinases Mec1ATR and Tel1ATM Reveal a Common Structural Organization. J Biol Chem. 2016;291:13436-47 pubmed publisher
..The kinase domains in the Mec1Â·Ddc2 dimer are located in close proximity to each other. However, in the Tel1 dimer they are fully separated, providing potential access of substrates to this kinase, even in its dimeric form. ..
Burgers P, Koonin E, Bruford E, Blanco L, Burtis K, Christman M, et al
. Eukaryotic DNA polymerases: proposal for a revised nomenclature. J Biol Chem. 2001;276:43487-90 pubmed
Burgers P, Stith C, Yoder B, Sparks J. Yeast exonuclease 5 is essential for mitochondrial genome maintenance. Mol Cell Biol. 2010;30:1457-66 pubmed publisher
..However, Exo5 has the capacity to slide across 5' double-stranded DNA or 5' RNA sequences and resumes cutting two nucleotides downstream of the double-stranded-to-single-stranded junction or RNA-to-DNA junction, respectively. ..
Makarova A, Nick McElhinny S, Watts B, Kunkel T, Burgers P. Ribonucleotide incorporation by yeast DNA polymerase ?. DNA Repair (Amst). 2014;18:63-7 pubmed publisher
..These results suggest that ribonucleotide incorporation into DNA during Pol ?-mediated mutagenesis in vivo may be rare. ..