David L Brody
Affiliation: Washington University School of Medicine
- Tau elevations in the brain extracellular space correlate with reduced amyloid-β levels and predict adverse clinical outcomes after severe traumatic brain injurySandra Magnoni
Department of Anaesthesia and Intensive Care, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milan University, Milano 20100, Italy
Brain 135:1268-80. 2012..Further studies with larger numbers of patients will be required to assess the reproducibility of these findings and to determine whether this approach provides added value when combined with clinical and radiological information...
- Morris water maze search strategy analysis in PDAPP mice before and after experimental traumatic brain injuryDavid L Brody
Department of Neurology, Washington University, 660 S Euclid Ave, Box 8111, St Louis, MO 63110, USA
Exp Neurol 197:330-40. 2006..Human TBI patients may have analogous poor use of problem solving strategies...
- Electromagnetic controlled cortical impact device for precise, graded experimental traumatic brain injuryDavid L Brody
Department of Neurology, Hope Center for Neurological Disorders, Washington University, St Louis, Missouri, USA
J Neurotrauma 24:657-73. 2007..0 mm with 7-8 mice per group. Thus, the EM impactor and refined surgical and behavioral testing techniques may offer a reliable and convenient framework for preclinical TBI research involving mice...
- Active and passive immunotherapy for neurodegenerative disordersDavid L Brody
Department of Neurology, Developmental Biology, Alzheimer s Disease Research Center, and Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, Missouri 63110, USA
Annu Rev Neurosci 31:175-93. 2008....
- Amyloid-beta dynamics correlate with neurological status in the injured human brainDavid L Brody
Department of Neurology, Washington University, St Louis, MO 63110, USA
Science 321:1221-4. 2008..Such dynamics fit well with the hypothesis that neuronal activity regulates extracellular Abeta concentration...
- Neurofilament light chain levels in ventricular cerebrospinal fluid after acute aneurysmal subarachnoid haemorrhageE R Zanier
Department of Neurology, Washington University School of Medicine, 660 S Euclid Avenue, Saint Louis, MO 63110, USA
J Neurol Neurosurg Psychiatry 82:157-9. 2011..We hypothesised that patients with aSAH would have elevated cerebrospinal fluid (CSF) NF-L levels and sought to explore the clinical correlates of CSF NF-L dynamics...
- Diffusion tensor imaging detects axonal injury in a mouse model of repetitive closed-skull traumatic brain injuryRachel E Bennett
Department of Neurology, Washington University School of Medicine, 660 S Euclid Ave, Campus Box 8111, Saint Louis, MO 63110, United States
Neurosci Lett 513:160-5. 2012..Further, this reflects a need to better understand the histological basis for DTI signal changes in mild TBI...
- Distinct temporal and anatomical distributions of amyloid-β and tau abnormalities following controlled cortical impact in transgenic miceHien T Tran
Department of Neurology, Washington University in St Louis, St Louis, Missouri, United States of America
PLoS ONE 6:e25475. 2011..These data provide further evidence for the causal effects of moderately severe contusional TBI on acceleration of acute Alzheimer-related abnormalities and the independent relationship between amyloid-β and tau in this setting...
- Human apolipoprotein E4 worsens acute axonal pathology but not amyloid-β immunoreactivity after traumatic brain injury in 3xTG-AD miceRachel E Bennett
Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
J Neuropathol Exp Neurol 72:396-403. 2013..These results suggest that the APOE4 genotype may have a primary effect on the severity of axonal injury in acute TBI...
- Inhibition of JNK by a peptide inhibitor reduces traumatic brain injury-induced tauopathy in transgenic miceHien T Tran
Department of Neurology, Washington University, St Louis, Missouri, USA
J Neuropathol Exp Neurol 71:116-29. 2012..Longer-term studies will be required to determine whether reducing acute tau pathology proves beneficial in brain trauma...
- Cerebellar white matter abnormalities following primary blast injury in US military personnelChristine Mac Donald
Department of Neurology, Washington University School of Medicine, St Louis, Missouri, USA
PLoS ONE 8:e55823. 2013..Furthermore, the effects of possible subconcussive impacts and other military-related exposures cannot be determined from the data presented. Thus many aspects of topic will require further investigation...
- Amyloid-β oligomerization in Alzheimer dementia versus high-pathology controlsThomas J Esparza
Department of Neurology, Washington University School of Medicine, St Louis, MO, USA
Ann Neurol 73:104-19. 2013..However, the lack of a sensitive, specific, and quantitative assay for Aβ oligomers has hampered rigorous tests of this hypothesis...
- Controlled cortical impact traumatic brain injury in 3xTg-AD mice causes acute intra-axonal amyloid-β accumulation and independently accelerates the development of tau abnormalitiesHien T Tran
Department of Neurology, Washington University in St Louis, St Louis, Missouri 63110, USA
J Neurosci 31:9513-25. 2011..Future studies will be required to assess the behavioral and long-term neurodegenerative consequences of these pathologies...
- Traumatic brain injury reduces soluble extracellular amyloid-β in mice: a methodologically novel combined microdialysis-controlled cortical impact studyKatherine E Schwetye
Washington University School of Medicine, Department of Neurology and Hope Center for Neurological Disorders, 660 S Euclid Ave Box 8111, St Louis, MO 63110, USA
Neurobiol Dis 40:555-64. 2010..Reduced neuronal activity may contribute, though the underlying mechanisms have not been definitively determined. Further work will be needed to assess the dynamics of insoluble and oligomeric Aβ after TBI...
- Repetitive closed-skull traumatic brain injury in mice causes persistent multifocal axonal injury and microglial reactivityYoshitsugu Shitaka
Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Neuropathol Exp Neurol 70:551-67. 2011..Thus, prominent and long-lasting abnormalities in this TBI model were underestimated using conventional approaches. The model may be useful for mechanistic investigations and preclinical assessment of candidate therapeutics...
- New perspectives on amyloid-beta dynamics after acute brain injury: moving between experimental approaches and studies in the human brainSandra Magnoni
Washington University, St Louis, MO 63110, USA
Arch Neurol 67:1068-73. 2010..We then discuss the clinical significance of these findings with their implications for translational neurobiology and conclude with further directions for traumatic brain injury and Alzheimer disease research...
- Detection of blast-related traumatic brain injury in U.S. military personnelChristine L Mac Donald
Washington University School of Medicine, St Louis, MO 63110, USA
N Engl J Med 364:2091-100. 2011..Blast-related traumatic brain injuries have been common in the Iraq and Afghanistan wars, but fundamental questions about the nature of these injuries remain unanswered...
- Amyloid-B and Apolipoprotein E in Traumatic Brain InjuryDavid Brody; Fiscal Year: 2007..This work may lead to improved therapeutic options for patients with TBI in the future. ..