Jeffrey Bradley

..The radiation dose was 74 Gy given in 37 fractions. Radiation therapy volumes included those of the gross tumor and involved nodes. The volume of lung at or exceeding 20 Gy (V20) was mandated to be <or= 30%...

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..We reviewed our experience using either three- or five-fraction SBRT for peripheral or central tumors, respectively...

..The reported toxicities following SBRT for both peripheral and central lung cancers are also reviewed...

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..Image artifacts were evaluated in the diaphragm, where high contrast interfaces intercepted the imaging plane. For patients, this respiratory gating technique reduced the blurring artifacts by 9%-41% at the lung-diaphragm interface...

..Current models are usually oversimplified. We describe alternative methods for building multivariable dose-response models...

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..9, 77.4, 83.8, or 90.3 Gy. The locoregional control and survival rates were similar among the various dose levels. We investigated the effect of the gross tumor volume (GTV) on the outcome...

..To evaluate prospectively the acute and late morbidities from a multiinstitutional three-dimensional radiotherapy dose-escalation study for inoperable non-small-cell lung cancer...

..The 4D reconstruction provides the CT data required to measure the three-dimensional trajectory of tumor and lung tissue during free breathing...

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..There are no reliable markers to predict recurrence in resected Stage I non-small cell lung cancer (NSCLC). A validated clinical model to estimate the risk of recurrence would help select patients for adjuvant therapy...

..The method provides heterogeneity-corrected dose data consistent with convolution-superposition calculations and is one feasible approach for improving dosimetric data for outcomes analyses...

..An insufficient number of patients developed Grade 3-5 esophageal toxicity in the absence of chemotherapy to allow a valid statistical analysis of the relationship between the maximal esophageal point dose and esophagitis...

..The phantom developed for this work enabled detailed quality-assurance testing under realistic conditions with heterogeneous media...

..The aim of this study was to examine the effect of respiratory irregularities on four-dimensional computed tomography, and to evaluate a novel image reconstruction algorithm using percentile-based tagging of the respiratory cycle...

..Overall, amplitude sorting performed better than phase angle sorting for 33 of the 35 patients and equally well for two patients who were immobilized with a stereotactic body frame and an abdominal compression plate...

..Therefore, our aim was to determine whether the irradiated esophageal surface area and/or esophageal volume are predictive of acute esophagitis in relation to other clinical and treatment-related factors...

..Patients with early stage but medically inoperable lung cancer have a poor rate of primary tumor control (30%-40%) and a high rate of mortality (3-year survival, 20%-35%) with current management...

..In an attempt to simplify their localization for treatment planning purposes, the position of the internal mammary lymph nodes was systematically studied in 65 breast cancer patients undergoing CT simulation...

..To quantify the amount of free-breathing motion measured using Four-dimensional (4D) CT scans of mediastinal and hilar lymph nodes and to compare this motion to the primary lung tumor motion...

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..This investigation compared the static and dynamic tracking accuracy of this system to that of an on-board imaging kilovoltage X-ray system for concurrent use of the two systems...

..Preventive strategies to minimize this toxicity also are explored. Overall, this article reviews the current understanding of radiation toxicity for the esophagus...

..The recent introduction of a combined CT and PET scanner will substantially simplify image acquisition and treatment planning...

..When concurrent chemotherapy and 3-dimensional conformal RT are used, the maximum tolerated dose of radiation is reduced, and current indications suggest that the maximum tolerated dose in this setting is in the range of 70 to 74 Gy...

..04; P=0.9). (60)Cu-ATSM-PET can be readily performed in patients with NSCLC and the tumor uptake of (60)Cu-ATSM reveals clinically unique information about tumor oxygenation that is predictive of tumor response to therapy...

..To quantitatively test a breathing motion model using the continuity equation and clinical data...

..This study compares short-term outcomes between stereotactic body radiation therapy and surgical treatment of non-small cell lung cancer...

..The rate of symptomatic pneumonitis is related to many dosimetric parameters, and there are no evident threshold "tolerance dose-volume" levels. There are strong volume and fractionation effects...

..To determine the quiet respiration breathing motion model parameters for lung cancer and nonlung cancer patients...

..In this review we address each of these points, with particular emphasis on recent or ongoing prospective trials...

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..Our proteomics strategy yielded promising protein candidates, but their role in RP as well as their interactions with dose-volume metrics remain to be determined...

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..Our initial results show that the proposed method provides a feasible framework for improving PET thoracic images, without the need for gated/4-D PET imaging, when 4-D CT is available to estimate tumor motion...

..Based on these data, the Radiation Therapy Oncology Group (RTOG) initiated a Phase III trial to test the efficacy of beta-interferon in poor-risk patients with Stages IIIA and IIIB non-small-cell lung carcinoma...

..Adding a medial breast port significantly decreases percentage volume (PV) of lung and heart receiving high doses, especially when the CLD is excessive...

..While still under development, this technology has the potential for revolutionizing the radiotherapy treatment planning for the thorax and upper abdomen...

..In this report, we will review the literature on PET-based radiation treatment planning, its potential benefits, and future challenges...

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..The purpose of this study is to identify prognostic factors in a population of NSCLC patients treated with definitive 3D-CRT...

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..By combining these two, a normalization of the drift-free metric to tidal volume may be generated and the overall metric precision may be improved...

..Time is an implicit variable in this model...

..On average for each of the 20 patients, 99% of 307 peaks and valleys were automatically detected in 2.8 s. This method was robust for bellows waveforms with large variations...

..To review the outcome for 56 Stage I non-small-cell lung cancer treated definitively with three-dimensional conformal radiotherapy (3D-CRT) and to investigate the value of elective nodal irradiation in this patient population...

..With the arm abducted beyond 55 degrees, humeral head blocking would result in blocking of some of the axillary nodes...

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..Seattle, WA). We evaluated the feasibility and fixation of electromagnetic transponders bronchoscopically implanted in small airways of canine lungs and compared to results using gold markers...

..To identify deficiencies with simulation and treatment planning orders and to develop corrective measures to improve safety and quality...

..The purpose of this study was to evaluate the performance of the first commercially available on-line retrospective amplitude-binning algorithm for comparison to the traditional phase-binning algorithm...

..These models have the capacity to predict on unseen data...

..We hypothesized that, in a cooperative group setting, preoperative chemoradiotherapy would induce a 20% pathologic complete response (pathCR) rate. Combined-modality therapy quality, survival, and safety were secondary end points...