David L Brody

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. pmc Distinct temporal and anatomical distributions of amyloid-β and tau abnormalities following controlled cortical impact in transgenic mice
    Hien T Tran
    Department of Neurology, Washington University in St Louis, St Louis, Missouri, United States of America
    PLoS ONE 6:e25475. 2011
  2. pmc Tau elevations in the brain extracellular space correlate with reduced amyloid-β levels and predict adverse clinical outcomes after severe traumatic brain injury
    Sandra Magnoni
    Department of Anaesthesia and Intensive Care, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milan University, Milano 20100, Italy
    Brain 135:1268-80. 2012
  3. pmc Morris water maze search strategy analysis in PDAPP mice before and after experimental traumatic brain injury
    David L Brody
    Department of Neurology, Washington University, 660 S Euclid Ave, Box 8111, St Louis, MO 63110, USA
    Exp Neurol 197:330-40. 2006
  4. pmc Amyloid-beta dynamics correlate with neurological status in the injured human brain
    David L Brody
    Department of Neurology, Washington University, St Louis, MO 63110, USA
    Science 321:1221-4. 2008
  5. pmc Electromagnetic controlled cortical impact device for precise, graded experimental traumatic brain injury
    David L Brody
    Department of Neurology, Hope Center for Neurological Disorders, Washington University, St Louis, Missouri, USA
    J Neurotrauma 24:657-73. 2007
  6. pmc Active and passive immunotherapy for neurodegenerative disorders
    David L Brody
    Department of Neurology, Developmental Biology, Alzheimer s Disease Research Center, and Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Annu Rev Neurosci 31:175-93. 2008
  7. pmc Neurofilament light chain levels in ventricular cerebrospinal fluid after acute aneurysmal subarachnoid haemorrhage
    E R Zanier
    Department of Neurology, Washington University School of Medicine, 660 S Euclid Avenue, Saint Louis, MO 63110, USA
    J Neurol Neurosurg Psychiatry 82:157-9. 2011
  8. pmc Diffusion tensor imaging detects axonal injury in a mouse model of repetitive closed-skull traumatic brain injury
    Rachel E Bennett
    Department of Neurology, Washington University School of Medicine, 660 S Euclid Ave, Campus Box 8111, Saint Louis, MO 63110, United States
    Neurosci Lett 513:160-5. 2012
  9. pmc Controlled cortical impact traumatic brain injury in 3xTg-AD mice causes acute intra-axonal amyloid-β accumulation and independently accelerates the development of tau abnormalities
    Hien T Tran
    Department of Neurology, Washington University in St Louis, St Louis, Missouri 63110, USA
    J Neurosci 31:9513-25. 2011
  10. doi request reprint Human apolipoprotein E4 worsens acute axonal pathology but not amyloid-β immunoreactivity after traumatic brain injury in 3xTG-AD mice
    Rachel E Bennett
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Neuropathol Exp Neurol 72:396-403. 2013

Research Grants

Collaborators

Detail Information

Publications21

  1. pmc Distinct temporal and anatomical distributions of amyloid-β and tau abnormalities following controlled cortical impact in transgenic mice
    Hien T Tran
    Department of Neurology, Washington University in St Louis, St Louis, Missouri, United States of America
    PLoS ONE 6:e25475. 2011
    ..These data provide further evidence for the causal effects of moderately severe contusional TBI on acceleration of acute Alzheimer-related abnormalities and the independent relationship between amyloid-β and tau in this setting...
  2. pmc Tau elevations in the brain extracellular space correlate with reduced amyloid-β levels and predict adverse clinical outcomes after severe traumatic brain injury
    Sandra Magnoni
    Department of Anaesthesia and Intensive Care, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milan University, Milano 20100, Italy
    Brain 135:1268-80. 2012
    ..Further studies with larger numbers of patients will be required to assess the reproducibility of these findings and to determine whether this approach provides added value when combined with clinical and radiological information...
  3. pmc Morris water maze search strategy analysis in PDAPP mice before and after experimental traumatic brain injury
    David L Brody
    Department of Neurology, Washington University, 660 S Euclid Ave, Box 8111, St Louis, MO 63110, USA
    Exp Neurol 197:330-40. 2006
    ..Human TBI patients may have analogous poor use of problem solving strategies...
  4. pmc Amyloid-beta dynamics correlate with neurological status in the injured human brain
    David L Brody
    Department of Neurology, Washington University, St Louis, MO 63110, USA
    Science 321:1221-4. 2008
    ..Such dynamics fit well with the hypothesis that neuronal activity regulates extracellular Abeta concentration...
  5. pmc Electromagnetic controlled cortical impact device for precise, graded experimental traumatic brain injury
    David L Brody
    Department of Neurology, Hope Center for Neurological Disorders, Washington University, St Louis, Missouri, USA
    J Neurotrauma 24:657-73. 2007
    ..0 mm with 7-8 mice per group. Thus, the EM impactor and refined surgical and behavioral testing techniques may offer a reliable and convenient framework for preclinical TBI research involving mice...
  6. pmc Active and passive immunotherapy for neurodegenerative disorders
    David L Brody
    Department of Neurology, Developmental Biology, Alzheimer s Disease Research Center, and Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Annu Rev Neurosci 31:175-93. 2008
    ....
  7. pmc Neurofilament light chain levels in ventricular cerebrospinal fluid after acute aneurysmal subarachnoid haemorrhage
    E R Zanier
    Department of Neurology, Washington University School of Medicine, 660 S Euclid Avenue, Saint Louis, MO 63110, USA
    J Neurol Neurosurg Psychiatry 82:157-9. 2011
    ..We hypothesised that patients with aSAH would have elevated cerebrospinal fluid (CSF) NF-L levels and sought to explore the clinical correlates of CSF NF-L dynamics...
  8. pmc Diffusion tensor imaging detects axonal injury in a mouse model of repetitive closed-skull traumatic brain injury
    Rachel E Bennett
    Department of Neurology, Washington University School of Medicine, 660 S Euclid Ave, Campus Box 8111, Saint Louis, MO 63110, United States
    Neurosci Lett 513:160-5. 2012
    ..Further, this reflects a need to better understand the histological basis for DTI signal changes in mild TBI...
  9. pmc Controlled cortical impact traumatic brain injury in 3xTg-AD mice causes acute intra-axonal amyloid-β accumulation and independently accelerates the development of tau abnormalities
    Hien T Tran
    Department of Neurology, Washington University in St Louis, St Louis, Missouri 63110, USA
    J Neurosci 31:9513-25. 2011
    ..Future studies will be required to assess the behavioral and long-term neurodegenerative consequences of these pathologies...
  10. doi request reprint Human apolipoprotein E4 worsens acute axonal pathology but not amyloid-β immunoreactivity after traumatic brain injury in 3xTG-AD mice
    Rachel E Bennett
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Neuropathol Exp Neurol 72:396-403. 2013
    ..These results suggest that the APOE4 genotype may have a primary effect on the severity of axonal injury in acute TBI...
  11. pmc Inhibition of JNK by a peptide inhibitor reduces traumatic brain injury-induced tauopathy in transgenic mice
    Hien T Tran
    Department of Neurology, Washington University, St Louis, Missouri, USA
    J Neuropathol Exp Neurol 71:116-29. 2012
    ..Longer-term studies will be required to determine whether reducing acute tau pathology proves beneficial in brain trauma...
  12. pmc Cerebellar white matter abnormalities following primary blast injury in US military personnel
    Christine Mac Donald
    Department of Neurology, Washington University School of Medicine, St Louis, Missouri, USA
    PLoS ONE 8:e55823. 2013
    ..Furthermore, the effects of possible subconcussive impacts and other military-related exposures cannot be determined from the data presented. Thus many aspects of topic will require further investigation...
  13. pmc Repetitive closed-skull traumatic brain injury in mice causes persistent multifocal axonal injury and microglial reactivity
    Yoshitsugu Shitaka
    Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neuropathol Exp Neurol 70:551-67. 2011
    ..Thus, prominent and long-lasting abnormalities in this TBI model were underestimated using conventional approaches. The model may be useful for mechanistic investigations and preclinical assessment of candidate therapeutics...
  14. pmc Amyloid-β oligomerization in Alzheimer dementia versus high-pathology controls
    Thomas J Esparza
    Department of Neurology, Washington University School of Medicine, St Louis, MO, USA
    Ann Neurol 73:104-19. 2013
    ..However, the lack of a sensitive, specific, and quantitative assay for Aβ oligomers has hampered rigorous tests of this hypothesis...
  15. pmc Repetitive concussive traumatic brain injury interacts with post-injury foot shock stress to worsen social and depression-like behavior in mice
    Kristen C Klemenhagen
    Department of Neurology, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS ONE 8:e74510. 2013
    ....
  16. pmc Traumatic brain injury reduces soluble extracellular amyloid-β in mice: a methodologically novel combined microdialysis-controlled cortical impact study
    Katherine E Schwetye
    Washington University School of Medicine, Department of Neurology and Hope Center for Neurological Disorders, 660 S Euclid Ave Box 8111, St Louis, MO 63110, USA
    Neurobiol Dis 40:555-64. 2010
    ..Reduced neuronal activity may contribute, though the underlying mechanisms have not been definitively determined. Further work will be needed to assess the dynamics of insoluble and oligomeric Aβ after TBI...
  17. pmc Functional status after blast-plus-impact complex concussive traumatic brain injury in evacuated United States military personnel
    Christine L MacDonald
    1 Washington University School of Medicine, St Louis, Missouri
    J Neurotrauma 31:889-98. 2014
    ..The relationship between these clinical outcomes and specific blast-related aspects of brain injuries versus other combat-related factors remains unknown...
  18. pmc Disrupted modular organization of resting-state cortical functional connectivity in U.S. military personnel following concussive 'mild' blast-related traumatic brain injury
    Kihwan Han
    Department of Neurology, Washington University School of Medicine, St Louis, MO, USA
    Neuroimage 84:76-96. 2014
    ..The underlying biological mechanisms and consequences of disrupted between-module connectivity are unknown, thus further studies are required. ..
  19. doi request reprint New perspectives on amyloid-beta dynamics after acute brain injury: moving between experimental approaches and studies in the human brain
    Sandra Magnoni
    Washington University, St Louis, MO 63110, USA
    Arch Neurol 67:1068-73. 2010
    ..We then discuss the clinical significance of these findings with their implications for translational neurobiology and conclude with further directions for traumatic brain injury and Alzheimer disease research...
  20. pmc Detection of blast-related traumatic brain injury in U.S. military personnel
    Christine L Mac Donald
    Washington University School of Medicine, St Louis, MO 63110, USA
    N Engl J Med 364:2091-100. 2011
    ..Blast-related traumatic brain injuries have been common in the Iraq and Afghanistan wars, but fundamental questions about the nature of these injuries remain unanswered...
  21. pmc Rapamycin attenuates the development of posttraumatic epilepsy in a mouse model of traumatic brain injury
    Dongjun Guo
    Department of Neurology and the Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, Missouri, USA
    PLoS ONE 8:e64078. 2013
    ..These results suggest that rapamycin may represent a rational treatment for preventing posttraumatic epilepsy in patients with TBI...

Research Grants2

  1. Amyloid-B and Apolipoprotein E in Traumatic Brain Injury
    David Brody; Fiscal Year: 2007
    ..This work may lead to improved therapeutic options for patients with TBI in the future. ..