Laura J Bierut

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. ncbi request reprint Familial transmission of substance dependence: alcohol, marijuana, cocaine, and habitual smoking: a report from the Collaborative Study on the Genetics of Alcoholism
    L J Bierut
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Arch Gen Psychiatry 55:982-8. 1998
  2. ncbi request reprint Major depressive disorder in a community-based twin sample: are there different genetic and environmental contributions for men and women?
    L J Bierut
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Arch Gen Psychiatry 56:557-63. 1999
  3. ncbi request reprint Family-based study of the association of the dopamine D2 receptor gene (DRD2) with habitual smoking
    L J Bierut
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Med Genet 90:299-302. 2000
  4. pmc A risk allele for nicotine dependence in CHRNA5 is a protective allele for cocaine dependence
    Richard A Grucza
    Department of Psychiatry, Washington University School of Medicine, 660 South Euclid Avenue, Box 8134, St Louis, Missouri 63110, USA
    Biol Psychiatry 64:922-9. 2008
  5. pmc Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes
    Nancy L Saccone
    Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Med Genet B Neuropsychiatr Genet 150:453-66. 2009
  6. pmc Nicotine dependence and comorbid psychiatric disorders: examination of specific genetic variants in the CHRNA5-A3-B4 nicotinic receptor genes
    Li Shiun Chen
    Department of Psychiatry, Washington University, St Louis, MO 63110, USA
    Drug Alcohol Depend 123:S42-51. 2012
  7. pmc Incorporating age at onset of smoking into genetic models for nicotine dependence: evidence for interaction with multiple genes
    Richard A Grucza
    Department of Psychiatry, Washington University School of Medicine, 660 South Euclid Ave, St Louis, MO 63110, USA
    Addict Biol 15:346-57. 2010
  8. pmc Genetic influences on craving for alcohol
    Arpana Agrawal
    Washington University School of Medicine, Dept of Psychiatry, 660 S Euclid, CB 8134, Saint Louis, MO 63110, USA
    Addict Behav 38:1501-8. 2013
  9. pmc Further evidence for an association between the gamma-aminobutyric acid receptor A, subunit 4 genes on chromosome 4 and Fagerström Test for Nicotine Dependence
    Arpana Agrawal
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Addiction 104:471-7. 2009
  10. pmc Use of a predictive model derived from in vivo endophenotype measurements to demonstrate associations with a complex locus, CYP2A6
    A Joseph Bloom
    Department of Psychiatry, Washington University School of Medicine, 660 South Euclid, Saint Louis, MO 63119, USA
    Hum Mol Genet 21:3050-62. 2012

Detail Information

Publications81

  1. ncbi request reprint Familial transmission of substance dependence: alcohol, marijuana, cocaine, and habitual smoking: a report from the Collaborative Study on the Genetics of Alcoholism
    L J Bierut
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Arch Gen Psychiatry 55:982-8. 1998
    ..Alcoholism and substance dependence frequently co-occur. Accordingly, we evaluated the familial transmission of alcohol, marijuana, and cocaine dependence and habitual smoking in the Collaborative Study on the Genetics of Alcoholism...
  2. ncbi request reprint Major depressive disorder in a community-based twin sample: are there different genetic and environmental contributions for men and women?
    L J Bierut
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Arch Gen Psychiatry 56:557-63. 1999
    ..Sex differences in genetic effects were also studied...
  3. ncbi request reprint Family-based study of the association of the dopamine D2 receptor gene (DRD2) with habitual smoking
    L J Bierut
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Med Genet 90:299-302. 2000
    ..There also was no evidence for unequal transmission of DRD2 alleles for the phenotypes "ever smoker" or comorbid alcohol dependence and habitual smoking. This study does not support linkage of the DRD2 with smoking...
  4. pmc A risk allele for nicotine dependence in CHRNA5 is a protective allele for cocaine dependence
    Richard A Grucza
    Department of Psychiatry, Washington University School of Medicine, 660 South Euclid Avenue, Box 8134, St Louis, Missouri 63110, USA
    Biol Psychiatry 64:922-9. 2008
    ..The goal of this study was to examine the association of this variant with cocaine dependence...
  5. pmc Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes
    Nancy L Saccone
    Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Med Genet B Neuropsychiatr Genet 150:453-66. 2009
    ....
  6. pmc Nicotine dependence and comorbid psychiatric disorders: examination of specific genetic variants in the CHRNA5-A3-B4 nicotinic receptor genes
    Li Shiun Chen
    Department of Psychiatry, Washington University, St Louis, MO 63110, USA
    Drug Alcohol Depend 123:S42-51. 2012
    ..We examined whether these genetic variants were associated with comorbid disorders and whether comorbid psychiatric disorders modified the genetic risk of nicotine dependence...
  7. pmc Incorporating age at onset of smoking into genetic models for nicotine dependence: evidence for interaction with multiple genes
    Richard A Grucza
    Department of Psychiatry, Washington University School of Medicine, 660 South Euclid Ave, St Louis, MO 63110, USA
    Addict Biol 15:346-57. 2010
    ..Incorporation of logically chosen interaction parameters, such as AOS, into genetic models of substance use disorders may increase the degree of explained phenotypic variation and constitutes a promising avenue for gene discovery...
  8. pmc Genetic influences on craving for alcohol
    Arpana Agrawal
    Washington University School of Medicine, Dept of Psychiatry, 660 S Euclid, CB 8134, Saint Louis, MO 63110, USA
    Addict Behav 38:1501-8. 2013
    ..However, little is known of its genetic underpinnings - specifically, whether genetic influences on craving are distinct from those influencing DSM-IV alcohol dependence...
  9. pmc Further evidence for an association between the gamma-aminobutyric acid receptor A, subunit 4 genes on chromosome 4 and Fagerström Test for Nicotine Dependence
    Arpana Agrawal
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Addiction 104:471-7. 2009
    ..In the present report, we extend the previous study by expanding our genotyping efforts significantly for these two genes...
  10. pmc Use of a predictive model derived from in vivo endophenotype measurements to demonstrate associations with a complex locus, CYP2A6
    A Joseph Bloom
    Department of Psychiatry, Washington University School of Medicine, 660 South Euclid, Saint Louis, MO 63119, USA
    Hum Mol Genet 21:3050-62. 2012
    ..Lastly, comprehensive genotyping and in vivo metabolism data are used to demonstrate that genome-wide significant associations between CPD and single nucleotide polymorphisms are the result of synthetic associations...
  11. pmc Variants located upstream of CHRNB4 on chromosome 15q25.1 are associated with age at onset of daily smoking and habitual smoking
    Manav Kapoor
    Department of Psychiatry, School of Medicine, Washington University, St Louis, Missouri, United States of America
    PLoS ONE 7:e33513. 2012
    ....
  12. pmc Multiple-domain predictors of problematic alcohol use in young adulthood
    John R Kramer
    Department of Psychiatry, Medical Education Building, University of Iowa School of Medicine, 500 Newton Road, Iowa City, Iowa 52242 1000, USA
    J Stud Alcohol Drugs 69:649-59. 2008
    ..The goal of this study was to identify predictors of problematic young adult alcohol use...
  13. pmc Dosage transmission disequilibrium test (dTDT) for linkage and association detection
    Zhehao Zhang
    Washington University School of Medicine, Department of Psychiatry, St Louis, Missouri, USA
    PLoS ONE 8:e63526. 2013
    ....
  14. pmc A principal components analysis of the abbreviated Desires for Alcohol Questionnaire (DAQ)
    John R Kramer
    Department of Psychiatry, Medical Education Building, University of Iowa School of Medicine, 500 Newton Road, Iowa City, Iowa 52242 1000, USA
    J Stud Alcohol Drugs 71:150-5. 2010
    ..The aim of this study was to examine the abbreviated Desires for Alcohol Questionnaire (DAQ) with respect to component structure and concurrent validity...
  15. ncbi request reprint Functional variants in TAS2R38 and TAS2R16 influence alcohol consumption in high-risk families of African-American origin
    Jen C Wang
    Washington University in St Louis, MO 63110, USA
    Alcohol Clin Exp Res 31:209-15. 2007
    ..The perceived bitterness of PROP has also been associated with oral sensation and drinking behaviors...
  16. pmc A comparison of diagnoses obtained from in-person and telephone interviews, using the semi-structured assessment for the genetics of alcoholism (SSAGA)
    John R Kramer
    Department of Psychiatry, Medical Education Building, University of Iowa School of Medicine, 500 Newton Road, Iowa City, Iowa 52242 1000, USA
    J Stud Alcohol Drugs 70:623-7. 2009
    ....
  17. pmc Copy number variations in 6q14.1 and 5q13.2 are associated with alcohol dependence
    Peng Lin
    Department of Psychiatry, Washington University, St Louis, Missouri, USA
    Alcohol Clin Exp Res 36:1512-8. 2012
    ....
  18. pmc CHRNB3 is more strongly associated with Fagerström test for cigarette dependence-based nicotine dependence than cigarettes per day: phenotype definition changes genome-wide association studies results
    John P Rice
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Addiction 107:2019-28. 2012
    ..e., CPD versus Fagerström test for cigarette dependence (FTCD) score as a measure of nicotine dependence) on genome-wide association studies of nicotine dependence...
  19. pmc A genome-wide association study of DSM-IV cannabis dependence
    Arpana Agrawal
    Department of Psychiatry, Washington University School of Medicine, 660 S Euclid, Saint Louis, MO 63110, USA
    Addict Biol 16:514-8. 2011
    ..While replication is required, this study represents an important first step toward clarifying the biological underpinnings of cannabis dependence...
  20. pmc The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans
    Nancy L Saccone
    Department of Genetics, Washington University, St Louis, Missouri 63110, UA
    Cancer Res 69:6848-56. 2009
    ..The nonsynonymous SNP rs16969968, a known risk variant in populations of European-descent, is also significantly associated with risk in African-Americans. Additional SNPs contribute to risk in distinct ways in these two populations...
  21. pmc Evidence for association between polymorphisms in the cannabinoid receptor 1 (CNR1) gene and cannabis dependence
    Arpana Agrawal
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Med Genet B Neuropsychiatr Genet 150:736-40. 2009
    ..05) and rs806380 (P = 0.009)]. Haplotype analyses revealed the association to be largely driven by the SNP rs806380. These results suggest a role for the cannabinoid receptor 1 gene in cannabis dependence...
  22. pmc Long-term effects of minimum drinking age laws on past-year alcohol and drug use disorders
    KAREN E NORBERG
    Department of Psychiatry, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Alcohol Clin Exp Res 33:2180-90. 2009
    ..Many studies have found that earlier drinking initiation predicts higher risk of later alcohol and substance use problems, but the causal relationship between age of initiation and later risk of substance use disorder remains unknown...
  23. doi request reprint Effects upon in-vivo nicotine metabolism reveal functional variation in FMO3 associated with cigarette consumption
    A Joseph Bloom
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63119, USA
    Pharmacogenet Genomics 23:62-8. 2013
    ....
  24. pmc Linkage scan for quantitative traits identifies new regions of interest for substance dependence in the Collaborative Study on the Genetics of Alcoholism (COGA) sample
    Arpana Agrawal
    Washington University School of Medicine, St Louis, MO 63110, USA
    Drug Alcohol Depend 93:12-20. 2008
    ..0 on chromosome 2 (3.2, 234 cM), 10 (2.4 and 2.6 at 60 cM and 116 cM) and 13 (2.1 at 64 cM). These regions may harbor genes that contribute to the biological basis of alcohol and drug dependence...
  25. pmc A genome-wide association study of alcohol dependence
    Laura J Bierut
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 107:5082-7. 2010
    ..11 and 1.16. Further dissection of the alcoholism phenotype, to disentangle the influence of comorbid substance-use disorders, will be a next step in identifying genetic variants associated with alcohol dependence...
  26. pmc An analysis of identical single-nucleotide polymorphisms genotyped by two different platforms
    Brian K Suarez
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA
    BMC Genet 6:S152. 2005
    ..Some of this clustering may be due to the presence of a second segregating SNP that obliterates a XbaI site (the restriction enzyme used in the Affymetrix platform), resulting in a fragment too long (>1,000 bp) to be amplified...
  27. pmc The emerging link between alcoholism risk and obesity in the United States
    Richard A Grucza
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Arch Gen Psychiatry 67:1301-8. 2010
    ..The prevalence of obesity has risen sharply in the United States in the past few decades. Etiologic links between obesity and substance use disorders have been hypothesized...
  28. pmc Risk for nicotine dependence and lung cancer is conferred by mRNA expression levels and amino acid change in CHRNA5
    Jen C Wang
    Department of Psychiatry, Washington University, 660 South Euclid, PO BOX 8134, St Louis, MO 63110, USA
    Hum Mol Genet 18:3125-35. 2009
    ....
  29. pmc Pathway analysis of smoking quantity in multiple GWAS identifies cholinergic and sensory pathways
    Oscar Harari
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS ONE 7:e50913. 2012
    ....
  30. pmc Increased genetic vulnerability to smoking at CHRNA5 in early-onset smokers
    Sarah M Hartz
    Washington University School of Medicine, St Louis, Missouri, USA
    Arch Gen Psychiatry 69:854-60. 2012
    ..Recent studies have shown an association between cigarettes per day (CPD) and a nonsynonymous single-nucleotide polymorphism in CHRNA5, rs16969968...
  31. pmc Smoking and genetic risk variation across populations of European, Asian, and African American ancestry--a meta-analysis of chromosome 15q25
    Li Shiun Chen
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Genet Epidemiol 36:340-51. 2012
    ..Using the cross-population study paradigm provides valuable insights to narrow regions of interest and inform future biological experiments...
  32. pmc Genetic association of bipolar disorder with the β(3) nicotinic receptor subunit gene
    Sarah M Hartz
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri, USA
    Psychiatr Genet 21:77-84. 2011
    ....
  33. ncbi request reprint Association of GABRA2 with drug dependence in the collaborative study of the genetics of alcoholism sample
    Arpana Agrawal
    Department of Psychiatry, Washington University in St Louis, St Louis, MO, USA
    Behav Genet 36:640-50. 2006
    ..There was no association with other genes in the GABAA cluster on chromosome 4 with illicit drug dependence...
  34. pmc Multipoint identity-by-descent computations for single-point polymorphism and microsatellite maps
    Anthony L Hinrichs
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri, USA
    BMC Genet 6:S34. 2005
    ..However, increased information has a computational cost: SNP maps require 100 times as many iterations as microsatellites to produce stable estimates...
  35. ncbi request reprint Alcohol dependence with comorbid drug dependence: genetic and phenotypic associations suggest a more severe form of the disorder with stronger genetic contribution to risk
    Danielle M Dick
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Addiction 102:1131-9. 2007
    ....
  36. pmc Rare missense variants in CHRNB4 are associated with reduced risk of nicotine dependence
    Gabe Haller
    Department of Psychiatry, Washington University, St Louis, MO 63110, USA
    Hum Mol Genet 21:647-55. 2012
    ..01, T91I P = 0.02, R37H P = 0.003), but the largest effect on in vitro receptor activity was seen in the presence of both CHRNB4 T91I and CHRNA3 R37H (P = 2 × 10(-6))...
  37. pmc Association of a single nucleotide polymorphism in neuronal acetylcholine receptor subunit alpha 5 (CHRNA5) with smoking status and with 'pleasurable buzz' during early experimentation with smoking
    Richard Sherva
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA
    Addiction 103:1544-52. 2008
    ..To extend the previously identified association between a single nucleotide polymorphism (SNP) in neuronal acetylcholine receptor subunit alpha-5 (CHRNA5) and nicotine dependence to current smoking and initial smoking-experience phenotypes...
  38. ncbi request reprint Co-occurring risk factors for alcohol dependence and habitual smoking: update on findings from the Collaborative Study on the Genetics of Alcoholism
    Richard A Grucza
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri, USA
    Alcohol Res Health 29:172-8. 2006
    ..The results to date suggest that both common and drug-specific genetic influences play a role in the development of alcohol and nicotine dependence...
  39. pmc Correspondence between secular changes in alcohol dependence and age of drinking onset among women in the United States
    Richard A Grucza
    Department of Psychiatry, Washington University School of Medicine, 660 South Euclid Avenue, Box 8134, St Louis, MO 63110, USA
    Alcohol Clin Exp Res 32:1493-501. 2008
    ..The present report sought to confirm the trends in AOD and to determine the extent to which they might account for secular trends in alcohol dependence...
  40. doi request reprint DSM-5 cannabis use disorder: A phenotypic and genomic perspective
    Arpana Agrawal
    Washington University School of Medicine, Department of Psychiatry, St Louis, MO, USA Electronic address
    Drug Alcohol Depend 134:362-9. 2014
    ..We also estimate the heritability of DSM-5 cannabis use disorders explained by these common SNPs...
  41. pmc Long-term effects of laws governing youth access to tobacco
    Richard A Grucza
    Department of Psychiatry, Washington University School of Medicine, 660 South Euclid Avenue, Box 8134, St Louis, MO 63110, USA
    Am J Public Health 103:1493-9. 2013
    ..We sought to examine the association between policies governing access to tobacco during adolescence and subsequent adult smoking...
  42. pmc The persistent effects of minimum legal drinking age laws on drinking patterns later in life
    Andrew D Plunk
    Department of Psychiatry ADP, PC R, LJB, RAG, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Alcohol Clin Exp Res 37:463-9. 2013
    ....
  43. doi request reprint Gamma-aminobutyric acid receptor genes and nicotine dependence: evidence for association from a case-control study
    Arpana Agrawal
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Addiction 103:1027-38. 2008
    ....
  44. pmc Binge drinking among youths and young adults in the United States: 1979-2006
    Richard A Grucza
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    J Am Acad Child Adolesc Psychiatry 48:692-702. 2009
    ....
  45. pmc Systematic biological prioritization after a genome-wide association study: an application to nicotine dependence
    Scott F Saccone
    Department of Psychiatry, Washington University School of Medicine, Saint Louis, Missouri 63110, USA
    Bioinformatics 24:1805-11. 2008
    ..A challenging problem after a genome-wide association study (GWAS) is to balance the statistical evidence of genotype-phenotype correlation with a priori evidence of biological relevance...
  46. pmc Uncovering hidden variance: pair-wise SNP analysis accounts for additional variance in nicotine dependence
    ROBERT C CULVERHOUSE
    Division of General Medical Sciences, Department of Medicine, Washington University, Saint Louis, MO 63110, USA
    Hum Genet 129:177-88. 2011
    ..Methodologies that limit analyses of joint effects to variants that demonstrate association in single SNP analyses, or require a significant interaction term, will likely miss important joint effects...
  47. ncbi request reprint Teenagers are right--parents do not know much: an analysis of adolescent-parent agreement on reports of adolescent substance use, abuse, and dependence
    Sherri L Fisher
    Washington University School of Medicine, St Louis, Missouri 63110, USA
    Alcohol Clin Exp Res 30:1699-710. 2006
    ..The purpose of this study was to analyze correspondence between adolescent and parent reports of adolescent substance use and abuse or dependence...
  48. pmc Cigarette smoking reduction and changes in nicotine dependence
    Marc E Mooney
    Department of Psychiatry, University of Minnesota, F 256 2B West, 2450 Riverside Ave, Minneapolis, MN 55454, USA
    Nicotine Tob Res 13:426-30. 2011
    ..The relationship of nicotine dependence (ND) to smoking behavior and cessation has been well characterized. However, little is known about the association between smoking reduction (SR) and ND...
  49. pmc The legacy of minimum legal drinking age law changes: long-term effects on suicide and homicide deaths among women
    Richard A Grucza
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Alcohol Clin Exp Res 36:377-84. 2012
    ..The objective of this study is to examine whether individuals who were legally permitted to drink prior to age 21 remained at elevated risk in adulthood...
  50. pmc Dissection of the phenotypic and genotypic associations with nicotinic dependence
    Li Shiun Chen
    Department of Psychiatry Box 8134, Washington University School of Medicine, 660S Euclid Ave, St Louis, MO 63110, USA
    Nicotine Tob Res 14:425-33. 2012
    ..We examined how these identified genetic variants relate to nicotine dependence defined by different categorical and dimensional measures...
  51. pmc A new statistic to evaluate imputation reliability
    Peng Lin
    Department of Psychiatry, Washington University, St Louis, Missouri, United States of America
    PLoS ONE 5:e9697. 2010
    ..Traditional measures of imputation cannot effectively address these problems...
  52. pmc Inclusion of African Americans in genetic studies: what is the barrier?
    Sarah M Hartz
    Department of Psychiatry, School of Medicine, Washington University, St Louis, Missouri 63110, USA
    Am J Epidemiol 174:336-44. 2011
    ..0001). The results of this study suggest that increasing the number of African Americans in genetic databases may be achieved by increasing efforts to locate and contact them...
  53. pmc Microsatellites versus single-nucleotide polymorphisms in linkage analysis for quantitative and qualitative measures
    Gerald Dunn
    Department of Psychiatry, Genetics, Washington University School of Medicine, St Louis, Missouri, USA
    BMC Genet 6:S122. 2005
    ..We also considered the effect of high linkage disequilibrium (LD) in regions near the linkage peaks by analysing a "sparse" SNP map obtained by dropping some markers in high LD with other markers in those regions...
  54. pmc The contribution of common CYP2A6 alleles to variation in nicotine metabolism among European-Americans
    Joseph Bloom
    Department of Psychiatry, Washington University School of Medicine, Saint Louis, Missouri, USA
    Pharmacogenet Genomics 21:403-16. 2011
    ..To study the association between cytochrome P450 2A6 (CYP2A6) genotype and metabolism of nicotine to cotinine, identify functional polymorphisms, and develop a predictive genetic model of nicotine metabolism...
  55. pmc Common polymorphisms in FMO1 are associated with nicotine dependence
    Anthony L Hinrichs
    Departments of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63119, USA
    Pharmacogenet Genomics 21:397-402. 2011
    ..A better understanding of the etiology of nicotine addiction may help to increase the success rate of cessation and to decrease the massive morbidity and mortality associated with smoking...
  56. pmc Variants in two adjacent genes, EGLN2 and CYP2A6, influence smoking behavior related to disease risk via different mechanisms
    A Joseph Bloom
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA
    Hum Mol Genet 23:555-61. 2014
    ..These results indicate a previously unappreciated novel mechanism behind genome-wide significant associations with cigarette consumption and disease risk unrelated to nicotine metabolism. ..
  57. pmc Cis-Regulatory Variants Affect CHRNA5 mRNA Expression in Populations of African and European Ancestry
    Jen Chyong Wang
    Department of Psychiatry, Washington University School of Medicine, Saint Louis, Missouri, United States of America
    PLoS ONE 8:e80204. 2013
    ....
  58. pmc Copy number variation accuracy in genome-wide association studies
    Peng Lin
    Department of Psychiatry, Washington University, St Louis, MO 63110, USA
    Hum Hered 71:141-7. 2011
    ..Data from genome-wide association studies and other microarrays may be used to identify CNVs by several different computer programs, but the reliability of the results has been questioned...
  59. pmc CYP2B6 non-coding variation associated with smoking cessation is also associated with differences in allelic expression, splicing, and nicotine metabolism independent of common amino-acid changes
    A Joseph Bloom
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS ONE 8:e79700. 2013
    ..These results indicate differences in mRNA expression and splicing as potential molecular mechanisms by which non-coding variation in CYP2B6 may affect enzymatic activity leading to differences in metabolism and smoking cessation. ..
  60. pmc Supplementing high-density SNP microarrays for additional coverage of disease-related genes: addiction as a paradigm
    Scott F Saccone
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA
    PLoS ONE 4:e5225. 2009
    ..This combination of biological prioritization scores and LD tagging annotation will enable addiction researchers to supplement commercial SNP microarrays to ensure comprehensive coverage of biologically relevant regions...
  61. ncbi request reprint Novelty seeking as a moderator of familial risk for alcohol dependence
    Richard A Grucza
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Alcohol Clin Exp Res 30:1176-83. 2006
    ..We examined this possibility by analyzing the association between NS and alcohol dependence in individuals at intermediate and high levels of familial risk for alcohol dependence...
  62. pmc Secular trends in the lifetime prevalence of alcohol dependence in the United States: a re-evaluation
    Richard A Grucza
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Alcohol Clin Exp Res 32:763-70. 2008
    ..However, it remains unclear whether such patterns truly reflect secular trends or are confounded by age-dependent factors such as differential recall, differential mortality, and other effects...
  63. pmc Understanding adolescent parenthood from a multisystemic perspective
    Patricia A Cavazos-Rehg
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri, USA
    J Adolesc Health 46:525-31. 2010
    ..This study examined the associations between social, behavioral, and environmental factors and adolescent parenthood...
  64. pmc Cigarette smoking and the risk for alcohol use disorders among adolescent drinkers
    Richard A Grucza
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Alcohol Clin Exp Res 30:2046-54. 2006
    ..We sought to address this issue using data from a nationally representative U.S. sample of adolescents and young adults. Specifically, we analyzed the relationship between cigarette smoking, drinking, and AUDs...
  65. pmc Genetics of addictions
    Sarah M Hartz
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110 1093, USA
    Psychiatr Clin North Am 33:107-24. 2010
    ..These associations highlight the importance of understanding the genetics of substance dependence in the context of its multiple medical and psychiatric comorbidities...
  66. pmc Measuring alcohol consumption for genomic meta-analyses of alcohol intake: opportunities and challenges
    Arpana Agrawal
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Clin Nutr 95:539-47. 2012
    ..In this review, we discuss the challenges associated with harmonizing alcohol-consumption data from studies with widely different assessment instruments, with a particular focus on large-scale genetic studies...
  67. ncbi request reprint The genetics of alcohol dependence
    Danielle M Dick
    Department of Psychiatry, Box 8134, 660 South Euclid Avenue, St Louis, MO 63130, USA
    Curr Psychiatry Rep 8:151-7. 2006
    ....
  68. pmc Genetics of addictions
    Sarah M Hartz
    Department of Psychiatry, Washington University School of Medicine, Campus Box 8134, 660 South Euclid Avenue, St Louis, MO 63110 1093, USA
    Clin Lab Med 30:847-64. 2010
    ..These associations highlight the importance of understanding the genetics of substance dependence in the context of its multiple medical and psychiatric comorbidities...
  69. pmc Occupation and workplace policies predict smoking behaviors: analysis of national data from the current population survey
    David Cal Ham
    Washington University School of Medicine, St Louis, MO, USA
    J Occup Environ Med 53:1337-45. 2011
    ..Describe differences in smoking behaviors associated with occupation, workplace rules against smoking, and workplace smoking cessation programs...
  70. pmc Identification of a novel tumor suppressor gene p34 on human chromosome 6q25.1
    Min Wang
    School of Medicine, Washington University, 660 Euclid Avenue, St Louis, MO, USA
    Cancer Res 67:93-9. 2007
    ..Our results suggest that p34 may be a novel tumor suppressor gene involved in sporadic lung cancer but it seems not to be the candidate familial lung cancer susceptibility gene linked to chromosomal region 6q23-25...
  71. pmc Functional variant in a bitter-taste receptor (hTAS2R16) influences risk of alcohol dependence
    Anthony L Hinrichs
    Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Hum Genet 78:103-11. 2006
    ..6%), whereas 45% of African Americans carry the allele (MAF 26%), which makes it a much more significant risk factor in the African American population...
  72. ncbi request reprint Comparison of psychiatric diagnoses from interview reports with those from best-estimate procedures
    Kathleen K Bucholz
    Department of Psychiatry, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8134, St Louis, Missouri 63110 1093, USA
    J Stud Alcohol 67:157-68. 2006
    ....
  73. ncbi request reprint Lack of association of alcohol dependence and habitual smoking with catechol-O-methyltransferase
    Tatiana Foroud
    Indiana University School of Medicine, Indianapolis, Indiana 46202 3002, USA
    Alcohol Clin Exp Res 31:1773-9. 2007
    ....
  74. pmc A novel non-parametric regression reveals linkage on chromosome 4 for the number of externalizing symptoms in sib-pairs
    Saurabh Ghosh
    Human Genetics Unit, Indian Statistical Institute, Kolkata, India
    Am J Med Genet B Neuropsychiatr Genet 147:1301-5. 2008
    ..We also obtain evidence for epistatic interaction between a region on Chromosome 1 and one on Chromosome 15. Although alcoholism as a covariate does not have any effect on the linkage scan, it has an effect on the epistatic interaction...
  75. ncbi request reprint Test of measurement invariance of the FTND across demographic groups: assessment, effect size, and prediction of cessation
    Eric O Johnson
    Behavioral Health Epidemiology, Division of Health, Social, and Economic Research, Research Triangle Institute International, PO Box 12194, 3040 Cornwallis Road, Research Triangle Park, NC 27709 2194, USA
    Drug Alcohol Depend 93:260-70. 2008
    ....
  76. ncbi request reprint Apparent replication of suggestive linkage on chromosome 16 in the NIMH genetics initiative bipolar pedigrees
    Danielle M Dick
    Indiana University School of Medicine, Indianapolis, Indiana 46202 4887, USA
    Am J Med Genet 114:407-12. 2002
    ..Combining the initial and replication samples further increased the evidence of linkage to this region, with a peak lod score of 2.8...
  77. ncbi request reprint Linkage for platelet monoamine oxidase (MAO) activity: results from a replication sample
    Nancy L Saccone
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Alcohol Clin Exp Res 26:603-9. 2002
    ..These families were recruited as part of the Collaborative Study on the Genetics of Alcoholism (COGA)...
  78. ncbi request reprint Evidence of common and specific genetic effects: association of the muscarinic acetylcholine receptor M2 (CHRM2) gene with alcohol dependence and major depressive syndrome
    Jen C Wang
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Hum Mol Genet 13:1903-11. 2004
    ..These findings provide strong evidence that variants within or close to the CHRM2 locus influence risk for two common psychiatric disorders...
  79. ncbi request reprint Correlations among first-degree relatives for responses on the Self-Rating of the Effects of Alcohol Questionnaire in teenagers
    Marc A Schuckit
    Department of Psychiatry 116A, University of California, San Diego, USA
    J Stud Alcohol 66:62-5. 2005
    ..This article presents data regarding the familial nature of SRE-based scores among a sample of teenagers...
  80. ncbi request reprint A comparison of factors associated with substance-induced versus independent depressions
    Marc A Schuckit
    Department of Psychiatry 116A, University of California, San Diego, California, USA
    J Stud Alcohol Drugs 68:805-12. 2007
    ....
  81. ncbi request reprint Similarities in the clinical characteristics related to alcohol dependence in two populations
    Marc A Schuckit
    Department of Psychiatry, University of California San Diego and the San Diego Veterans Affairs Healthcare System, 92161 2002, USA
    Am J Addict 11:1-9. 2002
    ....

Research Grants8

  1. IRPG2, R01, NOVEL PHENOTYPES FOR THE GENETIC ANALYSIS
    Laura Bierut; Fiscal Year: 2003
    ..A Positron Emission Tomography (PET) study in high and low risk subjects will test GABAergic hypotheses of disinhibition in alcohol dependence. ..
  2. Case Control Candidate Gene Study of Addiction
    Laura Bierut; Fiscal Year: 2007
    ..Data from this proposal will be become part of the NIDA Genetics Consortium to be made available to the scientific community. ..
  3. The Collaborative Genetic Study of Nicotine Dependence
    Laura Bierut; Fiscal Year: 2006
    ..We hope to translate these basic biological and environmental studies into strategies to reduce the massive health burden of nicotine dependence. ..
  4. Human Genetics of Addiction: A Study of Common and Specific Factors
    Laura Bierut; Fiscal Year: 2007
    ..By comparing and contrasting findings in three datasets, a more thorough understanding of common and specific factors underlying human addiction will be developed. ..
  5. Study of Addiction: Genetics and Environment
    Laura Bierut; Fiscal Year: 2007
    ....