Research Topics
| Kevin J BlackSummaryAffiliation: Washington University School of Medicine Country: USA Publications
Research Grants
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Detail Information
Publications
Levodopa challenge neuroimaging of levodopa-related mood fluctuations in Parkinson's diseaseKevin J Black
Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110 1093, USA
Neuropsychopharmacology 30:590-601. 2005..The findings require confirmation in larger and better-matched groups...- "Stop doing that"! Recognizing and managing ticsKevin J Black
Washington University School of Medicine, USA
Mo Med 105:53-6. 2008..TS is highly heritable though not yet convincingly associated with a specific gene. Many patients need no specific treatment, but certain medications and behavioral therapies have proven efficacy... 
Quantification of indirect pathway inhibition by the adenosine A2a antagonist SYN115 in Parkinson diseaseKevin J Black
Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Neurosci 30:16284-92. 2010....- Prospectively determined impact of type 1 diabetes on brain volume during developmentDana C Perantie
Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri, USA
Diabetes 60:3006-14. 2011..However, these studies cannot identify brain regions that change differentially over time depending on the degree of exposure to glycemic extremes... - Mood response to deep brain stimulation of the subthalamic nucleus in Parkinson's diseaseMeghan C Campbell
Dept of Neurology, Washington University School of Medicine, St Louis, MO, USA
J Neuropsychiatry Clin Neurosci 24:28-36. 2012..Left DBS improved mood more than right DBS. Right DBS-induced increase in positive mood was related to more medial and dorsal contact locations. These results highlight the functional heterogeneity of the STN... - Dopaminergic modulation of response inhibition: an fMRI studyTamara Hershey
Psychiatry Department, Washington University School of Medicine, USA
Brain Res Cogn Brain Res 20:438-48. 2004..In summary, right parietal and cerebellar regions important in mediating specific aspects of the GNG task were modulated by levodopa, suggesting a region-specific role for dopamine in response inhibition... - Hippocampal volumes in youth with type 1 diabetesTamara Hershey
Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri, USA
Diabetes 59:236-41. 2010..We examined whether hypoglycemia or hyperglycemia experienced during brain development in humans affects hippocampal volumes... - Cognitive-pharmacologic functional magnetic resonance imaging in tourette syndrome: a pilot studyTamara Hershey
Department of Psychiatry, Washington University, St. Louis, Missouri, USA
Biol Psychiatry 55:916-25. 2004..05). CONCLUSIONS: These results are consistent with a dopamine-influenced functional abnormality of brain response in TS and suggest testable hypotheses about the mechanism by which dopamine antagonists and agonists alleviate tics... - Intravenous levodopa administration in humans based on a two-compartment kinetic modelMollie Gordon
Department of Psychiatry, Washington University School of Medicine, Campus Box 8134, 660 S Euclid Avenue, St Louis, MO 63110, USA
J Neurosci Methods 159:300-7. 2007..Levodopa significantly reduced serum prolactin and raised serum growth hormone concentrations. Volunteers had no significant side effects... - Characterization of extrastriatal D2 in vivo specific binding of [¹⁸F](N-methyl)benperidol using PETSarah A Eisenstein
Department of Psychiatry, Washington University School of Medicine in St Louis, St Louis, Missouri 63110, USA
Synapse 66:770-80. 2012..Our findings indicate that PET with [¹⁸F]NMB measures specific binding in extrastriatal regions, making it a viable radioligand to study extrastriatal D2R levels in healthy and diseased states... - Rapid intravenous loading of levodopa for human research: clinical resultsKevin J Black
Department of Psychiatry and APDA Advanced Research Center for Parkinson Disease, Washington University School of Medicine, Campus Box 8134, 660 S Euclid Avenue, St Louis, MO 63110, USA
J Neurosci Methods 127:19-29. 2003..D.), and produced statistically significant antiparkinsonian benefit (16% mean reduction in a standard rating of parkinsonian motor signs, P<0.0005)... - A possible substrate for dopamine-related changes in mood and behavior: prefrontal and limbic effects of a D3-preferring dopamine agonistKevin J Black
Departments of Psychiatry, School of Medicine, Washington University, 660 South Euclid Avenue, St Louis, MO 63110, USA
Proc Natl Acad Sci U S A 99:17113-8. 2002.... - Motor asymmetry and substantia nigra volume are related to spatial delayed response performance in Parkinson diseaseErin R Foster
Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
Brain Cogn 67:1-10. 2008..In conclusion, left motor dysfunction and smaller right SN volume are associated with poorer spatial memory... - Atlas template images for nonhuman primate neuroimaging: baboon and macaqueKevin J Black
Departments of Psychiatry, Neurology, and Radiology, Washington University School of Medicine, St. Louis, MO 63110-1093, USA
Methods Enzymol 385:91-102. 2004 - Regional brain volume differences associated with hyperglycemia and severe hypoglycemia in youth with type 1 diabetesDana C Perantie
Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
Diabetes Care 30:2331-7. 2007..This study is the first to quantify regional brain volume differences in a large sample of youth with diabetes... - Asymmetric regional cerebral blood flow in sedated baboons measured by positron emission tomography (PET)Jason A Kaufman
Department of Anthropology, Washington University, St Louis, Missouri 63130, USA
Am J Phys Anthropol 121:369-77. 2003..Cerebral blood flow itself was uncorrelated with age, and differences between males and females were not significant... - Clinical features and comorbidity of mood fluctuations in Parkinson's diseaseBrad A Racette
Department of Neurology, Washington University School of Medicine, 660 South Euclid Avenue, Box 8111, St Louis, MO 63110, USA
J Neuropsychiatry Clin Neurosci 14:438-42. 2002..This association remained after removing effects of age and disease duration... - Validity of large-deformation high dimensional brain mapping of the basal ganglia in adults with Tourette syndromeLei Wang
Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
Psychiatry Res 154:181-90. 2007..We found no significant volume or shape differences in any of the structures in this small sample of subjects... - A perfusion MRI study of emotional valence and arousal in Parkinson's diseaseSunsern Limsoontarakul
Department of Psychiatry, Washington University School of Medicine St Louis, St Louis, MO 63110, USA
Parkinsons Dis 2011:742907. 2011..Conclusion. This study demonstrates that the temporal stability of perfusion MRI allows within-subject investigations of spontaneous fluctuations in mental state, such as mood, over relatively long-time intervals... - The cognitive correlates of functional status: a review from the Committee on Research of the American Neuropsychiatric AssociationDonald R Royall
Department of Psychiatry, UTHSCSA, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
J Neuropsychiatry Clin Neurosci 19:249-65. 2007..Better integration of cognitive and functional assessments would offer greater clinical utility. However, psychometric batteries may have to be redesigned to maximize their capacity to capture the variance in functional outcomes... - The value of quantitative electroencephalography in clinical psychiatry: a report by the Committee on Research of the American Neuropsychiatric AssociationKerry L Coburn
Department of Psychiatry and Behavioral Sciences, Mercer University School of Medicine, Macon, Georgia 31201, USA
J Neuropsychiatry Clin Neurosci 18:460-500. 2006..As a clinical laboratory test, qEEG's cautious use is recommended in attentional and learning disabilities of childhood, and in mood and dementing disorders of adulthood... - Blood flow imaging of the brain: 50 years experienceKatherine H Taber
Veterans Affairs Mid Atlantic Mental Illness Research, Education, and Clinical Center, Salisbury, North Carolina, USA
J Neuropsychiatry Clin Neurosci 17:441-6. 2005 - Cerebral mitochondrial metabolism in early Parkinson's diseaseWilliam J Powers
Department of Neurology, University of North Carolina Chapel Hill, Chapel Hill, North Carolina 27599 7025, USA
J Cereb Blood Flow Metab 28:1754-60. 2008..Whether this is the case in early PD and whether it is important in the pathogenesis of PD will require further study... - Psychiatric screening for DBSKevin J Black
Parkinsonism Relat Disord 13:546. 2007 - Repetitive and impulsive behaviors in treated Parkinson diseaseKevin J Black
Neurology 67:1118-9. 2006
Research Grants
- Testing Dopaminergic Function Using Pharmacologic FMRIKevin Black; Fiscal Year: 2003..abstract_text> ..
- Dopaminergic Effects on Cortical Function in Tourette'sKevin J Black; Fiscal Year: 2010..The significance of this research includes its potential to define an endophenotype for future developmental or genetic studies of TS. ..