Joseph Bloom

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. pmc CYP2B6 non-coding variation associated with smoking cessation is also associated with differences in allelic expression, splicing, and nicotine metabolism independent of common amino-acid changes
    A Joseph Bloom
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS ONE 8:e79700. 2013
  2. pmc A compensatory effect upon splicing results in normal function of the CYP2A6*14 allele
    A Joseph Bloom
    Department of Psychiatry bTissue Procurement Core, Laboratory for Translational Pathology, Washington University School of Medicine, St Louis, Missouri 63119, USA
    Pharmacogenet Genomics 23:107-16. 2013
  3. doi request reprint Effects upon in-vivo nicotine metabolism reveal functional variation in FMO3 associated with cigarette consumption
    A Joseph Bloom
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63119, USA
    Pharmacogenet Genomics 23:62-8. 2013
  4. pmc Use of a predictive model derived from in vivo endophenotype measurements to demonstrate associations with a complex locus, CYP2A6
    A Joseph Bloom
    Department of Psychiatry, Washington University School of Medicine, 660 South Euclid, Saint Louis, MO 63119, USA
    Hum Mol Genet 21:3050-62. 2012
  5. pmc The contribution of common CYP2A6 alleles to variation in nicotine metabolism among European-Americans
    Joseph Bloom
    Department of Psychiatry, Washington University School of Medicine, Saint Louis, Missouri, USA
    Pharmacogenet Genomics 21:403-16. 2011

Collaborators

Detail Information

Publications5

  1. pmc CYP2B6 non-coding variation associated with smoking cessation is also associated with differences in allelic expression, splicing, and nicotine metabolism independent of common amino-acid changes
    A Joseph Bloom
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS ONE 8:e79700. 2013
    ..These results indicate differences in mRNA expression and splicing as potential molecular mechanisms by which non-coding variation in CYP2B6 may affect enzymatic activity leading to differences in metabolism and smoking cessation. ..
  2. pmc A compensatory effect upon splicing results in normal function of the CYP2A6*14 allele
    A Joseph Bloom
    Department of Psychiatry bTissue Procurement Core, Laboratory for Translational Pathology, Washington University School of Medicine, St Louis, Missouri 63119, USA
    Pharmacogenet Genomics 23:107-16. 2013
    ..These results show the importance of common genetic variants that effect exonic splicing suppressor and ESEs to explain human variation regarding clinically-relevant phenotypes...
  3. doi request reprint Effects upon in-vivo nicotine metabolism reveal functional variation in FMO3 associated with cigarette consumption
    A Joseph Bloom
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63119, USA
    Pharmacogenet Genomics 23:62-8. 2013
    ....
  4. pmc Use of a predictive model derived from in vivo endophenotype measurements to demonstrate associations with a complex locus, CYP2A6
    A Joseph Bloom
    Department of Psychiatry, Washington University School of Medicine, 660 South Euclid, Saint Louis, MO 63119, USA
    Hum Mol Genet 21:3050-62. 2012
    ..Lastly, comprehensive genotyping and in vivo metabolism data are used to demonstrate that genome-wide significant associations between CPD and single nucleotide polymorphisms are the result of synthetic associations...
  5. pmc The contribution of common CYP2A6 alleles to variation in nicotine metabolism among European-Americans
    Joseph Bloom
    Department of Psychiatry, Washington University School of Medicine, Saint Louis, Missouri, USA
    Pharmacogenet Genomics 21:403-16. 2011
    ..To study the association between cytochrome P450 2A6 (CYP2A6) genotype and metabolism of nicotine to cotinine, identify functional polymorphisms, and develop a predictive genetic model of nicotine metabolism...