Laura Jean Bierut

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. ncbi Novel genes identified in a high-density genome wide association study for nicotine dependence
    Laura Jean Bierut
    Department of Psychiatry, Washington University School of Medicine, 660 South Euclid, Box 8134, St Louis, MO 63110, USA
    Hum Mol Genet 16:24-35. 2007
  2. ncbi Variants in nicotinic receptors and risk for nicotine dependence
    Laura Jean Bierut
    Department of Psychiatry, Washington University School of Medicine, Box 8134, 660 South Euclid Ave, St Louis, MO 63110, USA
    Am J Psychiatry 165:1163-71. 2008
  3. ncbi Number of sexual partners and associations with initiation and intensity of substance use
    Patricia A Cavazos-Rehg
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    AIDS Behav 15:869-74. 2011
  4. ncbi Using dimensional models of externalizing psychopathology to aid in gene identification
    Danielle M Dick
    Washington University, St Louis, Missouri, USA
    Arch Gen Psychiatry 65:310-8. 2008
  5. ncbi Predictors of sexual debut at age 16 or younger
    Patricia A Cavazos-Rehg
    Department of Psychiatry, Washington University, Campus Box 8134, 660 South Euclid, St Louis, MO 63110, USA
    Arch Sex Behav 39:664-73. 2010
  6. ncbi Risky sexual behaviors and sexually transmitted diseases: a comparison study of cocaine-dependent individuals in treatment versus a community-matched sample
    Patricia A Cavazos-Rehg
    Department of Psychiatry, Washington University in St Louis, 660 South Euclid, St Louis, MO 63110, USA
    AIDS Patient Care STDS 23:727-34. 2009
  7. ncbi Type of contraception method used at last intercourse and associations with health risk behaviors among US adolescents
    Patricia A Cavazos-Rehg
    Department of Psychiatry, Washington University School of Medicine, Campus Box 8134, St Louis, MO 63110, USA
    Contraception 82:549-55. 2010
  8. ncbi Substance use and the risk for sexual intercourse with and without a history of teenage pregnancy among adolescent females
    Patricia A Cavazos-Rehg
    Department of Psychiatry, Washington University, 660 South Euclid, St Louis, MO 63110, USA
    J Stud Alcohol Drugs 72:194-8. 2011
  9. ncbi Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs
    Scott F Saccone
    Department of Psychiatry, Box 8134, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Hum Mol Genet 16:36-49. 2007
  10. ncbi Associations between sexuality education in schools and adolescent birthrates: a state-level longitudinal model
    Patricia A Cavazos-Rehg
    Department of Psychiatry, Washington University, St Louis, MO 63110, USA
    Arch Pediatr Adolesc Med 166:134-40. 2012

Detail Information

Publications32

  1. ncbi Novel genes identified in a high-density genome wide association study for nicotine dependence
    Laura Jean Bierut
    Department of Psychiatry, Washington University School of Medicine, 660 South Euclid, Box 8134, St Louis, MO 63110, USA
    Hum Mol Genet 16:24-35. 2007
    ..This work anticipates the future directions of large-scale genome wide association studies with state-of-the-art methodological approaches and sharing of data with the scientific community...
  2. ncbi Variants in nicotinic receptors and risk for nicotine dependence
    Laura Jean Bierut
    Department of Psychiatry, Washington University School of Medicine, Box 8134, 660 South Euclid Ave, St Louis, MO 63110, USA
    Am J Psychiatry 165:1163-71. 2008
    ....
  3. ncbi Number of sexual partners and associations with initiation and intensity of substance use
    Patricia A Cavazos-Rehg
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    AIDS Behav 15:869-74. 2011
    ..Severity of substance use is more closely related to, and thus a better indicator of, higher number of sexual partners than age of substance use onset...
  4. ncbi Using dimensional models of externalizing psychopathology to aid in gene identification
    Danielle M Dick
    Washington University, St Louis, Missouri, USA
    Arch Gen Psychiatry 65:310-8. 2008
    ..However, this information has not been widely used in gene identification efforts, which have focused on specific disorders diagnosed using traditional psychiatric classification systems...
  5. ncbi Predictors of sexual debut at age 16 or younger
    Patricia A Cavazos-Rehg
    Department of Psychiatry, Washington University, Campus Box 8134, 660 South Euclid, St Louis, MO 63110, USA
    Arch Sex Behav 39:664-73. 2010
    ..These results provide evidence that specific variables in the self and familial systems of influence are important in predicting sexual debut at 16 years old or earlier...
  6. ncbi Risky sexual behaviors and sexually transmitted diseases: a comparison study of cocaine-dependent individuals in treatment versus a community-matched sample
    Patricia A Cavazos-Rehg
    Department of Psychiatry, Washington University in St Louis, 660 South Euclid, St Louis, MO 63110, USA
    AIDS Patient Care STDS 23:727-34. 2009
    ..It is important for clinicians to recognize that once released from treatment, cocaine-dependent individuals may be returning to high-risk environments where sexual risk behaviors are occurring in the context of cocaine use...
  7. ncbi Type of contraception method used at last intercourse and associations with health risk behaviors among US adolescents
    Patricia A Cavazos-Rehg
    Department of Psychiatry, Washington University School of Medicine, Campus Box 8134, St Louis, MO 63110, USA
    Contraception 82:549-55. 2010
    ..This study was conducted to examine associations with contraception methods used at last sexual intercourse among US adolescents...
  8. ncbi Substance use and the risk for sexual intercourse with and without a history of teenage pregnancy among adolescent females
    Patricia A Cavazos-Rehg
    Department of Psychiatry, Washington University, 660 South Euclid, St Louis, MO 63110, USA
    J Stud Alcohol Drugs 72:194-8. 2011
    ..The present study examined the associations between initiation and intensity of substance use and with sexual experience with and without a history of teenage pregnancy...
  9. ncbi Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs
    Scott F Saccone
    Department of Psychiatry, Box 8134, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Hum Mol Genet 16:36-49. 2007
    ..Other genes among the top signals were KCNJ6 and GABRA4. This study represents one of the most powerful and extensive studies of nicotine dependence to date and has found novel risk loci that require confirmation by replication studies...
  10. ncbi Associations between sexuality education in schools and adolescent birthrates: a state-level longitudinal model
    Patricia A Cavazos-Rehg
    Department of Psychiatry, Washington University, St Louis, MO 63110, USA
    Arch Pediatr Adolesc Med 166:134-40. 2012
    ..To examine the impact of sexuality education practices on adolescent birthrates while controlling for demographic characteristics and religious/political factors at a state level...
  11. ncbi Drug use and dependence in cocaine dependent subjects, community-based individuals, and their siblings
    Laura Jean Bierut
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Drug Alcohol Depend 95:14-22. 2008
    ....
  12. ncbi Age of sexual debut among US adolescents
    Patricia A Cavazos-Rehg
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Contraception 80:158-62. 2009
    ..This study examined gender and racial/ethnic differences in sexual debut...
  13. ncbi Associations between multiple pregnancies and health risk behaviors among U.S. adolescents
    Patricia A Cavazos-Rehg
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Adolesc Health 47:600-3. 2010
    ..This study examined the associations between health risk behaviors (i.e., substance use behaviors, physical violence, or carried a weapon) and multiple adolescent pregnancies (i.e., experiencing or causing more than one pregnancy)...
  14. ncbi Alcohol criteria endorsement and psychiatric and drug use disorders among DUI offenders: greater severity among women and multiple offenders
    Vivia V McCutcheon
    Department of Psychiatry, Washington University School of Medicine, 660 S Euclid Ave, Campus Box 8134, St Louis, MO 63110 1010, United States
    Addict Behav 34:432-9. 2009
    ....
  15. ncbi Family-based association analyses of alcohol dependence phenotypes across DRD2 and neighboring gene ANKK1
    Danielle M Dick
    Washington University in St Louis, St Louis, Missouri, USA
    Alcohol Clin Exp Res 31:1645-53. 2007
    ..Recently the genetic polymorphism most widely analyzed in DRD2, Taq1A, has been discovered to reside in a neighboring gene, ankyrin repeat and kinase domain containing 1 (ANKK1), located 10 kb downstream from DRD2...
  16. ncbi The efficacy of short tandem repeat polymorphisms versus single-nucleotide polymorphisms for resolving population structure
    John S K Kauwe
    Department of Psychiatry, Washington University of Medicine, St Louis, MO, USA
    BMC Genet 6:S84. 2005
    ..If SNPs with lower MAFs are used, then more than 250 SNPs may be required to obtain reliable results...
  17. ncbi Brief report: Pregnant by age 15 years and substance use initiation among US adolescent girls
    Patricia A Cavazos-Rehg
    Department of Psychiatry, Washington University School of Medicine, Campus Box 8134, 660 South Euclid, St Louis, MO 63110, USA
    J Adolesc 35:1393-7. 2012
    ..In the multivariable analysis, marijuana use by age 14 years and/or cigarette smoking by age 12 years clearly distinguished girls who became pregnant by age 15 years and is perhaps due to a common underlying risk factor...
  18. ncbi Associations between selected state laws and teenagers' drinking and driving behaviors
    Patricia A Cavazos-Rehg
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA
    Alcohol Clin Exp Res 36:1647-52. 2012
    ....
  19. ncbi The relationship between alcohol problems and dependence, conduct problems and diagnosis, and number of sex partners in a sample of young adults
    Patricia A Cavazos-Rehg
    Washington University in St Louis, St Louis, Missouri, USA
    Alcohol Clin Exp Res 31:2046-52. 2007
    ..This study examined the extent to which alcohol dependence and conduct disorder are associated with the number of sexual partners and membership in a risk group of having a high number of sexual partners (10 or more)...
  20. ncbi Convergence of genetic findings for nicotine dependence and smoking related diseases with chromosome 15q24-25
    Laura Jean Bierut
    Washington University School of Medicine, 660 South Euclid, Box 8134, St Louis, MO 63110, USA
    Trends Pharmacol Sci 31:46-51. 2010
    ..This represents an exciting convergence of genetic findings, and highlights the potential for research on smoking to inform public health...
  21. ncbi Exposure to trauma: a comparison of cocaine-dependent cases and a community-matched sample
    Stephanie E Afful
    Fontbonne University, St Louis, MO 63105, USA
    Drug Alcohol Depend 112:46-53. 2010
    ..The purpose of this study was to examine rates of traumatic events and PTSD in cocaine-dependent cases and a community comparison sample...
  22. ncbi Interplay of genetic risk factors (CHRNA5-CHRNA3-CHRNB4) and cessation treatments in smoking cessation success
    Li Shiun Chen
    Department of Psychiatry and the Department of Genetics, Washington University School of Medicine, St Louis, MO, USA
    Am J Psychiatry 169:735-42. 2012
    ....
  23. ncbi Nicotine dependence and genetic variation in the nicotinic receptors
    Laura Jean Bierut
    Washington University School of Medicine, Department of Psychiatry, St Louis, MO, USA
    Drug Alcohol Depend 104:S64-9. 2009
    ....
  24. ncbi A genomic scan for habitual smoking in families of alcoholics: common and specific genetic factors in substance dependence
    Laura Jean Bierut
    School of Medicine, Washington University School of Medicine, 4940 Children s Place, St Louis, MO 63110, USA
    Am J Med Genet A 124:19-27. 2004
    ..Finally, there is also evidence of an area on chromosome 2 that may reflect a common genetic vulnerability locus to both habitual smoking and alcohol dependence...
  25. ncbi Long-term stability of alcohol and other substance dependence diagnoses and habitual smoking: an evaluation after 5 years
    Robert Culverhouse
    Department of Internal Medicine, Washington University in St Louis School of Medicine, St Louis, MO 63110 1026, USA
    Arch Gen Psychiatry 62:753-60. 2005
    ..A major criterion to validate diagnoses is stability over time...
  26. ncbi Defining alcohol-related phenotypes in humans. The Collaborative Study on the Genetics of Alcoholism
    Laura Jean Bierut
    Washington University School of Medicine, St. Louis, Missouri, USA
    Alcohol Res Health 26:208-13. 2002
    ..Genetic analyses have identified regions on several chromosomes that are associated with these phenotypes and need to be studied further...
  27. ncbi Genetic vulnerability and susceptibility to substance dependence
    Laura Jean Bierut
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Neuron 69:618-27. 2011
    ..Substance dependence can be thought of as a pharmacogenetic illness, and most likely hundreds and more probably thousands of genetic variants will be required to fully explain the genetic input to this disease...
  28. ncbi Genetic research and smoking behavior
    Laura Jean Bierut
    JAMA 297:809; author reply 810. 2007
  29. ncbi Should DSM-V include dimensional diagnostic criteria for alcohol use disorders?
    John E Helzer
    Health Behavior Research Center, University of Vermont Medical School, South Burlington, Vermont 05403, USA
    Alcohol Clin Exp Res 30:303-10. 2006
    ..The discussion is by Marc Schuckit, who was chair of the Substance Use disorders (SUD) Committee for DSM-IV and cochair of the international group of experts reviewing the SUD definitions for DSM-V...
  30. ncbi Genetic variation that contributes to nicotine dependence
    Laura Jean Bierut
    Pharmacogenomics 8:881-3. 2007
  31. ncbi Race differences in nicotine dependence in the Collaborative Genetic study of Nicotine Dependence (COGEND)
    Zhehui Luo
    Department of Epidemiology, Michigan State University, MI, USA
    Nicotine Tob Res 10:1223-30. 2008
    ..The data support the hypothesis that the relationship between CPD and nicotine dependence as reflected in relapse varies by race, and that Black smokers are dependent at lower levels of CPD than Whites...
  32. ncbi Seeking the connections: alcoholism and our genes
    John I Nurnberger
    Indiana University School of Medicine, USA
    Sci Am 296:46-53. 2007