Laura Jean Bierut

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. pmc ADH1B is associated with alcohol dependence and alcohol consumption in populations of European and African ancestry
    L J Bierut
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Mol Psychiatry 17:445-50. 2012
  2. pmc Genetic vulnerability and susceptibility to substance dependence
    Laura Jean Bierut
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Neuron 69:618-27. 2011
  3. pmc Variants in nicotinic receptors and risk for nicotine dependence
    Laura Jean Bierut
    Department of Psychiatry, Washington University School of Medicine, Box 8134, 660 South Euclid Ave, St Louis, MO 63110, USA
    Am J Psychiatry 165:1163-71. 2008
  4. pmc Number of sexual partners and associations with initiation and intensity of substance use
    Patricia A Cavazos-Rehg
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    AIDS Behav 15:869-74. 2011
  5. pmc Type of contraception method used at last intercourse and associations with health risk behaviors among US adolescents
    Patricia A Cavazos-Rehg
    Department of Psychiatry, Washington University School of Medicine, Campus Box 8134, St Louis, MO 63110, USA
    Contraception 82:549-55. 2010
  6. ncbi request reprint Using dimensional models of externalizing psychopathology to aid in gene identification
    Danielle M Dick
    Washington University, St Louis, Missouri, USA
    Arch Gen Psychiatry 65:310-8. 2008
  7. pmc Predictors of sexual debut at age 16 or younger
    Patricia A Cavazos-Rehg
    Department of Psychiatry, Washington University, Campus Box 8134, 660 South Euclid, St Louis, MO 63110, USA
    Arch Sex Behav 39:664-73. 2010
  8. pmc Risky sexual behaviors and sexually transmitted diseases: a comparison study of cocaine-dependent individuals in treatment versus a community-matched sample
    Patricia A Cavazos-Rehg
    Department of Psychiatry, Washington University in St Louis, 660 South Euclid, St Louis, MO 63110, USA
    AIDS Patient Care STDS 23:727-34. 2009
  9. pmc Novel genes identified in a high-density genome wide association study for nicotine dependence
    Laura Jean Bierut
    Department of Psychiatry, Washington University School of Medicine, 660 South Euclid, Box 8134, St Louis, MO 63110, USA
    Hum Mol Genet 16:24-35. 2007
  10. pmc Substance use and the risk for sexual intercourse with and without a history of teenage pregnancy among adolescent females
    Patricia A Cavazos-Rehg
    Department of Psychiatry, Washington University, 660 South Euclid, St Louis, MO 63110, USA
    J Stud Alcohol Drugs 72:194-8. 2011

Research Grants

Detail Information

Publications35

  1. pmc ADH1B is associated with alcohol dependence and alcohol consumption in populations of European and African ancestry
    L J Bierut
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Mol Psychiatry 17:445-50. 2012
    ..This variant has the strongest effect on risk for alcohol dependence compared with any other tested variant in European populations...
  2. pmc Genetic vulnerability and susceptibility to substance dependence
    Laura Jean Bierut
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Neuron 69:618-27. 2011
    ..Substance dependence can be thought of as a pharmacogenetic illness, and most likely hundreds and more probably thousands of genetic variants will be required to fully explain the genetic input to this disease...
  3. pmc Variants in nicotinic receptors and risk for nicotine dependence
    Laura Jean Bierut
    Department of Psychiatry, Washington University School of Medicine, Box 8134, 660 South Euclid Ave, St Louis, MO 63110, USA
    Am J Psychiatry 165:1163-71. 2008
    ....
  4. pmc Number of sexual partners and associations with initiation and intensity of substance use
    Patricia A Cavazos-Rehg
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    AIDS Behav 15:869-74. 2011
    ..Severity of substance use is more closely related to, and thus a better indicator of, higher number of sexual partners than age of substance use onset...
  5. pmc Type of contraception method used at last intercourse and associations with health risk behaviors among US adolescents
    Patricia A Cavazos-Rehg
    Department of Psychiatry, Washington University School of Medicine, Campus Box 8134, St Louis, MO 63110, USA
    Contraception 82:549-55. 2010
    ..This study was conducted to examine associations with contraception methods used at last sexual intercourse among US adolescents...
  6. ncbi request reprint Using dimensional models of externalizing psychopathology to aid in gene identification
    Danielle M Dick
    Washington University, St Louis, Missouri, USA
    Arch Gen Psychiatry 65:310-8. 2008
    ..However, this information has not been widely used in gene identification efforts, which have focused on specific disorders diagnosed using traditional psychiatric classification systems...
  7. pmc Predictors of sexual debut at age 16 or younger
    Patricia A Cavazos-Rehg
    Department of Psychiatry, Washington University, Campus Box 8134, 660 South Euclid, St Louis, MO 63110, USA
    Arch Sex Behav 39:664-73. 2010
    ..These results provide evidence that specific variables in the self and familial systems of influence are important in predicting sexual debut at 16 years old or earlier...
  8. pmc Risky sexual behaviors and sexually transmitted diseases: a comparison study of cocaine-dependent individuals in treatment versus a community-matched sample
    Patricia A Cavazos-Rehg
    Department of Psychiatry, Washington University in St Louis, 660 South Euclid, St Louis, MO 63110, USA
    AIDS Patient Care STDS 23:727-34. 2009
    ..It is important for clinicians to recognize that once released from treatment, cocaine-dependent individuals may be returning to high-risk environments where sexual risk behaviors are occurring in the context of cocaine use...
  9. pmc Novel genes identified in a high-density genome wide association study for nicotine dependence
    Laura Jean Bierut
    Department of Psychiatry, Washington University School of Medicine, 660 South Euclid, Box 8134, St Louis, MO 63110, USA
    Hum Mol Genet 16:24-35. 2007
    ..This work anticipates the future directions of large-scale genome wide association studies with state-of-the-art methodological approaches and sharing of data with the scientific community...
  10. pmc Substance use and the risk for sexual intercourse with and without a history of teenage pregnancy among adolescent females
    Patricia A Cavazos-Rehg
    Department of Psychiatry, Washington University, 660 South Euclid, St Louis, MO 63110, USA
    J Stud Alcohol Drugs 72:194-8. 2011
    ..The present study examined the associations between initiation and intensity of substance use and with sexual experience with and without a history of teenage pregnancy...
  11. pmc Brief report: Pregnant by age 15 years and substance use initiation among US adolescent girls
    Patricia A Cavazos-Rehg
    Department of Psychiatry, Washington University School of Medicine, Campus Box 8134, 660 South Euclid, St Louis, MO 63110, USA
    J Adolesc 35:1393-7. 2012
    ..In the multivariable analysis, marijuana use by age 14 years and/or cigarette smoking by age 12 years clearly distinguished girls who became pregnant by age 15 years and is perhaps due to a common underlying risk factor...
  12. pmc Associations between selected state laws and teenagers' drinking and driving behaviors
    Patricia A Cavazos-Rehg
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA
    Alcohol Clin Exp Res 36:1647-52. 2012
    ....
  13. pmc Associations between sexuality education in schools and adolescent birthrates: a state-level longitudinal model
    Patricia A Cavazos-Rehg
    Department of Psychiatry, Washington University, St Louis, MO 63110, USA
    Arch Pediatr Adolesc Med 166:134-40. 2012
    ..To examine the impact of sexuality education practices on adolescent birthrates while controlling for demographic characteristics and religious/political factors at a state level...
  14. pmc Age of sexual debut among US adolescents
    Patricia A Cavazos-Rehg
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Contraception 80:158-62. 2009
    ..This study examined gender and racial/ethnic differences in sexual debut...
  15. pmc Drug use and dependence in cocaine dependent subjects, community-based individuals, and their siblings
    Laura Jean Bierut
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Drug Alcohol Depend 95:14-22. 2008
    ....
  16. ncbi request reprint Family-based association analyses of alcohol dependence phenotypes across DRD2 and neighboring gene ANKK1
    Danielle M Dick
    Washington University in St Louis, St Louis, Missouri, USA
    Alcohol Clin Exp Res 31:1645-53. 2007
    ..Recently the genetic polymorphism most widely analyzed in DRD2, Taq1A, has been discovered to reside in a neighboring gene, ankyrin repeat and kinase domain containing 1 (ANKK1), located 10 kb downstream from DRD2...
  17. pmc Associations between multiple pregnancies and health risk behaviors among U.S. adolescents
    Patricia A Cavazos-Rehg
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Adolesc Health 47:600-3. 2010
    ..This study examined the associations between health risk behaviors (i.e., substance use behaviors, physical violence, or carried a weapon) and multiple adolescent pregnancies (i.e., experiencing or causing more than one pregnancy)...
  18. pmc Alcohol criteria endorsement and psychiatric and drug use disorders among DUI offenders: greater severity among women and multiple offenders
    Vivia V McCutcheon
    Department of Psychiatry, Washington University School of Medicine, 660 S Euclid Ave, Campus Box 8134, St Louis, MO 63110 1010, United States
    Addict Behav 34:432-9. 2009
    ....
  19. pmc Interplay of genetic risk factors (CHRNA5-CHRNA3-CHRNB4) and cessation treatments in smoking cessation success
    Li Shiun Chen
    Department of Psychiatry and the Department of Genetics, Washington University School of Medicine, St Louis, MO, USA
    Am J Psychiatry 169:735-42. 2012
    ....
  20. pmc The efficacy of short tandem repeat polymorphisms versus single-nucleotide polymorphisms for resolving population structure
    John S K Kauwe
    Department of Psychiatry, Washington University of Medicine, St Louis, MO, USA
    BMC Genet 6:S84. 2005
    ..If SNPs with lower MAFs are used, then more than 250 SNPs may be required to obtain reliable results...
  21. ncbi request reprint A genomic scan for habitual smoking in families of alcoholics: common and specific genetic factors in substance dependence
    Laura Jean Bierut
    School of Medicine, Washington University School of Medicine, 4940 Children s Place, St Louis, MO 63110, USA
    Am J Med Genet A 124:19-27. 2004
    ..Finally, there is also evidence of an area on chromosome 2 that may reflect a common genetic vulnerability locus to both habitual smoking and alcohol dependence...
  22. pmc Characteristics of sexually active teenage girls who would be pleased with becoming pregnant
    Patricia A Cavazos-Rehg
    Department of Psychiatry, Washington University School of Medicine, Campus Box 8134, 660 South Euclid, St Louis, MO 63110, USA
    Matern Child Health J 17:470-6. 2013
    ..Pregnancy prevention efforts can be improved by acknowledging the structural and cultural factors that shape teenage pregnancy attitudes...
  23. ncbi request reprint Long-term stability of alcohol and other substance dependence diagnoses and habitual smoking: an evaluation after 5 years
    Robert Culverhouse
    Department of Internal Medicine, Washington University in St Louis School of Medicine, St Louis, MO 63110 1026, USA
    Arch Gen Psychiatry 62:753-60. 2005
    ..A major criterion to validate diagnoses is stability over time...
  24. pmc Convergence of genetic findings for nicotine dependence and smoking related diseases with chromosome 15q24-25
    Laura Jean Bierut
    Washington University School of Medicine, 660 South Euclid, Box 8134, St Louis, MO 63110, USA
    Trends Pharmacol Sci 31:46-51. 2010
    ..This represents an exciting convergence of genetic findings, and highlights the potential for research on smoking to inform public health...
  25. pmc Exposure to trauma: a comparison of cocaine-dependent cases and a community-matched sample
    Stephanie E Afful
    Fontbonne University, St Louis, MO 63105, USA
    Drug Alcohol Depend 112:46-53. 2010
    ..The purpose of this study was to examine rates of traumatic events and PTSD in cocaine-dependent cases and a community comparison sample...
  26. ncbi request reprint The relationship between alcohol problems and dependence, conduct problems and diagnosis, and number of sex partners in a sample of young adults
    Patricia A Cavazos-Rehg
    Washington University in St Louis, St Louis, Missouri, USA
    Alcohol Clin Exp Res 31:2046-52. 2007
    ..This study examined the extent to which alcohol dependence and conduct disorder are associated with the number of sexual partners and membership in a risk group of having a high number of sexual partners (10 or more)...
  27. pmc Incorporating age at onset of smoking into genetic models for nicotine dependence: evidence for interaction with multiple genes
    Richard A Grucza
    Department of Psychiatry, Washington University School of Medicine, 660 South Euclid Ave, St Louis, MO 63110, USA
    Addict Biol 15:346-57. 2010
    ..Incorporation of logically chosen interaction parameters, such as AOS, into genetic models of substance use disorders may increase the degree of explained phenotypic variation and constitutes a promising avenue for gene discovery...
  28. pmc A genome-wide association study of alcohol dependence
    Laura J Bierut
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 107:5082-7. 2010
    ..11 and 1.16. Further dissection of the alcoholism phenotype, to disentangle the influence of comorbid substance-use disorders, will be a next step in identifying genetic variants associated with alcohol dependence...
  29. pmc The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans
    Nancy L Saccone
    Department of Genetics, Washington University, St Louis, Missouri 63110, UA
    Cancer Res 69:6848-56. 2009
    ..The nonsynonymous SNP rs16969968, a known risk variant in populations of European-descent, is also significantly associated with risk in African-Americans. Additional SNPs contribute to risk in distinct ways in these two populations...
  30. pmc Further evidence for an association between the gamma-aminobutyric acid receptor A, subunit 4 genes on chromosome 4 and Fagerström Test for Nicotine Dependence
    Arpana Agrawal
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Addiction 104:471-7. 2009
    ..In the present report, we extend the previous study by expanding our genotyping efforts significantly for these two genes...
  31. pmc Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes
    Nancy L Saccone
    Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Med Genet B Neuropsychiatr Genet 150:453-66. 2009
    ....
  32. pmc Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs
    Scott F Saccone
    Department of Psychiatry, Box 8134, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Hum Mol Genet 16:36-49. 2007
    ..Other genes among the top signals were KCNJ6 and GABRA4. This study represents one of the most powerful and extensive studies of nicotine dependence to date and has found novel risk loci that require confirmation by replication studies...
  33. pmc Nicotine dependence and genetic variation in the nicotinic receptors
    Laura Jean Bierut
    Washington University School of Medicine, Department of Psychiatry, St Louis, MO, USA
    Drug Alcohol Depend 104:S64-9. 2009
    ....
  34. pmc Convergence of genome-wide association and candidate gene studies for alcoholism
    Emily Olfson
    Department of Human and Statistical Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Alcohol Clin Exp Res 36:2086-94. 2012
    ..This approach is particularly important for the field of alcoholism because the contribution of many candidate genes remains controversial...
  35. ncbi request reprint Defining alcohol-related phenotypes in humans. The Collaborative Study on the Genetics of Alcoholism
    Laura Jean Bierut
    Washington University School of Medicine, St Louis, Missouri, USA
    Alcohol Res Health 26:208-13. 2002
    ..Genetic analyses have identified regions on several chromosomes that are associated with these phenotypes and need to be studied further...

Research Grants11

  1. Genetics Study of Nicotine Dependence in African Americans
    Laura Bierut; Fiscal Year: 2009
    ....
  2. Case Control Candidate Gene Study of Addiction
    Laura Bierut; Fiscal Year: 2009
    ..Data from this proposal will be become part of the NIDA Genetics Consortium to be made available to the scientific community. ..
  3. FAMILY STUDY OF COCAINE DEPENDENCE
    Laura Bierut; Fiscal Year: 2004
    ....
  4. Genetics Study of Nicotine Dependence in African Americans
    Eric O Johnson; Fiscal Year: 2010
    ....