W L Beatty

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. pmc Inclusion biogenesis and reactivation of persistent Chlamydia trachomatis requires host cell sphingolipid biosynthesis
    D Kesley Robertson
    Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO, USA
    PLoS Pathog 5:e1000664. 2009
  2. pmc Late endocytic multivesicular bodies intersect the chlamydial inclusion in the absence of CD63
    Wandy L Beatty
    Department of Molecular Microbiology, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8230, St Louis, MO 63110 1093, USA
    Infect Immun 76:2872-81. 2008
  3. ncbi request reprint Lysosome repair enables host cell survival and bacterial persistence following Chlamydia trachomatis infection
    Wandy L Beatty
    Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Cell Microbiol 9:2141-52. 2007
  4. ncbi request reprint Trafficking from CD63-positive late endocytic multivesicular bodies is essential for intracellular development of Chlamydia trachomatis
    Wandy L Beatty
    Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Cell Sci 119:350-9. 2006
  5. pmc Trafficking of Shigella lipopolysaccharide in polarized intestinal epithelial cells
    W L Beatty
    Unite de Pathogenie Microbienne Moleculaire, U389, Institut National de la Sante et de la Recherche Medicale, Institut Pasteur, 75724 Paris Cedex 15, France
    J Cell Biol 145:689-98. 1999
  6. ncbi request reprint Mycobacterial surface moieties are released from infected macrophages by a constitutive exocytic event
    W L Beatty
    Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO USA
    Eur J Cell Biol 80:31-40. 2001
  7. pmc Identification of mycobacterial surface proteins released into subcellular compartments of infected macrophages
    W L Beatty
    Department of Molecular Microbiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Infect Immun 68:6997-7002. 2000
  8. ncbi request reprint Direct delivery of procathepsin D to phagosomes: implications for phagosome biogenesis and parasitism by Mycobacterium
    H J Ullrich
    Department of Molecular Microbiology, Washington University Medical School, St Louis, MO 63110, USA
    Eur J Cell Biol 78:739-48. 1999
  9. ncbi request reprint Interaction of Mycobacterium avium-containing phagosomes with the antigen presentation pathway
    H J Ullrich
    College of Veterinary Medicine, Cornell University, Ithaca, NY 14853 Department of Microbiology, Washington University, St Louis, MO 63110, USA
    J Immunol 165:6073-80. 2000
  10. pmc Artemisinin induces calcium-dependent protein secretion in the protozoan parasite Toxoplasma gondii
    Kisaburo Nagamune
    Department of Molecular Microbiology, Washington University School of Medicine, 660 S Euclid Ave, St Louis, MO 63110, USA
    Eukaryot Cell 6:2147-56. 2007

Collaborators

Detail Information

Publications13

  1. pmc Inclusion biogenesis and reactivation of persistent Chlamydia trachomatis requires host cell sphingolipid biosynthesis
    D Kesley Robertson
    Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO, USA
    PLoS Pathog 5:e1000664. 2009
    ..trachomatis infection...
  2. pmc Late endocytic multivesicular bodies intersect the chlamydial inclusion in the absence of CD63
    Wandy L Beatty
    Department of Molecular Microbiology, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8230, St Louis, MO 63110 1093, USA
    Infect Immun 76:2872-81. 2008
    ....
  3. ncbi request reprint Lysosome repair enables host cell survival and bacterial persistence following Chlamydia trachomatis infection
    Wandy L Beatty
    Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Cell Microbiol 9:2141-52. 2007
    ..A consequence of this lysosome-mediated repair process, was the retention of residual bacteria within the surviving host cell, providing a unique mechanism for intracellular persistence of C. trachomatis...
  4. ncbi request reprint Trafficking from CD63-positive late endocytic multivesicular bodies is essential for intracellular development of Chlamydia trachomatis
    Wandy L Beatty
    Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Cell Sci 119:350-9. 2006
    ..This study identifies a trafficking pathway from CD63-positive multivesicular bodies to the bacterial inclusion, a novel interaction that provides essential lipids necessary for maintenance of a productive intracellular infection...
  5. pmc Trafficking of Shigella lipopolysaccharide in polarized intestinal epithelial cells
    W L Beatty
    Unite de Pathogenie Microbienne Moleculaire, U389, Institut National de la Sante et de la Recherche Medicale, Institut Pasteur, 75724 Paris Cedex 15, France
    J Cell Biol 145:689-98. 1999
    ..In addition, analysis of LPS in association with markers of the endocytic network revealed that some LPS was sent to late endosomal and lysosomal compartments...
  6. ncbi request reprint Mycobacterial surface moieties are released from infected macrophages by a constitutive exocytic event
    W L Beatty
    Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO USA
    Eur J Cell Biol 80:31-40. 2001
    ....
  7. pmc Identification of mycobacterial surface proteins released into subcellular compartments of infected macrophages
    W L Beatty
    Department of Molecular Microbiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Infect Immun 68:6997-7002. 2000
    ..The fibronectin attachment protein and proteins of the antigen 85-kDa complex were identified among the mycobacterial proteins released from the bacterial phagosome...
  8. ncbi request reprint Direct delivery of procathepsin D to phagosomes: implications for phagosome biogenesis and parasitism by Mycobacterium
    H J Ullrich
    Department of Molecular Microbiology, Washington University Medical School, St Louis, MO 63110, USA
    Eur J Cell Biol 78:739-48. 1999
    ..In contrast phagosomes harboring dead mycobacteria demonstrated markedly enhanced acquisition of the 46kDa form within 4 h post internalization and only low levels of procathepsin D...
  9. ncbi request reprint Interaction of Mycobacterium avium-containing phagosomes with the antigen presentation pathway
    H J Ullrich
    College of Veterinary Medicine, Cornell University, Ithaca, NY 14853 Department of Microbiology, Washington University, St Louis, MO 63110, USA
    J Immunol 165:6073-80. 2000
    ....
  10. pmc Artemisinin induces calcium-dependent protein secretion in the protozoan parasite Toxoplasma gondii
    Kisaburo Nagamune
    Department of Molecular Microbiology, Washington University School of Medicine, 660 S Euclid Ave, St Louis, MO 63110, USA
    Eukaryot Cell 6:2147-56. 2007
    ..Collectively, these results demonstrate that artemisinin perturbs calcium homeostasis in T. gondii, supporting the idea that Ca2+-ATPases are potential drug targets in parasites...
  11. pmc Genomic transcriptional profiling of the developmental cycle of Chlamydia trachomatis
    Robert J Belland
    Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Disease, National Institutes of Health, Hamilton, MT 59840, USA
    Proc Natl Acad Sci U S A 100:8478-83. 2003
    ..Many of the genes expressed during the immediate-early and late differentiation stages are Chlamydia-specific and have evolutionary origins in eukaryotic lineages...
  12. pmc Rapid invasion of host cells by Toxoplasma requires secretion of the MIC2-M2AP adhesive protein complex
    My Hang Huynh
    W Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    EMBO J 22:2082-90. 2003
    ..M2AP knockout parasites were also unable to rapidly secrete MIC2, an event that normally accompanies parasite attachment to a target cell. These findings indicate a critical role for the MIC2-M2AP protein complex in parasite invasion...
  13. pmc Transcriptome analysis of chlamydial growth during IFN-gamma-mediated persistence and reactivation
    Robert J Belland
    Laboratories of Intracellular Parasites and Human Bacterial Pathogenesis, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    Proc Natl Acad Sci U S A 100:15971-6. 2003
    ..In contrast to the paradigm of persistence as a general stress response, our findings suggest that persistence is an alternative life cycle used by chlamydiae to avoid the host immune response...