Research Topics
| Randall J BatemanSummaryAffiliation: Washington University School of Medicine Country: USA Publications
| Collaborators
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Detail Information
Publications
Human amyloid-beta synthesis and clearance rates as measured in cerebrospinal fluid in vivoRandall J Bateman
Department of Neurology, Washington University School of Medicine, 660 South Euclid Avenue, Box 8111, St Louis, Missouri 63110, USA
Nat Med 12:856-61. 2006....- Clinical and biomarker changes in dominantly inherited Alzheimer's diseaseRandall J Bateman
Washington University School of Medicine, Department of Neurology, 660 S Euclid Ave, Box 8111, St Louis, MO 63110, USA
N Engl J Med 367:795-804. 2012..Autosomal dominant Alzheimer's disease has a predictable age at onset and provides an opportunity to determine the sequence and magnitude of pathologic changes that culminate in symptomatic disease... - Autosomal-dominant Alzheimer's disease: a review and proposal for the prevention of Alzheimer's diseaseRandall J Bateman
Department of Neurology, Washington University School of Medicine, 660 S, Euclid, Campus Box 8111, St Louis, MO 63110, USA
Alzheimers Res Ther 3:1. 2011..Clinical trials in autosomal-dominant Alzheimer's disease may test the amyloid hypothesis, determine the timing of treatment, and lead the way to Alzheimer's disease prevention... - A gamma-secretase inhibitor decreases amyloid-beta production in the central nervous systemRandall J Bateman
Department of Neurology, Washington University School of Medicine, St Louis, MO, USA
Ann Neurol 66:48-54. 2009..The objective of this study was to determine the effects of a gamma-secretase inhibitor on the production of Abeta in the human CNS... 
Fluctuations of CSF amyloid-beta levels: implications for a diagnostic and therapeutic biomarkerRandall J Bateman
Dept of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
Neurology 68:666-9. 2007..To investigate the stability and time course of human CSF amyloid-beta (Abeta) levels over hours...- Stable isotope labeling tandem mass spectrometry (SILT) to quantify protein production and clearance ratesRandall J Bateman
Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Am Soc Mass Spectrom 18:997-1006. 2007..The technique is adaptable to other macromolecules, such as carbohydrates or lipids... - Measuring target effect of proposed disease-modifying therapies in Alzheimer's diseaseRandall J Bateman
Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA
Neurotherapeutics 5:381-90. 2008..This review covers the current methods and technologies used in the therapeutic translation of proposed disease-modifying therapies for AD... - In vivo human apolipoprotein E isoform fractional turnover rates in the CNSKristin R Wildsmith
Department of Neurology, Washington University School of Medicine, Saint Louis, Missouri, United States of America
PLoS ONE 7:e38013. 2012..We also demonstrate a slower turnover rate for CSF ApoE than that for amyloid beta, another molecule critically important in AD pathogenesis... - Measurement of apolipoprotein E and amyloid β clearance rates in the mouse brain using bolus stable isotope labelingJacob M Basak
Department of Neurology, Saint Louis, Missouri 63110, USA
Mol Neurodegener 7:14. 2012..We have developed a bolus stable isotope-labeling kinetics (SILK) technique coupled with multiple reaction monitoring mass spectrometry to measure the clearance of proteins in the mouse brain... - Effects of age and amyloid deposition on Aβ dynamics in the human central nervous systemYafei Huang
Department of Neurology, Washington University School of Medicine, 660 S Euclid, PO Box 8111, St Louis, MO 63110, USA
Arch Neurol 69:51-8. 2012..The amyloid hypothesis predicts that increased production or decreased clearance of β-amyloid (Aβ) leads to amyloidosis, which ultimately culminates in Alzheimer disease (AD)... - Decreased clearance of CNS beta-amyloid in Alzheimer's diseaseKwasi G Mawuenyega
Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
Science 330:1774. 2010..On average, there were no differences in Aβ40 or Aβ42 production rates. Thus, the common late-onset form of Alzheimer's disease is characterized by an overall impairment in Aβ clearance... - Human apoE isoforms differentially regulate brain amyloid-β peptide clearanceJoseph M Castellano
Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
Sci Transl Med 3:89ra57. 2011..Our results suggest that APOE alleles contribute to AD risk by differentially regulating clearance of Aβ from the brain, suggesting that Aβ clearance pathways may be useful therapeutic targets for AD prevention... - Amyloid-beta oligomerization in Alzheimer dementia versus high-pathology controlsThomas J Esparza
Department of Neurology, Washington University School of Medicine, St Louis, MO
Ann Neurol 73:104-19. 2013..However, the lack of a sensitive, specific, and quantitative assay for Aβ oligomers has hampered rigorous tests of this hypothesis... - Amyloid-beta dynamics are regulated by orexin and the sleep-wake cycleJae Eun Kang
Department of Neurology, Washington University, St Louis, MO 63110, USA
Science 326:1005-7. 2009..Thus, the sleep-wake cycle and orexin may play a role in the pathogenesis of Alzheimer's disease... - Method for the simultaneous quantitation of apolipoprotein E isoforms using tandem mass spectrometryKristin R Wildsmith
Department of Neurology, Hope Center for Neurological Disorders and Alzheimer s Disease Research Center, Washington University School of Medicine, St Louis, MO 63110, USA
Anal Biochem 395:116-8. 2009..This method provides a less biased assessment of ApoE isoforms compared to antibody-dependent methods, and may lead to a better understanding of the biological differences between isoforms... 
Disruption of the sleep-wake cycle and diurnal fluctuation of β-amyloid in mice with Alzheimer's disease pathologyJee Hoon Roh
Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
Sci Transl Med 4:150ra122. 2012..Sleep-wake behavior and diurnal fluctuation of Aβ in the central nervous system may be functional and biochemical indicators, respectively, of Aβ-associated pathology...- Exposure of the lysine in the gamma chain dodecapeptide of human fibrinogen is not enhanced by adsorption to poly(ethylene terephthalate) as measured by biotinylation and mass spectrometryVitaliy Ovod
Department of Biomedical Engineering and Center for Materials Innovation, Washington University, St Louis, Missouri, USA
J Biomed Mater Res A 100:622-31. 2012..The results do not directly address but are consistent with the hypothesis that only activated platelets adhere to adsorbed fibrinogen... - Stable isotope labeling tandem mass spectrometry (SILT): integration with peptide identification and extension to data-dependent scansDonald L Elbert
Department of Biomedical Engineering and Center for Materials Innovation, Washington University, St Louis, Missouri, USA
J Proteome Res 7:4546-56. 2008..The combination of identification with SILT facilitates quantitation without peak detection and helps to ensure the appropriate use of variable modifications for kinetics experiments... - Matrix metalloproteinase-9 degrades amyloid-beta fibrils in vitro and compact plaques in situPing Yan
Department of Neurology and the Hope Center for Neurological Disorders, Division of Endocrinology, Diabetes, Metabolism, and Lipid Research, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Biol Chem 281:24566-74. 2006..These findings suggest that MMP-9 can degrade fAbeta and may contribute to ongoing clearance of plaques from amyloid-laden brains... - Testing a test for Alzheimer diseaseRandall J Bateman
Neurology 68:482-3. 2007