Michael R Bruchas

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. pmc Selective p38α MAPK deletion in serotonergic neurons produces stress resilience in models of depression and addiction
    Michael R Bruchas
    Department of Pharmacology, University of Washington, Seattle, WA 98195, USA
    Neuron 71:498-511. 2011
  2. pmc Repeated swim stress induces kappa opioid-mediated activation of extracellular signal-regulated kinase 1/2
    Michael R Bruchas
    Department of Pharmacology, University of Washington, Seattle, Washington, USA
    Neuroreport 19:1417-22. 2008
  3. pmc Ligand-directed c-Jun N-terminal kinase activation disrupts opioid receptor signaling
    Erica J Melief
    Department of Pharmacology, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 107:11608-13. 2010
  4. pmc Activation of the kappa opioid receptor in the dorsal raphe nucleus mediates the aversive effects of stress and reinstates drug seeking
    Benjamin B Land
    Department of Pharmacology, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 106:19168-73. 2009
  5. pmc CRF1-R activation of the dynorphin/kappa opioid system in the mouse basolateral amygdala mediates anxiety-like behavior
    Michael R Bruchas
    Department of Pharmacology, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 4:e8528. 2009
  6. pmc Stress-induced activation of the dynorphin/κ-opioid receptor system in the amygdala potentiates nicotine conditioned place preference
    Jeffrey S Smith
    Department of Pharmacology, University of Washington, Seattle, Washington 98195 7280, USA
    J Neurosci 32:1488-95. 2012
  7. pmc The dysphoric component of stress is encoded by activation of the dynorphin kappa-opioid system
    Benjamin B Land
    Department of Pharmacology, University of Washington, Seattle, Washington 98195 7280, USA
    J Neurosci 28:407-14. 2008
  8. pmc Kinase cascades and ligand-directed signaling at the kappa opioid receptor
    Michael R Bruchas
    Department of Pharmacology, University of Washington, Seattle, WA 98195, USA
    Psychopharmacology (Berl) 210:137-47. 2010
  9. pmc Phosphorylation of the mu-opioid receptor at tyrosine 166 (Tyr3.51) in the DRY motif reduces agonist efficacy
    Cecilea C Clayton
    Department of Pharmacology, University of Washington School of Medicine, Seattle, WA 98195 7280, USA
    Mol Pharmacol 77:339-47. 2010
  10. pmc Alpha-dystrobrevin-1 recruits alpha-catulin to the alpha1D-adrenergic receptor/dystrophin-associated protein complex signalosome
    John S Lyssand
    Department of Pharmacology and Physiology and Biophysics, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 107:21854-9. 2010

Collaborators

  • Mei Xu
  • Megumi Aita
  • John D Scott
  • Thomas S Hnasko
  • Catherine E Hagan
  • Sabiha K Barot
  • Chris Hague
  • Charles Chavkin
  • Benjamin B Land
  • Erica J Melief
  • Jeffrey S Smith
  • John S Lyssand
  • Cecilea C Clayton
  • Mayumi Miyatake
  • Abigail G Schindler
  • Richard M Gustin
  • Emma Martinelli
  • Jennifer L Wacker
  • Ryan Kastl
  • Jennifer L Whiting
  • Kyung Soon Lee
  • Marvin E Adams
  • Michael L Lee
  • Richard G Gardner
  • Lorene K Langeberg
  • William J Giardino
  • Daniel Messinger
  • Richard D Palmiter
  • Selena Schattauer
  • Julia C Lemos

Detail Information

Publications12

  1. pmc Selective p38α MAPK deletion in serotonergic neurons produces stress resilience in models of depression and addiction
    Michael R Bruchas
    Department of Pharmacology, University of Washington, Seattle, WA 98195, USA
    Neuron 71:498-511. 2011
    ..These findings suggest that stress initiates a cascade of molecular and cellular events in which p38α MAPK induces a hyposerotonergic state underlying depression-like and drug-seeking behaviors...
  2. pmc Repeated swim stress induces kappa opioid-mediated activation of extracellular signal-regulated kinase 1/2
    Michael R Bruchas
    Department of Pharmacology, University of Washington, Seattle, Washington, USA
    Neuroreport 19:1417-22. 2008
    ..These results indicate stress-induced activation of the dynorphin-KOR systems activates ERK1/2 MAPK signaling, and this may contribute to the behavioral responses to repeated stress exposure...
  3. pmc Ligand-directed c-Jun N-terminal kinase activation disrupts opioid receptor signaling
    Erica J Melief
    Department of Pharmacology, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 107:11608-13. 2010
    ..These findings suggest that ligand-directed activation of JNK kinases may generally provides an alternate mode of G protein-coupled receptor regulation...
  4. pmc Activation of the kappa opioid receptor in the dorsal raphe nucleus mediates the aversive effects of stress and reinstates drug seeking
    Benjamin B Land
    Department of Pharmacology, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 106:19168-73. 2009
    ..These results suggest that the adverse effects of stress may converge on the serotonergic system and offers an approach to controlling stress-induced dysphoria and relapse...
  5. pmc CRF1-R activation of the dynorphin/kappa opioid system in the mouse basolateral amygdala mediates anxiety-like behavior
    Michael R Bruchas
    Department of Pharmacology, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 4:e8528. 2009
    ....
  6. pmc Stress-induced activation of the dynorphin/κ-opioid receptor system in the amygdala potentiates nicotine conditioned place preference
    Jeffrey S Smith
    Department of Pharmacology, University of Washington, Seattle, Washington 98195 7280, USA
    J Neurosci 32:1488-95. 2012
    ..Together, these data implicate the amygdala as a key region modulating the appetitive properties of nicotine, and suggest that κ-opioid antagonists may be useful therapeutic tools to reduce stress-induced nicotine craving...
  7. pmc The dysphoric component of stress is encoded by activation of the dynorphin kappa-opioid system
    Benjamin B Land
    Department of Pharmacology, University of Washington, Seattle, Washington 98195 7280, USA
    J Neurosci 28:407-14. 2008
    ..The convergence of stress-induced aversive inputs on the dynorphin system was unexpected, implicates dynorphin as a key mediator of dysphoria, and emphasizes kappa-receptor antagonists as promising therapeutics...
  8. pmc Kinase cascades and ligand-directed signaling at the kappa opioid receptor
    Michael R Bruchas
    Department of Pharmacology, University of Washington, Seattle, WA 98195, USA
    Psychopharmacology (Berl) 210:137-47. 2010
    ..Stress-induced activation of dynorphin-KOR is well known to produce analgesia, and more recently, it has been implicated as a mediator of stress-induced responses including anxiety, depression, and reinstatement of drug seeking...
  9. pmc Phosphorylation of the mu-opioid receptor at tyrosine 166 (Tyr3.51) in the DRY motif reduces agonist efficacy
    Cecilea C Clayton
    Department of Pharmacology, University of Washington School of Medicine, Seattle, WA 98195 7280, USA
    Mol Pharmacol 77:339-47. 2010
    ....
  10. pmc Alpha-dystrobrevin-1 recruits alpha-catulin to the alpha1D-adrenergic receptor/dystrophin-associated protein complex signalosome
    John S Lyssand
    Department of Pharmacology and Physiology and Biophysics, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 107:21854-9. 2010
    ..Taken together, our study implicates α-catulin as a unique regulator of GPCR signaling and represents a unique expansion of the intricate and continually evolving array of GPCR signaling networks...
  11. pmc Stress-induced p38 mitogen-activated protein kinase activation mediates kappa-opioid-dependent dysphoria
    Michael R Bruchas
    Department of Pharmacology, University of Washington, Seattle, Washington 98195 7280, USA
    J Neurosci 27:11614-23. 2007
    ..Our results indicate that activation of p38 MAPK signaling by the endogenous dynorphin-kappa-opioid system likely constitutes a key component of the molecular mechanisms mediating the aversive properties of stress...